| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27116809P | 2009-07-17 | 2009-07-17 |
| Publication Number | Publication Date |
|---|---|
| SG10201505075TAtrue SG10201505075TA (en) | 2015-07-30 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012003356ASG177687A1 (en) | 2009-07-17 | 2010-07-16 | Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts |
| SG10201505075TASG10201505075TA (en) | 2009-07-17 | 2010-07-16 | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| SG10201700096VASG10201700096VA (en) | 2009-07-17 | 2010-07-16 | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012003356ASG177687A1 (en) | 2009-07-17 | 2010-07-16 | Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201700096VASG10201700096VA (en) | 2009-07-17 | 2010-07-16 | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| Country | Link |
|---|---|
| US (6) | US8859467B2 (en) |
| EP (6) | EP2454376B1 (en) |
| JP (3) | JP6193570B2 (en) |
| KR (5) | KR20210013294A (en) |
| CN (2) | CN102625848A (en) |
| AU (5) | AU2010273974B2 (en) |
| BR (2) | BR122015012748A2 (en) |
| CA (2) | CA2768247C (en) |
| DK (5) | DK3156485T3 (en) |
| ES (3) | ES2581318T3 (en) |
| HU (1) | HUE029328T2 (en) |
| IN (1) | IN2012DN00737A (en) |
| MX (3) | MX347654B (en) |
| MY (2) | MY173037A (en) |
| PL (2) | PL2907873T3 (en) |
| PT (1) | PT3042957T (en) |
| SG (3) | SG177687A1 (en) |
| WO (1) | WO2011009058A2 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122015012748A2 (en) | 2009-07-17 | 2020-01-07 | Bioatla, Llc | METHODS OF EVOLUTION, IDENTIFICATION AND PRODUCTION OF A PROTEIN |
| WO2011109726A2 (en)* | 2010-03-05 | 2011-09-09 | Bioatla Llc | Homologous multi-specific antibodies |
| AU2015242961B2 (en)* | 2010-07-16 | 2017-03-02 | Bioatla, Llc | Novel methods of protein evolution |
| EP2593797B1 (en)* | 2010-07-16 | 2019-05-08 | Bioatla, LLC | Novel methods of protein evolution |
| EP2614086A1 (en) | 2010-09-08 | 2013-07-17 | Halozyme, Inc. | Methods for assessing and identifying or evolving conditionally active therapeutic proteins |
| EP2773964A4 (en)* | 2011-11-03 | 2015-06-24 | Stc Biolog Inc | Method for determination of pharmacological properties of recombinant proteins |
| EP2991679A4 (en) | 2013-04-29 | 2016-12-07 | Adimab Llc | MULTISPECIFICITY REAGENTS, METHODS OF PREPARATION AND USE THEREOF |
| EP3092491B1 (en)* | 2014-01-07 | 2018-10-31 | Bioatla, LLC | Proteins targeting orthologs |
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| WO2015175375A1 (en)* | 2014-05-13 | 2015-11-19 | Short Jay M | Conditionally active biological proteins |
| WO2016004242A1 (en)* | 2014-07-01 | 2016-01-07 | Stc Biologics, Inc. | A method for development of recombinant proteins with fingerprint like similarity to the reference product |
| MX2017002605A (en)* | 2014-08-28 | 2017-05-19 | Bioatla Llc | Conditionally active chimeric antigen receptors for modified t-cells. |
| BR112017004131A2 (en) | 2014-09-03 | 2017-12-12 | Bioatla Llc | method of producing a conditionally active biological protein, conditionally active biological protein, chimeric antigen receptor, and cytotoxic cell. |
| JP7025214B2 (en) | 2015-02-24 | 2022-02-24 | バイオアトラ、エルエルシー | Conditionally active biological protein |
| CN108137681B (en)* | 2015-09-23 | 2024-06-18 | 豪夫迈·罗氏有限公司 | Optimized variants of anti-VEGF antibodies |
| KR20240150525A (en) | 2015-11-02 | 2024-10-15 | 바이오아트라, 인코퍼레이티드 | Conditionally active polypeptides |
| HUE060072T2 (en) | 2016-05-13 | 2023-01-28 | Bioatla Inc | Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| SG10201913147WA (en) | 2017-07-11 | 2020-02-27 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| EP3880716A4 (en) | 2018-11-13 | 2022-08-03 | Compass Therapeutics LLC | Multispecific binding constructs against checkpoint molecules and uses thereof |
| WO2020227515A1 (en) | 2019-05-07 | 2020-11-12 | Voyager Therapeutics, Inc. | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation |
| CN111048154B (en)* | 2019-12-10 | 2023-06-06 | 上海药明生物技术有限公司 | Method for mapping antibody epitope |
| CN111462815B (en)* | 2020-03-27 | 2023-05-02 | 上海祥耀生物科技有限责任公司 | Construction method and device of antibody library |
| US11506060B1 (en)* | 2021-07-15 | 2022-11-22 | Honeywell International Inc. | Radial turbine rotor for gas turbine engine |
| WO2023044483A2 (en) | 2021-09-20 | 2023-03-23 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
| US20250034559A1 (en) | 2021-11-17 | 2025-01-30 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| US20250295809A1 (en) | 2022-05-13 | 2025-09-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
| WO2024030976A2 (en) | 2022-08-03 | 2024-02-08 | Voyager Therapeutics, Inc. | Compositions and methods for crossing the blood brain barrier |
| WO2025122634A1 (en) | 2023-12-05 | 2025-06-12 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (en) | 1970-11-10 | 1977-09-15 | Organon Nv | PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4957858A (en) | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| AU622104B2 (en) | 1987-03-11 | 1992-04-02 | Sangtec Molecular Diagnostics Ab | Method of assaying of nucleic acids, a reagent combination and kit therefore |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| WO1989006700A1 (en) | 1988-01-21 | 1989-07-27 | Genentech, Inc. | Amplification and detection of nucleic acid sequences |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| EP0365627B1 (en) | 1988-03-24 | 1993-12-22 | University Of Iowa Research Foundation | Catalytic hybridization systems for the detection of nucleic acid sequences based on their activity as cofactors in catalytic reactions in which a complementary labeled nucleic acid probe is cleaved |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ATE251669T1 (en) | 1992-11-24 | 2003-10-15 | Searle & Co | MUTATED POLYPEPTIDES OF INTERLEUKIN-3(IL-3) |
| US6562594B1 (en) | 1999-09-29 | 2003-05-13 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US20030219752A1 (en)* | 1995-12-07 | 2003-11-27 | Diversa Corporation | Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof |
| US6764835B2 (en) | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
| US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
| US8137906B2 (en) | 1999-06-07 | 2012-03-20 | Sloning Biotechnology Gmbh | Method for the synthesis of DNA fragments |
| US7033781B1 (en) | 1999-09-29 | 2006-04-25 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
| US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| KR20040074587A (en) | 2001-02-19 | 2004-08-25 | 메르크 파텐트 게엠베하 | Artificial proteins with reduced immunogenicity |
| US7117096B2 (en) | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| JP2004532038A (en)* | 2001-05-17 | 2004-10-21 | ディヴァーサ コーポレイション | Application of novel antigen-binding molecules to therapeutic, diagnostic, prophylactic, enzymatic, industrial and agricultural fields, and methods for producing and screening novel antigen-binding molecules therefor |
| US7647184B2 (en)* | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
| JP4791960B2 (en)* | 2003-06-27 | 2011-10-12 | バイオレン，インク． | Look-through mutagenesis |
| GB0520169D0 (en)* | 2005-10-04 | 2005-11-09 | Celltech R&D Ltd | Biological products |
| KR20080073293A (en)* | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | Cell display of antibody library |
| EP2137308B1 (en)* | 2007-03-26 | 2016-08-03 | Agenus Inc. | Cell surface display, screening and production of proteins of interest |
| WO2009059235A2 (en) | 2007-11-01 | 2009-05-07 | Facet Biotech Corporation | Immunoglobulin display vectors |
| US9150849B2 (en) | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| US8312249B1 (en) | 2008-10-10 | 2012-11-13 | Apple Inc. | Dynamic trampoline and structured code generation in a signed code environment |
| BR122015012748A2 (en) | 2009-07-17 | 2020-01-07 | Bioatla, Llc | METHODS OF EVOLUTION, IDENTIFICATION AND PRODUCTION OF A PROTEIN |
| FR2957821B1 (en) | 2010-03-24 | 2014-08-29 | Inst Francais Du Petrole | NEW AREA OF CATALYST REGENERATION DIVIDED IN SECTORS FOR REGENERATIVE CATALYTIC UNITS |
| Publication | Publication Date | Title |
|---|---|---|
| SG10201505075TA (en) | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts | |
| EP3460064B8 (en) | Efficient protein expression in vivo using modified rna (mod-rna) | |
| IL250624A0 (en) | Anti-fgfr3 antibodies and methods using same | |
| GB0922434D0 (en) | antibodies and fragments thereof | |
| IL218753A0 (en) | Protein arrays and uses thereof | |
| BRPI0924535A2 (en) | Double-Direction Antibody in New Form, and Use of the Same | |
| PT3043182T (en) | Monoclonal antibodies to hemoglobin variants c, s, e and d | |
| EP2494062A4 (en) | Anti-glp-1r antibodies and their uses | |
| ZA201107486B (en) | Anti-tnf-x antibodies and their uses | |
| PL2246427T3 (en) | Antibodies capable of binding specifically to amyloid beta-oligomers, and use thereof | |
| ZA201006979B (en) | Antibodies to il-6 and their uses | |
| IL215291A0 (en) | NOVEL ANTI-a5BETA1 ANTIBODIES AND USES THEREOF | |
| IL236237A (en) | Tmem154 antibodies and fragments and uses thereof | |
| IL220536A0 (en) | Anti - bv8 antibodies and uses thereof | |
| PL3871674T3 (en) | Use of anatabine for reducing blood serum levels of c-reactive protein in an individual | |
| IL219136A0 (en) | Anti-hepsin antibodies and methods using same | |
| IL214527A0 (en) | Anti-mst1r antibodies and uses thereof | |
| ZA201100019B (en) | Variant hhip1 protein and methods and uses thereof | |
| GB0903151D0 (en) | Antibody uses and methods | |
| ZA201109283B (en) | Protein | |
| EP2540742A4 (en) | Anti-cyr61 protein monoclonal antibodies and uses thereof | |
| AU2009904099A0 (en) | Antibodies to C5L2 and C5aR | |
| HK1186743A (en) | Hiv core protein specific antibodies and uses thereof | |
| GB0902222D0 (en) | Protein expression | |
| GB0909384D0 (en) | Protein |