| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| US5126250A (en) | 1988-09-28 | 1992-06-30 | Eli Lilly And Company | Method for the reduction of heterogeneity of monoclonal antibodies |
| FI903489A7 (en) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligands containing one moiety, receptors containing these ligands, methods for their preparation and uses of the ligands and receptors |
| DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2113940T3 (en) | 1990-12-03 | 1998-05-16 | Genentech Inc | ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES. |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| ES2134212T3 (en) | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | HUMAN ANTIBODY RECONSTITUTED AGAINST THE RECEIVER OF INTERLEUKIN 6 HUMAN. |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| FI941572L (en) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Combination and method of use of anti-erbB-2 monoclonal antibodies |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
| EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| JPH08511420A (en) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | Body |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| TW416960B (en) | 1994-07-13 | 2001-01-01 | Chugai Pharmaceutical Co Ltd | Reshaped human antibody to human interleukin-8 |
| JP3865418B2 (en) | 1994-07-13 | 2007-01-10 | 中外製薬株式会社 | Reconstituted human antibody against human interleukin-8 |
| CN1156460A (en) | 1994-07-13 | 1997-08-06 | 中外制药株式会社 | Reconstructed hyman antibody against human interleukin-8 |
| US6048972A (en) | 1994-07-13 | 2000-04-11 | Chugai Pharmaceutical Co., Ltd. | Recombinant materials for producing humanized anti-IL-8 antibodies |
| ATE340590T1 (en) | 1994-07-13 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | RECONSTITUTED HUMAN ANTIBODY DIRECTED AGAINST HUMAN INTERLEUKIN-8 |
| EP2319535A3 (en) | 1994-10-21 | 2011-08-31 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for treatment of diseases caused by IL-6 production |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| AU3968897A (en) | 1996-08-02 | 1998-02-25 | Bristol-Myers Squibb Company | A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis |
| US6025158A (en) | 1997-02-21 | 2000-02-15 | Genentech, Inc. | Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| CN1068524C (en) | 1997-06-23 | 2001-07-18 | 叶庆炜 | Process for preparing medicine for curing intractable psoriasis |
| WO1998058964A1 (en) | 1997-06-24 | 1998-12-30 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| DE69840412D1 (en) | 1997-10-31 | 2009-02-12 | Genentech Inc | METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| DK1034298T3 (en) | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanization of murine antibody |
| US6458355B1 (en) | 1998-01-22 | 2002-10-01 | Genentech, Inc. | Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates |
| DK1074268T3 (en) | 1998-03-17 | 2008-04-28 | Chugai Pharmaceutical Co Ltd | IL-6 receptor antagonist antibody-containing preventative or therapeutic agents for inflammatory bowel diseases |
| ES2292236T3 (en) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| WO1999054342A1 (en) | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| HUP0104865A3 (en) | 1999-01-15 | 2004-07-28 | Genentech Inc | Polypeptide variants with altered effector function |
| AU2006225302B2 (en) | 1999-03-25 | 2010-08-12 | AbbVie Deutschland GmbH & Co. KG | Human antibodies that bind human IL-12 and methods for producing |
| EP3031917A1 (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| KR100797667B1 (en) | 1999-10-04 | 2008-01-23 | 메디카고 인코포레이티드 | How to regulate transcription of foreign genes |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| EP1229125A4 (en) | 1999-10-19 | 2005-06-01 | Kyowa Hakko Kogyo Kk | PROCESS FOR PRODUCING A POLYPEPTIDE |
| JP2003516755A (en) | 1999-12-15 | 2003-05-20 | ジェネンテック・インコーポレーテッド | Shotgun scanning, a combined method for mapping functional protein epitopes |
| NZ518764A (en) | 1999-12-29 | 2004-02-27 | Immunogen Inc | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
| KR20020093029A (en) | 2000-04-11 | 2002-12-12 | 제넨테크, 인크. | Multivalent Antibodies And Uses Therefor |
| EA013563B1 (en) | 2000-10-06 | 2010-06-30 | Киова Хакко Кирин Ко., Лтд. | A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies |
| US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| WO2002036165A1 (en) | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2405944T3 (en) | 2000-11-30 | 2013-06-04 | Medarex, Inc. | Nucleic acids encoding reorganized human immunoglobulin sequences from transgenic transchromosomal micezadas |
| ES2727425T3 (en) | 2000-12-12 | 2019-10-16 | Medimmune Llc | Molecules with prolonged half-lives, compositions and uses thereof |
| JP4234438B2 (en) | 2001-03-07 | 2009-03-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Expression technology of protein containing hybrid isotype antibody part |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| CN1561345B (en) | 2001-04-13 | 2011-09-14 | 比奥根艾迪克Ma公司 | Antibodies against VLA-1 |
| NZ592087A (en) | 2001-08-03 | 2012-11-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| PL213948B1 (en) | 2001-10-25 | 2013-05-31 | Genentech Inc | Glycoprotein compositions |
| EP1461423B1 (en) | 2001-12-03 | 2008-05-14 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| WO2003074679A2 (en) | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| ES2362419T3 (en) | 2002-04-09 | 2011-07-05 | Kyowa Hakko Kirin Co., Ltd. | CELLS WITH DEPRESSION OR DELETION OF THE ACTIVITY OF THE PROTEIN THAT PARTICIPATES IN THE TRANSPORT OF GDP-FUCOSA. |
| AU2003236015A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | Process for producing antibody composition |
| JPWO2003085119A1 (en) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | Method for enhancing binding activity of antibody composition to Fcγ receptor IIIa |
| PL373256A1 (en) | 2002-04-09 | 2005-08-22 | Kyowa Hakko Kogyo Co, Ltd. | Cells with modified genome |
| EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | MEDICAMENT CONTAINING ANTIBODY COMPOSITION APPROPRIATE TO PATIENT SUFFERING FROM POLYMORPHISM FC gammma RIIIA |
| CA2481920A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament |
| AU2003222664A1 (en) | 2002-04-18 | 2003-11-03 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| WO2003102580A1 (en) | 2002-05-31 | 2003-12-11 | Biacore Ab | Method of coupling binding agents to a substrate surface |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| CN101987871A (en) | 2002-09-27 | 2011-03-23 | 赞科股份有限公司 | Optimized fc variants and methods for their generation |
| ATE480562T1 (en) | 2002-10-15 | 2010-09-15 | Facet Biotech Corp | CHANGE IN FCRN BINDING AFFINITIES OR SERUM HALF-LIFE TIMES OF ANTIBODIES USING MUtagenesis |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP4739763B2 (en) | 2002-12-16 | 2011-08-03 | ゲンマブ エー/エス | Human monoclonal antibody against interleukin 8 (IL-8) |
| EP2301966A1 (en) | 2002-12-16 | 2011-03-30 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| KR101410692B1 (en) | 2002-12-24 | 2014-06-24 | 리나트 뉴로사이언스 코프. | Anti-ngf antibodies and methods using same |
| EP1585767A2 (en) | 2003-01-16 | 2005-10-19 | Genentech, Inc. | Synthetic antibody phage libraries |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| EP1636264A2 (en) | 2003-06-24 | 2006-03-22 | MERCK PATENT GmbH | Tumour necrosis factor receptor molecules with reduced immunogenicity |
| EP1644416A4 (en) | 2003-06-30 | 2007-08-29 | Centocor Inc | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
| US20080241884A1 (en) | 2003-10-08 | 2008-10-02 | Kenya Shitara | Fused Protein Composition |
| US20070134759A1 (en) | 2003-10-09 | 2007-06-14 | Harue Nishiya | Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase |
| JP2007531707A (en) | 2003-10-15 | 2007-11-08 | ピーディーエル バイオファーマ, インコーポレイテッド | Modification of Fc fusion protein serum half-life by mutagenesis of heavy chain constant region positions 250, 314 and / or 428 of IG |
| DE602004026470D1 (en) | 2003-11-05 | 2010-05-20 | Roche Glycart Ag | FC RECEPTOR AND EFFECTOR FUNCTION |
| EP3858387A1 (en) | 2003-11-06 | 2021-08-04 | Seagen Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| EP1697415A1 (en) | 2003-11-12 | 2006-09-06 | Biogen Idec MA Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| US20050142133A1 (en) | 2003-12-03 | 2005-06-30 | Xencor, Inc. | Optimized proteins that target the epidermal growth factor receptor |
| WO2005056759A2 (en) | 2003-12-04 | 2005-06-23 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| JPWO2005053742A1 (en) | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | Medicament containing antibody composition |
| AR048210A1 (en) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | A PREVENTIVE AGENT FOR VASCULITIS. |
| US20050249723A1 (en) | 2003-12-22 | 2005-11-10 | Xencor, Inc. | Fc polypeptides with novel Fc ligand binding sites |
| CA2561264A1 (en) | 2004-03-24 | 2005-10-06 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| AR048335A1 (en) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENTS FOR INTERNAL EAR DISORDERS CONTAINING AN IL-6 ANTAGONIST AS AN ACTIVE INGREDIENT |
| CN1961003B (en) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | Humanized anti-TGF-beta antibodies |
| WO2005123780A2 (en) | 2004-04-09 | 2005-12-29 | Protein Design Labs, Inc. | Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| PL1737891T3 (en) | 2004-04-13 | 2013-08-30 | Hoffmann La Roche | Anti-p-selectin antibodies |
| AU2005259992A1 (en) | 2004-06-25 | 2006-01-12 | Medimmune, Llc | Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis |
| WO2006085967A2 (en) | 2004-07-09 | 2006-08-17 | Xencor, Inc. | OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS |
| BRPI0510674A (en) | 2004-07-15 | 2007-12-26 | Xencor Inc | optimized fc variants |
| MX2007001345A (en) | 2004-08-04 | 2008-03-11 | Applied Molecular Evolution | Variant fc regions. |
| ZA200701715B (en) | 2004-08-19 | 2008-07-30 | Genentech Inc | Polypeptide variants with altered effector function |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| WO2006034488A2 (en) | 2004-09-23 | 2006-03-30 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
| WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
| BRPI0517457A (en) | 2004-10-22 | 2008-10-07 | Amgen Inc | methods for refolding recombinant antibodies |
| JP2008518936A (en) | 2004-10-29 | 2008-06-05 | メディミューン,インコーポレーテッド | Methods for preventing and treating RSV infections and related conditions |
| CA2587766A1 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP1817340B1 (en) | 2004-11-12 | 2012-05-16 | Xencor, Inc. | Fc variants with altered binding to fcrn |
| AU2005321974B2 (en) | 2004-12-27 | 2011-11-17 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| KR20130105885A (en) | 2005-01-05 | 2013-09-26 | 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| EP1858925A2 (en) | 2005-01-12 | 2007-11-28 | Xencor, Inc. | Antibodies and fc fusion proteins with altered immunogenicity |
| US8716451B2 (en) | 2005-01-12 | 2014-05-06 | Kyowa Hakko Kirin Co., Ltd | Stabilized human IgG2 and IgG3 antibodies |
| US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
| WO2006105338A2 (en) | 2005-03-31 | 2006-10-05 | Xencor, Inc. | Fc VARIANTS WITH OPTIMIZED PROPERTIES |
| MX2007013058A (en) | 2005-04-20 | 2008-02-22 | Amgen Fremont Inc | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies. |
| EP1896503B1 (en) | 2005-05-31 | 2014-10-29 | Board of Regents, The University of Texas System | IgG1 ANTIBODIES WITH MUTATED Fc PORTION FOR INCREASED BINDING TO FcRn RECEPTOR AND USES TEHEREOF |
| US7557190B2 (en) | 2005-07-08 | 2009-07-07 | Xencor, Inc. | Optimized proteins that target Ep-CAM |
| US8217147B2 (en) | 2005-08-10 | 2012-07-10 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| CU23578A1 (en)* | 2005-09-16 | 2010-09-30 | Ct Ingenieria Genetica Biotech | VIRUS CAPSID PROTEIN DENGES INDUCTIVE PROTECTION RESPONSE AND VACCINE COMPOSITION |
| AU2006297173A1 (en) | 2005-09-29 | 2007-04-12 | Viral Logic Systems Technology Corp. | Immunomodulatory compositions and uses therefor |
| DK1931709T3 (en) | 2005-10-03 | 2017-03-13 | Xencor Inc | FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES |
| WO2007044616A2 (en) | 2005-10-06 | 2007-04-19 | Xencor, Inc. | Optimized anti-cd30 antibodies |
| BRPI0617378B8 (en) | 2005-10-14 | 2022-09-20 | Chugai Pharmaceutical Co Ltd | USE OF AN IL-6 INHIBITOR TO PRODUCE A PHARMACEUTICAL COMPOSITION TO SUPPRESS DAMAGE TO AN ISLE TRANSPLANTATION AFTER ISLE TRANSPLANTATION; AND IMPROVE THE FEASIBILITY OF AN ISLAND IN AN ISLAND TRANSPLANTATION |
| BRPI0617664B8 (en) | 2005-10-21 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | use of an antibody recognizing IL-6 for the production of a pharmaceutical composition to treat myocardial infarction or suppress left ventricular remodeling after myocardial infarction |
| ES2577292T3 (en) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Binding polypeptides with diversified VH / VL hypervariable sequences and consensus |
| CU23586A1 (en)* | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS |
| US20070237764A1 (en) | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| AU2007212147A1 (en) | 2006-02-03 | 2007-08-16 | Medimmune, Llc | Protein formulations |
| AU2007227292B2 (en) | 2006-03-17 | 2012-04-12 | Biogen Ma Inc. | Stabilized polypeptide compositions |
| JP4294082B2 (en) | 2006-03-23 | 2009-07-08 | 協和発酵キリン株式会社 | Agonist antibody to human thrombopoietin receptor |
| AU2007245164A1 (en) | 2006-03-28 | 2007-11-08 | Biogen Idec Ma Inc. | Anti-IGF-IR antibodies and uses thereof |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| JP5754875B2 (en) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | Muscle regeneration promoter |
| JP2009536527A (en) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | Binding polypeptide with optimized scaffold |
| CL2007001829A1 (en) | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | N- [4-Chloro-2-hydroxy-3- (piperazine-1-sulfonyl) phenyl] -n- (2-chloro-3-fluorophenyl) urea P-toluenesulfonate; preparation process; pharmaceutical composition; pharmaceutical combination; and use in the treatment of a disease mediated by chemokine il-8, such as asthma and epoc. |
| AR062223A1 (en) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | MOLECULES OF ADHESION TO THE ANTIGEN THAT ADHER TO EGFR, VECTORS THAT CODE THEM, AND THEIR USES OF THESE |
| EP2059536B1 (en) | 2006-08-14 | 2014-01-08 | Xencor, Inc. | Optimized antibodies that target cd19 |
| WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
| ES2383710T3 (en) | 2006-09-08 | 2012-06-25 | Medimmune, Llc | Humanized anti-CD19 antibodies and their use in the treatment of tumors, transplants and autoimmune diseases |
| JP5562031B2 (en) | 2006-09-18 | 2014-07-30 | ゼンコー・インコーポレイテッド | Optimized antibody targeting HM1.24 |
| WO2008121160A2 (en) | 2006-11-21 | 2008-10-09 | Xencor, Inc. | Optimized antibodies that target cd5 |
| CN100455598C (en) | 2006-11-29 | 2009-01-28 | 中国抗体制药有限公司 | Functional humanized anti-human CD20 antibody and application thereof |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| WO2008091798A2 (en) | 2007-01-22 | 2008-07-31 | Xencor, Inc. | Optimized ca9 antibodies and methods of using the same |
| CA2669412A1 (en) | 2007-01-23 | 2008-07-31 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| WO2008092117A2 (en) | 2007-01-25 | 2008-07-31 | Xencor, Inc. | Immunoglobulins with modifications in the fcr binding region |
| WO2008098115A2 (en) | 2007-02-07 | 2008-08-14 | Xencor, Inc. | Optimized igf-1r antibodies and methods of using the same |
| US8337854B2 (en)* | 2007-04-04 | 2012-12-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Monoclonal antibodies against dengue and other viruses with deletion in Fc region |
| CL2008001071A1 (en) | 2007-04-17 | 2009-05-22 | Smithkline Beecham Corp | Method to obtain penta-specific antibody against human il-8 / cxcl8, gro-alpha / cxcl1, gro-beta / cxcl2), gro-gamma / cxcl3 and ena-78 / cxcl5; penta-specific antibody; production process of the same; vector, hybridoma or cella that comprises it; pharmaceutical composition; use to treat copd, other diseases. |
| CN100592373C (en) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | Liquid crystal display panel driving device and driving method thereof |
| EP3392273A1 (en) | 2007-05-30 | 2018-10-24 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| EP2155790A1 (en) | 2007-05-31 | 2010-02-24 | Genmab A/S | Method for extending the half-life of exogenous or endogenous soluble molecules |
| NZ581470A (en) | 2007-06-25 | 2013-04-26 | Esbatech Alcon Biomed Res Unit | Sequence based engineering and optimization of single chain antibodies |
| BRPI0813645A2 (en) | 2007-06-25 | 2014-12-30 | Esbatech Alcon Biomed Res Unit | METHODS FOR MODIFYING ANTIBODIES, AND MODIFIED ANTIBODIES WITH PERFECT FUNCTIONAL PROPERTIES |
| US20110105724A1 (en) | 2007-08-16 | 2011-05-05 | Stephanie Jane Clegg | Novel compounds |
| CN101842116A (en) | 2007-08-28 | 2010-09-22 | 比奥根艾迪克Ma公司 | Compositions binding multiple epitopes of IGF-1R |
| WO2009032145A1 (en) | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Anti-igf-1r antibodies and uses thereof |
| EP2031064A1 (en) | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Method for increasing protein titres |
| MX2010002683A (en) | 2007-09-14 | 2010-03-26 | Amgen Inc | POPULATIONS OF HOMOGENEO ANTIBODIES. |
| JP5334319B2 (en) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
| PE20091205A1 (en) | 2007-09-26 | 2009-09-09 | Chugai Pharmaceutical Co Ltd | IL-6 ANTI-RECEPTOR ANTIBODY |
| ES2566957T3 (en) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Constant region of modified antibody |
| JO3076B1 (en) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | Immunotherapy regimes dependent on apoe status |
| AU2008345242B2 (en) | 2007-10-31 | 2014-02-27 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| JP5682995B2 (en) | 2007-12-05 | 2015-03-11 | 中外製薬株式会社 | Anti-NR10 antibody and use thereof |
| PL2235064T3 (en) | 2008-01-07 | 2016-06-30 | Amgen Inc | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| BRPI0907735B1 (en) | 2008-02-08 | 2021-10-05 | Astrazeneca Ab | MODIFIED IGG-CLASS MONOCLONAL ANTIBODY SPECIFIC TO IFNAR1, ISOLATED NUCLEIC ACID AND PHARMACEUTICAL COMPOSITION |
| CN101343319B (en)* | 2008-04-10 | 2012-05-09 | 中国人民解放军第三军医大学 | Monoclonal antibody of anti-dengue virus E protein, preparation method and application thereof |
| CN107469077A (en) | 2008-04-11 | 2017-12-15 | 中外制药株式会社 | The antigen binding molecules combined repeatedly with the antigen of multiple molecules |
| PL2853545T3 (en) | 2008-09-17 | 2016-12-30 | | Antibody specific for IgE |
| MX2011003588A (en) | 2008-10-13 | 2011-10-14 | Inst Research In Biomedicine | Dengue virus neutralizing antibodies and uses thereof. |
| ES2828721T3 (en) | 2008-10-14 | 2021-05-27 | Genentech Inc | Immunoglobulin variants and their uses |
| TWI682995B (en) | 2009-03-19 | 2020-01-21 | 日商中外製藥股份有限公司 | Antibody constant region alteration |
| EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
| GB0914691D0 (en) | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
| JP5837821B2 (en) | 2009-09-24 | 2015-12-24 | 中外製薬株式会社 | Antibody constant region variants |
| US8362210B2 (en) | 2010-01-19 | 2013-01-29 | Xencor, Inc. | Antibody variants with enhanced complement activity |
| WO2011100271A2 (en) | 2010-02-09 | 2011-08-18 | Glaxosmithkline Llc | Novel uses |
| US10435458B2 (en) | 2010-03-04 | 2019-10-08 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variants with reduced Fcgammar binding |
| TWI667257B (en) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | Antibodies with modified affinity to fcrn that promote antigen clearance |
| DK3029066T3 (en) | 2010-07-29 | 2019-05-20 | Xencor Inc | ANTIBODIES WITH MODIFIED ISOELECTRIC ITEMS |
| BR112013013354A2 (en) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | antigen-binding molecule capable of binding to a plurality of antigen molecules repeatedly |
| BR112013015129B1 (en) | 2010-12-14 | 2022-11-16 | National University Of Singapore | ISOLATED ANTIBODY OR FRAGMENT THEREOF AND PHARMACEUTICAL COMPOSITION |
| JP6043629B2 (en) | 2011-01-07 | 2016-12-14 | 中外製薬株式会社 | Methods for improving antibody physical properties |
| WO2012132067A1 (en) | 2011-03-30 | 2012-10-04 | 中外製薬株式会社 | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
| EP2679681B2 (en) | 2011-02-25 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIB-specific FC antibody |
| RU2636038C2 (en) | 2011-05-04 | 2017-11-17 | Омерос Корпорейшн | Compositions for inhibition of masp-2-dependent complement activation |
| WO2013012733A1 (en) | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
| SG11201401102VA (en) | 2011-09-30 | 2014-09-26 | Chugai Pharmaceutical Co Ltd | Ion concentration-dependent binding molecule library |
| TW201817744A (en) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | Therapeutic antigen-binding molecule having an FcRn binding domain that promotes antigen clearance |
| TWI827333B (en) | 2011-09-30 | 2023-12-21 | 日商中外製藥股份有限公司 | Antigen-binding molecules that promote antigen disappearance |
| WO2013081143A1 (en) | 2011-11-30 | 2013-06-06 | 中外製薬株式会社 | Drug containing carrier into cell for forming immune complex |
| US20140349321A1 (en)* | 2011-12-16 | 2014-11-27 | Agency For Science, Technology And Research | Binding molecules against dengue virus and uses thereof |
| TWI593705B (en)* | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
| CN104244980B (en) | 2012-02-24 | 2017-11-10 | 中外制药株式会社 | Antigen binding molecules that promote antigen elimination via Fc γ IIB |
| US9821050B2 (en) | 2012-04-02 | 2017-11-21 | The University Of North Carolina At Chapel Hill | Chimeric dengue virus E glycoproteins comprising mutant domain I and domain II hinge regions |
| JP6211597B2 (en) | 2012-05-01 | 2017-10-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | New antibody |
| US9556254B2 (en) | 2012-05-14 | 2017-01-31 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Cross-reactive antibodies against dengue virus and uses thereof |
| JPWO2013180201A1 (en) | 2012-05-30 | 2016-01-21 | 中外製薬株式会社 | Antigen-binding molecules that eliminate associated antigens |
| WO2013180200A1 (en) | 2012-05-30 | 2013-12-05 | 中外製薬株式会社 | Target-tissue-specific antigen-binding molecule |
| EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
| CN104768574B (en) | 2012-08-07 | 2017-12-22 | 麻省理工学院 | Anti-dengue virus antibody and use thereof |
| WO2014030728A1 (en) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | Fcγriib-specific fc region variant |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| EP2948473A1 (en) | 2013-01-24 | 2015-12-02 | GlaxoSmithKline Intellectual Property Development Limited | Tnf-alpha antigen-binding proteins |
| EP2970508A4 (en) | 2013-03-15 | 2016-12-14 | Permeon Biologics Inc | Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| KR102211176B1 (en) | 2013-03-15 | 2021-02-01 | 젠코어 인코포레이티드 | Heterodimeric proteins |
| CA2908350C (en)* | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| KR20160021125A (en) | 2013-05-17 | 2016-02-24 | 쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스) | Anti-cxcl1, cxcl7 and cxcl8 antibodies and their applications |
| BR112015029788B1 (en) | 2013-05-31 | 2024-01-02 | Zymeworks Inc | HETERO-MULTIMER, USE AND METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND METHOD FOR REDUCING EFFECTOR FUNCTION OF AN IgG FC CONSTRUCT |
| EP3080159A4 (en)* | 2013-12-13 | 2017-08-02 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs and method of using same |
| SG11201606624WA (en) | 2014-02-11 | 2016-09-29 | Visterra Inc | Antibody moleules to dengue virus and uses thereof |
| KR20160119806A (en) | 2014-02-11 | 2016-10-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | Novel full spectrum anti-dengue antibody |
| GB201413086D0 (en) | 2014-07-23 | 2014-09-03 | Imp Innovations Ltd And Inst Pasteur | Methods |
| PE20221834A1 (en)* | 2014-12-19 | 2022-11-29 | Chugai Pharmaceutical Co Ltd | ANTIMYOSTATIN ANTIBODIES |
| TWI844507B (en) | 2015-02-05 | 2024-06-11 | 日商中外製藥股份有限公司 | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, and uses therof |
| US10457737B2 (en) | 2015-02-09 | 2019-10-29 | Research Development Foundation | Engineered immunoglobulin Fc polypeptides displaying improved complement activation |
| EP3271390B1 (en) | 2015-03-17 | 2023-09-27 | Agency For Science, Technology And Research | A serotype cross-reactive, dengue neutralizing antibody and uses thereof |
| US10940126B2 (en) | 2015-07-03 | 2021-03-09 | Camilla Svensson | Inhibition of IL-8 in the treatment of pain and/or bone loss |
| BR112018002432A2 (en) | 2015-09-18 | 2018-09-18 | Chugai Pharmaceutical Co Ltd | il-8 binding antibodies and uses thereof |
| GB201610162D0 (en) | 2016-06-10 | 2016-07-27 | Imp Innovations Ltd And Inst Pasteur | Methods |
| TW201815821A (en) | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | Anti-zika virus antibodies and methods of use |
| US11053308B2 (en) | 2016-08-05 | 2021-07-06 | Chugai Seiyaku Kabushiki Kaisha | Method for treating IL-8-related diseases |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |