Movatterモバイル変換


[0]ホーム

URL:


SG11201404243WA - Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation - Google Patents

Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation

Info

Publication number
SG11201404243WA
SG11201404243WASG11201404243WASG11201404243WASG11201404243WASG 11201404243W ASG11201404243W ASG 11201404243WASG 11201404243W ASG11201404243W ASG 11201404243WASG 11201404243W ASG11201404243W ASG 11201404243WASG 11201404243W ASG11201404243W ASG 11201404243WA
Authority
SG
Singapore
Prior art keywords
compositions
methods
nucleic acid
acid sequence
high efficiency
Prior art date
Application number
SG11201404243WA
Inventor
Doug Amorese
Chris Armour
Nurith Kurn
Original Assignee
Nugen Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=48873972&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201404243W(A)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nugen Technologies IncfiledCriticalNugen Technologies Inc
Publication of SG11201404243WApublicationCriticalpatent/SG11201404243WA/en

Links

Classifications

Landscapes

SG11201404243WA2012-01-262013-01-25Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generationSG11201404243WA (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US201261591241P2012-01-262012-01-26
PCT/US2013/023278WO2013112923A1 (en)2012-01-262013-01-25Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation

Publications (1)

Publication NumberPublication Date
SG11201404243WAtrue SG11201404243WA (en)2014-08-28

Family

ID=48873972

Family Applications (2)

Application NumberTitlePriority DateFiling Date
SG11201404243WASG11201404243WA (en)2012-01-262013-01-25Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
SG10201504490QASG10201504490QA (en)2012-01-262013-01-25Compositions And Methods For Targeted Nucleic Acid Sequence Enrichment And High Efficiency Library Generation

Family Applications After (1)

Application NumberTitlePriority DateFiling Date
SG10201504490QASG10201504490QA (en)2012-01-262013-01-25Compositions And Methods For Targeted Nucleic Acid Sequence Enrichment And High Efficiency Library Generation

Country Status (7)

CountryLink
US (4)US9650628B2 (en)
EP (3)EP2807292B1 (en)
CN (2)CN105861487B (en)
CA (1)CA2862552A1 (en)
GB (2)GB2513793B (en)
SG (2)SG11201404243WA (en)
WO (1)WO2013112923A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
BR0205268A (en)2001-03-092004-11-30Nugen Technologies Inc Processes and compositions for mRNA sequence mplification
CA2521084A1 (en)2003-04-142004-10-28Nugen Technologies, Inc.Global amplification using a randomly primed composite primer
US7939258B2 (en)2005-09-072011-05-10Nugen Technologies, Inc.Nucleic acid amplification procedure using RNA and DNA composite primers
WO2010028288A2 (en)2008-09-052010-03-11Aueon, Inc.Methods for stratifying and annotating cancer drug treatment options
AU2011305445B2 (en)2010-09-242017-03-16The Board Of Trustees Of The Leland Stanford Junior UniversityDirect capture, amplification and sequencing of target DNA using immobilized primers
WO2013059746A1 (en)2011-10-192013-04-25Nugen Technologies, Inc.Compositions and methods for directional nucleic acid amplification and sequencing
SG11201404243WA (en)2012-01-262014-08-28Nugen Technologies IncCompositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
CN108018343B (en)2012-05-102023-01-03通用医疗公司Method for determining nucleotide sequence
EP2861787B1 (en)2012-06-182017-09-20Nugen Technologies, Inc.Compositions and methods for negative selection of non-desired nucleic acid sequences
US20150011396A1 (en)2012-07-092015-01-08Benjamin G. SchroederMethods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140024542A1 (en)*2012-07-172014-01-23Counsyl, Inc.Methods and compositions for enrichment of target polynucleotides
US20140274738A1 (en)2013-03-152014-09-18Nugen Technologies, Inc.Sequential sequencing
WO2014151117A1 (en)2013-03-152014-09-25The Board Of Trustees Of The Leland Stanford Junior UniversityIdentification and use of circulating nucleic acid tumor markers
US9546399B2 (en)2013-11-132017-01-17Nugen Technologies, Inc.Compositions and methods for identification of a duplicate sequencing read
CN116426520A (en)*2013-11-262023-07-14杭州联川基因诊断技术有限公司Selective amplification of nucleic acid sequences
CA2936564C (en)*2014-01-072022-10-18Fundacio Privada Institut De Medicina Predictiva I Personalitzada Del CancerMethods for generating double stranded dna libraries and sequencing methods for the identification of methylated cytosines
EP3099820A4 (en)2014-01-272018-01-03The General Hospital CorporationMethods of preparing nucleic acids for sequencing
WO2015112948A2 (en)*2014-01-272015-07-30Iafrate Anthony JohnMethods for determining a nucleotide sequence
CN109971826B (en)2014-01-312022-12-30斯威夫特生物科学股份有限公司Improved method for processing DNA substrates
CN110819621B (en)2014-02-112024-03-26豪夫迈·罗氏有限公司Targeted sequencing and UID filtration
WO2015131107A1 (en)2014-02-282015-09-03Nugen Technologies, Inc.Reduced representation bisulfite sequencing with diversity adaptors
WO2016022833A1 (en)*2014-08-062016-02-11Nugen Technologies, Inc.Digital measurements from targeted sequencing
WO2016033251A2 (en)*2014-08-262016-03-03Nugen Technologies, Inc.Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
AU2014406026B2 (en)*2014-09-122018-08-23Mgi Tech Co., Ltd.Isolated oligonucleotide and use thereof in nucleic acid sequencing
US11085084B2 (en)2014-09-122021-08-10The Board Of Trustees Of The Leland Stanford Junior UniversityIdentification and use of circulating nucleic acids
US20160083724A1 (en)*2014-09-242016-03-24University Of Southern CaliforniaMethods for sample preparation
CN107075512B (en)*2014-10-142021-01-15深圳华大智造科技股份有限公司Linker element and method for constructing sequencing library by using same
JP6430631B2 (en)2014-10-142018-11-28深▲せん▼華大智造科技有限公司 Linker elements and methods for constructing sequencing libraries using them
US10435736B2 (en)*2014-12-182019-10-08Mgi Tech Co., Ltd.Target region enrichment method based on multiplex PCR, and reagent
CN105714383B (en)*2014-12-222018-01-23深圳华大基因研究院A kind of sequencing library construction method and reagent based on the reverse probe of molecule
US11661597B2 (en)*2015-04-152023-05-30The Board Of Trustees Of The Leland Stanford Junior UniversityRobust quantification of single molecules in next-generation sequencing using non-random combinatorial oligonucleotide barcodes
US20180195060A1 (en)*2015-04-202018-07-12Bgi ShenzhenMethod for constructing long fragment dna library
US11274333B2 (en)2015-05-292022-03-15Molecular Cloning Laboratories (MCLAB) LLCCompositions and methods for preparing sequencing libraries
DK3325621T3 (en)*2015-07-172021-10-04Max Planck Gesellschaft Cloning of single-stranded nucleic acid
EP3118313A1 (en)*2015-07-172017-01-18Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Cloning of single-stranded rna
ES2841077T3 (en)2015-08-062021-07-07Hoffmann La Roche Target Enrichment by Single Probe Primer Extension
CA2997929A1 (en)2015-09-082017-03-16Cold Spring Harbor LaboratoryGenetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
CN109072294A (en)2015-12-082018-12-21特温斯特兰德生物科学有限公司For the improvement adapter of dual sequencing, method and composition
ES3019936T3 (en)2016-03-222025-05-21Myriad Womens Health IncCombinatorial dna screening
CN105734679B (en)*2016-03-292018-10-30重庆市肿瘤研究所Nucleic acid target sequence captures the preparation method of sequencing library
US12416047B2 (en)2016-05-062025-09-16Myriad Women's Health, Inc.Noninvasive prenatal diagnostic methods
US11414686B2 (en)2016-05-062022-08-16William Marsh Rice UniversityStoichiometric nucleic acid purification using randomer capture probe libraries
KR20170133270A (en)*2016-05-252017-12-05주식회사 셀레믹스Method for preparing libraries for massively parallel sequencing using molecular barcoding and the use thereof
US11098360B2 (en)2016-06-012021-08-24Roche Sequencing Solutions, Inc.Immuno-PETE
WO2017214557A1 (en)2016-06-102017-12-14Counsyl, Inc.Nucleic acid sequencing adapters and uses thereof
US10676734B2 (en)2016-07-122020-06-09Life Technologies CorporationCompositions and methods for detecting nucleic acid regions
CN118562788A (en)*2016-08-302024-08-30元素生物科学公司 Methods and compositions for phased sequencing
WO2018053362A1 (en)2016-09-152018-03-22ArcherDX, Inc.Methods of nucleic acid sample preparation
US10683531B2 (en)2016-09-152020-06-16ArcherDX, Inc.Methods of nucleic acid sample preparation for analysis of cell-free DNA
EP3518974A4 (en)2016-09-292020-05-27Myriad Women's Health, Inc.Noninvasive prenatal screening using dynamic iterative depth optimization
DK3519612T3 (en)*2016-10-012022-06-20Berkeley Lights Inc DNA BARCODE COMPOSITIONS AND METHODS FOR IN SITUATION IDENTIFICATION IN A MICROFLUID DEVICE
US10190155B2 (en)2016-10-142019-01-29Nugen Technologies, Inc.Molecular tag attachment and transfer
WO2018081113A1 (en)2016-10-242018-05-03Sawaya SterlingConcealing information present within nucleic acids
AU2017355460B2 (en)*2016-11-022022-12-08Archerdx, LlcMethods of nucleic acid sample preparation for immune repertoire sequencing
US10968447B2 (en)2017-01-312021-04-06Myriad Women's Health, Inc.Methods and compositions for enrichment of target polynucleotides
US10752946B2 (en)2017-01-312020-08-25Myriad Women's Health, Inc.Methods and compositions for enrichment of target polynucleotides
US12297491B2 (en)2017-03-082025-05-13Roche Sequencing Solutions, Inc.Primer extension target enrichment and improvements thereto including simultaneous enrichment of DNA and RNA
EP3592863A1 (en)2017-03-082020-01-15H. Hoffnabb-La Roche AgPrimer extension target enrichment and improvements thereto including simultaneous enrichment of dna and rna
US11479807B2 (en)2017-03-232022-10-25University Of WashingtonMethods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing
EP3602359A4 (en)2017-03-242021-01-06Myriad Women's Health, Inc.Copy number variant caller
US20180291443A1 (en)*2017-04-112018-10-11Nugen Technologies, Inc.Library Quantitation And Qualification
EP3610031A4 (en)*2017-04-112020-11-18Nugen Technologies, Inc. LIBRARY QUANTIFICATION AND QUALIFICATION
SG11201909914RA (en)2017-04-232019-11-28Illumina Cambridge LtdCompositions and methods for improving sample identification in indexed nucleic acid libraries
US10934584B2 (en)2017-04-232021-03-02Illumina, Inc.Compositions and methods for improving sample identification in indexed nucleic acid libraries
FI3872187T3 (en)*2017-04-232022-12-15Compositions and methods for improving sample identification in indexed nucleic acid libraries
SG11201909916YA (en)*2017-04-232019-11-28Illumina Cambridge LtdCompositions and methods for improving sample identification in indexed nucleic acid libraries
IL271205B2 (en)2017-06-122025-02-01Twist Bioscience CorpMethods for seamless nucleic acid assembly
CN107723354B (en)*2017-08-232021-09-07广州永诺健康科技有限公司 A multiplex PCR primer, kit and method for detecting oncogene mutations in non-small cell lung cancer based on high-throughput sequencing
US11099202B2 (en)2017-10-202021-08-24Tecan Genomics, Inc.Reagent delivery system
US20190119746A1 (en)*2017-10-202019-04-25Nugen Technologies, Inc.Oligonucleotides for selective amplification of nucleic acids
WO2019090251A2 (en)*2017-11-062019-05-09Illumina, Inc.Nucleic acid indexing techniques
US11739367B2 (en)2017-11-082023-08-29Twinstrand Biosciences, Inc.Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
CN111788316B (en)*2018-02-072024-11-29帝肯基因组学公司Library preparation
CN111868257B (en)*2018-03-022025-03-14豪夫迈·罗氏有限公司 Generation of double-stranded DNA templates for single-molecule sequencing
WO2019191900A1 (en)*2018-04-032019-10-10Burning Rock BiotechCompositions and methods for preparing nucleic acid libraries
WO2019238765A1 (en)*2018-06-122019-12-19Keygene N.V.Nucleic acid amplification method
BR112021000409A2 (en)2018-07-122021-04-06Twinstrand Biosciences, Inc. METHODS AND REAGENTS TO CHARACTERIZE GENOMIC EDITION, CLONAL EXPANSION AND ASSOCIATED APPLICATIONS
GB201811813D0 (en)*2018-07-192018-09-05Oxford Nanopore Tech LtdMethod
GB201811811D0 (en)2018-07-192018-09-05Oxford Nanopore Tech LtdMethod
JP7397874B2 (en)2018-08-302023-12-13エイチシーダブリュー バイオロジックス インコーポレイテッド Multichain chimeric polypeptides and their uses
US11401324B2 (en)*2018-08-302022-08-02HCW Biologics, Inc.Single-chain chimeric polypeptides and uses thereof
AU2019368024A1 (en)*2018-10-242021-04-15University Of WashingtonMethods and kits for depletion and enrichment of nucleic acid sequences
US20220127661A1 (en)*2019-03-042022-04-28King Abdullah University Of Science And TechnologyCompositions and methods of targeted nucleic acid enrichment by loop adapter protection and exonuclease digestion
WO2020236939A2 (en)2019-05-232020-11-26Paradigm DiagnosticsTissue preparation using nuclease
US11738052B2 (en)2019-06-212023-08-29HCW Biologics, Inc.Multi-chain chimeric polypeptides and uses thereof
CN114269917A (en)*2019-08-192022-04-01豪夫迈·罗氏有限公司Single tube preparation of DNA and RNA for sequencing
US20230193373A1 (en)*2019-08-202023-06-22Director-General Of National Institute Of Infectious DiseasesMethod for amplifying nucleotide sequence, and sequence determination
US12059674B2 (en)2020-02-032024-08-13Tecan Genomics, Inc.Reagent storage system
KR20220140572A (en)2020-02-112022-10-18에이치씨더블유 바이올로직스, 인크. How to Activate Regulatory T Cells
CN116670163A (en)2020-02-112023-08-29Hcw生物科技公司Methods of treating age-related and inflammatory diseases
CA3169625A1 (en)2020-02-112021-08-19HCW Biologics, Inc.Chromatography resin and uses thereof
CN111440846B (en)*2020-04-092020-12-18江苏先声医学诊断有限公司Position anchoring bar code system for nanopore sequencing library building
US12024545B2 (en)2020-06-012024-07-02HCW Biologics, Inc.Methods of treating aging-related disorders
CN115605590A (en)*2021-02-102023-01-13清华大学(Cn)Method for preparing site-directed modified long-chain DNA
JP2024537806A (en)*2021-09-292024-10-16シークウェル, インコーポレイテッド. Kits and methods for preparing nucleic acid libraries for sequencing
EP4422792A1 (en)2021-10-262024-09-04Singular Genomics Systems, Inc.Multiplexed targeted amplification of polynucleotides
WO2024197081A1 (en)2023-03-202024-09-26Hc Bioscience, Inc.Minimally-sized dna threads for trna therapy
CN120041539A (en)*2023-06-282025-05-27深圳赛陆医疗科技有限公司Library construction method combining low-depth whole genome sequencing and targeted sequencing

Family Cites Families (333)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4458066A (en)1980-02-291984-07-03University Patents, Inc.Process for preparing polynucleotides
US4469863A (en)1980-11-121984-09-04Ts O Paul O PNonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4362867A (en)1980-12-101982-12-07Research CorporationRecombinant cDNA construction method and hybrid nucleotides useful in cloning
US5171534A (en)1984-01-161992-12-15California Institute Of TechnologyAutomated DNA sequencing technique
US4582877A (en)1984-07-271986-04-15The Dow Chemical CompanyTransamidated poly-2-oxazoline compositions useful as wetting agents for polymer and absorbents for polar materials
US5242794A (en)1984-12-131993-09-07Applied Biosystems, Inc.Detection of specific sequences in nucleic acids
US5034506A (en)1985-03-151991-07-23Anti-Gene Development GroupUncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en)1985-03-151993-08-10Anti-Gene Development GroupAlpha-morpholino ribonucleoside derivatives and polymers thereof
US4876187A (en)1985-12-051989-10-24Meiogenics, Inc.Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US5011769A (en)1985-12-051991-04-30Meiogenics U.S. Limited PartnershipMethods for detecting nucleic acid sequences
US4996143A (en)1985-12-231991-02-26Syngene, Inc.Fluorescent stokes shift probes for polynucleotide hybridization
US5721098A (en)1986-01-161998-02-24The Regents Of The University Of CaliforniaComparative genomic hybridization
US4935357A (en)1986-02-051990-06-19New England Biolabs, Inc.Universal restriction endonuclease
US6270961B1 (en)1987-04-012001-08-07Hyseq, Inc.Methods and apparatus for DNA sequencing and DNA identification
US6090591A (en)1987-07-312000-07-18The Board Of Trustees Of The Leland Stanford Junior UniversitySelective amplification of target polynucleotide sequences
US4942124A (en)1987-08-111990-07-17President And Fellows Of Harvard CollegeMultiplex sequencing
US6004745A (en)1987-09-211999-12-21Gen-Probe IncorporatedHybridization protection assay
CA1340807C (en)1988-02-241999-11-02Lawrence T. MalekNucleic acid amplification process
JP2650159B2 (en)1988-02-241997-09-03アクゾ・ノベル・エヌ・ベー Nucleic acid amplification method
US5082830A (en)1988-02-261992-01-21Enzo Biochem, Inc.End labeled nucleotide probe
EP0365627B1 (en)1988-03-241993-12-22University Of Iowa Research FoundationCatalytic hybridization systems for the detection of nucleic acid sequences based on their activity as cofactors in catalytic reactions in which a complementary labeled nucleic acid probe is cleaved
US4988617A (en)1988-03-251991-01-29California Institute Of TechnologyMethod of detecting a nucleotide change in nucleic acids
US5216141A (en)1988-06-061993-06-01Benner Steven AOligonucleotide analogs containing sulfur linkages
US6107023A (en)1988-06-172000-08-22Genelabs Technologies, Inc.DNA amplification and subtraction techniques
US5130238A (en)1988-06-241992-07-14Cangene CorporationEnhanced nucleic acid amplification process
US5681726A (en)1988-09-191997-10-28StratageneMethod of double stranded DNA synthesis
ATE139802T1 (en)1989-01-051996-07-15Leti Lab USE OF SPECIFIC PROPERTIES OF ANIMAL ALLERGENS AND METHOD FOR THEIR PRODUCTION
US5508178A (en)1989-01-191996-04-16Rose; SamuelNucleic acid amplification using single primer
US5708154A (en)1989-02-241998-01-13City Of HopeRNA-DNA hybrid molecules of nucleic acid
US5234809A (en)1989-03-231993-08-10Akzo N.V.Process for isolating nucleic acid
US5043272A (en)1989-04-271991-08-27Life Technologies, IncorporatedAmplification of nucleic acid sequences using oligonucleotides of random sequence as primers
US5683896A (en)1989-06-011997-11-04Life Technologies, Inc.Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en)1989-06-011991-07-30Life Technologies, Inc.Process for controlling contamination of nucleic acid amplification reactions
US5143854A (en)1989-06-071992-09-01Affymax Technologies N.V.Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ATE282716T1 (en)1989-07-112004-12-15Gen Probe Inc METHOD FOR AMPLIFICATION OF NUCLEIC ACID SEQUENCES
CA2020958C (en)1989-07-112005-01-11Daniel L. KacianNucleic acid sequence amplification methods
US5545522A (en)1989-09-221996-08-13Van Gelder; Russell N.Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5391785A (en)1990-01-161995-02-21La Jolla Pharmaceutial CompanyIntermediates for providing functional groups on the 5' end of oligonucleotides
CA2037349C (en)1990-03-262008-06-17James G. WetmurBranch migration of nucleotides
CA2036946C (en)1990-04-062001-10-16Kenneth V. DeugauIndexing linkers
HU218095B (en)1990-05-012000-05-28Amgen Inc.Process for reducing transitional contaminations in amplification processes
US5494810A (en)1990-05-031996-02-27Cornell Research Foundation, Inc.Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5667976A (en)1990-05-111997-09-16Becton Dickinson And CompanySolid supports for nucleic acid hybridization assays
US5194370A (en)1990-05-161993-03-16Life Technologies, Inc.Promoter ligation activated transcription amplification of nucleic acid sequences
EP0540693B1 (en)1990-07-241999-01-20F. Hoffmann-La Roche AgTHE REDUCTION OF NON-SPECIFIC AMPLIFICATION DURING $i(IN VITRO) NUCLEIC ACID AMPLIFICATION USING MODIFIED NUCLEIC ACID BASES
US5386023A (en)1990-07-271995-01-31Isis PharmaceuticalsBackbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en)1990-07-271997-02-11Ciba Geigy Ag.Backbone modified oligonucleotide analogs
WO1992007951A1 (en)1990-10-191992-05-14Yoke Wah KowQuantitation of aldehyde-containing lesions in nucleic acids
US5518900A (en)1993-01-151996-05-21Molecular Tool, Inc.Method for generating single-stranded DNA molecules
US6004744A (en)1991-03-051999-12-21Molecular Tool, Inc.Method for determining nucleotide identity through extension of immobilized primer
US5888819A (en)1991-03-051999-03-30Molecular Tool, Inc.Method for determining nucleotide identity through primer extension
US5090591A (en)1991-03-181992-02-25Longford Equipment International LimitedArticle dispenser for use with continuous strip of articles
US5169766A (en)1991-06-141992-12-08Life Technologies, Inc.Amplification of nucleic acid molecules
US5644048A (en)1992-01-101997-07-01Isis Pharmaceuticals, Inc.Process for preparing phosphorothioate oligonucleotides
US5965362A (en)1992-03-041999-10-12The Regents Of The University Of CaliforniaComparative genomic hybridization (CGH)
JP3645903B2 (en)1992-03-042005-05-11ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Comparative genomic hybridization (CGH)
WO1993018052A1 (en)1992-03-051993-09-16Isis Pharmaceuticals, Inc.Covalently cross-linked oligonucleotides
CA2102784A1 (en)1992-03-111993-09-12Peng LiangIdentifying, isolating and cloning messenger rnas
JP4137996B2 (en)1992-05-062008-08-20ジェン−プローブ・インコーポレイテッド Nucleic acid sequence amplification method, composition and kit
US5710028A (en)1992-07-021998-01-20Eyal; NuritMethod of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US6172208B1 (en)1992-07-062001-01-09Genzyme CorporationOligonucleotides modified with conjugate groups
WO1994003637A1 (en)1992-07-311994-02-17Syntex (Usa) Inc.Method for introducing defined sequences at the 3' end of polynucleotides
US5445935A (en)1992-11-231995-08-29Royer; Catherine A.Quantitative detection of macromolecules with fluorescent oligonucleotides
US5591575A (en)1993-04-071997-01-07Amersham International PlcSubtraction hybridization employing aziridinylbenoquinone cross-linking agents
US5837832A (en)1993-06-251998-11-17Affymetrix, Inc.Arrays of nucleic acid probes on biological chips
US6027923A (en)1993-07-232000-02-22Bio-Rad Laboratories, Inc.Linked linear amplification of nucleic acids
DE4344726C2 (en)1993-12-271997-09-25Deutsches Krebsforsch Method for the detection of unbalanced genetic material of a species or for the detection of gene expression in cells of a species
CA2140081C (en)1994-01-132008-04-01Dean L. EngelhardtProcess, construct and conjugate for producing multiple nucleic acid copies
US5654419A (en)1994-02-011997-08-05The Regents Of The University Of CaliforniaFluorescent labels and their use in separations
US5578832A (en)1994-09-021996-11-26Affymetrix, Inc.Method and apparatus for imaging a sample on a device
US5637684A (en)1994-02-231997-06-10Isis Pharmaceuticals, Inc.Phosphoramidate and phosphorothioamidate oligomeric compounds
DE4406524A1 (en)1994-02-281995-08-31Boehringer Mannheim Gmbh 3 'RNA tag with terminal transferase
US6110709A (en)1994-03-182000-08-29The General Hospital CorporationCleaved amplified modified polymorphic sequence detection methods
US5641658A (en)1994-08-031997-06-24Mosaic Technologies, Inc.Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5705628A (en)1994-09-201998-01-06Whitehead Institute For Biomedical ResearchDNA purification and isolation using magnetic particles
US5525471A (en)1994-10-121996-06-11The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesEnzymatic degrading subtraction hybridization
US6280935B1 (en)1994-10-132001-08-28Lynx Therapeutics, Inc.Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
US5556752A (en)1994-10-241996-09-17Affymetrix, Inc.Surface-bound, unimolecular, double-stranded DNA
US6309843B1 (en)1994-10-252001-10-30The Curators Of The University Of MissouriGlycoprotein for use in determining endometrial receptivity
US6194211B1 (en)1994-11-182001-02-27Glaxo Wellcome Inc.Transcriptional regulatory sequence of carcinoembryonic antigen for expression targeting
US5565340A (en)1995-01-271996-10-15Clontech Laboratories, Inc.Method for suppressing DNA fragment amplification during PCR
US5750341A (en)1995-04-171998-05-12Lynx Therapeutics, Inc.DNA sequencing by parallel oligonucleotide extensions
US5882867A (en)1995-06-071999-03-16Dade Behring Marburg GmbhDetection of nucleic acids by formation of template-dependent product
US5763178A (en)1995-06-071998-06-09Trevigen, Inc.Oscillating signal amplifier for nucleic acid detection
WO1996040998A1 (en)*1995-06-071996-12-19Pioneer Hi-Bred International, Inc.PCR-BASED cDNA SUBTRACTIVE CLONING METHOD
US5789206A (en)1995-07-071998-08-04Myriad Genetics, Inc.Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes
WO1997003210A1 (en)1995-07-111997-01-30FORFÁS (trading as BIORESEARCH IRELAND)Glycosylase mediated detection of nucleotide sequences at candidate loci
FR2737223B1 (en)1995-07-241997-09-12Bio Merieux METHOD OF AMPLIFYING NUCLEIC ACID SEQUENCES BY MOVEMENT USING CHIMERIC PRIMERS
US5712126A (en)1995-08-011998-01-27Yale UniversityAnalysis of gene expression by display of 3-end restriction fragments of CDNA
US6068829A (en)1995-09-112000-05-30The Burnham InstituteMethod of identifying molecules that home to a selected organ in vivo
US6190865B1 (en)1995-09-272001-02-20Epicentre Technologies CorporationMethod for characterizing nucleic acid molecules
GB9600384D0 (en)1996-01-091996-03-13Nyfotek AsDna glycosylases
US6825011B1 (en)1998-12-172004-11-30Yuri RumantichikovMethods for insertion of nucleic acids into circular vectors
EP1736554B1 (en)1996-05-292013-10-09Cornell Research Foundation, Inc.Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
EP2264045B1 (en)1996-08-142015-10-21Life Technologies CorporationStable compositions for nucleic acid amplification and sequencing
GB9620209D0 (en)1996-09-271996-11-13Cemu Bioteknik AbMethod of sequencing DNA
US6449562B1 (en)1996-10-102002-09-10Luminex CorporationMultiplexed analysis of clinical specimens apparatus and method
US6258533B1 (en)1996-11-012001-07-10The University Of Iowa Research FoundationIterative and regenerative DNA sequencing method
IL120337A0 (en)1997-02-271997-06-10Gesher Israel Advanced BiotecsMethod for joining DNA fragments
US6197557B1 (en)1997-03-052001-03-06The Regents Of The University Of MichiganCompositions and methods for analysis of nucleic acids
US6770748B2 (en)1997-03-072004-08-03Takeshi ImanishiBicyclonucleoside and oligonucleotide analogue
ATE545710T1 (en)1997-04-012012-03-15Illumina Cambridge Ltd METHOD FOR THE DUPLICATION OF NUCLEIC ACIDS
CA2268368A1 (en)1997-08-281999-03-11The Perkin-Elmer CorporationImproved detection of mutations in nucleic acids by chemical cleavage
AR017023A1 (en)1997-08-292001-08-22Lopez Osvaldo J GENOMIC TYPE OF DNA METHYLTRANSPHERASE
US6794499B2 (en)1997-09-122004-09-21Exiqon A/SOligonucleotide analogues
US6169194B1 (en)1997-10-162001-01-02Michael ThompsonHigh surface density covalent immobilization of oligonucleotide monolayers using a 1-(thiotrifluoroacetato)-11-(trichlorososilyl)-undecane linker
JP4502502B2 (en)1997-10-282010-07-14ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Identification method of DNA polymorphism using flow cytometry
US6090553A (en)1997-10-292000-07-18Beckman Coulter, Inc.Use of uracil-DNA glycosylase in genetic analysis
US20010000077A1 (en)1998-02-032001-03-29Engelhardt Dean L.Novel process, construct and conjugate for producing multiple nucleic acid copies
US6365346B1 (en)1998-02-182002-04-02Dade Behring Inc.Quantitative determination of nucleic acid amplification products
US6174680B1 (en)1998-12-302001-01-16Dana-Farber Cancer Institute, Inc.Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof
US6087103A (en)1998-03-042000-07-11Lifespan Biosciences, Inc.Tagged ligand arrays for identifying target-ligand interactions
US6225451B1 (en)1998-04-062001-05-01Myriad Genetics, Inc.Chromosome 11-linked coronary heart disease susceptibility gene CHD1
AU753661B2 (en)1998-04-222002-10-24Enterprise Ireland Trading As Bioresearch IrelandA method for the characterisation of nucleic acid molecules involving generation of extendible upstream DNA fragments resulting from the cleavage of nucleic acid at an abasic site
US7875440B2 (en)1998-05-012011-01-25Arizona Board Of RegentsMethod of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB0002310D0 (en)2000-02-012000-03-22Solexa LtdPolynucleotide sequencing
US6787308B2 (en)1998-07-302004-09-07Solexa Ltd.Arrayed biomolecules and their use in sequencing
US20030022207A1 (en)1998-10-162003-01-30Solexa, Ltd.Arrayed polynucleotides and their use in genome analysis
GB9817055D0 (en)1998-08-051998-09-30Medical Res CouncilReverse transcription and amplification processes and primers therefore
US6232067B1 (en)1998-08-172001-05-15The Perkin-Elmer CorporationAdapter directed expression analysis
US6160105A (en)1998-10-132000-12-12Incyte Pharmaceuticals, Inc.Monitoring toxicological responses
US6150112A (en)1998-09-182000-11-21Yale UniversityMethods for identifying DNA sequences for use in comparison of DNA samples by their lack of polymorphism using Y shape adaptors
US6287825B1 (en)1998-09-182001-09-11Molecular Staging Inc.Methods for reducing the complexity of DNA sequences
AR021833A1 (en)1998-09-302002-08-07Applied Research Systems METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID
US6440705B1 (en)1998-10-012002-08-27Vincent P. Stanton, Jr.Method for analyzing polynucleotides
WO2000039345A1 (en)1998-12-302000-07-06Dana-Farber Cancer Institute, Inc.Mutation scanning array, and methods of use thereof
WO2000040758A2 (en)1999-01-062000-07-13Hyseq Inc.Enhanced sequencing by hybridization using pools of probes
US7074556B2 (en)1999-03-022006-07-11Invitrogen CorporationcDNA synthesis improvements
CA2362771A1 (en)1999-03-122000-09-21Amersham Pharmacia Biotech Uk LimitedGenetic analysis
WO2000070039A1 (en)1999-05-172000-11-23Mcgill UniversityMETHOD FOR SUBTRACTING cDNAs BY SUPPRESSING THE SYNTHESIS OF SPECIFICALLY TARGETED mRNAs
US7056661B2 (en)1999-05-192006-06-06Cornell Research Foundation, Inc.Method for sequencing nucleic acid molecules
US6225109B1 (en)1999-05-272001-05-01Orchid Biosciences, Inc.Genetic analysis device
US6056661A (en)1999-06-142000-05-02General Motors CorporationMulti-range transmission with input split planetary gear set and continuously variable transmission unit
US7501245B2 (en)1999-06-282009-03-10Helicos Biosciences Corp.Methods and apparatuses for analyzing polynucleotide sequences
US6339147B1 (en)1999-07-292002-01-15Epoch Biosciences, Inc.Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
US6232104B1 (en)1999-08-172001-05-15Dade Behring Inc.Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
PT1218542E (en)1999-09-132004-08-31Nugen Technologies Inc METHODS AND COMPOSITIONS FOR LINEAR ISOTHERMAL AMPLIFICATION OF POLYNUCLEOTIDIC SEQUENCES
US6692918B2 (en)1999-09-132004-02-17Nugen Technologies, Inc.Methods and compositions for linear isothermal amplification of polynucleotide sequences
US6262490B1 (en)1999-11-052001-07-17Advanced Semiconductor Engineering, Inc.Substrate strip for use in packaging semiconductor chips
US7244559B2 (en)1999-09-162007-07-17454 Life Sciences CorporationMethod of sequencing a nucleic acid
US7211390B2 (en)1999-09-162007-05-01454 Life Sciences CorporationMethod of sequencing a nucleic acid
AU7537200A (en)1999-09-292001-04-30Solexa Ltd.Polynucleotide sequencing
US6617442B1 (en)1999-09-302003-09-09Isis Pharmaceuticals, Inc.Human Rnase H1 and oligonucleotide compositions thereof
US6077674A (en)1999-10-272000-06-20Agilent Technologies Inc.Method of producing oligonucleotide arrays with features of high purity
US6958225B2 (en)1999-10-272005-10-25Affymetrix, Inc.Complexity management of genomic DNA
US6582938B1 (en)2001-05-112003-06-24Affymetrix, Inc.Amplification of nucleic acids
WO2001046213A2 (en)1999-12-212001-06-28Vbc-Genomics Bioscience Research GmbhCompound comprising a peptide moiety and an organo-silane moiety.
US20010031739A1 (en)1999-12-212001-10-18Dare Akintade OyedeleMethod and kit for quantitating genomic DNA damage and repair capicity
US6913884B2 (en)2001-08-162005-07-05Illumina, Inc.Compositions and methods for repetitive use of genomic DNA
US7205129B1 (en)2000-02-282007-04-17Qiagen GmbhMethod for reducing artifacts in nucleic acid amplification
CN100390275C (en)2000-03-152008-05-28茵维特罗根公司High fidelity reverse transcriptases and uses thereof
US6917726B2 (en)2001-09-272005-07-12Cornell Research Foundation, Inc.Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en)2000-06-072005-08-30Li-Cor, Inc.Charge-switch nucleotides
EP1356094B1 (en)2000-06-262010-01-13Nugen Technologies, Inc.Methods and compositions for transcription-based nucleic acid amplification
US7846733B2 (en)2000-06-262010-12-07Nugen Technologies, Inc.Methods and compositions for transcription-based nucleic acid amplification
US20020164634A1 (en)2000-08-262002-11-07Perlegen Sciences, Inc.Methods for reducing complexity of nucleic acid samples
JP3353149B2 (en)2000-08-282002-12-03ホーコス株式会社 Spindle device of machine tool
EP1325118B1 (en)2000-10-052016-05-25RikenOligonucleotide linkers comprising a variable cohesive portion and method for the preparation of polynucleotide libraries by using said linkers.
JP2004537257A (en)2000-10-062004-12-16ニューゲン テクノロジーズ, インコーポレイテッド Methods and probes for detecting and / or quantifying nucleic acid sequences
WO2002034949A2 (en)2000-10-272002-05-02Molecular Staging Inc.Methods for identifying genes associated with diseases or specific phenotypes
IE20000887A1 (en)2000-11-032002-12-11Univ College Cork Nat Univ IeMethod for the amplification and optional characterisation of nucleic acids
US7001724B1 (en)2000-11-282006-02-21Applera CorporationCompositions, methods, and kits for isolating nucleic acids using surfactants and proteases
US6777180B1 (en)2000-11-282004-08-17Trustees Of Columbia University In The City Of New YorkMethod for full-length cDNA cloning using degenerate stem-loop annealing primers
EP1427847B1 (en)2000-12-132010-07-28Nugen Technologies, Inc.Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
US6893820B1 (en)2001-01-312005-05-17The Ohio State University Research FoundationDetection of methylated CpG rich sequences diagnostic for malignant cells
BR0205268A (en)2001-03-092004-11-30Nugen Technologies Inc Processes and compositions for mRNA sequence mplification
WO2002072773A2 (en)2001-03-092002-09-19Nugen Technologies, Inc.Methods and compositions for amplification of rna sequences
WO2002081753A1 (en)2001-04-042002-10-17Advanced Research & Technology InstituteMethod for identifying and characterizing individual dna molecules
FR2824335A1 (en)2001-05-042002-11-08Bio Merieux DNA MARKING AND FRAGMENTATION PROCESS
US7060441B2 (en)2001-05-042006-06-13BiomerieuxMethod for fragmenting and labeling DNA involving abasic sites and phosphate labeling
US6849404B2 (en)2001-05-072005-02-01Bioneer CorporationPolymerase chain reaction of DNA of which base sequence is completely unidentified
WO2002101353A2 (en)2001-06-082002-12-19U.S. Genomics, Inc.Methods and products for analyzing nucleic acids based on methylation status
GB0114853D0 (en)2001-06-182001-08-08Medical Res CouncilHappier Mapping
EP1404825A2 (en)2001-06-272004-04-07Roche Diagnostics GmbHA WALK-THROUGH TECHNIQUE FOR i IN VITRO /i RECOMBINATION OF POLYNUCLEOTIDE SEQUENCES
EP1275735A1 (en)2001-07-112003-01-15Roche Diagnostics GmbHComposition and method for hot start nucleic acid amplification
US6632611B2 (en)2001-07-202003-10-14Affymetrix, Inc.Method of target enrichment and amplification
AU2002341891A1 (en)2001-09-262003-04-07Epigenx Pharmaceuticals, Inc.Assays for dna methylation changes
US20040002371A1 (en)2001-10-012004-01-01Claude PaquinMethod and apparatus for automated system for validating a set of collectible lottery tickets
US6977148B2 (en)2001-10-152005-12-20Qiagen GmbhMultiple displacement amplification
US7176025B2 (en)2002-03-112007-02-13Nugen Technologies, Inc.Methods for generating double stranded DNA comprising a 3′ single stranded portion and uses of these complexes for recombination
AU2003220291A1 (en)2002-03-152003-09-29Epigenomics AgDiscovery and diagnostic methods using 5-methylcytosine dna glycosylase
JP2005521409A (en)2002-03-292005-07-21ニューゲン テクノロジーズ, インコーポレイテッド Single primer isothermal nucleic acid amplification-enhanced analyte detection and quantification
US20040137456A1 (en)2002-04-042004-07-15Hiroki YokotaMethod for identifying and characterizing individual dna molecules
US6815167B2 (en)2002-04-252004-11-09Geneohm SciencesAmplification of DNA to produce single-stranded product of defined sequence and length
US20040005614A1 (en)2002-05-172004-01-08Nurith KurnMethods for fragmentation, labeling and immobilization of nucleic acids
AU2003240795A1 (en)2002-05-242003-12-12Invitrogen CorporationNested pcr employing degradable primers
US7291460B2 (en)2002-05-312007-11-06Verenium CorporationMultiplexed systems for nucleic acid sequencing
US7108976B2 (en)2002-06-172006-09-19Affymetrix, Inc.Complexity management of genomic DNA by locus specific amplification
JP2005533504A (en)2002-07-242005-11-10イミューソル インコーポレイテッド Single promoter system for production of siRNA expression cassette and expression library using polymerase primer hairpin linker
EP1546345B1 (en)2002-09-052007-03-28Plant Bioscience LimitedGenome partitioning
US7459273B2 (en)*2002-10-042008-12-02Affymetrix, Inc.Methods for genotyping selected polymorphism
US7414117B2 (en)2002-12-262008-08-19Ngk Insulators, Ltd.Nucleotide derivative and DNA microarray
DE602004026033D1 (en)*2003-01-292010-04-29454 Corp SECONDARY SEQUENCING
US7189512B2 (en)2003-02-202007-03-13Noga PoratMethods for variation detection
US20090124514A1 (en)2003-02-262009-05-14Perlegen Sciences, Inc.Selection probe amplification
EP1606417A2 (en)*2003-03-072005-12-21Rubicon Genomics Inc.In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
US7745116B2 (en)2003-04-082010-06-29Pacific Biosciences Of California, Inc.Composition and method for nucleic acid sequencing
CA2521084A1 (en)2003-04-142004-10-28Nugen Technologies, Inc.Global amplification using a randomly primed composite primer
US7300755B1 (en)2003-05-122007-11-27Fred Hutchinson Cancer Research CenterMethods for haplotyping genomic DNA
AU2004253882B2 (en)2003-06-202010-06-10Illumina, Inc.Methods and compositions for whole genome amplification and genotyping
US20050123956A1 (en)2003-09-252005-06-09Affymetrix, Inc.Methods for modifying DNA for microarray analysis
US7169560B2 (en)2003-11-122007-01-30Helicos Biosciences CorporationShort cycle methods for sequencing polynucleotides
US20050136417A1 (en)2003-12-192005-06-23Affymetrix, Inc.Amplification of nucleic acids
CA2552007A1 (en)2003-12-292005-07-21Nugen Technologies, Inc.Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US20050191682A1 (en)2004-02-172005-09-01Affymetrix, Inc.Methods for fragmenting DNA
US7595179B2 (en)2004-04-192009-09-29Applied Biosystems, LlcRecombinant reverse transcriptases
US7462452B2 (en)2004-04-302008-12-09Pacific Biosciences Of California, Inc.Field-switch sequencing
SE0401270D0 (en)*2004-05-182004-05-18Fredrik Dahl Method for amplifying specific nucleic acids in parallel
US7622281B2 (en)2004-05-202009-11-24The Board Of Trustees Of The Leland Stanford Junior UniversityMethods and compositions for clonal amplification of nucleic acid
US20060051789A1 (en)2004-07-012006-03-09Somagenics, Inc.Methods of preparation of gene-specific oligonucleotide libraries and uses thereof
US20060024711A1 (en)2004-07-022006-02-02Helicos Biosciences CorporationMethods for nucleic acid amplification and sequence determination
US7361468B2 (en)2004-07-022008-04-22Affymetrix, Inc.Methods for genotyping polymorphisms in humans
US7276720B2 (en)2004-07-192007-10-02Helicos Biosciences CorporationApparatus and methods for analyzing samples
US20060024678A1 (en)2004-07-282006-02-02Helicos Biosciences CorporationUse of single-stranded nucleic acid binding proteins in sequencing
US20060216724A1 (en)2004-07-302006-09-28Affymetrix, Inc.Methods for normalized amplification of nucleic acids
US7867703B2 (en)2004-08-262011-01-11Agilent Technologies, Inc.Element defined sequence complexity reduction
US7170050B2 (en)2004-09-172007-01-30Pacific Biosciences Of California, Inc.Apparatus and methods for optical analysis of molecules
US7302146B2 (en)2004-09-172007-11-27Pacific Biosciences Of California, Inc.Apparatus and method for analysis of molecules
GB0422551D0 (en)2004-10-112004-11-10Univ LiverpoolLabelling and sequencing of nucleic acids
EP1817572A2 (en)2004-11-162007-08-15Helicos Biosciences CorporationAn optical train and method for tirf single molecule detection and analysis
US7579153B2 (en)2005-01-252009-08-25Population Genetics Technologies, Ltd.Isothermal DNA amplification
US7462468B1 (en)2005-01-282008-12-09Pacific Biosciences Of California, Inc.DNA intercalating agents and methods of use
US7476504B2 (en)2005-01-312009-01-13Pacific Biosciences Of California, Inc.Use of reversible extension terminator in nucleic acid sequencing
US20060286566A1 (en)2005-02-032006-12-21Helicos Biosciences CorporationDetecting apparent mutations in nucleic acid sequences
WO2006086668A2 (en)2005-02-092006-08-17Epicentre TechnologiesCompositions and methods employing 5'-phosphate-dependent nucleic acid exonucleases
US7452671B2 (en)2005-04-292008-11-18Affymetrix, Inc.Methods for genotyping with selective adaptor ligation
US20060263789A1 (en)2005-05-192006-11-23Robert KincaidUnique identifiers for indicating properties associated with entities to which they are attached, and methods for using
GB0514909D0 (en)2005-07-202005-08-24Solexa LtdMethods of nucleic acid amplification and sequencing
GB0514910D0 (en)2005-07-202005-08-24Solexa LtdMethod for sequencing a polynucleotide template
ATE510930T1 (en)2005-08-022011-06-15Rubicon Genomics Inc COMPOSITIONS AND METHODS FOR EDITING AND AMPLIFICATION OF DNA USING MULTIPLE ENZYMES IN A SINGLE REACTION
US20090137415A1 (en)2005-08-052009-05-28Euclid Diagnostics LlcSUBTRACTIVE SEPARATION AND AMPLIFICATION OF NON-RIBOSOMAL TRANSCRIBED RNA (nrRNA)
US7939258B2 (en)2005-09-072011-05-10Nugen Technologies, Inc.Nucleic acid amplification procedure using RNA and DNA composite primers
CN101263227A (en)*2005-09-162008-09-10454生命科学公司CDNA library preparation
US7405281B2 (en)2005-09-292008-07-29Pacific Biosciences Of California, Inc.Fluorescent nucleotide analogs and uses therefor
GB0522310D0 (en)2005-11-012005-12-07Solexa LtdMethods of preparing libraries of template polynucleotides
US20070141604A1 (en)2005-11-152007-06-21Gormley Niall AMethod of target enrichment
CA2631248C (en)2005-11-282016-01-12Pacific Biosciences Of California, Inc.Uniform surfaces for hybrid material substrates and methods for making and using same
CA2642854A1 (en)2006-02-182007-08-30Michael StrathmannMassively multiplexed sequencing
US20080038727A1 (en)2006-03-102008-02-14Applera CorporationMicroRNA and Messenger RNA Detection on Arrays
WO2007111937A1 (en)*2006-03-232007-10-04Applera CorporationDirected enrichment of genomic dna for high-throughput sequencing
EP2010668A4 (en)2006-04-102009-04-29Univ California SYSTEMS AND METHODS FOR EFFICIENT COLLECTION OF UNIQUE CELLS AND COLONIES OF CELLS AND RAPID FORMATION OF STABLE TRANSFECTORS
EP2010657A2 (en)2006-04-242009-01-07Nimblegen Systems, Inc.Use of microarrays for genomic representation selection
US20080269476A1 (en)2006-04-262008-10-30Helicos Biosciences CorporationMolecules and methods for nucleic acid sequencing
WO2007136717A1 (en)2006-05-162007-11-29Nugen Technologies, Inc.Nucleic acid separation and purification method based on reversible charge interactions
CA2656315A1 (en)2006-06-302008-01-10Nugen Technologies, Inc.Methods for fragmentation and labeling of nucleic acids
EP2049682A2 (en)2006-07-312009-04-22Illumina Cambridge LimitedMethod of library preparation avoiding the formation of adaptor dimers
US8293501B2 (en)2006-09-122012-10-23The Board Of Trustees Of The Leland Stanford Junior UniversityMethods and compositions for performing low background multiplex nucleic acid amplification reactions
US20080242560A1 (en)2006-11-212008-10-02Gunderson Kevin LMethods for generating amplified nucleic acid arrays
CA2672315A1 (en)*2006-12-142008-06-26Ion Torrent Systems IncorporatedMethods and apparatus for measuring analytes using large scale fet arrays
US8262900B2 (en)2006-12-142012-09-11Life Technologies CorporationMethods and apparatus for measuring analytes using large scale FET arrays
WO2008093098A2 (en)2007-02-022008-08-07Illumina Cambridge LimitedMethods for indexing samples and sequencing multiple nucleotide templates
US20080194416A1 (en)2007-02-082008-08-14Sigma AldrichDetection of mature small rna molecules
US20080241831A1 (en)2007-03-282008-10-02Jian-Bing FanMethods for detecting small RNA species
US7767805B2 (en)2007-05-032010-08-03Helicos Biosciences CorporationMethods and compositions for sequencing a nucleic acid
EP2155855B1 (en)2007-06-062016-10-12Pacific Biosciences of California, Inc.Methods and processes for calling bases in sequence by incorporation methods
CA2693979A1 (en)2007-07-262009-02-05Pacific Biosciences Of California, Inc.Molecular redundant sequencing
US8748100B2 (en)2007-08-302014-06-10The Chinese University Of Hong KongMethods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
US9388457B2 (en)2007-09-142016-07-12Affymetrix, Inc.Locus specific amplification using array probes
EP2053132A1 (en)2007-10-232009-04-29Roche Diagnostics GmbHEnrichment and sequence analysis of geomic regions
EP2209912A1 (en)2007-10-262010-07-28Rosetta Inpharmatics LLCCdna synthesis using non-random primers
US8518640B2 (en)2007-10-292013-08-27Complete Genomics, Inc.Nucleic acid sequencing and process
WO2009102896A2 (en)2008-02-122009-08-20Nugen Technologies, Inc.Isothermal nucleic acid amplification methods and compositions
US8034568B2 (en)2008-02-122011-10-11Nugen Technologies, Inc.Isothermal nucleic acid amplification methods and compositions
GB0804690D0 (en)*2008-03-132008-04-16Netherlands Cancer Inst TheMethod
US7846666B2 (en)2008-03-212010-12-07Nugen Technologies, Inc.Methods of RNA amplification in the presence of DNA
US8236499B2 (en)2008-03-282012-08-07Pacific Biosciences Of California, Inc.Methods and compositions for nucleic acid sample preparation
CA2719747C (en)2008-03-282018-02-20Pacific Biosciences Of California, Inc.Compositions and methods for nucleic acid sequencing
WO2009124255A2 (en)2008-04-042009-10-08Helicos Biosciences CorporationMethods for transcript analysis
WO2010003153A2 (en)2008-07-032010-01-07Life Technologies CorporationMethylation analysis of mate pairs
US8361746B2 (en)2008-07-242013-01-29Brookhaven Science Associates, LlcMethods for detection of methyl-CpG dinucleotides
JP5221248B2 (en)2008-08-262013-06-26株式会社日立ハイテクノロジーズ Method for preparing a cDNA library with a reduced content of cDNA clones derived from highly expressed genes
CN102203273A (en)2008-09-092011-09-28生命技术公司Methods of generating gene specific libraries
US8476013B2 (en)2008-09-162013-07-02Sequenom, Inc.Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9156010B2 (en)2008-09-232015-10-13Bio-Rad Laboratories, Inc.Droplet-based assay system
WO2010039991A2 (en)2008-10-022010-04-08The Texas A&M University SystemMethod of generating informative dna templates for high-throughput sequencing applications
US20100137143A1 (en)2008-10-222010-06-03Ion Torrent Systems IncorporatedMethods and apparatus for measuring analytes
US20100113296A1 (en)2008-11-052010-05-06Joel MyersonMethods And Kits For Nucleic Acid Analysis
US8017328B2 (en)2008-11-212011-09-13Agilent Technologies, Inc.Genome partitioning using a nicking endonuclease
EP2367937B1 (en)2008-12-042013-04-17Keygene N.V.Method for the reduction of repetitive sequences in adapter-ligated restriction fragments
GB2465986A (en)2008-12-042010-06-09Angeletti P Ist Richerche BioMethod of generating diversity in polynucleotide sequences
WO2010085715A1 (en)2009-01-222010-07-29Quanta BiosciencesMethod for enrichment of selected rna molecules
US20100323348A1 (en)2009-01-312010-12-23The Regents Of The University Of Colorado, A Body CorporateMethods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
CN102439177B (en)2009-04-022014-10-01弗卢伊蒂格姆公司 Multi-primer amplification method for barcoding target nucleic acids
US20110003301A1 (en)2009-05-082011-01-06Life Technologies CorporationMethods for detecting genetic variations in dna samples
EP2272976A1 (en)2009-07-062011-01-12Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Method for differentiation of polynucleotide strands
US8481699B2 (en)*2009-07-142013-07-09Academia SinicaMultiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing
GB0912909D0 (en)2009-07-232009-08-26Olink Genomics AbProbes for specific analysis of nucleic acids
WO2011019964A1 (en)2009-08-122011-02-17Nugen Technologies, Inc.Methods, compositions, and kits for generating nucleic acid products substantially free of template nucleic acid
CA2773887A1 (en)2009-09-112011-03-17Nugen Technologies, Inc.Compositions and methods for whole transcriptome analysis
WO2011041695A1 (en)2009-10-022011-04-07Ibis Biosciences, Inc.Determination of methylation status of polynucleotides
GB2487341A (en)2009-11-022012-07-18Nugen Technologies IncCompositions and methods for targeted nucleic acid sequence selection and amplification
WO2011055232A2 (en)2009-11-042011-05-12Population Genetics Technologies Ltd.Base-by-base mutation screening
EP2464755B1 (en)*2009-11-052016-03-09Epicentre Technologies CorporationMethods and kits for 3'-end-tagging of rna
GB0921264D0 (en)2009-12-032010-01-20Olink Genomics AbMethod for amplification of target nucleic acid
WO2011133695A2 (en)2010-04-202011-10-27Swift Biosciences, Inc.Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
WO2011140510A2 (en)*2010-05-062011-11-10Bioo Scientific CorporationOligonucleotide ligation, barcoding and methods and compositions for improving data quality and throughput using massively parallel sequencing
US10017812B2 (en)*2010-05-182018-07-10Natera, Inc.Methods for non-invasive prenatal ploidy calling
EP2854057B1 (en)*2010-05-182018-03-07Natera, Inc.Methods for non-invasive pre-natal ploidy calling
ITRM20100293A1 (en)2010-05-312011-12-01Consiglio Nazionale Ricerche METHOD FOR THE PREPARATION AND AMPLIFICATION OF REPRESENTATIVE LIBRARIES OF CDNA FOR MAXIMUM SEQUENCING, THEIR USE, KITS AND CARTRIDGES FOR AUTOMATION KITS
WO2011156529A2 (en)*2010-06-082011-12-15Nugen Technologies, Inc.Methods and composition for multiplex sequencing
WO2012003374A2 (en)2010-07-022012-01-05The Board Of Trustees Of The Leland Stanford Junior UniversityTargeted sequencing library preparation by genomic dna circularization
WO2012012037A1 (en)2010-07-192012-01-26New England Biolabs, Inc.Oligonucleotide adaptors: compositions and methods of use
GB201012748D0 (en)2010-07-292010-09-15Univ St AndrewsImproved RACE
EP3115468B1 (en)2010-09-212018-07-25Agilent Technologies, Inc.Increasing confidence of allele calls with molecular counting
AU2011305445B2 (en)2010-09-242017-03-16The Board Of Trustees Of The Leland Stanford Junior UniversityDirect capture, amplification and sequencing of target DNA using immobilized primers
US8715933B2 (en)2010-09-272014-05-06Nabsys, Inc.Assay methods using nicking endonucleases
US20120102054A1 (en)2010-10-252012-04-26Life Technologies CorporationSystems and Methods for Annotating Biomolecule Data
CA2817066C (en)2010-10-272017-07-11President And Fellows Of Harvard CollegeCompositions of toehold primer duplexes and methods of use
CN118086471A (en)2010-12-172024-05-28生命技术公司Methods, compositions, systems, instruments and kits for nucleic acid amplification
AU2011348100B2 (en)2010-12-222016-08-25Natera, Inc.Methods for non-invasive prenatal paternity testing
WO2012103154A1 (en)2011-01-242012-08-02Nugen Technologies, Inc.Stem-loop composite rna-dna adaptor-primers: compositions and methods for library generation, amplification and other downstream manipulations
US8759036B2 (en)2011-03-212014-06-24Affymetrix, Inc.Methods for synthesizing pools of probes
US20130059738A1 (en)2011-04-282013-03-07Life Technologies CorporationMethods and compositions for multiplex pcr
US8722585B2 (en)2011-05-082014-05-13Yan WangMethods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides
US8841071B2 (en)*2011-06-022014-09-23Raindance Technologies, Inc.Sample multiplexing
WO2013059746A1 (en)2011-10-192013-04-25Nugen Technologies, Inc.Compositions and methods for directional nucleic acid amplification and sequencing
WO2013059740A1 (en)2011-10-212013-04-25Foundation Medicine, Inc.Novel alk and ntrk1 fusion molecules and uses thereof
SG11201404243WA (en)2012-01-262014-08-28Nugen Technologies IncCompositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
US20160153039A1 (en)2012-01-262016-06-02Nugen Technologies, Inc.Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
ES2928691T3 (en)2012-05-212022-11-22Scripps Research Inst Sample preparation methods
EP2861787B1 (en)2012-06-182017-09-20Nugen Technologies, Inc.Compositions and methods for negative selection of non-desired nucleic acid sequences
US20150011396A1 (en)2012-07-092015-01-08Benjamin G. SchroederMethods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140378345A1 (en)2012-08-142014-12-2510X Technologies, Inc.Compositions and methods for sample processing
WO2014093330A1 (en)2012-12-102014-06-19Clearfork Bioscience, Inc.Methods for targeted genomic analysis
EP2971148A4 (en)2013-03-142016-08-17Seres Therapeutics IncMethods for pathogen detection and enrichment from materials and compositions
US20140274729A1 (en)2013-03-152014-09-18Nugen Technologies, Inc.Methods, compositions and kits for generation of stranded rna or dna libraries
US20140274738A1 (en)2013-03-152014-09-18Nugen Technologies, Inc.Sequential sequencing
JP6416939B2 (en)2014-02-132018-10-31タカラ バイオ ユーエスエー,インコーポレイティド Method for depleting target molecules from an initial collection of nucleic acids, and compositions and kits for performing the same
WO2015131107A1 (en)2014-02-282015-09-03Nugen Technologies, Inc.Reduced representation bisulfite sequencing with diversity adaptors
WO2016033251A2 (en)2014-08-262016-03-03Nugen Technologies, Inc.Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
JP6947638B2 (en)2014-12-202021-10-13アーク バイオ, エルエルシー Compositions and Methods for Targeted Depletion, Enrichment and Division of Nucleic Acids Using CRISPR / CAS Proteins
US20160275240A1 (en)2015-02-182016-09-22Nugen Technologies, Inc.Methods and compositions for pooling amplification primers
US20160362680A1 (en)2015-05-152016-12-15Nugen Technologies, Inc.Compositions and methods for negative selection of non-desired nucleic acid sequences

Also Published As

Publication numberPublication date
SG10201504490QA (en)2015-07-30
GB201605067D0 (en)2016-05-11
US9650628B2 (en)2017-05-16
CN105861487A (en)2016-08-17
CA2862552A1 (en)2013-08-01
GB2533882A (en)2016-07-06
US20210071171A1 (en)2021-03-11
US20170298345A1 (en)2017-10-19
CN104093890B (en)2016-04-20
EP2807292B1 (en)2019-05-22
GB2513793B (en)2016-11-02
GB2513793A (en)2014-11-05
EP4372084A3 (en)2024-08-14
EP3578697B1 (en)2024-03-06
US10036012B2 (en)2018-07-31
EP4372084A2 (en)2024-05-22
US20190078082A1 (en)2019-03-14
EP3578697A1 (en)2019-12-11
GB2533882B (en)2016-10-12
EP2807292A4 (en)2015-08-26
US20130231253A1 (en)2013-09-05
CN104093890A (en)2014-10-08
US10876108B2 (en)2020-12-29
GB201414884D0 (en)2014-10-08
EP2807292A1 (en)2014-12-03
CN105861487B (en)2020-05-05
WO2013112923A1 (en)2013-08-01

Similar Documents

PublicationPublication DateTitle
GB2513793B (en)Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
IL290273A (en)Methods and compositions for increasing efficiency of increased efficiency of targeted gene modification using oligonucleotide-mediated gene repair
IL293796A (en)Methods for nucleic acid assembly and high throughput sequencing
IL280334B1 (en)Compositions and methods for high fidelity assembly of nucleic acids
IL253372B (en)Compositions and methods for modifying a predetermined target nucleic acid sequence
ZA201509111B (en)Compositions for introducing rna into cells
PL3290528T3 (en)Methods and compositions for nucleic acid sequencing
ZA201403601B (en)Systems and methods for engineering nucleic acid constructs using scoring techniques
PL2884999T3 (en) METHOD AND COMPOSITIONS FOR CELL IMMUNOTHERAPY
EP2675918A4 (en)Compositions and methods for delivering nucleic acid to a cell
SG11201408697QA (en)Methods and compositions for natural killer cells
SG10201606482TA (en)Compositions and methods relating to nucleic acid nano-and micro-technology
EP2680837A4 (en)COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE
IL241145A0 (en)Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
EP2909343A4 (en)Methods and apparatus to sequence a nucleic acid
ZA201307904B (en)Low energy cyclic psa process
PL2748320T3 (en)Compositions and methods for nucleic acid hybridization
IL232832A0 (en)Compositions and methods for modifying a predetermined target nucleic acid sequence
GB201118815D0 (en)Methods and compositions for identifying nucleic acids
GB201118795D0 (en)Methods and compositions for identifying nucleic acids
GB201107644D0 (en)Methods and compositions for identifying nucleic acids
GB201102812D0 (en)Methods and compositions for identifying nucleic acids
GB201206429D0 (en)Methods and compositions for identifying nucleic acids
GB201206427D0 (en)Methods and compositions for identifying nucleic acids
GB201206428D0 (en)Methods and compositions for identifying nucleic acids

[8]ページ先頭

©2009-2025 Movatter.jp