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PE20020265A1 - CARBOXIALKYLETER - ACAT INHIBITOR COMBINATIONS - Google Patents

CARBOXIALKYLETER - ACAT INHIBITOR COMBINATIONS

Info

Publication number
PE20020265A1
PE20020265A1PE2001000517APE2001000517APE20020265A1PE 20020265 A1PE20020265 A1PE 20020265A1PE 2001000517 APE2001000517 APE 2001000517APE 2001000517 APE2001000517 APE 2001000517APE 20020265 A1PE20020265 A1PE 20020265A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
cholesterol
carboxialkyleter
cycloalkyl
Prior art date
Application number
PE2001000517A
Other languages
Spanish (es)
Inventor
Donna Lee Zobel
Bruce Jeffrey Auerbach
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert CofiledCriticalWarner Lambert Co
Publication of PE20020265A1publicationCriticalpatent/PE20020265A1/en

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Abstract

Translated fromSpanish

SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)UN CARBOXIALQUILETER DE FORMULA ( Y1)(R1)(R2)C-(CH2)n-O-(CH2)m-C(Y2)(R3)(R4) DONDE, n Y m SON 2-9; R1, R2, R3, R4 SON ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6, R1 Y R2 O R3 Y R4 JUNTOS FORMAN CARBOCICLO C3-C6; Y1 E Y2 SON COOH, CHO, TETRAZOL, COOR5; R5 ES ALQUILO C1-C5, ALQUENILO C2-C6, ALQUINILO C2-C6; b)UN INHIBIDOR DE LA ENZIMA ACETIL-COENZIMA A:COLESTEROL ACILTRANSFERASA (ACAT) QUE PREVIENE LA ABSORCION DEL COLESTEROL DIETARIO EN EL FLUJO SANGUINEO O LA REABSORCION DE COLESTEROL QUE PREVIAMENTE HA SIDO LIBERADO EN EL INTESTINO A TRAVES DE LA PROPIA ACCION REGULADORA DEL CUERPO; DE FORMULA R1-X-S(=O)2-NR-C(=O)-Y-R2; DONDE X E Y SON S, O; (CR'R")n; n ES 1-4; R' Y R" SON H, ALQUILO, ALCOXI, HALOGENO, OH, ACILOXI, CICLOALQUILO, FENILO R' Y R" FORMAN ESPIROCICLOALQUILO, CARBONILO; UNO DE X E Y ES (CR'R")n; Y R' Y R" SON H; n ES 1; R1 Y R2 SON ARILO; R ES H, ALQUILO C1-C8, BENCILO; R1 Y R2 SON FENILO, FENOXI, NAFTILO, ARILALQUILO, ALQUILO C1-C20, ADAMANTILO, CICLOALQUILO C3-C6; SIENDO COMPUESTOS PREFERIDOS 2,6-DIISOPROPIL-FENIL ESTER DEL ACIDO [(2,4,6-TRIISOPROPIL-FENIL)-ACETIL]SULFAMICO, ACIDO 6,6'-OXIBIS(2,2-DIMETILHEXANOICO). LA COMPOSICION PUEDE SER UTIL PARA LOGRAR UN EFECTO DE DISLIPIDEMIA MEJORADA Y UN EFECTO DE SINDROME ISQUEMICO MEJORADOREFERS TO A COMPOSITION THAT INCLUDES a) A CARBOXIALKYLETER OF FORMULA (Y1) (R1) (R2) C- (CH2) nO- (CH2) mC (Y2) (R3) (R4) WHERE, n AND m ARE 2- 9; R1, R2, R3, R4 ARE C1-C6 ALKYL, C1-C6 ALKENYL, C1-C6 ALKYNYL, R1 AND R2 OR R3 AND R4 TOGETHER FORMING C3-C6 CARBOCICLE; Y1 AND Y2 ARE COOH, CHO, TETRAZOLE, COOR5; R5 IS C1-C5 ALKYL, C2-C6 ALKENYL, C2-C6 ALKYL; b) AN INHIBITOR OF THE ACETYL-COENZYME ENZYME A: CHOLESTEROL ACILTRANSFERASE (ACAT) THAT PREVENTS THE ABSORPTION OF DIETARY CHOLESTEROL IN THE BLOOD FLOW OR THE REABSORPTION OF CHOLESTEROL THAT HAS BEEN PREVIOUSLY RELEASED BY THE BODY ACROSS ACROSS ACTION ; OF FORMULA R1-X-S (= O) 2-NR-C (= O) -Y-R2; WHERE X AND Y ARE S, O; (CR'R ") n; n IS 1-4; R 'YR" ARE H, ALKYL, ALCOXY, HALOGEN, OH, ACILOXY, CYCLOALKYL, PHENYL R' AND R "FORM SPIROCYCLOALKYL, CARBONYL; ONE OF XEY IS (CR ' R ") n; YR 'YR "ARE H; n IS 1; R1 AND R2 ARE ARYL; R IS H, C1-C8 ALKYL, BENZYL; R1 AND R2 ARE PHENYL, PHENOXY, NAPHTHYL, ARYLALKYL, C1-C20 ALKYL, ADAMANTHYL, C3- CYCLOALKYL C6; PREFERRED COMPOUNDS 2,6-DIISOPROPYL-PHENYL ESTER OF SULFAMIC ACID [(2,4,6-TRIISOPROPYL-PHENYL) -ACETILE], 6,6'-OXIBIS (2,2-DIMETHYLHEXANOIC) ACID. THE COMPOSITION MAY BE USEFUL TO ACHIEVE AN IMPROVED DYSLIPIDEMIA EFFECT AND IMPROVED ISCHEMIC SYNDROME EFFECT

PE2001000517A2000-06-072001-06-05 CARBOXIALKYLETER - ACAT INHIBITOR COMBINATIONSPE20020265A1 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
US21005600P2000-06-072000-06-07

Publications (1)

Publication NumberPublication Date
PE20020265A1true PE20020265A1 (en)2002-04-19

Family

ID=22781424

Family Applications (1)

Application NumberTitlePriority DateFiling Date
PE2001000517APE20020265A1 (en)2000-06-072001-06-05 CARBOXIALKYLETER - ACAT INHIBITOR COMBINATIONS

Country Status (14)

CountryLink
EP (1)EP1292363A2 (en)
JP (1)JP2003535125A (en)
AR (1)AR034255A1 (en)
AU (1)AU2001263003A1 (en)
BR (1)BR0111428A (en)
CA (1)CA2413906A1 (en)
GT (1)GT200100106A (en)
MX (1)MXPA02010762A (en)
PA (1)PA8518601A1 (en)
PE (1)PE20020265A1 (en)
SV (1)SV2002000466A (en)
TN (1)TNSN01085A1 (en)
UY (1)UY26752A1 (en)
WO (1)WO2001093845A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US7387236B2 (en)2001-10-092008-06-17Delaware Capital Formation, Inc.Dispensing of currency

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
ES2257824T3 (en)*1998-01-282006-08-01Warner-Lambert Company Llc METHOD TO TREAT ALZHEIMER'S DISEASE.

Also Published As

Publication numberPublication date
UY26752A1 (en)2001-07-31
GT200100106A (en)2002-05-20
AR034255A1 (en)2004-02-18
SV2002000466A (en)2002-04-03
WO2001093845A2 (en)2001-12-13
EP1292363A2 (en)2003-03-19
JP2003535125A (en)2003-11-25
PA8518601A1 (en)2002-07-30
AU2001263003A1 (en)2001-12-17
WO2001093845A3 (en)2002-10-10
BR0111428A (en)2003-06-10
TNSN01085A1 (en)2005-11-10
MXPA02010762A (en)2003-03-10
CA2413906A1 (en)2001-12-13

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