| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| CU22545A1 (en) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4169888A (en) | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS6023084B2 (en) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | blood substitute |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| US4364935A (en) | 1979-12-04 | 1982-12-21 | Ortho Pharmaceutical Corporation | Monoclonal antibody to a human prothymocyte antigen and methods of preparing same |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | Method for enhancing glycoprotein stability. |
| DE3783588T2 (en) | 1986-04-17 | 1993-06-09 | Kyowa Hakko Kogyo Kk | NEW DC-88A AND DC-89A1 CONNECTIONS AND THEIR PRODUCTION METHOD. |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| US5084468A (en) | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2598116B2 (en) | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | New substance DC113 |
| JP2510335B2 (en) | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | DC-88A derivative |
| US5187186A (en) | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| AU652936B2 (en) | 1990-05-07 | 1994-09-15 | Scripps Clinic And Research Foundation | Intermediates in the formation of the calicheamicin and esperamicin oligosaccharides |
| US5968509A (en) | 1990-10-05 | 1999-10-19 | Btp International Limited | Antibodies with binding affinity for the CD3 antigen |
| WO1992015683A1 (en) | 1991-03-06 | 1992-09-17 | MERCK Patent Gesellschaft mit beschränkter Haftung | Humanized and chimeric monoclonal antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| ES2149768T3 (en) | 1992-03-25 | 2000-11-16 | Immunogen Inc | CONJUGATES OF BINDING AGENTS OF CELLS DERIVED FROM CC-1065. |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| US6329507B1 (en) | 1992-08-21 | 2001-12-11 | The Dow Chemical Company | Dimer and multimer forms of single chain polypeptides |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| AU690528B2 (en) | 1992-12-04 | 1998-04-30 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| JP3312357B2 (en) | 1992-12-11 | 2002-08-05 | ザ ダウ ケミカル カンパニー | Multivalent single chain antibody |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| DE69434136T2 (en) | 1993-10-01 | 2005-12-01 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin DERIVATIVES |
| GB9401182D0 (en) | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
| KR100350260B1 (en) | 1994-04-22 | 2003-01-06 | 교와 핫꼬 고교 가부시끼가이샤 | Pyrroloindole derivatives |
| JPH07309761A (en) | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | Stabilization of duocarmycin derivatives |
| US5945311A (en) | 1994-06-03 | 1999-08-31 | GSF--Forschungszentrumfur Umweltund Gesundheit | Method for producing heterologous bi-specific antibodies |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5550246A (en) | 1994-09-07 | 1996-08-27 | The Scripps Research Institute | Calicheamicin mimics |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| EP0831880A4 (en) | 1995-06-07 | 2004-12-01 | Imclone Systems Inc | Antibody and antibody fragments for inhibiting the growth of tumors |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US7696338B2 (en) | 1995-10-30 | 2010-04-13 | The United States Of America As Represented By The Department Of Health And Human Services | Immunotoxin fusion proteins and means for expression thereof |
| DK0871490T3 (en) | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Branched hydrazone linkers |
| US6451308B1 (en) | 1996-04-26 | 2002-09-17 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
| JP2001502521A (en) | 1996-04-26 | 2001-02-27 | ベス イスラエル デアコネス メディカル センター | Interleukin-15 antagonist |
| EP0915987A2 (en) | 1997-04-21 | 1999-05-19 | Donlar Corporation | POLY-($g(a)-L-ASPARTIC ACID), POLY-($g(a)-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| DK0979281T3 (en) | 1997-05-02 | 2005-11-21 | Genentech Inc | Process for the preparation of multispecific antibodies with heteromultimers and common components |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ATE283364T1 (en) | 1998-01-23 | 2004-12-15 | Vlaams Interuniv Inst Biotech | MULTIPURPOSE ANTIBODIES DERIVATIVES |
| WO1999054342A1 (en) | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| ID27512A (en) | 1998-04-21 | 2001-04-12 | Microment Ges Fur Biomedizinis | PRIVATE POLIPEPTIDES CD19XCD3 AND ITS USES |
| US6455677B1 (en) | 1998-04-30 | 2002-09-24 | Boehringer Ingelheim International Gmbh | FAPα-specific antibody with improved producibility |
| ATE460946T1 (en) | 1998-06-22 | 2010-04-15 | Immunomedics Inc | USE OF BISPECIFIC ANTIBODIES IN DIAGNOSIS AND THERAPY |
| GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6723538B2 (en) | 1999-03-11 | 2004-04-20 | Micromet Ag | Bispecific antibody and chemokine receptor constructs |
| EP3031917A1 (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| US6939545B2 (en) | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| JP4793971B2 (en) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | Complex cytokine-antibody complex |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| EP1229125A4 (en) | 1999-10-19 | 2005-06-01 | Kyowa Hakko Kogyo Kk | PROCESS FOR PRODUCING A POLYPEPTIDE |
| US6716410B1 (en) | 1999-10-26 | 2004-04-06 | The Regents Of The University Of California | Reagents and methods for diagnosing, imaging and treating atherosclerotic disease |
| HUP0204142A3 (en) | 2000-02-25 | 2004-12-28 | Univ Durham | Anti-egfrviii scfv-antibodies with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US20010035606A1 (en) | 2000-03-28 | 2001-11-01 | Schoen Alan H. | Set of blocks for packing a cube |
| EP1278778A2 (en) | 2000-05-03 | 2003-01-29 | Amgen Inc., | Modified peptides, comprising an fc domain, as therapeutic agents |
| JP2003533987A (en) | 2000-05-19 | 2003-11-18 | イス ケミカル カンパニー リミテッド | Humanized antibodies against epidermal growth factor receptor |
| WO2001090192A2 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| US6586207B2 (en) | 2000-05-26 | 2003-07-01 | California Institute Of Technology | Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues |
| CA2417185A1 (en) | 2000-07-25 | 2002-01-31 | Shui-On Leung | Multivalent target binding protein |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| DE10043437A1 (en) | 2000-09-04 | 2002-03-28 | Horst Lindhofer | Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites |
| EA013563B1 (en) | 2000-10-06 | 2010-06-30 | Киова Хакко Кирин Ко., Лтд. | A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies |
| EP1333032A4 (en) | 2000-10-06 | 2005-03-16 | Kyowa Hakko Kogyo Kk | METHOD FOR PURIFYING ANTIBODIES |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20020147312A1 (en) | 2001-02-02 | 2002-10-10 | O'keefe Theresa | Hybrid antibodies and uses thereof |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| AU2002307037B2 (en) | 2001-04-02 | 2008-08-07 | Biogen Idec Inc. | Recombinant antibodies coexpressed with GnTIII |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| KR20030033007A (en) | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | Cytotoxins, prodrugs, linkers and stabilizers useful therefor |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| CN1966525A (en) | 2001-06-13 | 2007-05-23 | 根马布股份公司 | Human monoclonal antibodies to epidermal growth factor receptor (egfr) |
| CA2452058A1 (en) | 2001-06-26 | 2003-01-09 | Imclone Systems Incorporated | Bispecific antibodies that bind to vegf receptors |
| PL213948B1 (en) | 2001-10-25 | 2013-05-31 | Genentech Inc | Glycoprotein compositions |
| WO2003073238A2 (en) | 2002-02-27 | 2003-09-04 | California Institute Of Technology | Computational method for designing enzymes for incorporation of amino acid analogs into proteins |
| US20080219974A1 (en) | 2002-03-01 | 2008-09-11 | Bernett Matthew J | Optimized antibodies that target hm1.24 |
| US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| NZ554740A (en) | 2002-05-24 | 2009-01-31 | Schering Corp | Neutralizing human anti-IGFR antibody |
| CA2802205C (en) | 2002-07-31 | 2016-01-19 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| US8946387B2 (en) | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| US7705045B2 (en) | 2002-11-14 | 2010-04-27 | Syntarga, B.V. | Prodrugs built as multiple self-elimination-release spacers |
| BRPI0316282B8 (en) | 2002-11-15 | 2021-05-25 | Genmab As | monoclonal isolated human antibody, composition, immunoconjugate, bispecific or multispecific molecule, method and diagnostic kit to detect the presence of cd25 antigen or a cell expressing cd25, and, expression vector |
| JP2006524039A (en) | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | Identification and production of antibody containing mutant Fc region and use thereof |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| US7610156B2 (en) | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
| MX340862B (en) | 2003-05-20 | 2016-07-28 | Immunogen Inc | Improved cytotoxic agents comprising new maytansinoids. |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| KR20060015602A (en) | 2003-05-31 | 2006-02-17 | 마이크로메트 에이지 | Pharmaceutical composition comprising a bispecific antibody against EVCA |
| CN100509850C (en) | 2003-05-31 | 2009-07-08 | 麦克罗梅特股份公司 | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| US7888134B2 (en) | 2003-06-05 | 2011-02-15 | Oakland University | Immunosensors: scFv-linker design for surface immobilization |
| CA2678736A1 (en) | 2003-07-21 | 2005-02-17 | Transgene S.A. | Novel multifunctional il-2 - il-18 fusion proteins |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| US20150071948A1 (en) | 2003-09-26 | 2015-03-12 | Gregory Alan Lazar | Novel immunoglobulin variants |
| JP4890253B2 (en) | 2003-10-09 | 2012-03-07 | アンブレツクス・インコーポレイテツド | Azide or acetylene-terminated water-soluble polymer |
| US20050176028A1 (en) | 2003-10-16 | 2005-08-11 | Robert Hofmeister | Deimmunized binding molecules to CD3 |
| EP3858387A1 (en) | 2003-11-06 | 2021-08-04 | Seagen Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| US20050142133A1 (en) | 2003-12-03 | 2005-06-30 | Xencor, Inc. | Optimized proteins that target the epidermal growth factor receptor |
| WO2005056759A2 (en) | 2003-12-04 | 2005-06-23 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| BRPI0417107A (en) | 2003-12-19 | 2007-02-06 | Genentech Inc | antibody fragment, antibody fragment preparation methods, isolated nucleic acid, compositions, host cell, and antibody fragment manufacture and generation methods |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| AU2005211385B2 (en) | 2004-02-02 | 2008-12-11 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| ATE516305T1 (en)* | 2004-02-27 | 2011-07-15 | Inst Nat Sante Rech Med | IL-15 BINDING SITE FOR IL-15-RALPHA AND SPECIFIC IL-15 MUTANTS ACTING AS AGONISTS/ANTAGONISTS |
| CA2561264A1 (en) | 2004-03-24 | 2005-10-06 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| RU2402548C2 (en) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Chemical linkers and conjugates thereof |
| BRPI0510909A2 (en) | 2004-05-19 | 2008-12-16 | Medarex Inc | cytotoxic drug-binder binding compound, pharmaceutical formulation, method for killing a cell and method for retarding or stopping tumor growth |
| EP1753783B1 (en) | 2004-06-03 | 2014-08-06 | Novimmune SA | Anti-cd3 antibodies and methods of use thereof |
| WO2006004910A2 (en) | 2004-06-28 | 2006-01-12 | Transtarget Inc. | Improved bispecific antibodies |
| JP2008512352A (en) | 2004-07-17 | 2008-04-24 | イムクローン システムズ インコーポレイティド | Novel tetravalent bispecific antibody |
| CN101052653A (en) | 2004-09-02 | 2007-10-10 | 健泰科生物技术公司 | Anti-Fc-gamma RIIB receptor antibody and uses therefor |
| CU23472A1 (en) | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | ANTAGONIST PEPTIDE OF INTERLEUCINE-15 |
| WO2006034488A2 (en) | 2004-09-23 | 2006-03-30 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CA2580796C (en) | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
| CA2587766A1 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8066989B2 (en) | 2004-11-30 | 2011-11-29 | Trion Pharma Gmbh | Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy |
| KR20070089186A (en) | 2004-12-13 | 2007-08-30 | 사이토스 바이오테크놀로지 아게 | IL-15 Antigen Arrays and Uses |
| KR20130105885A (en) | 2005-01-05 | 2013-09-26 | 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| US8716451B2 (en) | 2005-01-12 | 2014-05-06 | Kyowa Hakko Kirin Co., Ltd | Stabilized human IgG2 and IgG3 antibodies |
| WO2006106905A1 (en) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| US20060257361A1 (en) | 2005-04-12 | 2006-11-16 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Novel form of interleukin-15, Fc-IL-15, and methods of use |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| EP1899364B2 (en) | 2005-05-17 | 2024-10-30 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| AU2006265936A1 (en) | 2005-07-01 | 2007-01-11 | Medimmune, Llc | An integrated approach for generating multidomain protein therapeutics |
| EP1919930B1 (en) | 2005-07-01 | 2016-09-14 | Dako Denmark A/S | New nucleic acid base pairs |
| EP2586798A3 (en) | 2005-07-25 | 2013-08-07 | Emergent Product Development Seattle, LLC | B-cell reduction using CD37-specific and CD20-specific binding molecules |
| EP1919505A2 (en) | 2005-07-25 | 2008-05-14 | Trubion Pharmaceuticals, Inc. | Single dose use of cd20-specific binding molecules |
| WO2007018431A2 (en) | 2005-08-05 | 2007-02-15 | Syntarga B.V. | Triazole-containing releasable linkers and conjugates comprising the same |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2007033230A2 (en) | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
| DK1931709T3 (en) | 2005-10-03 | 2017-03-13 | Xencor Inc | FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES |
| CA2625440C (en) | 2005-10-11 | 2023-06-13 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
| KR20080073293A (en) | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | Cell display of antibody library |
| WO2007047829A2 (en) | 2005-10-19 | 2007-04-26 | Laboratoires Serono S.A. | Novel heterodimeric proteins and uses thereof |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| TW200732350A (en) | 2005-10-21 | 2007-09-01 | Amgen Inc | Methods for generating monovalent IgG |
| CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| CA2627446A1 (en) | 2005-11-21 | 2007-05-31 | Laboratoires Serono S.A. | Compositions and methods of producing hybrid antigen binding molecules and uses thereof |
| CN101426521A (en) | 2005-12-21 | 2009-05-06 | 医疗免疫有限责任公司 | EPHA2 BiTE molecules and uses thereof |
| JP5709356B2 (en)* | 2006-01-13 | 2015-04-30 | アメリカ合衆国 | Codon optimized IL-15 and IL-15R-α genes for expression in mammalian cells |
| KR20080114709A (en) | 2006-02-02 | 2008-12-31 | 신타가 비.브이. | Water Soluble CC-1065 Analogues and Their Conjugates |
| EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| AU2007227292B2 (en) | 2006-03-17 | 2012-04-12 | Biogen Ma Inc. | Stabilized polypeptide compositions |
| EP1999154B1 (en) | 2006-03-24 | 2012-10-24 | Merck Patent GmbH | Engineered heterodimeric protein domains |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| CA2647282A1 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| CN101437847A (en) | 2006-05-08 | 2009-05-20 | 菲洛根有限公司 | Antibody-targeted cytokines for therapy |
| EP2035456A1 (en) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production of bispecific antibodies |
| AT503861B1 (en) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | METHOD FOR MANIPULATING T-CELL RECEPTORS |
| AT503902B1 (en) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | METHOD FOR MANIPULATING IMMUNE LOBULINS |
| AT503889B1 (en) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | MULTIVALENT IMMUNE LOBULINE |
| AU2007303572A1 (en) | 2006-10-02 | 2008-04-10 | Sea Lane Biotechnologies, Llc | Design and construction of diverse synthetic peptide and polypeptide libraries |
| JP5779350B2 (en) | 2007-03-27 | 2015-09-16 | シー レーン バイオテクノロジーズ, エルエルシー | Constructs and libraries containing antibody surrogate light chain sequences |
| EP1975178A1 (en) | 2007-03-30 | 2008-10-01 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Transcytotic modular antibody |
| KR101589759B1 (en) | 2007-04-03 | 2016-01-29 | 암젠 리서치 (뮌헨) 게엠베하 | Species specific CD3-epsilon binding domain |
| MX2009010611A (en) | 2007-04-03 | 2010-03-26 | Micromet Ag | Cross-species-specific bispecific binders. |
| WO2008124858A2 (en) | 2007-04-11 | 2008-10-23 | F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. | Targeted receptor |
| WO2008137475A2 (en) | 2007-05-01 | 2008-11-13 | Research Development Foundation | Immunoglobulin fc libraries |
| PT2769984T (en) | 2007-05-11 | 2017-10-05 | Altor Bioscience Corp | MOLECULES OF FUSION AND VARIANTS OF IL-15 |
| KR20100021601A (en) | 2007-05-14 | 2010-02-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| EP3392273A1 (en) | 2007-05-30 | 2018-10-24 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| EP4119579A1 (en) | 2007-05-31 | 2023-01-18 | Genmab A/S | Stable igg4 antibodies |
| JP2010531137A (en) | 2007-06-12 | 2010-09-24 | ワイス・エルエルシー | Anti-CD20 therapeutic compositions and methods |
| CN101802006B (en) | 2007-06-26 | 2013-08-14 | F-星生物技术研究与开发有限公司 | display binder |
| NZ582330A (en) | 2007-06-27 | 2012-05-25 | Marinepolymer Tech Inc | COMPLEXES OF IL-15 AND IL-15Ra (RECEPTOR ALPHA) AND USES THEREOF |
| WO2009017823A2 (en) | 2007-08-01 | 2009-02-05 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | A fold-back diabody diphtheria toxin immunotoxin and methods of use |
| EP2173739B1 (en) | 2007-08-01 | 2013-07-31 | Syntarga B.V. | Substituted cc-1065 analogs and their conjugates |
| CN101842116A (en) | 2007-08-28 | 2010-09-22 | 比奥根艾迪克Ma公司 | Compositions binding multiple epitopes of IGF-1R |
| EP2033657A1 (en) | 2007-09-04 | 2009-03-11 | Trion Pharma Gmbh | Intraoperative trifunctional antibody application for prophylatic intraperitonal tumour cell dissemination |
| MX2010002683A (en) | 2007-09-14 | 2010-03-26 | Amgen Inc | POPULATIONS OF HOMOGENEO ANTIBODIES. |
| JP5334319B2 (en) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
| EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
| ES2566957T3 (en) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Constant region of modified antibody |
| AU2008345242B2 (en) | 2007-10-31 | 2014-02-27 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| PL2235064T3 (en) | 2008-01-07 | 2016-06-30 | Amgen Inc | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| WO2009106096A1 (en) | 2008-02-27 | 2009-09-03 | Fresenius Biotech Gmbh | Treatment of resistant tumors with trifunctional antibodies |
| RU2531754C2 (en) | 2008-04-11 | 2014-10-27 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,US | Immunotherapeutic agent combined with cd37, and its combination with bifunctional chemotherapeutic agent |
| EP2280997A2 (en) | 2008-04-18 | 2011-02-09 | Xencor, Inc. | Human equivalent monoclonal antibodies engineered from nonhuman variable regions |
| JP5624535B2 (en) | 2008-05-02 | 2014-11-12 | シアトル ジェネティクス,インコーポレーテッド | Methods and compositions for preparing antibodies and antibody derivatives having low core fucosylation |
| RU2010153580A (en) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION |
| WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
| WO2010028796A1 (en) | 2008-09-10 | 2010-03-18 | F. Hoffmann-La Roche Ag | Trispecific hexavalent antibodies |
| PL2853545T3 (en) | 2008-09-17 | 2016-12-30 | | Antibody specific for IgE |
| US20170247470A9 (en) | 2008-09-17 | 2017-08-31 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| EP2342231A1 (en) | 2008-09-26 | 2011-07-13 | Roche Glycart AG | Bispecific anti-egfr/anti-igf-1r antibodies |
| JP6126782B2 (en) | 2008-10-01 | 2017-05-10 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | Cross-species specific PSMA × CD3 bispecific single chain antibody |
| KR101942694B1 (en) | 2008-10-01 | 2019-01-25 | 암젠 리서치 (뮌헨) 게엠베하 | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxcd3, igf-1rxcd3 or fapalphaxcd3 bispecific single chain antibody |
| WO2010037838A2 (en) | 2008-10-01 | 2010-04-08 | Micromet Ag | Cross-species-specific single domain bispecific single chain antibody |
| CA2738566C (en) | 2008-10-01 | 2024-04-30 | Micromet Ag | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| KR101901458B1 (en) | 2008-10-10 | 2018-09-21 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | TCR Complex immunotherapeutics |
| HUE035798T2 (en) | 2008-11-03 | 2018-05-28 | Syntarga Bv | Cc-1065 analogs and their conjugates |
| US8057507B2 (en) | 2009-01-16 | 2011-11-15 | Novate Medical Limited | Vascular filter |
| MX2011007833A (en) | 2009-01-23 | 2011-10-06 | Biogen Idec Inc | Stabilized fc polypeptides with reduced effector function and methods of use. |
| JP2012519706A (en) | 2009-03-06 | 2012-08-30 | ジェネンテック, インコーポレイテッド | Antibody preparation |
| EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
| EP2414391B1 (en) | 2009-04-02 | 2018-11-28 | Roche Glycart AG | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| PT2417156E (en) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| AU2010233993A1 (en) | 2009-04-07 | 2011-09-08 | Roche Glycart Ag | Bispecific anti-ErbB-1/anti-c-Met antibodies |
| EP2417159A1 (en) | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Bispecific anti-erbb-3/anti-c-met antibodies |
| EP2241576A1 (en) | 2009-04-17 | 2010-10-20 | Trion Pharma Gmbh | Use of trifunctional bispecific antibodies for the treatment of tumors associated with CD133+/EpCAM+ cancer stem cells |
| ES2439802T3 (en) | 2009-05-27 | 2014-01-24 | F. Hoffmann-La Roche Ag | Tri- or tetra-specific antibodies |
| KR20180017231A (en) | 2009-06-26 | 2018-02-20 | 아이2 파마슈티컬스, 인크. | Expression of surrogate light chains |
| PL2975051T3 (en) | 2009-06-26 | 2021-09-20 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| WO2011008517A2 (en) | 2009-06-30 | 2011-01-20 | Research Development Foundation | Immunoglobulin fc polypeptides |
| AU2010270844A1 (en) | 2009-07-08 | 2011-12-22 | Amgen Inc. | Design of stable and aggregation free antibody Fc molecules through CH3 domain interface engineering |
| WO2011020047A1 (en) | 2009-08-14 | 2011-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| DE102009045006A1 (en) | 2009-09-25 | 2011-04-14 | Technische Universität Dresden | Anti-CD33 antibodies and their use for immuno-targeting in the treatment of CD33-associated diseases |
| AU2010321720B2 (en) | 2009-11-23 | 2017-03-02 | Amgen Inc. | Monomeric antibody Fc |
| JP2013512251A (en) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Simultaneous inhibition of PD-L1 / PD-L2 |
| EP2506871B1 (en) | 2009-11-30 | 2016-10-19 | Janssen Biotech, Inc. | ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS |
| PL2522724T3 (en) | 2009-12-25 | 2020-07-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide modification method for purifying polypeptide multimers |
| US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| EA022984B1 (en) | 2009-12-29 | 2016-04-29 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | Ron binding constructs and methods of use thereof |
| US20110189178A1 (en) | 2010-02-04 | 2011-08-04 | Xencor, Inc. | Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions |
| CA2794708C (en) | 2010-03-29 | 2021-11-16 | Zymeworks Inc. | Antibodies with enhanced or suppressed effector function |
| TWI667257B (en) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | Antibodies with modified affinity to fcrn that promote antigen clearance |
| KR101930964B1 (en) | 2010-04-20 | 2018-12-19 | 젠맵 에이/에스 | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| MX346731B (en) | 2010-04-23 | 2017-03-30 | Genentech Inc * | Production of heteromultimeric proteins. |
| CA2797981C (en) | 2010-05-14 | 2019-04-23 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
| DK2580243T3 (en) | 2010-06-09 | 2020-01-13 | Genmab As | ANTIBODIES AGAINST HUMAN CD38 |
| JP2013532153A (en) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease |
| DK3029066T3 (en) | 2010-07-29 | 2019-05-20 | Xencor Inc | ANTIBODIES WITH MODIFIED ISOELECTRIC ITEMS |
| ES2667100T3 (en) | 2010-08-02 | 2018-05-09 | Macrogenics, Inc. | Covalent Diabodies and Their Uses |
| CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| WO2012032080A1 (en) | 2010-09-07 | 2012-03-15 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H | Stabilised human fc |
| CN107880136B (en)* | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | Multimeric IL-15 soluble fusion molecules and methods of making and using the same |
| KR101973930B1 (en) | 2010-11-05 | 2019-04-29 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| DK2637670T4 (en) | 2010-11-10 | 2024-03-25 | Amgen Res Munich Gmbh | PREVENTION OF ADVERSE EVENTS CAUSED BY SPECIFIC CD3 BINDING DOMAINS |
| JP5878182B2 (en) | 2011-02-10 | 2016-03-08 | ロシュ グリクアート アーゲー | Mutant interleukin-2 polypeptide |
| US9499605B2 (en) | 2011-03-03 | 2016-11-22 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| EP2686682A4 (en) | 2011-03-11 | 2015-03-11 | Amgen Inc | Method of correlated mutational analysis to improve therapeutic antibodies |
| EP2686345B1 (en) | 2011-03-16 | 2018-04-25 | Amgen Inc. | Fc variants |
| EA201791693A1 (en) | 2011-03-25 | 2018-05-31 | Гленмарк Фармасьютикалс С.А. | HETERODIMERNY IMMUNOHLOBULINS |
| TWI803876B (en) | 2011-03-28 | 2023-06-01 | 法商賽諾菲公司 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
| SG193554A1 (en) | 2011-03-29 | 2013-11-29 | Roche Glycart Ag | Antibody fc variants |
| KR102345943B1 (en) | 2011-04-28 | 2021-12-31 | 암젠 리서치 (뮌헨) 게엠베하 | Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects |
| EA201892619A1 (en) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS |
| NZ703939A (en) | 2011-05-21 | 2016-01-29 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| US9328170B2 (en) | 2011-05-25 | 2016-05-03 | Merck Sharp & Dohme Corp. | Method for preparing Fc containing polypeptides having improved properties |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| WO2013006544A1 (en) | 2011-07-06 | 2013-01-10 | Medimmune, Llc | Methods for making multimeric polypeptides |
| CA2842860A1 (en) | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies, Llc | Sur-binding proteins |
| WO2013022855A1 (en) | 2011-08-05 | 2013-02-14 | Xencor, Inc. | Antibodies with modified isoelectric points and immunofiltering |
| SI2748201T1 (en) | 2011-08-23 | 2018-03-30 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| KR20140054268A (en) | 2011-08-26 | 2014-05-08 | 메리맥 파마슈티컬즈, 인크. | Tandem fc bispecific antibodies |
| TWI827333B (en) | 2011-09-30 | 2023-12-21 | 日商中外製藥股份有限公司 | Antigen-binding molecules that promote antigen disappearance |
| WO2013047748A1 (en) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| JP6310394B2 (en) | 2011-10-10 | 2018-04-11 | ゼンコア インコーポレイテッド | Methods for purifying antibodies |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| AU2012325232B2 (en) | 2011-10-20 | 2017-08-31 | Esbatech - A Novartis Company Llc | Stable multiple antigen-binding antibody |
| RU2681885C2 (en) | 2011-10-31 | 2019-03-13 | Чугаи Сейяку Кабусики Кайся | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
| KR102052774B1 (en) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| WO2013096828A1 (en) | 2011-12-22 | 2013-06-27 | Sea Lane Biotechnologies, Llc | Surrogate binding proteins |
| AU2013211059B8 (en) | 2012-01-20 | 2017-12-21 | Centre Hospitalier Regional Universitaire De Montpellier | Targeted mutant alpha-helical bundle cytokines |
| CN104244980B (en) | 2012-02-24 | 2017-11-10 | 中外制药株式会社 | Antigen binding molecules that promote antigen elimination via Fc γ IIB |
| CN114163530B (en) | 2012-04-20 | 2025-04-29 | 美勒斯公司 | Methods and means for producing immunoglobulin-like molecules |
| JPWO2013180201A1 (en) | 2012-05-30 | 2016-01-21 | 中外製薬株式会社 | Antigen-binding molecules that eliminate associated antigens |
| WO2014004586A1 (en) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
| AU2013289883B2 (en) | 2012-07-13 | 2018-11-01 | Zymeworks Bc Inc. | Bispecific asymmetric heterodimers comprising anti-CD3 constructs |
| CN104640561A (en) | 2012-07-23 | 2015-05-20 | 酵活有限公司 | Immunoglobulin constructs comprising selective pairing of light and heavy chains |
| JOP20200236A1 (en) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof |
| US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
| CN104271602B (en) | 2012-11-21 | 2020-08-21 | 武汉友芝友生物制药有限公司 | Bispecific antibodies |
| EP2934577A1 (en) | 2012-12-19 | 2015-10-28 | Adimab, LLC | Multivalent antibody analogs, and methods of their preparation and use |
| DK2943511T3 (en)* | 2013-01-14 | 2019-10-21 | Xencor Inc | NEW HETERODIMERIC PROTEINS |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| WO2014113510A1 (en) | 2013-01-15 | 2014-07-24 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| AU2014249243C1 (en) | 2013-03-13 | 2019-08-08 | Imaginab, Inc. | Antigen binding constructs to CD8 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| KR102211176B1 (en)* | 2013-03-15 | 2021-02-01 | 젠코어 인코포레이티드 | Heterodimeric proteins |
| US10544187B2 (en) | 2013-03-15 | 2020-01-28 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| KR102539359B1 (en) | 2013-04-19 | 2023-06-02 | 싸이튠 파마 | Cytokine derived treatment with reduced vascular leak syndrome |
| WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| JP6474797B2 (en) | 2013-06-27 | 2019-02-27 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Interleukin 15 (IL-15) antagonists and their use for the treatment of autoimmune and inflammatory diseases |
| CN105593059B (en) | 2013-07-19 | 2018-07-31 | 萤火虫医疗公司 | Devices for mobility aids and infusion management |
| SI3030262T1 (en) | 2013-08-08 | 2020-03-31 | Cytune Pharma | Combined pharmaceutical composition |
| BR112016002614B8 (en) | 2013-08-08 | 2023-11-07 | Hopitaux Paris Assist Publique | Immunocytokine and pharmaceutical composition |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| EA036577B1 (en) | 2013-11-04 | 2020-11-25 | Икнос Сайенсиз Са | Production of t cell retargeting hetero-dimeric immunoglobulins |
| RS60443B1 (en) | 2013-12-17 | 2020-07-31 | Genentech Inc | Anti-cd3 antibodies and methods of use |
| RU2016128726A (en) | 2013-12-17 | 2018-01-23 | Дженентек, Инк. | METHODS FOR TREATING MALIGNANT TUMORS USING PD-1 BINDING ANTAGONISTS AND ANTIBODIES AGAINST CD20 |
| JP6706578B2 (en) | 2013-12-30 | 2020-06-10 | エピムアブ バイオセラピューティクス インコーポレイテッド | Tandem Fab immunoglobulins and uses thereof |
| EP3093295B1 (en) | 2014-01-08 | 2020-05-27 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Il-15 heterogeneous dimer protein and uses thereof |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| TWI754319B (en) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | Methods and antibody compositions for tumor treatment |
| BR112016022385A2 (en) | 2014-03-28 | 2018-06-19 | Xencor, Inc | specific antibodies that bind to cd38 and cd3 |
| WO2015168379A2 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| ES2890079T3 (en) | 2014-05-29 | 2022-01-17 | Macrogenics Inc | Trispecific binding molecules and methods of using same |
| US20150351275A1 (en) | 2014-05-30 | 2015-12-03 | Johanson Manufacturing Corporation | Thin-Film Radio Frequency Power Terminator |
| WO2015195163A1 (en)* | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
| US9925247B2 (en) | 2014-06-30 | 2018-03-27 | Altor Bioscience Corporation | IL-15-based molecules and methods of use thereof |
| WO2016014984A1 (en) | 2014-07-24 | 2016-01-28 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| RU2020117196A (en) | 2014-08-19 | 2020-10-15 | Новартис Аг | CHIMERIC ANTIGENIC RECEPTOR (CAR) AGAINST CD123 FOR USE IN THE TREATMENT OF MALIGNANT TUMORS |
| JO3663B1 (en) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
| US9763705B2 (en) | 2014-10-03 | 2017-09-19 | Globus Medical, Inc. | Orthopedic stabilization devices and methods for installation thereof |
| JP2017536098A (en) | 2014-10-14 | 2017-12-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | Interleukin-15 composition and use thereof |
| RU2017119185A (en) | 2014-11-05 | 2018-12-05 | Дженентек, Инк. | ANTIBODIES AGAINST FGFR2 / 3 AND WAYS OF THEIR APPLICATION |
| MY192999A (en) | 2014-11-20 | 2022-09-20 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
| US20160176969A1 (en) | 2014-11-26 | 2016-06-23 | Xencor, Inc. | Heterodimeric antibodies including binding to cd8 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| ES2886523T3 (en)* | 2014-11-26 | 2021-12-20 | Xencor Inc | Heterodimeric antibodies that bind to CD3 and CD20 |
| EA037065B1 (en) | 2014-11-26 | 2021-02-01 | Ксенкор, Инк. | Heterodimeric antibodies that bind cd3 and cd38 |
| AU2015366795B2 (en) | 2014-12-19 | 2020-12-17 | Jiangsu Hengrui Medicine Co., Ltd. | Interleukin 15 protein complex and use thereof |
| EP3237446B1 (en) | 2014-12-22 | 2021-05-05 | PD-1 Acquisition Group, LLC | Anti-pd-1 antibodies |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| WO2016141387A1 (en)* | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| EP3064507A1 (en) | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
| MX390190B (en) | 2015-05-08 | 2025-03-20 | Xencor Inc | HETERODIMERIC ANTIBODIES THAT BIND TO CD3 AND TUMOR ANTIGENS. |
| TWI762879B (en) | 2015-07-30 | 2022-05-01 | 美商宏觀基因股份有限公司 | Pd-1-binding molecules and methods of use thereof |
| KR20180125435A (en) | 2015-09-25 | 2018-11-23 | 알토 바이오사이언스 코포레이션 | Interleukin-15 superagens that significantly improve graft-versus-tumor activity |
| SMT202300304T1 (en) | 2015-12-22 | 2023-11-13 | Regeneron Pharma | Combination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer |
| EP3464370A1 (en) | 2016-06-01 | 2019-04-10 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma |
| US20170349660A1 (en) | 2016-06-01 | 2017-12-07 | Xencor. Inc. | Bispecific antibodies that bind cd123 and cd3 |
| EP3252078A1 (en) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| RU2018145961A (en) | 2016-06-07 | 2020-07-14 | Макродженикс, Инк. | COMBINATION THERAPY |
| HUE068801T2 (en) | 2016-06-14 | 2025-01-28 | Xencor Inc | Bispecific checkpoint inhibitor antibodies |
| US20190256454A1 (en) | 2016-07-05 | 2019-08-22 | Novartis Ag | New process for early sacubitril intermediates |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| MY203000A (en) | 2016-10-14 | 2024-06-01 | Xencor Inc | Il15/il15r� heterodimeric fc-fusion proteins |
| EP4613776A2 (en) | 2016-10-21 | 2025-09-10 | Altor BioScience Corporation | Multimeric il-15-based molecules |
| CN110214153B (en) | 2016-11-18 | 2024-03-29 | 法国施维雅药厂 | anti-PD-1 antibodies and compositions |
| WO2019006472A1 (en) | 2017-06-30 | 2019-01-03 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| EP3749363A1 (en) | 2018-02-08 | 2020-12-16 | Amgen Inc. | Low ph pharmaceutical antibody formulation |
| JP2021516045A (en) | 2018-02-28 | 2021-07-01 | ファイザー・インク | IL-15 variant and its use |
| JP2021521784A (en)* | 2018-04-18 | 2021-08-30 | ゼンコア インコーポレイテッド | PD-1 targeted heterodimer fusion proteins containing IL-15 / IL-15RaFc fusion proteins and PD-1 antigen binding domains and their use |
| IL310398A (en)* | 2018-04-18 | 2024-03-01 | Xencor Inc | Il-15/il-15rα heterodimeric fc fusion proteins and uses thereof |
| EP3864047A2 (en) | 2018-10-12 | 2021-08-18 | Xencor, Inc. | Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof |
| WO2020132646A1 (en) | 2018-12-20 | 2020-06-25 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
| US20220135682A1 (en) | 2019-03-11 | 2022-05-05 | Jounce Therapeutics, Inc. | Anti-ICOS Antibodies for the Treatment of Cancer |
| TW202128757A (en)* | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | Pd-1 targeted il-15/il-15ralpha fc fusion proteins with improved properties |