SG11201503558SA - Dihydropyrazole gpr40 modulators - Google Patents

Dihydropyrazole gpr40 modulators

Info

Publication number: SG11201503558SA
Authority: SG; Singapore
Prior art keywords: gpr40 modulators; dihydropyrazole; dihydropyrazole gpr40; modulators; gpr40
Prior art date: 2012-11-16

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-11-15Application filed by Bristol Myers Squibb CofiledCriticalBristol Myers Squibb Co

2015-06-29Publication of SG11201503558SApublicationCriticalpatent/SG11201503558SA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Optical Integrated Circuits (AREA)

SG11201503558SA2012-11-162013-11-15Dihydropyrazole gpr40 modulatorsSG11201503558SA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261727262P	2012-11-16	2012-11-16
US201361777294P	2013-03-12	2013-03-12
PCT/US2013/070215WO2014078610A1 (en)	2012-11-16	2013-11-15	Dihydropyrazole gpr40 modulators

Publications (1)

Publication Number	Publication Date
SG11201503558SAtrue SG11201503558SA (en)	2015-06-29

Family

ID=49876965

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201503558SASG11201503558SA (en)	2012-11-16	2013-11-15	Dihydropyrazole gpr40 modulators

Country Status (26)

Country	Link
US (1)	US9133163B2 (en)
EP (1)	EP2920165B1 (en)
JP (1)	JP6322203B2 (en)
KR (1)	KR102204804B1 (en)
CN (1)	CN104812748B (en)
AU (1)	AU2013344604B2 (en)
BR (1)	BR112015010779A2 (en)
CA (1)	CA2891574A1 (en)
CY (1)	CY1118365T1 (en)
DK (1)	DK2920165T3 (en)
EA (1)	EA026913B1 (en)
ES (1)	ES2606685T3 (en)
HR (1)	HRP20161631T1 (en)
HU (1)	HUE032401T2 (en)
IL (1)	IL238741A0 (en)
LT (1)	LT2920165T (en)
MX (1)	MX358499B (en)
PL (1)	PL2920165T3 (en)
PT (1)	PT2920165T (en)
RS (1)	RS55363B1 (en)
SG (1)	SG11201503558SA (en)
SI (1)	SI2920165T1 (en)
SM (1)	SMT201600410B (en)
TW (1)	TW201427971A (en)
UY (1)	UY35143A (en)
WO (1)	WO2014078610A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6322204B2 (en)*	2012-11-16	2018-05-09	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	GPR40 modulator of dihydropyrazole
US10011609B2 (en)	2013-11-14	2018-07-03	Cadila Healthcare Limited	Heterocyclic compounds
JP6488320B2 (en)*	2014-05-07	2019-03-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Pyrrolidine GPR40 modulator for the treatment of diseases such as diabetes
NZ727146A (en)*	2014-05-07	2020-01-31	Bristol Myers Squibb Co	Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes
WO2016022446A1 (en)	2014-08-08	2016-02-11	Merck Sharp & Dohme Corp.	[5,6]-fused bicyclic antidiabetic compounds
WO2016019587A1 (en)	2014-08-08	2016-02-11	Merck Sharp & Dohme Corp.	[7, 6]-fused bicyclic antidiabetic compounds
US10968193B2 (en)	2014-08-08	2021-04-06	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
WO2016022448A1 (en)	2014-08-08	2016-02-11	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
WO2018181847A1 (en)	2017-03-31	2018-10-04	武田薬品工業株式会社	Aromatic compound
EP4227302A1 (en)	2018-02-13	2023-08-16	Gilead Sciences, Inc.	Pd-1/pd-l1 inhibitors
CN112041311B (en)	2018-04-19	2023-10-03	吉利德科学公司	PD-1/PD-L1 inhibitors
CA3103286C (en)	2018-07-13	2023-05-09	Gilead Sciences, Inc.	Pd-1/pd-l1 inhibitors
CN112955435B (en)	2018-10-24	2024-09-06	吉利德科学公司	PD-1/PD-L1 inhibitors
CN115490638A (en)*	2022-09-22	2022-12-20	哈尔滨理工大学	5-functionalized pyrazolines and process for their preparation
CN115671105B (en)*	2022-11-22	2023-10-27	北京箭牧科技有限公司	Application of LY2922470 in preparation of medicines for preventing or treating kidney diseases
CN119431272B (en)*	2024-11-13	2025-07-25	北京斯利安药业有限公司	Preparation method of (S) -3-methyl- (2-piperidylphenyl) -1-butylamine acetyl glutamate

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5614492A (en)	1986-05-05	1997-03-25	The General Hospital Corporation	Insulinotropic hormone GLP-1 (7-36) and uses thereof
EP1513817A1 (en)	2002-05-24	2005-03-16	Takeda Pharmaceutical Company Limited	1, 2-azole derivatives with hypoglycemic and hypolipidemic activity
EP1656368A4 (en)	2002-07-09	2009-08-26	Bristol Myers Squibb Co	Substituted hertocyclic derivatives useful as antidiabetic and antiobesity agents and method
US7501440B2 (en)	2003-03-07	2009-03-10	Sanofi-Aventis Deutschland Gmbh	Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
AU2005212817A1 (en)*	2004-02-17	2005-08-25	Laboratorios Dr. Esteve S.A.	Substituted pyrazoline compounds for reducing triglycerides in blood
EP1637522A1 (en)*	2004-09-16	2006-03-22	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds for reducing triglycerides in blood
CN1946666A (en)	2004-02-27	2007-04-11	埃姆艮股份有限公司	Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
EP1731505B1 (en)	2004-03-30	2015-01-14	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
JP2007284350A (en)	2004-07-27	2007-11-01	Takeda Chem Ind Ltd	Diabetes treatment
US7465804B2 (en)	2005-05-20	2008-12-16	Amgen Inc.	Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
EP1743894A1 (en)*	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	Heterocyclyl-substituted pyrazoline compounds, their preparation and use as medicaments
WO2007013689A1 (en)	2005-07-29	2007-02-01	Takeda Pharmaceutical Company Limited	Cyclopropanecarboxylic acid compound
US7582803B2 (en)	2005-09-14	2009-09-01	Amgen Inc.	Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders
JP2009530281A (en)	2006-03-14	2009-08-27	アムジエン・インコーポレーテツド	Bicyclic carboxylic acid derivatives useful for the treatment of metabolic disorders
CA2656003C (en)	2006-06-27	2014-03-25	Tsuneo Yasuma	Fused cyclic compounds
AU2007293028B2 (en)	2006-09-07	2012-05-31	Amgen Inc.	Heterocyclic GPR40 modulators
US8039484B2 (en)	2006-10-31	2011-10-18	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
JP2010524932A (en)	2007-04-16	2010-07-22	アムジエン・インコーポレーテツド	Substituted biphenylphenoxy-, thiophenyl- and aminophenylpropanoic acid GPR40 modulators
CN102083783A (en)	2007-10-10	2011-06-01	安姆根有限公司	Substituted biphenyl GPR40 modulators
MX2010004435A (en)	2007-10-26	2010-05-13	Japan Tobacco Inc	Spiro-ring compound and use thereof for medical purposes.
AR070898A1 (en)*	2008-03-18	2010-05-12	Solvay Pharm Bv	ARILSULFONIL PIRAZOLIN CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS
US8236821B2 (en)	2008-05-19	2012-08-07	Jenrin Discovery, Inc.	Substituted N-phenyl-5-phenyl-pyrazolin-3-yl amides as cannabinoid receptor antagonists/inverse agonists useful for treating obesity
CA2777041A1 (en)*	2009-10-06	2011-04-14	Bristol-Myers Squibb Company	Pyrrolidine gpr40 modulators
AR078522A1 (en)	2009-10-15	2011-11-16	Lilly Co Eli	SPIROPIPERIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT DIABETES AND INTERMEDIARY COMPOUND FOR SYNTHESIS
EP2640381A4 (en)*	2010-11-18	2014-05-21	Jenrin Discovery	Cannabinoid receptor antagonists-inverse agonists useful for treating metabolic disorders, including obesity and diabetes
US9000175B2 (en)*	2010-11-26	2015-04-07	Lupin Limited	Bicyclic GPR119 modulators
US8791091B2 (en)	2011-12-02	2014-07-29	Bristol-Myers Squibb Company	Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
US9326218B2 (en)*	2012-11-02	2016-04-26	Telefonaktiebolaget L M Ericsson (Publ)	Base-station-to-base-station gateway and related devices, methods, and systems
JP6322204B2 (en)*	2012-11-16	2018-05-09	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	GPR40 modulator of dihydropyrazole
US8962660B2 (en)*	2013-03-14	2015-02-24	Bristol-Myers Squibb Company	Oxabicyclo [2.2.2] acid GPR120 modulators

2013
- 2013-11-15SGSG11201503558SApatent/SG11201503558SA/enunknown
- 2013-11-15LTLTEP13811645.4Tpatent/LT2920165T/enunknown
- 2013-11-15PLPL13811645Tpatent/PL2920165T3/enunknown
- 2013-11-15SISI201330340Tpatent/SI2920165T1/enunknown
- 2013-11-15USUS14/081,094patent/US9133163B2/enactiveActive
- 2013-11-15HUHUE13811645Apatent/HUE032401T2/enunknown
- 2013-11-15CNCN201380059799.5Apatent/CN104812748B/ennot_activeExpired - Fee Related
- 2013-11-15RSRS20161061Apatent/RS55363B1/enunknown
- 2013-11-15UYUY0001035143Apatent/UY35143A/ennot_activeApplication Discontinuation
- 2013-11-15BRBR112015010779Apatent/BR112015010779A2/ennot_activeApplication Discontinuation
- 2013-11-15AUAU2013344604Apatent/AU2013344604B2/ennot_activeCeased
- 2013-11-15WOPCT/US2013/070215patent/WO2014078610A1/enactiveApplication Filing
- 2013-11-15EAEA201590954Apatent/EA026913B1/ennot_activeIP Right Cessation
- 2013-11-15HRHRP20161631TTpatent/HRP20161631T1/enunknown
- 2013-11-15TWTW102141762Apatent/TW201427971A/enunknown
- 2013-11-15KRKR1020157015541Apatent/KR102204804B1/enactiveActive
- 2013-11-15ESES13811645.4Tpatent/ES2606685T3/enactiveActive
- 2013-11-15EPEP13811645.4Apatent/EP2920165B1/enactiveActive
- 2013-11-15PTPT138116454Tpatent/PT2920165T/enunknown
- 2013-11-15MXMX2015005735Apatent/MX358499B/enactiveIP Right Grant
- 2013-11-15JPJP2015542798Apatent/JP6322203B2/ennot_activeExpired - Fee Related
- 2013-11-15CACA2891574Apatent/CA2891574A1/ennot_activeAbandoned
- 2013-11-15DKDK13811645.4Tpatent/DK2920165T3/enactive
2015
- 2015-05-11ILIL238741Apatent/IL238741A0/ennot_activeIP Right Cessation
2016
- 2016-11-14SMSM201600410Tpatent/SMT201600410B/enunknown
- 2016-12-16CYCY20161101309Tpatent/CY1118365T1/enunknown

Also Published As

Publication number	Publication date
US9133163B2 (en)	2015-09-15
CN104812748A (en)	2015-07-29
EP2920165B1 (en)	2016-09-28
AU2013344604B2 (en)	2017-07-27
PT2920165T (en)	2016-12-20
MX2015005735A (en)	2015-09-16
SMT201600410B (en)	2017-01-10
MX358499B (en)	2018-08-23
CY1118365T1 (en)	2017-06-28
SI2920165T1 (en)	2017-02-28
CN104812748B (en)	2017-10-24
LT2920165T (en)	2016-12-12
UY35143A (en)	2014-05-30
US20140142139A1 (en)	2014-05-22
HUE032401T2 (en)	2017-09-28
EA201590954A1 (en)	2015-08-31
PL2920165T3 (en)	2017-04-28
JP2016500063A (en)	2016-01-07
KR102204804B1 (en)	2021-01-18
TW201427971A (en)	2014-07-16
EP2920165A1 (en)	2015-09-23
ES2606685T3 (en)	2017-03-27
CA2891574A1 (en)	2014-05-22
JP6322203B2 (en)	2018-05-09
HRP20161631T1 (en)	2017-01-13
DK2920165T3 (en)	2017-01-16
WO2014078610A1 (en)	2014-05-22
EA026913B1 (en)	2017-05-31
BR112015010779A2 (en)	2017-07-11
AU2013344604A1 (en)	2015-07-02
RS55363B1 (en)	2017-03-31
IL238741A0 (en)	2015-06-30
KR20150082616A (en)	2015-07-15

Publication	Publication Date	Title
IL238780A0 (en)	2015-06-30	Dihydropyrazole gpr40 modulators
IL238741A0 (en)	2015-06-30	Dihydropyrazole gpr40 modulators
IL238779A0 (en)	2015-06-30	Dihydropyrazole gpr40 modulators
GB2509180B (en)	2015-04-08	Projector
IL238742A0 (en)	2015-06-30	Pyrrolidine gpr40 modulators
EP2793080A4 (en)	2015-05-27	Automatic-focus projection system
IL236304A0 (en)	2015-02-26	Diclofenac formulations
IL266719A (en)	2019-07-31	Tetracycline compounds
GB201812591D0 (en)	2018-09-19	Brake
IL239395A0 (en)	2015-07-30	Diclofenac composition
GB201222958D0 (en)	2013-01-30	Film
GB201420527D0 (en)	2014-12-31	Electrical-wire-protecting member
GB201219116D0 (en)	2012-12-05	Optical modulator
EP2860422A4 (en)	2016-01-13	Brake device
GB201222955D0 (en)	2013-01-30	Film
GB201108481D0 (en)	2011-07-06	Electro-optic modulator
GB2518076B (en)	2017-09-06	Electrical-wire-protecting member
GB201220595D0 (en)	2013-01-02	Keysafe application
GB201212028D0 (en)	2012-08-22	Epit
GB201216899D0 (en)	2012-11-07	Image solution
GB201207606D0 (en)	2012-06-13	Prodrugs
GB201203451D0 (en)	2012-04-11	Thin devices
GB201216524D0 (en)	2012-10-31	Project P
GB201213825D0 (en)	2012-09-19	Damper-device for bouncing-device

Movatterモバイル変換

SG11201503558SA - Dihydropyrazole gpr40 modulators - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=49876965

Family Applications (1)

Country Status (26)

Families Citing this family (16)

Family Cites Families (31)

Also Published As

Similar Documents