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SG11201403402VA - Compounds - Google Patents

Compounds

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Publication number
SG11201403402VA
SG11201403402VASG11201403402VASG11201403402VASG11201403402VASG 11201403402V ASG11201403402V ASG 11201403402VASG 11201403402V ASG11201403402V ASG 11201403402VASG 11201403402V ASG11201403402V ASG 11201403402VASG 11201403402V ASG11201403402V ASG 11201403402VA
Authority
SG
Singapore
Prior art keywords
osaka
evotec
abingdon
oxfordshire
doshomachi
Prior art date
Application number
SG11201403402VA
Inventor
Steve Courtney
Chris Yarnold
Stuart Flanagan
Gareth Brace
John Barker
Osamu Ichihara
Elise Gadouleau
Anthony Richardson
Takashi Kondo
Akira Imagawa
Shingo Nakatani
Ryo Suzuki
Sho Kouyama
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1122139.7Aexternal-prioritypatent/GB2497806A/en
Priority claimed from GB201217290Aexternal-prioritypatent/GB201217290D0/en
Application filed by Ono Pharmaceutical CofiledCriticalOno Pharmaceutical Co
Publication of SG11201403402VApublicationCriticalpatent/SG11201403402VA/en

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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2013/093484 A1 27 June 2013 (27.06.2013) WIPO I PCT (51) International Patent Classification: C07D 401/14 (2006.01) A61K 31/437 (2006.01) C07D 471/04 (2006.01) A61K31/519 (2006.01) C07D 487/04 (2006.01) A61P 9/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/GB2012/053217 20 December 2012 (20.12.2012) English (30) Priority Data: 1122139.7 21 December 2011 (21.12.2011) 1217290.4 27 September 2012 (27.09.2012) English GB GB (71) Applicant (for all designated States except US): ONO PHARMACEUTICAL CO., LTD. [ JP/JP] ; 1-5 Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541 - 8526 (JP). (72) Inventors; and (71) Applicants (for US only): COURTNEY, Steve [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxford­ shire OX14 4SA (GB). YARNOLD, Chris [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA (GB). FLANAGAN, Stuart [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA (GB). BRACE, Gareth [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX 14 4SA (GB). BARKER, John [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX 14 4SA (GB). ICHIHARA, Osamu [JP/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire (GB). GADOULEAU, Elise [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA (GB). RICHARDSON, Anthony [GB/GB]; c/o Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire (GB). KONDO, Takashi [JP/JP]; c/o Ono Pharmaceutical Co., Ltd., 1-5 Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8526 (JP). IMAGAWA, Akira [JP/JP]; c/o Ono Pharmaceutical Co., Ltd., 1-5 Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8526 (JP). NAKATANI, Shingo [JP/JP]; c/o Ono Pharmaceutical Co., Ltd., 1-5 Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541 - 8526 (JP). SUZUKI, Ryo [JP/JP]; c/o Ono Pharmaceutical Co., Ltd., 1-5 Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541 8526 (JP). KOUYAMA, Sho [JP/JP]; c/o Ono Pharmaceutical Co., Ltd., 1-5 Doshomachi 2-chome, Chuo- ku, Osaka-shi, Osaka 541 8526 (JP). (74) Agent: WRIGHT, Simon Mark; J.A. Kemp & Co., 14 South Square, Gray's Inn, London, Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS (I) 00 m o\ © rn i-H (57) Abstract: The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and © prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors ^ of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.
SG11201403402VA2011-12-212012-12-20CompoundsSG11201403402VA (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
GB1122139.7AGB2497806A (en)2011-12-212011-12-21Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
GB201217290AGB201217290D0 (en)2012-09-272012-09-27Compounds
PCT/GB2012/053217WO2013093484A1 (en)2011-12-212012-12-20Pyridinone and pyrimidinone derivatives as factor xia inhibitors

Publications (1)

Publication NumberPublication Date
SG11201403402VAtrue SG11201403402VA (en)2015-01-29

Family

ID=47553259

Family Applications (1)

Application NumberTitlePriority DateFiling Date
SG11201403402VASG11201403402VA (en)2011-12-212012-12-20Compounds

Country Status (22)

CountryLink
US (2)US9732085B2 (en)
EP (2)EP2794597B1 (en)
JP (2)JP6137193B2 (en)
KR (1)KR102011534B1 (en)
CN (1)CN104136431B (en)
AU (1)AU2012356374B2 (en)
BR (1)BR112014015669B1 (en)
CA (1)CA2859604C (en)
DK (1)DK2794597T3 (en)
ES (2)ES2655669T3 (en)
HU (1)HUE036010T2 (en)
IL (1)IL233154A (en)
IN (1)IN2014CN04676A (en)
MX (1)MX351471B (en)
NO (1)NO2794597T3 (en)
PH (1)PH12014501365B1 (en)
PL (1)PL2794597T3 (en)
PT (1)PT2794597T (en)
RU (1)RU2630677C2 (en)
SG (1)SG11201403402VA (en)
TW (1)TWI613199B (en)
WO (1)WO2013093484A1 (en)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2011100401A1 (en)2010-02-112011-08-18Bristol-Myers Squibb CompanyMacrocycles as factor xia inhibitors
ES2562903T3 (en)*2011-07-132016-03-09Santen Pharmaceutical Co., Ltd New compound that has PARP inhibitory activity
EP2766346B1 (en)2011-10-142017-03-29Bristol-Myers Squibb CompanySubstituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9079929B2 (en)2011-10-142015-07-14Bristol-Myers Squibb CompanySubstituted tetrahydroisoquinoline compounds as factor XIa inhibitors
IN2014CN02806A (en)2011-10-142015-07-03Bristol Myers Squibb Co
PT2794597T (en)*2011-12-212018-01-16Ono Pharmaceutical CoPyridinone and pyrimidinone derivatives as factor xia inhibitors
JP2015503504A (en)*2011-12-232015-02-02ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Heteroaryl and uses thereof
EP2876105A4 (en)2012-07-192016-01-13Sumitomo Dainippon Pharma Co Ltd1-(cycloalkyl-carbonyl)proline derivative
SMT201700003T1 (en)2012-08-032017-03-08Bristol Myers Squibb CoDihydropyridone as factor xia inhibitors
BR112015002081A2 (en)2012-08-032017-07-04Bristol Myers Squibb Co dihydropyridone p1 as factor xia inhibitors
US9403774B2 (en)2012-10-122016-08-02Bristol-Myers Squibb CompanyGuanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9920034B2 (en)2012-10-122018-03-20Bristol-Myers Squibb CompanyCrystalline forms of a factor XIa inhibitor
EP2906552B1 (en)2012-10-122017-11-22Bristol-Myers Squibb CompanyGuanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
ES2712699T3 (en)2013-03-252019-05-14Bristol Myers Squibb Co Tetrahydroisoquinolines containing substituted azoles as inhibitors of factor XIa
EP2978425B1 (en)*2013-03-272017-09-27Merck Sharp & Dohme Corp.Factor xia inhibitors
TWI633089B (en)*2013-03-282018-08-21拜耳製藥股份有限公司Substituted oxopyridine derivatives
WO2015011087A1 (en)2013-07-232015-01-29Bayer Pharma AktiengesellschaftSubstituted oxopyridine derivatives and use thereof as factor xia/plasma
EP3063150B1 (en)*2013-10-302017-11-22Bayer Pharma AktiengesellschaftSubstituted oxopyridine derivatives
WO2015116885A1 (en)*2014-01-312015-08-06Bristol-Myers Squibb CompanyMacrocycles with aromatic p2' groups as factor xia inhibitors
NO2760821T3 (en)2014-01-312018-03-10
EP3104702B1 (en)2014-02-112022-08-10Merck Sharp & Dohme LLCFactor xia inhibitors
WO2015123093A1 (en)2014-02-112015-08-20Merck Sharp & Dohme Corp.Factor xia inhibitors
WO2015120777A1 (en)*2014-02-142015-08-20四川海思科制药有限公司Pyridone or pyrimidone derivative, preparation method therefor and application thereof
WO2015164308A1 (en)2014-04-222015-10-29Merck Sharp & Dohme Corp.FACTOR XIa INHIBITORS
WO2016011940A1 (en)*2014-07-252016-01-28江苏恒瑞医药股份有限公司Indole-amide derivative, preparation method therefor and application thereof in medicine
EP3180317B1 (en)2014-07-282021-04-14Merck Sharp & Dohme Corp.FACTOR XIa INHIBITORS
ES2714283T3 (en)2014-09-042019-05-28Bristol Myers Squibb Co Macrocycles of diamide that are inhibitors of FXIa
CN104311537B (en)*2014-09-192016-08-24广东东阳光药业有限公司Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes
US10077265B2 (en)2014-09-242018-09-18Bayer Pharma AktiengesellschaftSubstituted oxopyridine derivatives
ES2713624T3 (en)*2014-09-242019-05-23Bayer Pharma AG Substituted oxopyridine derivatives
NO2721243T3 (en)*2014-10-012018-10-20
US9453018B2 (en)2014-10-012016-09-27Bristol-Myers Squibb CompanyPyrimidinones as factor XIa inhibitors
HUE051080T2 (en)*2014-12-102021-03-01Ono Pharmaceutical CoDihydroindolizinone derivative
RU2649141C2 (en)*2015-04-202018-03-30государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России)3,4-dimethyl-6-(3-pyridyl)-n-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide with antifungal activity against the candida albicans strain
GB201506660D0 (en)2015-04-202015-06-03Cellcentric LtdPharmaceutical compounds
GB201506658D0 (en)2015-04-202015-06-03Cellcentric LtdPharmaceutical compounds
JO3703B1 (en)*2015-07-092021-01-31Bayer Pharma AGSubstituted oxopyridine derivatives
RU2653511C2 (en)*2015-07-292018-05-10государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России)4-methyl-n-2,4-dimethylphenyl-6-(3-fluorophenyl)-2-thyoxo-1,2,3,6-tetragydropyrimidine-5-carboxamide that has analgetic action
CN108137549B (en)2015-08-052021-07-20百时美施贵宝公司Substituted glycine derived FXIA inhibitors
CN106496249B (en)*2015-09-072019-12-13江苏恒瑞医药股份有限公司Oxazoloindole derivative, preparation method and medical application thereof
US10344039B2 (en)*2015-10-292019-07-09Merck Sharp & Dohme Corp.Macrocyclic spirocarbamate derivatives as factor XIa inhibitors, pharmaceutically acceptable compositions and their use
JP6892858B2 (en)2015-10-292021-06-23メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Factor XIa inhibitor
JP6992284B2 (en)*2016-06-062022-01-13小野薬品工業株式会社 Pharmaceutical composition containing dihydroindridinone derivative
EP3500556B1 (en)2016-08-222023-08-02Merck Sharp & Dohme LLCPyridine-1-oxide derivatives and their use as factor xia inhibitors
CN108495850B (en)*2016-08-312021-11-26江苏恒瑞医药股份有限公司Oxopyridine amide derivatives, preparation method thereof and application thereof in medicines
EP3305538A1 (en)2016-10-072018-04-11Mitsubishi HiTec Paper Europe GmbHHeat sensitive recording material
WO2018065330A1 (en)2016-10-072018-04-12Mitsubishi Hitec Paper Europe GmbhHeat-sensitive recording material
CN106950319B (en)*2017-04-202019-08-30西安科技大学 A method for detecting the content of optical isomers of trutroban
CN109507345B (en)*2017-09-152022-08-05万特制药(海南)有限公司 Separation and determination method of rivastigmine bitartrate intermediate and its impurities
JP2021514944A (en)*2018-02-272021-06-17ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. Crystal form of oxopicolinamide derivative and method for producing them
US11225462B2 (en)2018-07-022022-01-18Jiangsu Hengrui Medicine Co., Ltd.Crystal forms of oxypyridine amide derivative and preparation method therefor
TWI825144B (en)2018-08-102023-12-11美商思達利醫藥公司Transglutaminase 2 (tg2) inhibitors
WO2020094156A1 (en)*2018-11-112020-05-14上海海雁医药科技有限公司Diheterocycle-substituted pyridine-2(1h)-ketone derivative, preparation method therefore and pharmaceutical use thereof
BR112021010476A2 (en)*2018-11-302021-08-24Ono Pharmaceutical Co., Ltd. New crystal of (3s)-3-[2-(6-amino-2-fluoropyridin-3-yl)-4-fluoro-1h-imidazol-5-yl]-7-[5-chloro-2-(1h) -tetrazol-1-yl)phenyl]-2,3-dihydroindolizin-5(1h)-one
CN109836360B (en)*2019-03-192021-08-13南京恩泰医药科技有限公司Preparation method of edoxaban tosylate intermediate and intermediate compound
CN112028877B (en)*2019-06-042021-11-26江西济民可信集团有限公司Alkoxy pyridone compound and preparation method and application thereof
BR112021026556A2 (en)*2019-06-282022-02-15Jiangxi Jemincare Group Co Ltd Tricyclic compound, method of preparation for it and use of it
CN114206854B (en)*2019-09-272023-02-24深圳信立泰药业股份有限公司FXIa inhibitor and preparation method and medical application thereof
CN112778277B (en)*2019-11-112024-04-02江西济民可信集团有限公司Cyclic ketone pyridone biaryl compound, preparation method and application thereof
CA3189771A1 (en)*2020-07-222022-01-27Janssen Pharmaceutica NvCompounds useful as factor xia inhibitors
JP2024125436A (en)*2021-07-202024-09-19小野薬品工業株式会社 Method for producing imidazole compounds
US11958856B2 (en)2021-07-222024-04-16Janssen Pharmaceutica NvSubstituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors
US20230097157A1 (en)*2021-07-222023-03-30Janssen Pharmaceutica NvBicyclic Pyridin-2-one and pyrimidin-4-one Derivatives Useful As a Factor XIa Inhibitors
CN113735770B (en)*2021-09-302023-06-06四川大学Method for synthesizing 1-aminoisoquinoline skeleton by rhodium-catalyzed 4-phenyl oxadiazolone and vinylene carbonate
WO2023179624A1 (en)*2022-03-212023-09-28上海济煜医药科技有限公司Preparation method for tricyclic compound, and intermediate thereof
CN116283908A (en)*2023-03-102023-06-23合肥工业大学 A kind of N-aryl methyl pyridone derivatives and its preparation method and application
CN118406037B (en)*2024-06-252025-02-25四川师范大学 A triazole derivative and its preparation method and use
CN118894814B (en)*2024-07-152025-09-12上海康鹏科技股份有限公司 Preparation method of 1-(2-bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP0042675A1 (en)1980-06-201981-12-30Norton CompanyMethod of mounting a grinding wheel on a spindle
WO1983003968A1 (en)1982-05-181983-11-24University Of FloridaBrain-specific drug delivery
CA1241120A (en)1985-10-011988-08-23Sami A. AlyAlternate mark inversion (ami) receiver
CA1334092C (en)*1986-07-111995-01-24David John CariniAngiotensin ii receptor blocking imidazoles
EP0407342A3 (en)*1989-07-061991-07-10Ciba-Geigy AgPyrimidine derivatives
DE4221583A1 (en)*1991-11-121993-05-13Bayer Ag SUBSTITUTED BIPHENYLPYRIDONE
DE4407488A1 (en)*1994-03-071995-09-14Bayer AgUse of bi:phenylyl-methyl- or phenyl-pyridyl-methyl- pyridone cpds.
CN100486576C (en)2002-02-142009-05-13法玛西雅公司Substituted pyridones as modulators of P38MAP kinase
US20050070531A1 (en)2003-08-132005-03-31Syrrx, Inc.Dipeptidyl peptidase inhibitors
GB0420722D0 (en)*2004-09-172004-10-20Addex Pharmaceuticals SaNovel allosteric modulators
AU2005293384A1 (en)2004-10-152006-04-20Astrazeneca AbQuinoxalines as B Raf inhibitors
WO2006057961A1 (en)2004-11-242006-06-01Vertex Pharmaceuticals Incorporated3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors
TW200730485A (en)2005-07-292007-08-16Kalypsys IncMulticyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
CN101341129B (en)*2005-12-142011-12-14布里斯托尔-迈尔斯斯奎布公司Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
AU2006325754B2 (en)2005-12-142012-04-12Bristol-Myers Squibb CompanyArylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors
JP2010510962A (en)*2006-11-242010-04-08武田薬品工業株式会社 Heteromonocyclic compounds and uses thereof
ES2546815T3 (en)*2006-12-152015-09-28Bristol-Myers Squibb Company Analogs of arylpropylamide, arylacrylamide, arylpropinamide or arylmethylurea as inhibitors of factor XIa
CA2708151A1 (en)2007-12-112009-06-18Schering CorporationGamma secretase modulators
JP5537442B2 (en)*2008-03-132014-07-02ブリストル−マイヤーズ スクイブ カンパニー Pyridazine derivatives as factor XIA inhibitors
UA106360C2 (en)2009-02-062014-08-26Янссен Фармасьютікелз, ІнкSubstituted bicyclic heterocyclic compounds as gamma secretase modulators
PH12013500657A1 (en)*2010-10-072013-05-06Takeda Pharmaceuticals Co1,4-oxazepane derivatives
PT2794597T (en)*2011-12-212018-01-16Ono Pharmaceutical CoPyridinone and pyrimidinone derivatives as factor xia inhibitors

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AU2012356374B2 (en)2017-06-22
BR112014015669A8 (en)2017-07-04
CN104136431A (en)2014-11-05
TWI613199B (en)2018-02-01
ES2655669T3 (en)2018-02-21
CA2859604C (en)2019-12-17
US20170305917A1 (en)2017-10-26
PT2794597T (en)2018-01-16
JP2015500868A (en)2015-01-08
EP3290413B9 (en)2020-04-29
US10717738B2 (en)2020-07-21
RU2014129797A (en)2016-02-10
EP3290413B1 (en)2019-11-13
IL233154A (en)2016-12-29
PH12014501365A1 (en)2014-09-22
ES2765891T3 (en)2020-06-11
CA2859604A1 (en)2013-06-27
KR102011534B1 (en)2019-08-16
KR20140103286A (en)2014-08-26
MX2014007269A (en)2014-07-22
HK1198386A1 (en)2015-04-17
MX351471B (en)2017-10-17
US20150152112A1 (en)2015-06-04
BR112014015669B1 (en)2021-10-13
IN2014CN04676A (en)2015-09-18
EP2794597A1 (en)2014-10-29
BR112014015669A2 (en)2017-06-13
AU2012356374A1 (en)2014-07-10
IL233154A0 (en)2014-08-03
CN104136431B (en)2017-03-15
PL2794597T3 (en)2018-03-30
EP3290413A1 (en)2018-03-07
AU2012356374A8 (en)2014-08-07
PH12014501365B1 (en)2014-09-22
WO2013093484A1 (en)2013-06-27
JP6137193B2 (en)2017-05-31
RU2630677C2 (en)2017-09-12
EP2794597B1 (en)2017-11-15
TW201339157A (en)2013-10-01
NZ626176A (en)2015-09-25
JP6447660B2 (en)2019-01-09
US9732085B2 (en)2017-08-15
JP2017160239A (en)2017-09-14
HUE036010T2 (en)2018-06-28
DK2794597T3 (en)2018-01-15
NO2794597T3 (en)2018-04-14

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