Movatterモバイル変換


[0]ホーム

URL:


NZ332645A - use of a bis-indolylmaleimide derivative for treating VEGF related diseases - Google Patents

use of a bis-indolylmaleimide derivative for treating VEGF related diseases

Info

Publication number
NZ332645A
NZ332645ANZ332645ANZ33264597ANZ332645ANZ 332645 ANZ332645 ANZ 332645ANZ 332645 ANZ332645 ANZ 332645ANZ 33264597 ANZ33264597 ANZ 33264597ANZ 332645 ANZ332645 ANZ 332645A
Authority
NZ
New Zealand
Prior art keywords
bis
indolylmaleimide
related diseases
nhco
heterocycle
Prior art date
Application number
NZ332645A
Inventor
Michael R Jirousek
Louis Vignati
Douglas Kirk Ways
Lloyd P Aiello
George L King
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co ElifiledCriticalLilly Co Eli
Publication of NZ332645ApublicationCriticalpatent/NZ332645A/en

Links

Classifications

Landscapes

Abstract

An inhibitor of the b-isozyme of protein kinase C is used in the manufacture of a medicament for treating neoplasia, rheumatoid arthritis or keloid or for inhibiting VEGF stimulated capillary permeability associated with pulmonary edema. The preferred inhibitor is a bis-indolylmaleimide or a macrocyclic bis-indolylmaleimide. The bis-indolylmaleimide can have the formula I wherein W is O, S(O)q, CO, optionally substituted alkylene, alkenylene, aryl, aryl-(CH2)m-O-, fused bicyclic, fused bicyclic-(CH2)m-O-, heterocycle, heterocycle-(CH2)m-O-, NR3, NOR3, CONH or NHCO; X and Y are independently optionally substituted alkylene or together X, Y and W combine to form -(CH2)n-AA-; each R1 is H or up to four of halo, alkyl, hydroxy, alkoxy, haloalkyl, nitro, NR4R5 or NHCO-alkyl; R2 is H, CH3CO, NH2 or OH; n is 2 to 5; q is 0 to 2 and m is 0 to 3; AA is an amino residue and R3, R4 and R5 are as defined in the specification.
NZ332645A1996-05-011997-05-01use of a bis-indolylmaleimide derivative for treating VEGF related diseasesNZ332645A (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
US1665896P1996-05-011996-05-01
US84163597A1997-04-301997-04-30
PCT/US1997/007752WO1997040830A1 (en)1996-05-011997-05-01Therapeutic treatment for vegf related diseases

Publications (1)

Publication NumberPublication Date
NZ332645Atrue NZ332645A (en)2000-07-28

Family

ID=26688913

Family Applications (1)

Application NumberTitlePriority DateFiling Date
NZ332645ANZ332645A (en)1996-05-011997-05-01use of a bis-indolylmaleimide derivative for treating VEGF related diseases

Country Status (15)

CountryLink
US (1)US6284751B1 (en)
EP (1)EP0915698A4 (en)
JP (1)JP2002504086A (en)
KR (1)KR20000065171A (en)
CN (1)CN1233177A (en)
AU (1)AU736333B2 (en)
BR (1)BR9710706A (en)
CA (1)CA2253608A1 (en)
CZ (1)CZ350098A3 (en)
EA (1)EA001779B1 (en)
IL (1)IL126837A0 (en)
NO (1)NO985066L (en)
NZ (1)NZ332645A (en)
PL (1)PL329851A1 (en)
WO (1)WO1997040830A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6093740A (en)*1997-04-302000-07-25Eli Lilly And CompanyTherapeutic treatment for skin disorders
US6103713A (en)*1998-03-052000-08-15Eli Lilly And CompanyTherapeutic treatment for autoimmune diseases
US6103712A (en)*1998-03-052000-08-15Eli Lilly And CompanyTherapeutic treatment for asthma
US6306383B1 (en)*1998-09-162001-10-23Wilson T CrandallMethod for topical treatment of scars with protein kinase C inhibitors
US6979441B2 (en)*1998-09-162005-12-27Wilson T CrandallMethod for topical treatment of carpal tunnel syndrome
US6921763B2 (en)1999-09-172005-07-26Abbott LaboratoriesPyrazolopyrimidines as therapeutic agents
SK12712002A3 (en)2000-02-072003-02-04Abbott Gmbh & Co. Kg2-Benzothiazolyl urea derivatives and their use as protein kinase inhibitors
AU2001296558A1 (en)2000-10-032002-04-15Oncopharmaceutical, Inc.Inhibitors of angiogenesis and tumor growth for local and systemic administration
US6875165B2 (en)2001-02-222005-04-05Retinalabs, Inc.Method of radiation delivery to the eye
MXPA03008560A (en)2001-03-222004-06-30Abbot Gmbh & Co KgSingle-stage pfc + ballast control circuit/general purpose power converter.
KR101501870B1 (en)2003-08-272015-03-12옵쏘테크 코포레이션Combination therapy for the treatment of ocular neovascular disorders
US7803103B2 (en)2005-02-112010-09-28Neovista Inc.Methods and apparatus for intraocular brachytherapy
BRPI0507690A (en)2004-02-122007-07-24Neovista Inc methods and apparatus for intraocular brachytherapy
US7563222B2 (en)2004-02-122009-07-21Neovista, Inc.Methods and apparatus for intraocular brachytherapy
ATE433979T1 (en)2004-04-022009-07-15Osi Pharm Inc HETEROBICYCLIC PROTEIN KINASE INHIBITORS SUBSTITUTED WITH A 6,6-BICYCLIC RING
ES2671522T3 (en)2004-04-022018-06-06The Regents Of The University Of California Methods and compositions for treating and preventing a disease associated with integrin alpha V beta 5
US7795205B2 (en)*2004-04-122010-09-14Canyon Pharmaceuticals, Inc.Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
MY139689A (en)2004-07-202009-10-30Osi Pharm IncImidazotriazines as protein kinase inhibitors
US7973032B2 (en)*2005-11-142011-07-05University Of ZurichStaurosporine derivatives for use in alveolar rhabdomyosarcoma
AR057960A1 (en)2005-12-022007-12-26Osi Pharm Inc BICYCLE PROTEIN QUINASE INHIBITORS
EP2050441A1 (en)2007-10-192009-04-22Université Victor Segalen Bordeaux 2Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US8987262B2 (en)2007-10-192015-03-24Universite de BordeauxUse of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
AU2014201660B2 (en)*2007-10-192015-09-03Centre Hospitalier Universitaire De BordeauxUse of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
US8353812B2 (en)2008-06-042013-01-15Neovista, Inc.Handheld radiation delivery system
WO2013043644A1 (en)*2011-09-212013-03-28The University Of North Carolina At Chapel HillMethods using liver disease biomarkers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
SK75289A3 (en)1988-02-101998-05-06Hoffmann La RocheSubstituted pyrroles, their use for producing a drug, and the drug on their base
NZ267337A (en)*1993-05-282005-01-28Kyowa Hakko Kogyo KkIndolocarbazole derivatives and pharmaceutical compositions thereof
AU687909B2 (en)*1993-12-071998-03-05Eli Lilly And CompanyProtein kinase C inhibitors
FI945705A7 (en)1993-12-071996-06-03Lilly Co Eli Improved synthesis of bisindolylmaleimides
US5624949A (en)*1993-12-071997-04-29Eli Lilly And CompanyProtein kinase C inhibitors
US5545636A (en)1993-12-231996-08-13Eli Lilly And CompanyProtein kinase C inhibitors
US5491242A (en)1994-06-221996-02-13Eli Lilly And CompanyProtein kinase C inhibitors
US5481003A (en)1994-06-221996-01-02Eli Lilly And CompanyProtein kinase C inhibitors

Also Published As

Publication numberPublication date
NO985066D0 (en)1998-10-30
WO1997040830A1 (en)1997-11-06
AU2935597A (en)1997-11-19
EA001779B1 (en)2001-08-27
CZ350098A3 (en)1999-11-17
AU736333B2 (en)2001-07-26
BR9710706A (en)1999-08-17
NO985066L (en)1998-12-21
US6284751B1 (en)2001-09-04
EP0915698A4 (en)1999-08-11
EA199800969A1 (en)1999-06-24
KR20000065171A (en)2000-11-06
EP0915698A1 (en)1999-05-19
CN1233177A (en)1999-10-27
CA2253608A1 (en)1997-11-06
JP2002504086A (en)2002-02-05
IL126837A0 (en)1999-09-22
PL329851A1 (en)1999-04-12

Similar Documents

PublicationPublication DateTitle
NZ332645A (en)use of a bis-indolylmaleimide derivative for treating VEGF related diseases
ATE86256T1 (en) THIENO(TRIAZOLO)DIAZEPIN COMPOUNDS, AND MEDICAL USE OF SAME.
ATE177101T1 (en) PYRROLOPYRIMIDINES AS CRF ANTAGONISTS
NO944643D0 (en) Protein kinase C inhibitors
NZ508268A (en)Bicyclic pyrimidines and bicyclic 3,4- dihydropyrimidines as inhibitors of cellular proliferation
TR200000197T2 (en) New combinations
NZ333706A (en)Benzenesulfone derivatives and medicaments
NO302700B1 (en) 1,2,4-Oxadiazolylphenoxyalkylisoxazoles Preparations Containing These Compounds And Their Use For Preparation Of Antiviral Agents
HUP9801704A2 (en)Pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation and medicaments containing them
IL104244A (en)FUNGICIDAL COMPOSITIONS CONTAINING SUBSTITUTED 7-AMINO-1, 2, 4-TRIAZOLO £1, 5-a| PYRIMIDINE DERIVATIVES AND THEIR PREPARATION
MX9700557A (en) DIHYDROBENZOFURANES.
MY118068A (en)Protein kinase c inhibitor
ES2103479T3 (en) ANILIDA DERIVATIVES.
FI113964B (en) Pyrrolitsin and pyrrolo [2,1-b] thiazole derivatives, their intermediates and use in pharmacin
SE9702564D0 (en) New compounds
DE69924292D1 (en) PYRAZOL COMPOUNDS AND ITS USE
TR200101779T2 (en) New bicyclic components
AU2413995A (en)Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
DK1014990T3 (en) Anti-tumor combination of 3 amino-1,2,4 benzotriazine-1,4 dioxide / paclitaxel / platinum
AU554959B2 (en)Triazolo(4,3-a) quinazolin-5-ones
NZ512222A (en)Lung function impairment in chronic obstructive pulmonary disease (COPD) treated with 1-phenyl-4-oxo-3,4,6,7-tetrahydro-[1,4]-diazepinoindoles as phosphodiesterase 4 (PDE4) inhibitors
ES8303417A1 (en)Mitomycin derivatives their preparation and use
ES8507517A1 (en)Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same.
MXPA02006863A (en)Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof.
IT1182855B (en)Poly:aza:heterocyclic derivs.

[8]ページ先頭

©2009-2025 Movatter.jp