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PE20051089A1 - PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS - Google Patents

PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

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Publication number
PE20051089A1
PE20051089A1PE2005000080APE2005000080APE20051089A1PE 20051089 A1PE20051089 A1PE 20051089A1PE 2005000080 APE2005000080 APE 2005000080APE 2005000080 APE2005000080 APE 2005000080APE 20051089 A1PE20051089 A1PE 20051089A1
Authority
PE
Peru
Prior art keywords
phenyl
pyrimidin
piperazin
methyl
pyrazole
Prior art date
Application number
PE2005000080A
Other languages
Spanish (es)
Inventor
Guido Bold
Andreas Floersheimer
Pascal Furet
Patricia Imbach
Keiichi Masuya
Joseph Schoepfer
Georg Martiny-Baron
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=34807167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20051089(A1)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AgfiledCriticalNovartis Ag
Publication of PE20051089A1publicationCriticalpatent/PE20051089A1/en

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Abstract

Translated fromSpanish

SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLO [1,5-a] PIRIMIDIN-7-IL-AMINA DE FORMULA (I), EN DONDE R1 ES H, HALOGENO O ALQUILO INFERIOR; R2 ES H, ARILO, HETEROARILO, ALQUILO INFERIOR, CICLOALQUILO, BENCILO, BENZOTIENILO, INDOLILO ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDOS; A ES H, HALOGENO, BENZOTIENILO, PIRIDILO, FENILO, PIPERAZINILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: 3-{7-AMINO-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO-[1,5-A]-PIPRIMIDIN-6-IL}-FENOL, 6-(3-BENCILOXI-FENIL)-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL)-FENOL, 6-(3-METOXI-FENIL)-4-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL-AMINA, ENTRE OTROS. SE REFIERE A UNA COMPOSICION Y UN PROCESO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA DE DIFERENTES GRADOS DE ESPECIFICIDAD, POR LO QUE SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO TUMOR BENIGNO O MALIGNOREFERS TO COMPOUNDS DERIVED FROM PYRAZOLO [1,5-a] PYRIMIDIN-7-IL-AMINE OF FORMULA (I), WHERE R1 IS H, HALOGEN OR LOWER ALKYL; R2 IS H, ARYL, HETEROARYL, LOWER ALKYL, CYCLOALKYL, BENZYL, BENZOTHENYL, INDOLYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED; R3 IS H, LOWER RENT, OPTIONALLY REPLACED; A IS H, HALOGEN, BENZOTHENYL, PYRIDYL, PHENYL, PIPERAZINYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED. PREFERRED COMPOUNDS ARE: 3- {7-AMINO-3- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PIRAZOLO- [1,5-A] -PIPRIMIDIN-6-IL} -PHENOL, 6- (3-BENZYLOXY-PHENYL) -3- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PYRAZOLO [1,5-A] PYRIMIDIN-7-IL) -PHENOL, 6- ( 3-METHOXY-PHENYL) -4- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PIRAZOLO [1,5-A] PYRIMIDIN-7-IL-AMINE, AMONG OTHERS. IT REFERS TO A COMPOSITION AND A PREPARATION PROCESS. THESE COMPOUNDS ARE INHIBITORS OF KINASE OF DIFFERENT DEGREES OF SPECIFICITY, SO THEY ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS BENIGN OR MALIGNANT TUMOR

PE2005000080A2004-01-222005-01-20 PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORSPE20051089A1 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
US53822004P2004-01-222004-01-22

Publications (1)

Publication NumberPublication Date
PE20051089A1true PE20051089A1 (en)2006-01-25

Family

ID=34807167

Family Applications (1)

Application NumberTitlePriority DateFiling Date
PE2005000080APE20051089A1 (en)2004-01-222005-01-20 PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Country Status (17)

CountryLink
EP (1)EP1708710A1 (en)
JP (1)JP2007519662A (en)
KR (1)KR20070009546A (en)
CN (1)CN1909908A (en)
AR (1)AR049769A1 (en)
AU (1)AU2005205915B2 (en)
BR (1)BRPI0507071A (en)
CA (1)CA2552885A1 (en)
EC (1)ECSP066718A (en)
IL (1)IL176737A0 (en)
MA (1)MA28400B1 (en)
NO (1)NO20063758L (en)
PE (1)PE20051089A1 (en)
RU (1)RU2006130003A (en)
TN (1)TNSN06226A1 (en)
TW (1)TW200528103A (en)
WO (1)WO2005070431A1 (en)

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Also Published As

Publication numberPublication date
BRPI0507071A (en)2007-06-19
CN1909908A (en)2007-02-07
EP1708710A1 (en)2006-10-11
CA2552885A1 (en)2005-08-04
TNSN06226A1 (en)2007-12-03
RU2006130003A (en)2008-04-10
AU2005205915B2 (en)2009-05-21
MA28400B1 (en)2007-01-02
KR20070009546A (en)2007-01-18
TW200528103A (en)2005-09-01
AU2005205915A1 (en)2005-08-04
NO20063758L (en)2006-10-23
WO2005070431A1 (en)2005-08-04
JP2007519662A (en)2007-07-19
ECSP066718A (en)2006-10-31
AR049769A1 (en)2006-09-06
IL176737A0 (en)2006-10-31

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