| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735417P | 2012-12-10 | 2012-12-10 | |
| US201361794049P | 2013-03-15 | 2013-03-15 | |
| PCT/US2013/074102WO2014093330A1 (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| Publication Number | Publication Date |
|---|---|
| SG11201504334WAtrue SG11201504334WA (en) | 2015-07-30 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201504334WASG11201504334WA (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| SG10201704633UASG10201704633UA (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| SG10202009015SASG10202009015SA (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201704633UASG10201704633UA (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| SG10202009015SASG10202009015SA (en) | 2012-12-10 | 2013-12-10 | Methods for targeted genomic analysis |
| Country | Link |
|---|---|
| US (5) | US9932576B2 (en) |
| EP (3) | EP2929056A4 (en) |
| JP (5) | JP6410726B2 (en) |
| CN (3) | CN105531375B (en) |
| CA (1) | CA2892646A1 (en) |
| HK (1) | HK1213944A1 (en) |
| SG (3) | SG11201504334WA (en) |
| WO (1) | WO2014093330A1 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| HUE026666T2 (en) | 2010-04-05 | 2016-07-28 | Prognosys Biosciences Inc | Spatially encoded biological assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| WO2013059746A1 (en) | 2011-10-19 | 2013-04-25 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| SG11201404243WA (en) | 2012-01-26 | 2014-08-28 | Nugen Technologies Inc | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| EP2861787B1 (en) | 2012-06-18 | 2017-09-20 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| ES2906714T3 (en) | 2012-09-04 | 2022-04-20 | Guardant Health Inc | Methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| WO2014060483A1 (en) | 2012-10-17 | 2014-04-24 | Spatial Transcriptomics Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| WO2014093330A1 (en) | 2012-12-10 | 2014-06-19 | Clearfork Bioscience, Inc. | Methods for targeted genomic analysis |
| AU2014219180A1 (en)* | 2013-02-20 | 2015-10-08 | Emory University | Methods of sequencing nucleic acids in mixtures and compositions related thereto |
| US20140274738A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| CN105849275B (en) | 2013-06-25 | 2020-03-17 | 普罗格诺西斯生物科学公司 | Method and system for detecting spatial distribution of biological targets in a sample |
| KR102423377B1 (en) | 2013-08-05 | 2022-07-25 | 트위스트 바이오사이언스 코포레이션 | De novo synthesized gene libraries |
| US9546399B2 (en) | 2013-11-13 | 2017-01-17 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| ES2784450T3 (en) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Methods and systems to detect genetic variants |
| WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| PT3194612T (en)* | 2014-08-22 | 2024-10-02 | Resolution Bioscience Inc | Methods for quantitative genetic analysis of cell free dna |
| JP7441584B6 (en)* | 2014-08-22 | 2024-03-15 | レゾリューション バイオサイエンス， インコーポレイテッド | Method for quantitative genetic analysis of cell-free DNA (cfDNA) |
| JP2017537657A (en)* | 2014-12-11 | 2017-12-21 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | Target sequence enrichment |
| US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016161177A1 (en)* | 2015-03-31 | 2016-10-06 | Fred Hutchinson Cancer Research Center | Compositions and methods for target nucleic acid molecule enrichment |
| CA2982146A1 (en) | 2015-04-10 | 2016-10-13 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| JP6698708B2 (en) | 2015-06-09 | 2020-05-27 | ライフ テクノロジーズ コーポレーション | Methods, systems, compositions, kits, devices, and computer-readable media for molecular tagging |
| CA2998169A1 (en) | 2015-09-18 | 2017-03-23 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| KR102794025B1 (en) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | Flexible substrates for nucleic acid synthesis |
| EP3889257A1 (en)* | 2015-11-11 | 2021-10-06 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| EP3384077A4 (en) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | FUNCTIONALIZED SURFACES AND THEIR PREPARATION |
| CA3008651A1 (en) | 2015-12-17 | 2017-06-22 | Guardant Health, Inc. | Methods to determine tumor gene copy number by analysis of cell-free dna |
| JP6908615B2 (en)* | 2016-02-11 | 2021-07-28 | エイチティージー モレキュラー ダイアグノスティクス， インコーポレイテッド | Direct target sequencing methods using nuclease protection |
| US10240196B2 (en) | 2016-05-27 | 2019-03-26 | Agilent Technologies, Inc. | Transposase-random priming DNA sample preparation |
| CN107058310A (en)* | 2016-08-12 | 2017-08-18 | 艾吉泰康生物科技(北京)有限公司 | A kind of amplicon library constructing method for improving gene low frequency abrupt climatic change sensitivity |
| SG11201901563UA (en) | 2016-08-22 | 2019-03-28 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
| MX2019002093A (en)* | 2016-08-25 | 2019-06-20 | Resolution Bioscience Inc | Methods for the detection of genomic copy changes in dna samples. |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| EA201991262A1 (en) | 2016-12-16 | 2020-04-07 | Твист Байосайенс Корпорейшн | LIBRARIES OF OPTIONS OF IMMUNOLOGICAL SYNAPSIS AND THEIR SYNTHESIS |
| CN110892485B (en) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | Nucleic acid-based data storage |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CA3066047A1 (en) | 2017-06-14 | 2018-12-20 | Technische Universitat Dresden | Methods and means for genetic alteration of genomes utilizing designer dna recombining enzymes |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| KR102637566B1 (en) | 2017-10-20 | 2024-02-16 | 트위스트 바이오사이언스 코포레이션 | Heated nanowells for polynucleotide synthesis |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| WO2019113563A1 (en)* | 2017-12-09 | 2019-06-13 | Viome, Inc. | Methods for nucleic acid library creation |
| SG11202006460SA (en) | 2018-01-04 | 2020-08-28 | Twist Bioscience Corp | Dna-based digital information storage |
| WO2019139994A1 (en)* | 2018-01-10 | 2019-07-18 | Memorial Sloan Kettering Cancer Center | Generating configurable text strings based on raw genomic data |
| EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
| CN108866155B (en)* | 2018-06-11 | 2022-07-26 | 中国农业科学院深圳农业基因组研究所 | A kind of preparation method of next generation sequencing library |
| WO2020005159A1 (en)* | 2018-06-25 | 2020-01-02 | Lucence Life Sciences Pte. Ltd. | Method for detection and quantification of genetic alterations |
| FI3827011T3 (en)* | 2018-07-24 | 2024-09-09 | Salish Bioscience Inc | Methods and composition for targeted genomic analysis |
| EP3837358A4 (en)* | 2018-08-17 | 2022-05-04 | Dana-Farber Cancer Institute, Inc. | DNA AMPLIFICATION PROCEDURE FOR PROBE GENERATION |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| JP7124877B2 (en) | 2018-09-07 | 2022-08-24 | 富士通株式会社 | Identification method, identification program and information processing device |
| WO2020123319A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| CN119708086A (en) | 2018-12-26 | 2025-03-28 | 特韦斯特生物科学公司 | Highly accurate de novo polynucleotide synthesis |
| EP3906318A1 (en)* | 2019-01-06 | 2021-11-10 | 10X Genomics, Inc. | Methods and systems for enrichment of barcodes |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11492727B2 (en) | 2019-02-26 | 2022-11-08 | Twist Bioscience Corporation | Variant nucleic acid libraries for GLP1 receptor |
| CN113785057A (en) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | Variant nucleic acid libraries for antibody optimization |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2020257612A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| EP3994258A4 (en) | 2019-07-03 | 2022-10-26 | Integrated Dna Technologies, Inc. | IDENTIFICATION, CHARACTERIZATION, AND QUANTIFICATION OF CRISPR-INITIATED DOUBLE STRAND DNA BREAK REPAIRS |
| JP2022544578A (en)* | 2019-08-16 | 2022-10-19 | レゾリューション バイオサイエンス， インコーポレイテッド | Targeted hybrid capture method for determining T cell repertoire |
| WO2021061842A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for single domain antibodies |
| WO2021061829A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| CN119193713A (en) | 2019-10-24 | 2024-12-27 | 合成Dna技术公司 | Modified double-stranded donor template |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| EP3831939A1 (en)* | 2019-12-06 | 2021-06-09 | Technische Universität Dresden | Fusion of site-specific recombinases for efficient and specific genome editing |
| WO2021133842A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| AU2020412766C1 (en) | 2019-12-23 | 2025-01-02 | 10X Genomics, Inc. | Methods for spatial analysis using RNA-templated ligation |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12059674B2 (en) | 2020-02-03 | 2024-08-13 | Tecan Genomics, Inc. | Reagent storage system |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US12399123B1 (en) | 2020-02-14 | 2025-08-26 | 10X Genomics, Inc. | Spatial targeting of analytes |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| ES3014967T3 (en) | 2020-04-22 | 2025-04-28 | 10X Genomics Inc | Methods for spatial analysis using targeted rna depletion |
| WO2021236625A1 (en) | 2020-05-19 | 2021-11-25 | 10X Genomics, Inc. | Electrophoresis cassettes and instrumentation |
| EP4414459B1 (en) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| EP4158054B1 (en) | 2020-06-02 | 2025-04-16 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
| EP4025692A2 (en) | 2020-06-02 | 2022-07-13 | 10X Genomics, Inc. | Nucleic acid library methods |
| US12265079B1 (en) | 2020-06-02 | 2025-04-01 | 10X Genomics, Inc. | Systems and methods for detecting analytes from captured single biological particles |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| EP4446430A3 (en) | 2020-06-10 | 2024-12-18 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| US12435363B1 (en) | 2020-06-10 | 2025-10-07 | 10X Genomics, Inc. | Materials and methods for spatial transcriptomics |
| AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| KR20230040370A (en)* | 2020-07-23 | 2023-03-22 | 인티그레이티드 디엔에이 테크놀로지스 아이엔씨. | Designation method of nuclease on-/off-target editing sites designated by ″CTL-seq″ (CRISPR Tag Linear-seq) |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| EP4491742A3 (en) | 2020-09-18 | 2025-05-21 | 10x Genomics, Inc. | Sample handling apparatus and image registration methods |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| CN112481371A (en)* | 2020-12-11 | 2021-03-12 | 长沙金域医学检验实验室有限公司 | Kit for detecting copy number variation of PLP1 gene |
| AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| WO2022178267A2 (en) | 2021-02-19 | 2022-08-25 | 10X Genomics, Inc. | Modular assay support devices |
| EP4524261A3 (en) | 2021-03-18 | 2025-05-14 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
| JP2024512156A (en)* | 2021-03-30 | 2024-03-18 | レゾリューション バイオサイエンス， インコーポレイテッド | Compositions and methods for simultaneous genetic analysis of multiple libraries |
| EP4305196B1 (en) | 2021-04-14 | 2025-04-02 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| US12176070B2 (en)* | 2021-04-19 | 2024-12-24 | University Of Utah Research Foundation | Systems and methods for facilitating rapid genome sequence analysis |
| EP4320271B1 (en) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4347879B1 (en) | 2021-06-03 | 2025-02-19 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| CN113684259B (en)* | 2021-08-20 | 2024-08-30 | 陕西佰美基因股份有限公司 | Method for detecting CYP2D6 gene copy number based on non-labeled probe melting technology, primer pair and non-labeled probe combination and kit |
| EP4196605B1 (en) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Methods for blocking a capture probe on a spatial array |
| EP4419707A1 (en) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| EP4441711A1 (en) | 2021-12-20 | 2024-10-09 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
| CN114898802B (en)* | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | Terminal sequence frequency distribution characteristic determination method, evaluation method and device based on plasma free DNA methylation sequencing data |
| US20250223632A1 (en)* | 2024-01-05 | 2025-07-10 | Harbinger Health, Inc. | Probe blockers for enrichment of target nucleic acid sequences |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| CA2185239C (en) | 1994-03-16 | 2002-12-17 | Nanibhushan Dattagupta | Isothermal strand displacement nucleic acid amplification |
| US5514551A (en) | 1994-10-14 | 1996-05-07 | Gen-Probe Incorporated | Compositions for the detection of Chlamydia trachomatis |
| US5888731A (en) | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| US6025133A (en) | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| CA2268368A1 (en) | 1997-08-28 | 1999-03-11 | The Perkin-Elmer Corporation | Improved detection of mutations in nucleic acids by chemical cleavage |
| AU1450699A (en) | 1997-10-31 | 1999-05-24 | Gen-Probe Incorporated | Methods of nucleic acid detection |
| US6480791B1 (en)* | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| JP2004527221A (en) | 2000-09-12 | 2004-09-09 | ジェン−プロウブ インコーポレイテッド | Compositions, methods and kits for determining the presence of Cryptosporidium organisms in a test sample |
| US6812341B1 (en) | 2001-05-11 | 2004-11-02 | Ambion, Inc. | High efficiency mRNA isolation methods and compositions |
| US7183052B2 (en)* | 2001-07-17 | 2007-02-27 | Stratagene California | Methods for detection of a target nucleic acid using multi-subunit probes |
| US7432084B2 (en)* | 2001-08-31 | 2008-10-07 | Rosetta Inpharmatics Llc | Methods for preparing nucleic acid samples |
| US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
| JP4441623B2 (en) | 2002-12-11 | 2010-03-31 | 学校法人慶應義塾 | Method for producing and using library of mapping molecule and component thereof |
| TW200506052A (en) | 2003-05-07 | 2005-02-16 | Takara Bio Inc | Method of analyzing DNA region |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| EP1910565A4 (en) | 2005-07-07 | 2009-10-28 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
| GB0522310D0 (en)* | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US7572643B2 (en) | 2005-11-21 | 2009-08-11 | E. I. Du Pont De Nemours And Company | Nanoparticle composite-coated glass microspheres for use in bioassays |
| US20070117089A1 (en) | 2005-11-21 | 2007-05-24 | Croker Kevin M | Sol-gel coated glass microspheres for use in bioassay |
| EP1989318B1 (en) | 2006-01-06 | 2014-07-30 | Agilent Technologies, Inc. | Reaction buffer composition for nucleic acid replication with packed dna polymerases |
| WO2007087312A2 (en)* | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US7754429B2 (en)* | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| WO2008045158A1 (en) | 2006-10-10 | 2008-04-17 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
| WO2008070375A2 (en) | 2006-11-09 | 2008-06-12 | Complete Genomics, Inc. | Selection of dna adaptor orientation |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| US8067164B2 (en) | 2007-08-12 | 2011-11-29 | Integrated Dna Technologies, Inc. | Microarray system with improved sequence specificity |
| US9388457B2 (en)* | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
| WO2009076238A2 (en) | 2007-12-05 | 2009-06-18 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| WO2009091798A1 (en) | 2008-01-16 | 2009-07-23 | Helicos Biosciences Corporation | Quantitative genetic analysis |
| US8202691B2 (en) | 2008-01-25 | 2012-06-19 | Illumina, Inc. | Uniform fragmentation of DNA using binding proteins |
| US20100029498A1 (en) | 2008-02-04 | 2010-02-04 | Andreas Gnirke | Selection of nucleic acids by solution hybridization to oligonucleotide baits |
| DE102008008313A1 (en) | 2008-02-07 | 2009-08-13 | Qiagen Gmbh | Amplification of bisulfited nucleic acids |
| AU2009226248B8 (en)* | 2008-03-17 | 2014-10-02 | Stichting Genetwister Ip | Expression-linked gene discovery |
| US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
| WO2010038042A1 (en) | 2008-10-02 | 2010-04-08 | Illumina Cambridge Ltd. | Nucleic acid sample enrichment for sequencing applications |
| ES2550237T3 (en)* | 2008-10-24 | 2015-11-05 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
| WO2010068856A1 (en) | 2008-12-11 | 2010-06-17 | Trustees Of Boston University | Isolation of rna |
| CN102439177B (en)* | 2009-04-02 | 2014-10-01 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding target nucleic acids |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20110003301A1 (en) | 2009-05-08 | 2011-01-06 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
| ES2595055T3 (en) | 2009-08-25 | 2016-12-27 | Illumina, Inc. | Methods to select and amplify polynucleotides |
| US8835358B2 (en)* | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US10378064B1 (en) | 2010-04-16 | 2019-08-13 | Chronix Biomedical | Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10017812B2 (en) | 2010-05-18 | 2018-07-10 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US8828688B2 (en)* | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| WO2011156529A2 (en) | 2010-06-08 | 2011-12-15 | Nugen Technologies, Inc. | Methods and composition for multiplex sequencing |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| AU2011305445B2 (en)* | 2010-09-24 | 2017-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target DNA using immobilized primers |
| KR101891847B1 (en) | 2010-11-30 | 2018-08-24 | 더 차이니즈 유니버시티 오브 홍콩 | Detection of genetic or molecular aberrations associated with cancer |
| IL290139B2 (en) | 2010-12-30 | 2025-02-01 | Found Medicine Inc | Optimization of multigene analysis of tumor samples |
| WO2012129363A2 (en)* | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| WO2012138365A1 (en) | 2011-04-05 | 2012-10-11 | E. I. Du Pont De Nemours And Company | Amine-accelerated process for the surface treatment of colloidal silica and products thereof |
| ES2692333T3 (en) | 2011-04-12 | 2018-12-03 | Verinata Health, Inc | Resolution of genome fractions using polymorphism count |
| CN110016499B (en) | 2011-04-15 | 2023-11-14 | 约翰·霍普金斯大学 | Safe sequencing system |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| CN103103624B (en) | 2011-11-15 | 2014-12-31 | 深圳华大基因科技服务有限公司 | Method for establishing high-throughput sequencing library and application thereof |
| US10227587B2 (en) | 2012-01-10 | 2019-03-12 | Berry Genomics Co., Ltd. | Method for constructing a plasma DNA sequencing library |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| US20130288915A1 (en) | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| AU2013267609C1 (en) | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| WO2014008447A1 (en) | 2012-07-03 | 2014-01-09 | Integrated Dna Technologies, Inc. | Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection |
| ES2742285T3 (en) | 2012-07-31 | 2020-02-13 | Novartis Ag | Markers associated with sensitivity to human double minute inhibitors 2 (MDM2) |
| WO2014022830A2 (en) | 2012-08-03 | 2014-02-06 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| ES2906714T3 (en) | 2012-09-04 | 2022-04-20 | Guardant Health Inc | Methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CA2886605A1 (en) | 2012-09-28 | 2014-04-03 | Cepheid | Two-primer pcr for microrna multiplex assay |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA3120521A1 (en) | 2012-10-04 | 2014-04-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2014071295A1 (en) | 2012-11-02 | 2014-05-08 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| WO2014093330A1 (en) | 2012-12-10 | 2014-06-19 | Clearfork Bioscience, Inc. | Methods for targeted genomic analysis |
| PL2931922T3 (en) | 2012-12-14 | 2019-04-30 | Chronix Biomedical | Personalized biomarkers for cancer |
| US11158425B2 (en) | 2013-01-05 | 2021-10-26 | Foundation Medicine, Inc. | System and method for managing genomic information |
| WO2014116881A1 (en) | 2013-01-23 | 2014-07-31 | Reproductive Genetics And Technology Solutions, Llc | Compositions and methods for genetic analysis of embryos |
| US10745686B2 (en) | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
| WO2014151117A1 (en) | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| CA3156663A1 (en) | 2013-03-15 | 2014-09-18 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| HK1222466A1 (en) | 2013-05-10 | 2017-06-30 | Foundation Medicine, Inc | Analysis of genetic variants |
| US20150072344A1 (en) | 2013-09-10 | 2015-03-12 | Imdaptive Incorporated | Barcoded Universal Marker Indicator (BUMI) Tags |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US9546399B2 (en) | 2013-11-13 | 2017-01-17 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| CN103668471B (en) | 2013-12-19 | 2015-09-30 | 上海交通大学 | A kind of method of constructed dna high-throughput sequencing library and matched reagent box thereof |
| ES2784450T3 (en) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Methods and systems to detect genetic variants |
| CN109971826B (en) | 2014-01-31 | 2022-12-30 | 斯威夫特生物科学股份有限公司 | Improved method for processing DNA substrates |
| WO2015134552A1 (en) | 2014-03-03 | 2015-09-11 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| US10975371B2 (en) | 2014-04-29 | 2021-04-13 | Illumina, Inc. | Nucleic acid sequence analysis from single cells |
| AU2015279617A1 (en) | 2014-06-26 | 2017-01-12 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| WO2016022833A1 (en) | 2014-08-06 | 2016-02-11 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| PT3194612T (en) | 2014-08-22 | 2024-10-02 | Resolution Bioscience Inc | Methods for quantitative genetic analysis of cell free dna |
| US10648031B2 (en) | 2014-09-05 | 2020-05-12 | Qiagen Gmbh | Preparation of adapter-ligated amplicons |
| US11085084B2 (en) | 2014-09-12 | 2021-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| AU2014406026B2 (en) | 2014-09-12 | 2018-08-23 | Mgi Tech Co., Ltd. | Isolated oligonucleotide and use thereof in nucleic acid sequencing |
| ES2989276T3 (en) | 2014-12-05 | 2024-11-25 | Found Medicine Inc | Multigene analysis of tumor samples |
| EP3502273B1 (en) | 2014-12-12 | 2020-07-08 | Verinata Health, Inc. | Cell-free dna fragment |
| AU2015374259B2 (en) | 2014-12-31 | 2020-08-13 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| CN107771221B (en) | 2015-02-10 | 2021-11-02 | 香港中文大学 | Mutation Detection for Cancer Screening and Fetal Analysis |
| EP3325664B1 (en) | 2015-07-23 | 2021-12-29 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
| US10954609B2 (en) | 2015-07-29 | 2021-03-23 | Dupont Safety & Construction, Inc. | Yarn from polymers having different decomposition temperatures and process for forming same |
| CN108474040B (en) | 2015-10-09 | 2023-05-16 | 夸登特健康公司 | Population-based treatment recommendations using cell-free DNA |
| EP3693459A1 (en) | 2015-10-10 | 2020-08-12 | Guardant Health, Inc. | Methods and applications of gene fusion detection in cell-free dna analysis |
| EP3889257A1 (en) | 2015-11-11 | 2021-10-06 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| JP6930992B2 (en) | 2016-02-29 | 2021-09-01 | ファウンデーション・メディシン・インコーポレイテッド | Methods and systems for assessing tumor mutation loading |
| WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
| MX2019002093A (en) | 2016-08-25 | 2019-06-20 | Resolution Bioscience Inc | Methods for the detection of genomic copy changes in dna samples. |
| JP6560465B1 (en) | 2016-09-30 | 2019-08-21 | ガーダント ヘルス， インコーポレイテッド | Method for multi-resolution analysis of cell-free nucleic acids |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| DK3541934T5 (en) | 2016-11-17 | 2024-10-07 | Lgc Clinical Diagnostics Inc | Methods for preparing dna reference material and controls |
| CA3048420A1 (en) | 2016-12-09 | 2018-06-14 | Boreal Genomics, Inc. | Linked ligation |
| ES2868074T3 (en) | 2017-04-14 | 2021-10-21 | Guardant Health Inc | Methods for binding adapters to sample nucleic acids |
| EP3884047B1 (en) | 2018-11-21 | 2025-10-08 | Agilent Technologies, Inc. | Methods for targeted nucleic acid library formation |
| JP2023540782A (en) | 2020-09-08 | 2023-09-26 | レゾリューション バイオサイエンス， インコーポレイテッド | Adapters and methods for highly efficient construction of gene libraries and genetic analysis |
| JP2024512156A (en) | 2021-03-30 | 2024-03-18 | レゾリューション バイオサイエンス， インコーポレイテッド | Compositions and methods for simultaneous genetic analysis of multiple libraries |
| Publication number | Publication date |
|---|---|
| US20250154496A1 (en) | 2025-05-15 |
| CN111254500B (en) | 2024-01-23 |
| US20240360437A1 (en) | 2024-10-31 |
| WO2014093330A1 (en) | 2014-06-19 |
| US11999949B2 (en) | 2024-06-04 |
| EP2929056A1 (en) | 2015-10-14 |
| JP7223790B2 (en) | 2023-02-16 |
| US20210198658A1 (en) | 2021-07-01 |
| JP2021078515A (en) | 2021-05-27 |
| CN105531375B (en) | 2020-03-03 |
| HK1213944A1 (en) | 2016-07-15 |
| JP2019004910A (en) | 2019-01-17 |
| US20140274731A1 (en) | 2014-09-18 |
| JP2023182855A (en) | 2023-12-26 |
| SG10201704633UA (en) | 2017-07-28 |
| JP6842450B2 (en) | 2021-03-17 |
| US20180142234A1 (en) | 2018-05-24 |
| CN111254500A (en) | 2020-06-09 |
| EP4293125A3 (en) | 2024-02-28 |
| JP2022025140A (en) | 2022-02-09 |
| CA2892646A1 (en) | 2014-06-19 |
| CN105531375A (en) | 2016-04-27 |
| EP3561072A1 (en) | 2019-10-30 |
| US9932576B2 (en) | 2018-04-03 |
| JP7377247B2 (en) | 2023-11-09 |
| JP7710016B2 (en) | 2025-07-17 |
| JP6410726B2 (en) | 2018-10-24 |
| SG10202009015SA (en) | 2020-10-29 |
| EP2929056A4 (en) | 2016-11-09 |
| EP4293125A2 (en) | 2023-12-20 |
| JP2015536156A (en) | 2015-12-21 |
| CN117845337A (en) | 2024-04-09 |
| US10907149B2 (en) | 2021-02-02 |
| Publication | Publication Date | Title |
|---|---|---|
| SG11201504334WA (en) | Methods for targeted genomic analysis | |
| IL255724A (en) | Malware analysis system | |
| IL245935A0 (en) | Methods for rna analysis | |
| EP3965111B8 (en) | Methods for genomic analysis | |
| ZA201307225B (en) | Methods for genomic modification | |
| LT3305918T (en) | Methods for epigenetic sequencing | |
| EP2768983A4 (en) | Analysis methods | |
| ZA201501833B (en) | Method for obtaining 1-kestone | |
| GB201217018D0 (en) | Methods | |
| GB201223172D0 (en) | Method | |
| EP2832465A4 (en) | Press-forming analysis method | |
| EP2693217A4 (en) | Analysis device | |
| LT2852602T (en) | Method for conjugating oligonucleotides | |
| EP2878953A4 (en) | Analysis device | |
| EP2685257A4 (en) | Analysis method | |
| GB2507760B (en) | Methods | |
| GB201208874D0 (en) | Methods | |
| EP2899655A4 (en) | Analysis device | |
| GB201211393D0 (en) | Method | |
| GB201204280D0 (en) | Methods | |
| GB201223316D0 (en) | Method | |
| GB201209689D0 (en) | Methods | |
| GB201210147D0 (en) | Method | |
| GB201201332D0 (en) | Method | |
| HK40108136A (en) | Methods for targeted genomic analysis |