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NO20085323L - Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase - Google Patents

Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase

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Publication number
NO20085323L
NO20085323LNO20085323ANO20085323ANO20085323LNO 20085323 LNO20085323 LNO 20085323LNO 20085323 ANO20085323 ANO 20085323ANO 20085323 ANO20085323 ANO 20085323ANO 20085323 LNO20085323 LNO 20085323L
Authority
NO
Norway
Prior art keywords
melted
compounds
formula
gamma secretase
sulfonamide inhibitors
Prior art date
Application number
NO20085323A
Other languages
English (en)
Inventor
Andrei W Konradi
Gary Probst
Danielle L Aubele
Albert W Garofalo
Roy Hom
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm IncfiledCriticalElan Pharm Inc
Publication of NO20085323LpublicationCriticalpatent/NO20085323L/no

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Abstract

Oppfinnelsen tilveiebringer forbindelser med formel I: eller farmasøytisk akseptable salter derav, hvor Ri, R2 og A-, B- og C-ringene er som definert heri. Forbindelser med formel I er anvendelige ved behandling eller hindring av kognitive forstyrrelser, slik som Alzheimer's sykdom. Oppfinnelsen omfatter også farmasøytiske sammensetninger som innbefatter forbindelser og salter med formel I, fremgangsmåter for fremstilling av de ønskede forbindelsene, og fremgangsmåter for behandling av kognitive forstyrrelser slik som Alzheimer's sykdom, ved anvendelse av forbindelsene eller saltene med formel I.
NO20085323A2006-06-022008-12-19Smeltede, tricykliske sulfonamidinhibitorer av gammasekretaseNO20085323L (no)

Applications Claiming Priority (4)

Application NumberPriority DateFiling DateTitle
US81043106P2006-06-022006-06-02
US87693206P2006-12-222006-12-22
US92277107P2007-04-102007-04-10
PCT/US2007/070176WO2007143523A2 (en)2006-06-022007-06-01Fused, tricyclic sulfonamide inhibitors of gamma secretase

Publications (1)

Publication NumberPublication Date
NO20085323Ltrue NO20085323L (no)2009-02-24

Family

ID=38686795

Family Applications (1)

Application NumberTitlePriority DateFiling Date
NO20085323ANO20085323L (no)2006-06-022008-12-19Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase

Country Status (22)

CountryLink
US (1)US20080021056A1 (no)
EP (2)EP2450358A1 (no)
JP (1)JP2009539773A (no)
KR (1)KR20090015159A (no)
CN (2)CN101501032B (no)
AR (1)AR061161A1 (no)
AU (1)AU2007256860A1 (no)
BR (1)BRPI0712123A2 (no)
CA (1)CA2651550A1 (no)
EA (1)EA200870577A1 (no)
EC (1)ECSP089019A (no)
IL (1)IL195078A0 (no)
MA (1)MA30532B1 (no)
MX (1)MX2008014947A (no)
MY (1)MY169274A (no)
NO (1)NO20085323L (no)
NZ (1)NZ572885A (no)
PE (1)PE20080988A1 (no)
SG (1)SG172629A1 (no)
TW (1)TW200813054A (no)
UY (1)UY30377A1 (no)
WO (1)WO2007143523A2 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
MX2008009414A (es)2006-01-202008-10-01Schering CorpArilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa.
FR2913886B1 (fr)2007-03-222012-03-02Guerbet SaUtilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
BRPI0812014A2 (pt)2007-05-252014-11-18Elan Pharm IncPirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos
WO2009008980A2 (en)*2007-07-052009-01-15Schering CorporationTetrahydropyranochromene gamma secretase inhibitors
EP2178882B1 (en)*2007-07-172013-04-17Merck Sharp & Dohme Corp.Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
CN102203089A (zh)*2008-09-052011-09-28伊兰医药品公司N-磺酰氨基多环吡唑基化合物
US20110034691A1 (en)*2009-03-252011-02-10Elan Pharmaceuticals, Inc.Process for the Production of Fused, Tricyclic Sulfonamides
US8293744B2 (en)2009-04-202012-10-23Merck Sharp & Dohme Corp.Heterocyclic fused cinnoline M1 receptor positive allosteric modulators
US9023767B2 (en)*2009-05-072015-05-05Memorial Sloan-Kettering Cancer Centerγ-Secretase substrates and methods of use
US9632088B2 (en)2010-09-072017-04-25Memorial Sloan-Kettering Cancer CenterMethods and compositions for gamma-secretase assay
US10319527B2 (en)*2017-04-042019-06-11Samsung Electro-Mechanics Co., Ltd.Multilayer capacitor
CN110526913B (zh)*2019-08-302022-04-29中国药科大学一种抗凝药物阿哌沙班相关物质的制备方法
CN110885329B (zh)*2019-12-162020-12-15诚达药业股份有限公司一种1,7-萘啶衍生物的合成方法
CN114853707B (zh)*2022-06-132024-01-26上饶师范学院一种合成二氟氢甲基化2,3-二氢苯并吡喃-4-酮衍生物的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4666829A (en)1985-05-151987-05-19University Of CaliforniaPolypeptide marker for Alzheimer's disease and its use for diagnosis
US5766846A (en)1992-07-101998-06-16Athena NeurosciencesMethods of screening for compounds which inhibit soluble β-amyloid peptide production
JPH0977752A (ja)*1995-09-121997-03-25Kao CorpＮ−無置換イソオキサゾリジンの製造法
GB9720899D0 (en)1997-10-011997-12-03Pharmacia & Upjohn SpaCondensed heterocyclic compounds
CA2455863C (en)*2001-08-032010-10-12Schering CorporationTetrahydroquinoline derivatives as gamma secretase inhibitors
BR0212617A (pt)*2001-09-192005-02-09Pharmacia CorpCompostos de pirazolila substituìdo para o tratamento de inflamação
JP2006151810A (ja)*2002-12-262006-06-15Daiichi Asubio Pharma Co Ltdジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤
US20060264380A1 (en)2003-07-212006-11-23Mats HellstromCompounds and Methods for Promoting Angiogenesis
US20060035884A1 (en)*2004-05-202006-02-16Elan Pharmaceuticals, Inc.N-cyclic sulfonamido inhibitors of gamma secretase
WO2006068928A1 (en)*2004-12-202006-06-29WyethPyrrolo[1,2-a]quinoxalin-5-(4h)-yl)sulfonyls and carbonyls and their use as estrogenic agents

Also Published As

Publication numberPublication date
KR20090015159A (ko)2009-02-11
WO2007143523A2 (en)2007-12-13
TW200813054A (en)2008-03-16
EA200870577A1 (ru)2009-06-30
BRPI0712123A2 (pt)2012-07-10
AU2007256860A1 (en)2007-12-13
UY30377A1 (es)2008-01-02
WO2007143523A8 (en)2008-01-31
WO2007143523A3 (en)2008-06-12
JP2009539773A (ja)2009-11-19
EP2450358A1 (en)2012-05-09
PE20080988A1 (es)2008-08-15
SG172629A1 (en)2011-07-28
AR061161A1 (es)2008-08-06
CN101501032A (zh)2009-08-05
CN101501032B (zh)2012-10-10
EP2038280A2 (en)2009-03-25
MA30532B1 (fr)2009-06-01
IL195078A0 (en)2009-08-03
ECSP089019A (es)2009-02-27
CN102850349A (zh)2013-01-02
NZ572885A (en)2012-02-24
CA2651550A1 (en)2007-12-13
MX2008014947A (es)2008-12-10
US20080021056A1 (en)2008-01-24
MY169274A (en)2019-03-21

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