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MY203000A - Il15/il15r� heterodimeric fc-fusion proteins - Google Patents

Il15/il15r� heterodimeric fc-fusion proteins

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Publication number
MY203000A
MY203000AMYPI2019001995AMYPI2019001995AMY203000AMY 203000 AMY203000 AMY 203000AMY PI2019001995 AMYPI2019001995 AMY PI2019001995AMY PI2019001995 AMYPI2019001995 AMY PI2019001995AMY 203000 AMY203000 AMY 203000A
Authority
MY
Malaysia
Prior art keywords
heterodimeric
fusion proteins
il15r
il15ra
directed
Prior art date
Application number
MYPI2019001995A
Inventor
John Desjarlais
Matthew Bernett
Rumana Rashid
Rajat Varma
Christine Bonzon
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor IncfiledCriticalXencor Inc
Publication of MY203000ApublicationCriticalpatent/MY203000A/en

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Abstract

The present disclosure is directed to several IL15/IL15Ra heterodimeric Fc fusion proteins.
MYPI2019001995A2016-10-142017-10-16Il15/il15r� heterodimeric fc-fusion proteinsMY203000A (en)

Applications Claiming Priority (5)

Application NumberPriority DateFiling DateTitle
US201662408655P2016-10-142016-10-14
US201662416087P2016-11-012016-11-01
US201762443465P2017-01-062017-01-06
US201762477926P2017-03-282017-03-28
PCT/US2017/056829WO2018071919A1 (en)2016-10-142017-10-16IL15/IL15Rα HETERODIMERIC FC-FUSION PROTEINS

Publications (1)

Publication NumberPublication Date
MY203000Atrue MY203000A (en)2024-06-01

Family

ID=60452718

Family Applications (2)

Application NumberTitlePriority DateFiling Date
MYPI2019001995AMY203000A (en)2016-10-142017-10-16Il15/il15r� heterodimeric fc-fusion proteins
MYPI2019001994AMY205418A (en)2016-10-142017-10-16Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments

Family Applications After (1)

Application NumberTitlePriority DateFiling Date
MYPI2019001994AMY205418A (en)2016-10-142017-10-16Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments

Country Status (23)

CountryLink
US (6)US10550185B2 (en)
EP (2)EP3526241A1 (en)
JP (5)JP7142630B2 (en)
KR (3)KR102649972B1 (en)
CN (2)CN110214147A (en)
AU (5)AU2017342560B2 (en)
BR (2)BR112019007288A2 (en)
CA (2)CA3039930A1 (en)
CL (4)CL2019001000A1 (en)
CO (2)CO2019003943A2 (en)
CR (2)CR20190227A (en)
IL (3)IL265998B2 (en)
MA (2)MA46533A (en)
MX (3)MX2019004328A (en)
MY (2)MY203000A (en)
PE (3)PE20191034A1 (en)
PH (2)PH12019500781A1 (en)
RU (1)RU2019114175A (en)
SA (1)SA519401562B1 (en)
SG (2)SG11201903304YA (en)
UA (1)UA128669C2 (en)
WO (2)WO2018071918A1 (en)
ZA (2)ZA201902383B (en)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US9605084B2 (en)2013-03-152017-03-28Xencor, Inc.Heterodimeric proteins
US11053316B2 (en)2013-01-142021-07-06Xencor, Inc.Optimized antibody variable regions
DK2943511T3 (en)2013-01-142019-10-21Xencor Inc NEW HETERODIMERIC PROTEINS
US10968276B2 (en)2013-03-122021-04-06Xencor, Inc.Optimized anti-CD3 variable regions
US10858417B2 (en)*2013-03-152020-12-08Xencor, Inc.Heterodimeric proteins
BR112016005408B1 (en)*2013-09-132023-03-21Beigene Switzerland Gmbh ANTI-PD1, F(AB) OR F(AB)2 ANTIBODIES AND REFERRED USE ANTIBODY FOR TREATMENT OF CANCER OR VIRAL INFECTION
US11040111B2 (en)*2014-03-032021-06-22Academia SinicaBi-specific antibodies and uses thereof
BR112016022385A2 (en)2014-03-282018-06-19Xencor, Inc specific antibodies that bind to cd38 and cd3
KR102130600B1 (en)2014-07-032020-07-08베이진 엘티디Anti-PD-L1 Antibodies and Their Use as Therapeutics and Diagnostics
ES2886523T3 (en)2014-11-262021-12-20Xencor Inc Heterodimeric antibodies that bind to CD3 and CD20
EA037065B1 (en)2014-11-262021-02-01Ксенкор, Инк.Heterodimeric antibodies that bind cd3 and cd38
US10259887B2 (en)2014-11-262019-04-16Xencor, Inc.Heterodimeric antibodies that bind CD3 and tumor antigens
PL3283508T3 (en)2015-04-172021-10-11Alpine Immune Sciences, Inc.Immunomodulatory proteins with tunable affinities
AU2016365742A1 (en)2015-12-072018-06-21Xencor, Inc.Heterodimeric antibodies that bind CD3 and PSMA
MA43552A (en)2016-04-152018-11-07Alpine Immune Sciences Inc CD80 VARIANT IMMUNOMODULATOR PROTEINS AND THEIR USES
EP3458092A1 (en)2016-05-182019-03-27Modernatx, Inc.Mrna combination therapy for the treatment of cancer
HUE068801T2 (en)*2016-06-142025-01-28Xencor IncBispecific checkpoint inhibitor antibodies
CN109715663B (en)2016-06-282022-11-25Xencor股份有限公司Heterodimeric antibodies binding to somatostatin receptor 2
US10864203B2 (en)2016-07-052020-12-15Beigene, Ltd.Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer
US11471488B2 (en)2016-07-282022-10-18Alpine Immune Sciences, Inc.CD155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en)2016-07-282023-12-05Alpine Immune Sciences, Inc.CD112 variant immunomodulatory proteins and uses thereof
BR112019002394B1 (en)2016-08-102021-12-21Ajou University Industry-Academic Cooperation Foundation HETERODIMERIC PROTEIN FLUTED WITH CF AND ITS USE
HUE065528T2 (en)2016-08-192024-06-28Beigene Switzerland GmbhCombination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
US10793632B2 (en)2016-08-302020-10-06Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
MY203000A (en)2016-10-142024-06-01Xencor IncIl15/il15r� heterodimeric fc-fusion proteins
MA47130B1 (en)2016-12-212025-05-30Cephalon, Inc. ANTIBODIES SPECIFICALLY BINDING TO HUMAN IL-15 AND THEIR USES
EP3573989A4 (en)2017-01-252020-11-18Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF
US11629340B2 (en)2017-03-032023-04-18Obsidian Therapeutics, Inc.DHFR tunable protein regulation
KR20190141146A (en)2017-03-162019-12-23알파인 이뮨 사이언시즈, 인코포레이티드 PD-L2 variant immunomodulatory protein and uses thereof
MX2019010887A (en)2017-03-162019-10-15Alpine Immune Sciences IncCd80 variant immunomodulatory proteins and uses thereof.
JOP20190260A1 (en)2017-05-022019-10-31Merck Sharp & DohmeStable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
KR102757960B1 (en)2017-06-262025-01-22베이진 엘티디 Immunotherapy for hepatocellular carcinoma (HCC)
WO2019006472A1 (en)*2017-06-302019-01-03Xencor, Inc.Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains
CN111801347A (en)2017-10-102020-10-20高山免疫科学股份有限公司CTLA-4 variant immunomodulatory proteins and uses thereof
CN109705211B (en)2017-10-262020-08-18苏州复融生物技术有限公司 A kind of IgG1 Fc monomer and its application
US10981992B2 (en)2017-11-082021-04-20Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
EP3706793A1 (en)2017-11-082020-09-16Xencor, Inc.Bispecific and monospecific antibodies using novel anti-pd-1 sequences
US11786529B2 (en)2017-11-292023-10-17Beigene Switzerland GmbhTreatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
SG11202005732XA (en)2017-12-192020-07-29Xencor IncEngineered il-2 fc fusion proteins
EP3735417A1 (en)2018-01-032020-11-11Alpine Immune Sciences, Inc.Multi-domain immunomodulatory proteins and methods of use thereof
JP2021516045A (en)2018-02-282021-07-01ファイザー・インク IL-15 variant and its use
EP3773911A2 (en)2018-04-042021-02-17Xencor, Inc.Heterodimeric antibodies that bind fibroblast activation protein
KR20210003814A (en)2018-04-182021-01-12젠코어 인코포레이티드 TIM-3 targeting heterodimer fusion protein containing IL-15/IL-15Rα Fc-fusion protein and TIM-3 antigen binding domain
US20190352362A1 (en)*2018-04-182019-11-21Xencor, Inc.LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
IL310398A (en)2018-04-182024-03-01Xencor IncIl-15/il-15rα heterodimeric fc fusion proteins and uses thereof
JP2021521784A (en)2018-04-182021-08-30ゼンコア インコーポレイテッド PD-1 targeted heterodimer fusion proteins containing IL-15 / IL-15RaFc fusion proteins and PD-1 antigen binding domains and their use
CN110437339B (en)*2018-05-042021-08-13免疫靶向有限公司Fusion protein type prodrug with interleukin 15 as active component
CA3100007A1 (en)2018-05-142019-11-21Werewolf Therapeutics, Inc.Activatable interleukin-2 polypeptides and methods of use thereof
WO2019222294A1 (en)2018-05-142019-11-21Werewolf Therapeutics, Inc.Activatable cytokine polypeptides and methods of use thereof
TWI869346B (en)2018-05-302025-01-11瑞士商諾華公司Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
WO2019241758A1 (en)2018-06-152019-12-19Alpine Immune Sciences, Inc.Pd-1 variant immunomodulatory proteins and uses thereof
TW202504917A (en)*2018-06-212025-02-01美商再生元醫藥公司Methods for treating cancer with bispecific anti-cd3xmuc16 antibodies and anti-pd-1 antibodies
CN112584851B (en)*2018-06-222025-09-05科优基因公司 Novel interleukin-15 (IL-15) fusion protein and its use
CN120424233A (en)2018-06-222025-08-05科优基因公司Cytokine-based bioactive agents and methods of use thereof
KR20210087027A (en)2018-09-272021-07-09실리오 디벨럽먼트, 인크. Masked cytokine polypeptide
MA53822A (en)2018-10-032021-08-11Xencor Inc IL-12 HETERODIMER FC FUSION PROTEINS
EP3864047A2 (en)*2018-10-122021-08-18Xencor, Inc.Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof
KR20210080460A (en)2018-10-232021-06-30드래곤플라이 쎄라퓨틱스, 인크. Heterodimeric Fc-fused protein
CN109627342B (en)*2018-12-102022-12-06苏州近岸蛋白质科技股份有限公司Protein and culture medium formula combination applied to NK cell culture and preparation method
US20230045048A1 (en)*2018-12-142023-02-09Proviva Therapeutics (Hong Kong) LimitedIl-15 compositions and methods of use thereof
WO2020132646A1 (en)*2018-12-202020-06-25Xencor, Inc.Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
US20220106375A1 (en)*2019-01-112022-04-07Memorial Sloan Kettering Cancer CenterMultimerization of il-15/il-15r-alpha-fc complexes to enhance immunotherapy
CN111100210B (en)*2019-01-302022-04-19武汉九州钰民医药科技有限公司Fc fusion protein and application thereof
WO2020165374A1 (en)2019-02-142020-08-20Ose ImmunotherapeuticsBifunctional molecule comprising il-15ra
WO2020172631A2 (en)*2019-02-212020-08-27Xencor, Inc.Untargeted and targeted il-10 fc-fusion proteins
CN114173875B (en)2019-03-012025-04-15Xencor股份有限公司 Heterodimeric antibodies that bind ENPP3 and CD3
JP7249432B2 (en)*2019-03-292023-03-30エフ. ホフマン-ラ ロシュ アーゲー SPR-based binding assays for functional analysis of multivalent molecules
US20220218789A1 (en)2019-05-102022-07-14Nant Holdings Ip, LlcNogapendekin Alfa-Inbakicept For Immune Stimulant Therapies And Treatment Of Viral Infections
EP3969035A4 (en)2019-05-142023-06-21Werewolf Therapeutics, Inc. SEPARATION UNITS AND METHODS AND THEIR USE
SG11202111409YA (en)2019-05-202021-12-30Cytune PharmaIL-2/IL-15Rßy AGONIST DOSING REGIMENS FOR TREATING CANCER OR INFECTIOUS DISEASES
AU2020291012B2 (en)2019-06-122025-09-25AskGene Pharma, Inc.Novel IL-15 prodrugs and methods of use thereof
AU2019456283B2 (en)2019-07-082023-06-08Immunitybio, Inc.Mononuclear cell derived NK cells
US11453862B2 (en)2019-07-082022-09-27Immunitybio, Inc.Mononuclear cell derived NK cells
CA3146341A1 (en)2019-07-302021-02-04Aaron L. KurtzmanBispecific anti lrrc15 and cd3epsilun antibudies
BR112022002780A2 (en)2019-08-152022-05-10Igm Biosciences Inc Immunostimulatory multimeric binding molecules
US20220289838A1 (en)*2019-08-192022-09-15Nantong Yichen Biopharma. Co. Ltd.Immunocytokine, Preparation for the Same, and Uses Thereof
EP4017529A4 (en)*2019-08-222024-03-13Cidara Therapeutics, Inc.Variant fc domains and uses thereof
CN112409484B (en)*2019-08-222023-03-21盛禾(中国)生物制药有限公司Multifunctional antibodies, their preparation and uses
CN116574183A (en)*2019-08-222023-08-11盛禾(中国)生物制药有限公司Multifunctional antibodies, their preparation and use
WO2021053559A1 (en)2019-09-182021-03-25Novartis AgEntpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
RU2753282C2 (en)2019-09-192021-08-12Закрытое Акционерное Общество "Биокад"IMMUNOCYTOKIN INCLUDING A HETERODIMERIC PROTEIN COMPLEX BASED ON ОСНОВЕ IL-15/IL-15Rα AND ITS APPLICATION
AU2020355253A1 (en)*2019-09-272022-03-24Agenus Inc.Heterodimeric proteins
US11851466B2 (en)*2019-10-032023-12-26Xencor, Inc.Targeted IL-12 heterodimeric Fc-fusion proteins
CN116583298A (en)*2019-10-112023-08-11基因泰克公司 PD-1 targeting IL-15/IL-15RαFC fusion protein with improved properties
TW202128757A (en)*2019-10-112021-08-01美商建南德克公司Pd-1 targeted il-15/il-15ralpha fc fusion proteins with improved properties
WO2021092719A1 (en)*2019-11-112021-05-20王盛典Fusion protein that targets antigen-specific t cells to induce differentiation thereof into memory stem cells
CN111690069B (en)*2019-11-132022-04-19中国科学技术大学 A kind of IL-15/SuIL-15Rα-mFc-γ4 complex protein and its construction method and application
CN111690068B (en)*2019-11-132022-04-19中国科学技术大学 A kind of IL-15/SuIL-15Rα-dFc-γ4 complex protein and its construction method and application
MX2022005666A (en)2019-11-142022-10-07Werewolf Therapeutics Inc ACTIVABLE CYTOKINE POLYPEPTIDES AND METHODS OF USE THEREOF.
TW202128961A (en)2019-11-202021-08-01美商安維塔生物科學股份有限公司Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications
US20230034677A1 (en)*2019-11-212023-02-02INSERM (Institut National de la Santé et la Recherche (Médicale)Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines
WO2021119429A1 (en)*2019-12-132021-06-17Cugene Inc.Novel interleukin-15 (il-15) fusion proteins and uses thereof
KR20220132598A (en)*2020-01-282022-09-30제넨테크, 인크. IL15/IL15R alpha heterodimer Fc-fusion protein for cancer treatment
CA3168469A1 (en)*2020-02-052021-08-12Novartis AgCho cell expressing il-15 heterodimers
CN113307879A (en)*2020-02-272021-08-27启愈生物技术(上海)有限公司TAA/CTLA-4/IL15 three-function fusion protein and application thereof
CN113321738A (en)*2020-02-272021-08-31启愈生物技术(上海)有限公司Tumor-targeting, anti-CD 3 and T cell activation tri-functional fusion protein and application thereof
US20240368239A1 (en)*2020-03-122024-11-07Sl MetagenNovel bispecific protein and use thereof
WO2021188187A1 (en)*2020-03-182021-09-23City Of HopeMultivalent chemokine receptor binding complexes
US11365233B2 (en)2020-04-102022-06-21Cytomx Therapeutics, Inc.Activatable cytokine constructs and related compositions and methods
JP7644777B2 (en)*2020-04-222025-03-12ドラゴンフライ セラピューティクス, インコーポレイテッド Formulations, Dosage Regimens, and Manufacturing Processes for Heterodimeric Fc-Fusion Proteins
WO2021231976A1 (en)2020-05-142021-11-18Xencor, Inc.Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
EP4155316A4 (en)*2020-05-182024-05-08Shandong Simcere Biopharmaceutical Co., Ltd. HUMAN IL-15 MUTANT AND USE THEREOF
EP4610275A2 (en)*2020-06-232025-09-03Kadmon Corporation, LLCAnti-pd-1 antibodies and fusion proteins
CN116234830A (en)*2020-08-072023-06-06基因泰克公司 FLT3 ligand fusion proteins and methods of use
JP2023538891A (en)2020-08-192023-09-12ゼンコア インコーポレイテッド Anti-CD28 composition
US20230270823A1 (en)*2020-09-012023-08-31WuXi Biologics Ireland LimitedLong-acting il-15 and uses thereof
CN112898436A (en)*2020-10-232021-06-04广州医科大学附属肿瘤医院Expression of mouse PD1 and mouse IL-15 gene fusion protein with targeting function and application thereof
CA3195276A1 (en)2020-10-262022-05-05Stefano FERRARAIl-2/il-15rb?? agonist for treating non-melanoma skin cancer
WO2022090203A1 (en)2020-10-262022-05-05Cytune PharmaIL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA
CN114437228B (en)*2020-10-302024-02-06中国科学院生物物理研究所 A bifunctional fusion protein composed of IL-2 and antibody subunits
WO2022115865A2 (en)2020-11-252022-06-02Xilio Development, Inc.Tumor-specific cleavable linkers
WO2022113056A1 (en)2020-11-302022-06-02Crispr Therapeutics AgGene-edited natural killer cells
US20220227867A1 (en)*2020-12-242022-07-21Xencor, Inc.ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS
EP4271798A1 (en)2020-12-302023-11-08CRISPR Therapeutics AGCompositions and methods for differentiating stem cells into nk cells
CN113321736B (en)*2020-12-302024-01-09苏州复融生物技术有限公司Long-acting interleukin 15 fusion protein and preparation method and application thereof
CN114712494B (en)*2021-01-062024-09-17盛禾(中国)生物制药有限公司PD-1-targeting multifunctional antibody composition
CN114712495B (en)*2021-01-062024-08-20盛禾(中国)生物制药有限公司Multifunctional antibody composition
WO2022192403A1 (en)2021-03-092022-09-15Xencor, Inc.Heterodimeric antibodies that bind cd3 and cldn6
US11859012B2 (en)2021-03-102024-01-02Xencor, Inc.Heterodimeric antibodies that bind CD3 and GPC3
AU2022237504A1 (en)2021-03-162023-10-05Cytomx Therapeutics, Inc.Masked activatable cytokine constructs and related compositions and methods
EP4317184A4 (en)*2021-04-222024-10-16Guangdong Fapon Biopharma Inc. BISPECIFIC MULTIFUNCTIONAL FUSION POLYPEPTIDE
JP2024517759A (en)*2021-04-282024-04-23ミノトール セラピューティクス インコーポレイテッド Humanized chimeric bovine antibodies and methods of use
CN113185600A (en)*2021-05-282021-07-30苏州复融生物技术有限公司Development and application of novel interleukin 15 mutant polypeptide
BR112023027305A2 (en)2021-06-232024-03-12Cytune Pharma INTERLEUCIN-15 VARIANT, CONJUGATE, FUSION PROTEIN, NUCLEIC ACID, VECTOR, HOST CELL AND PHARMACEUTICAL COMPOSITION
KR20240024242A (en)*2021-06-232024-02-23싸이튠 파마 Interleukin-15 based immune cytokines
WO2023010031A1 (en)2021-07-282023-02-02Genentech, Inc.Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers
CN116284430A (en)*2021-07-302023-06-23广东菲鹏制药股份有限公司 Tumor-targeted IL15 fusion protein and its application
WO2023015198A1 (en)2021-08-042023-02-09Genentech, Inc.Il15/il15r alpha heterodimeric fc-fusion proteins for the expansion of nk cells in the treatment of solid tumours
WO2023017191A1 (en)2021-08-132023-02-16Cytune PharmaIl-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
WO2023048518A1 (en)*2021-09-242023-03-30바이오엔시스템스 주식회사Fusion protein dimer comprising pd-1 and il-15 and use thereof
KR102595699B1 (en)2021-11-032023-10-31주식회사 드론위더스Drone shelter
WO2023086772A1 (en)2021-11-122023-05-19Xencor, Inc.Bispecific antibodies that bind to b7h3 and nkg2d
WO2023083379A1 (en)*2021-11-152023-05-19中国科学院生物物理研究所Fusion protein construct taking interleukin 15 as active ingredient and use thereof
EP4434998A4 (en)*2021-11-182025-06-18Shandong Simcere Biopharmaceutical Co., Ltd. Pharmaceutical composition containing IL-15 mutant fusion protein
WO2023196905A1 (en)2022-04-072023-10-12Xencor, Inc.Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
WO2023222886A1 (en)2022-05-202023-11-23Depth Charge LtdAntibody-cytokine fusion proteins
JP2025522865A (en)2022-07-072025-07-17ジェネンテック, インコーポレイテッド Combination of IL15/IL15R alpha heterodimeric FC fusion protein and FCRH5XCD3 bispecific antibody for the treatment of hematological cancers
WO2024014808A1 (en)*2022-07-112024-01-18주식회사 지뉴브Cytokine fusion protein
CN119790078A (en)*2022-08-312025-04-08苏州复融生物技术有限公司Agonistic interleukin 15 complex and uses thereof
CN116162171B (en)2022-10-132025-06-03深圳市百士通科技开发有限公司 Application of antibody mutation methods in therapeutic antibody drugs
CN116178546B (en)*2022-10-132024-06-18深圳市百士通科技开发有限公司Multifunctional recombinant antibody and preparation method and application thereof
KR20250113537A (en)2022-10-252025-07-25아블렉시스, 엘엘씨 anti-CD3 antibody
WO2024102636A1 (en)2022-11-072024-05-16Xencor, Inc.Bispecific antibodies that bind to b7h3 and mica/b
WO2024107731A2 (en)2022-11-142024-05-23Ablexis, LlcAnti-pd-l1 antibodies
WO2024215987A1 (en)2023-04-142024-10-17Sotio Biotech Inc.IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
WO2024215989A1 (en)2023-04-142024-10-17Sotio Biotech Inc.ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS
KR20240156564A (en)*2023-04-212024-10-30상트네어바이오사이언스 주식회사ANTIGEN BINDING PROTEINS WITH TWO Fc DOMAINS AND USE THEREOF
WO2025064951A1 (en)2023-09-202025-03-27Immunome, Inc.Anti-tumor antibodies
WO2025075057A1 (en)*2023-10-022025-04-10国立大学法人 熊本大学Method for inhibiting formation of aggregates of polypeptide
US20250243279A1 (en)2023-10-172025-07-31Xencor, Inc.Bispecific antibodies that bind to nkp46 and mica/b
WO2025085744A1 (en)*2023-10-182025-04-24Memorial Sloan-Kettering Cancer CenterFusion polypeptides and uses thereof
WO2025085781A1 (en)2023-10-192025-04-24Genentech, Inc.Combinations of il15/il15r alpha heterodimeric fc-fusion proteins and her2xcd3 bispecific antibodies for the treatment of her2-positive cancers

Family Cites Families (386)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3773919A (en)1969-10-231973-11-20Du PontPolylactide-drug mixtures
CU22545A1 (en)1994-11-181999-03-31Centro Inmunologia Molecular OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE
US4179337A (en)1973-07-201979-12-18Davis Frank FNon-immunogenic polypeptides
US4169888A (en)1977-10-171979-10-02The Upjohn CompanyComposition of matter and process
US4307016A (en)1978-03-241981-12-22Takeda Chemical Industries, Ltd.Demethyl maytansinoids
US4256746A (en)1978-11-141981-03-17Takeda Chemical IndustriesDechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en)1979-01-311980-08-05Takeda Chem Ind Ltd20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en)1979-06-051980-12-18Takeda Chem Ind LtdAntibiotic c-15003pnd and its preparation
JPS6023084B2 (en)1979-07-111985-06-05味の素株式会社 blood substitute
JPS5645483A (en)1979-09-191981-04-25Takeda Chem Ind LtdC-15003phm and its preparation
EP0028683A1 (en)1979-09-211981-05-20Takeda Chemical Industries, Ltd.Antibiotic C-15003 PHO and production thereof
JPS5645485A (en)1979-09-211981-04-25Takeda Chem Ind LtdProduction of c-15003pnd
US4364935A (en)1979-12-041982-12-21Ortho Pharmaceutical CorporationMonoclonal antibody to a human prothymocyte antigen and methods of preparing same
WO1982001188A1 (en)1980-10-081982-04-15Takeda Chemical Industries Ltd4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en)1980-11-031984-05-22Standard Oil CompanyImpact improvement of high nitrile resins
US4315929A (en)1981-01-271982-02-16The United States Of America As Represented By The Secretary Of AgricultureMethod of controlling the European corn borer with trewiasine
US4313946A (en)1981-01-271982-02-02The United States Of America As Represented By The Secretary Of AgricultureChemotherapeutically active maytansinoids from Trewia nudiflora
JPS57192389A (en)1981-05-201982-11-26Takeda Chem Ind LtdNovel maytansinoid
US4640835A (en)1981-10-301987-02-03Nippon Chemiphar Company, Ltd.Plasminogen activator derivatives
US4496689A (en)1983-12-271985-01-29Miles Laboratories, Inc.Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4943533A (en)1984-03-011990-07-24The Regents Of The University Of CaliforniaHybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US4970198A (en)1985-10-171990-11-13American Cyanamid CompanyAntitumor antibiotics (LL-E33288 complex)
EP0206448B1 (en)1985-06-191990-11-14Ajinomoto Co., Inc.Hemoglobin combined with a poly(alkylene oxide)
EP0272253A4 (en)1986-03-071990-02-05Massachusetts Inst TechnologyMethod for enhancing glycoprotein stability.
DE3783588T2 (en)1986-04-171993-06-09Kyowa Hakko Kogyo Kk NEW DC-88A AND DC-89A1 CONNECTIONS AND THEIR PRODUCTION METHOD.
US4791192A (en)1986-06-261988-12-13Takeda Chemical Industries, Ltd.Chemically modified protein with polyethyleneglycol
US4880935A (en)1986-07-111989-11-14Icrf (Patents) LimitedHeterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
IL85035A0 (en)1987-01-081988-06-30Int Genetic EngPolynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5053394A (en)1988-09-211991-10-01American Cyanamid CompanyTargeted forms of methyltrithio antitumor agents
US5606040A (en)1987-10-301997-02-25American Cyanamid CompanyAntitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5770701A (en)1987-10-301998-06-23American Cyanamid CompanyProcess for preparing targeted forms of methyltrithio antitumor agents
WO1989006692A1 (en)1988-01-121989-07-27Genentech, Inc.Method of treating tumor cells by inhibiting growth factor receptor function
IL89220A (en)1988-02-111994-02-27Bristol Myers Squibb CoAnthracycline immunoconjugates, their production and pharmaceutical compositions containing them
US5084468A (en)1988-08-111992-01-28Kyowa Hakko Kogyo Co., Ltd.Dc-88a derivatives
US5530101A (en)1988-12-281996-06-25Protein Design Labs, Inc.Humanized immunoglobulins
JP2598116B2 (en)1988-12-281997-04-09協和醗酵工業株式会社 New substance DC113
JP2510335B2 (en)1989-07-031996-06-26協和醗酵工業株式会社 DC-88A derivative
US5187186A (en)1989-07-031993-02-16Kyowa Hakko Kogyo Co., Ltd.Pyrroloindole derivatives
US5208020A (en)1989-10-251993-05-04Immunogen Inc.Cytotoxic agents comprising maytansinoids and their therapeutic use
CA2026147C (en)1989-10-252006-02-07Ravi J. ChariCytotoxic agents comprising maytansinoids and their therapeutic use
US5859205A (en)1989-12-211999-01-12Celltech LimitedHumanised antibodies
AU652936B2 (en)1990-05-071994-09-15Scripps Clinic And Research FoundationIntermediates in the formation of the calicheamicin and esperamicin oligosaccharides
US5968509A (en)1990-10-051999-10-19Btp International LimitedAntibodies with binding affinity for the CD3 antigen
WO1992015683A1 (en)1991-03-061992-09-17MERCK Patent Gesellschaft mit beschränkter HaftungHumanized and chimeric monoclonal antibodies
WO1994004679A1 (en)1991-06-141994-03-03Genentech, Inc.Method for making humanized antibodies
US6407213B1 (en)1991-06-142002-06-18Genentech, Inc.Method for making humanized antibodies
US5264586A (en)1991-07-171993-11-23The Scripps Research InstituteAnalogs of calicheamicin gamma1I, method of making and using the same
US5622929A (en)1992-01-231997-04-22Bristol-Myers Squibb CompanyThioether conjugates
GB9206422D0 (en)1992-03-241992-05-06Bolt Sarah LAntibody preparation
ES2149768T3 (en)1992-03-252000-11-16Immunogen Inc CONJUGATES OF BINDING AGENTS OF CELLS DERIVED FROM CC-1065.
ZA932522B (en)1992-04-101993-12-20Res Dev FoundationImmunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US6329507B1 (en)1992-08-212001-12-11The Dow Chemical CompanyDimer and multimer forms of single chain polypeptides
US5736137A (en)1992-11-131998-04-07Idec Pharmaceuticals CorporationTherapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5635483A (en)1992-12-031997-06-03Arizona Board Of Regents Acting On Behalf Of Arizona State UniversityTumor inhibiting tetrapeptide bearing modified phenethyl amides
AU690528B2 (en)1992-12-041998-04-30Medical Research CouncilMultivalent and multispecific binding proteins, their manufacture and use
JP3312357B2 (en)1992-12-112002-08-05ザ ダウ ケミカル カンパニー Multivalent single chain antibody
US5780588A (en)1993-01-261998-07-14Arizona Board Of RegentsElucidation and synthesis of selected pentapeptides
US6214345B1 (en)1993-05-142001-04-10Bristol-Myers Squibb Co.Lysosomal enzyme-cleavable antitumor drug conjugates
DE69434136T2 (en)1993-10-012005-12-01Teikoku Hormone Mfg. Co., Ltd. Dolastatin DERIVATIVES
GB9401182D0 (en)1994-01-211994-03-16Inst Of Cancer The ResearchAntibodies to EGF receptor and their antitumour effect
KR100350260B1 (en)1994-04-222003-01-06교와 핫꼬 고교 가부시끼가이샤 Pyrroloindole derivatives
JPH07309761A (en)1994-05-201995-11-28Kyowa Hakko Kogyo Co Ltd Stabilization of duocarmycin derivatives
US5945311A (en)1994-06-031999-08-31GSF--Forschungszentrumfur Umweltund GesundheitMethod for producing heterologous bi-specific antibodies
US5773001A (en)1994-06-031998-06-30American Cyanamid CompanyConjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5550246A (en)1994-09-071996-08-27The Scripps Research InstituteCalicheamicin mimics
US5541087A (en)1994-09-141996-07-30Fuji Immunopharmaceuticals CorporationExpression and export technology of proteins as immunofusins
US5663149A (en)1994-12-131997-09-02Arizona Board Of Regents Acting On Behalf Of Arizona State UniversityHuman cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5731168A (en)1995-03-011998-03-24Genentech, Inc.Method for making heteromultimeric polypeptides
US5712374A (en)1995-06-071998-01-27American Cyanamid CompanyMethod for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
EP0831880A4 (en)1995-06-072004-12-01Imclone Systems IncAntibody and antibody fragments for inhibiting the growth of tumors
US5714586A (en)1995-06-071998-02-03American Cyanamid CompanyMethods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US7696338B2 (en)1995-10-302010-04-13The United States Of America As Represented By The Department Of Health And Human ServicesImmunotoxin fusion proteins and means for expression thereof
DK0871490T3 (en)1995-12-222003-07-07Bristol Myers Squibb Co Branched hydrazone linkers
US6451308B1 (en)1996-04-262002-09-17Beth Israel Deaconess Medical CenterAntagonists of interleukin-15
JP2001502521A (en)1996-04-262001-02-27ベス イスラエル デアコネス メディカル センター Interleukin-15 antagonist
EP0915987A2 (en)1997-04-211999-05-19Donlar CorporationPOLY-($g(a)-L-ASPARTIC ACID), POLY-($g(a)-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE
DK0979281T3 (en)1997-05-022005-11-21Genentech Inc Process for the preparation of multispecific antibodies with heteromultimers and common components
US6235883B1 (en)1997-05-052001-05-22Abgenix, Inc.Human monoclonal antibodies to epidermal growth factor receptor
ATE283364T1 (en)1998-01-232004-12-15Vlaams Interuniv Inst Biotech MULTIPURPOSE ANTIBODIES DERIVATIVES
WO1999054342A1 (en)1998-04-201999-10-28Pablo UmanaGlycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
ID27512A (en)1998-04-212001-04-12Microment Ges Fur Biomedizinis PRIVATE POLIPEPTIDES CD19XCD3 AND ITS USES
US6455677B1 (en)1998-04-302002-09-24Boehringer Ingelheim International GmbhFAPα-specific antibody with improved producibility
ATE460946T1 (en)1998-06-222010-04-15Immunomedics Inc USE OF BISPECIFIC ANTIBODIES IN DIAGNOSIS AND THERAPY
GB9815909D0 (en)1998-07-211998-09-16Btg Int LtdAntibody preparation
US6737056B1 (en)1999-01-152004-05-18Genentech, Inc.Polypeptide variants with altered effector function
US6723538B2 (en)1999-03-112004-04-20Micromet AgBispecific antibody and chemokine receptor constructs
EP3031917A1 (en)1999-04-092016-06-15Kyowa Hakko Kirin Co., Ltd.Method for controlling the activity of immunologically functional molecule
US6939545B2 (en)1999-04-282005-09-06Genetics Institute, LlcComposition and method for treating inflammatory disorders
JP4793971B2 (en)1999-08-092011-10-12メルク パテント ゲーエムベーハー Complex cytokine-antibody complex
US7303749B1 (en)1999-10-012007-12-04Immunogen Inc.Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP2289549A3 (en)1999-10-012011-06-15Immunogen, Inc.Immunoconjugates for treating cancer
EP1229125A4 (en)1999-10-192005-06-01Kyowa Hakko Kogyo Kk PROCESS FOR PRODUCING A POLYPEPTIDE
US6716410B1 (en)1999-10-262004-04-06The Regents Of The University Of CaliforniaReagents and methods for diagnosing, imaging and treating atherosclerotic disease
HUP0204142A3 (en)2000-02-252004-12-28Univ DurhamAnti-egfrviii scfv-antibodies with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof
US7449443B2 (en)2000-03-232008-11-11California Institute Of TechnologyMethod for stabilization of proteins using non-natural amino acids
US20010035606A1 (en)2000-03-282001-11-01Schoen Alan H.Set of blocks for packing a cube
EP1278778A2 (en)2000-05-032003-01-29Amgen Inc.,Modified peptides, comprising an fc domain, as therapeutic agents
JP2003533987A (en)2000-05-192003-11-18イス ケミカル カンパニー リミテッド Humanized antibodies against epidermal growth factor receptor
WO2001090192A2 (en)2000-05-242001-11-29Imclone Systems IncorporatedBispecific immunoglobulin-like antigen binding proteins and method of production
US6586207B2 (en)2000-05-262003-07-01California Institute Of TechnologyOverexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
CA2417185A1 (en)2000-07-252002-01-31Shui-On LeungMultivalent target binding protein
US6333410B1 (en)2000-08-182001-12-25Immunogen, Inc.Process for the preparation and purification of thiol-containing maytansinoids
DE10043437A1 (en)2000-09-042002-03-28Horst Lindhofer Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites
EA013563B1 (en)2000-10-062010-06-30Киова Хакко Кирин Ко., Лтд.A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies
EP1333032A4 (en)2000-10-062005-03-16Kyowa Hakko Kogyo Kk METHOD FOR PURIFYING ANTIBODIES
US20030133939A1 (en)2001-01-172003-07-17Genecraft, Inc.Binding domain-immunoglobulin fusion proteins
US20020147312A1 (en)2001-02-022002-10-10O'keefe TheresaHybrid antibodies and uses thereof
EP1243276A1 (en)2001-03-232002-09-25Franciscus Marinus Hendrikus De GrootElongated and multiple spacers containing activatible prodrugs
AU2002307037B2 (en)2001-04-022008-08-07Biogen Idec Inc.Recombinant antibodies coexpressed with GnTIII
US6884869B2 (en)2001-04-302005-04-26Seattle Genetics, Inc.Pentapeptide compounds and uses related thereto
KR20030033007A (en)2001-05-312003-04-26코울터 파머수티컬, 인코포레이티드Cytotoxins, prodrugs, linkers and stabilizers useful therefor
US6441163B1 (en)2001-05-312002-08-27Immunogen, Inc.Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
CN1966525A (en)2001-06-132007-05-23根马布股份公司Human monoclonal antibodies to epidermal growth factor receptor (egfr)
CA2452058A1 (en)2001-06-262003-01-09Imclone Systems IncorporatedBispecific antibodies that bind to vegf receptors
PL213948B1 (en)2001-10-252013-05-31Genentech IncGlycoprotein compositions
WO2003073238A2 (en)2002-02-272003-09-04California Institute Of TechnologyComputational method for designing enzymes for incorporation of amino acid analogs into proteins
US20080219974A1 (en)2002-03-012008-09-11Bernett Matthew JOptimized antibodies that target hm1.24
US8188231B2 (en)2002-09-272012-05-29Xencor, Inc.Optimized FC variants
US7332580B2 (en)2002-04-052008-02-19The Regents Of The University Of CaliforniaBispecific single chain Fv antibody molecules and methods of use thereof
NZ554740A (en)2002-05-242009-01-31Schering CorpNeutralizing human anti-IGFR antibody
CA2802205C (en)2002-07-312016-01-19Seattle Genetics, Inc.Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US8946387B2 (en)2002-08-142015-02-03Macrogenics, Inc.FcγRIIB specific antibodies and methods of use thereof
US20060235208A1 (en)2002-09-272006-10-19Xencor, Inc.Fc variants with optimized properties
US7820166B2 (en)2002-10-112010-10-26Micromet AgPotent T cell modulating molecules
US7705045B2 (en)2002-11-142010-04-27Syntarga, B.V.Prodrugs built as multiple self-elimination-release spacers
BRPI0316282B8 (en)2002-11-152021-05-25Genmab As monoclonal isolated human antibody, composition, immunoconjugate, bispecific or multispecific molecule, method and diagnostic kit to detect the presence of cd25 antigen or a cell expressing cd25, and, expression vector
JP2006524039A (en)2003-01-092006-10-26マクロジェニクス,インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
US7960512B2 (en)2003-01-092011-06-14Macrogenics, Inc.Identification and engineering of antibodies with variant Fc regions and methods of using same
US8084582B2 (en)2003-03-032011-12-27Xencor, Inc.Optimized anti-CD20 monoclonal antibodies having Fc variants
US7610156B2 (en)2003-03-312009-10-27Xencor, Inc.Methods for rational pegylation of proteins
MX340862B (en)2003-05-202016-07-28Immunogen IncImproved cytotoxic agents comprising new maytansinoids.
US7276497B2 (en)2003-05-202007-10-02Immunogen Inc.Cytotoxic agents comprising new maytansinoids
KR20060015602A (en)2003-05-312006-02-17마이크로메트 에이지 Pharmaceutical composition comprising a bispecific antibody against EVCA
CN100509850C (en)2003-05-312009-07-08麦克罗梅特股份公司Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
US7888134B2 (en)2003-06-052011-02-15Oakland UniversityImmunosensors: scFv-linker design for surface immobilization
CA2678736A1 (en)2003-07-212005-02-17Transgene S.A.Novel multifunctional il-2 - il-18 fusion proteins
US20060134105A1 (en)2004-10-212006-06-22Xencor, Inc.IgG immunoglobulin variants with optimized effector function
US20150071948A1 (en)2003-09-262015-03-12Gregory Alan LazarNovel immunoglobulin variants
JP4890253B2 (en)2003-10-092012-03-07アンブレツクス・インコーポレイテツド Azide or acetylene-terminated water-soluble polymer
US20050176028A1 (en)2003-10-162005-08-11Robert HofmeisterDeimmunized binding molecules to CD3
EP3858387A1 (en)2003-11-062021-08-04Seagen Inc.Monomethylvaline compounds capable of conjugation to ligands
US20050142133A1 (en)2003-12-032005-06-30Xencor, Inc.Optimized proteins that target the epidermal growth factor receptor
WO2005056759A2 (en)2003-12-042005-06-23Xencor, Inc.Methods of generating variant proteins with increased host string content and compositions thereof
BRPI0417107A (en)2003-12-192007-02-06Genentech Inc antibody fragment, antibody fragment preparation methods, isolated nucleic acid, compositions, host cell, and antibody fragment manufacture and generation methods
US7235641B2 (en)2003-12-222007-06-26Micromet AgBispecific antibodies
AU2005211385B2 (en)2004-02-022008-12-11Ambrx, Inc.Modified human growth hormone polypeptides and their uses
ATE516305T1 (en)*2004-02-272011-07-15Inst Nat Sante Rech Med IL-15 BINDING SITE FOR IL-15-RALPHA AND SPECIFIC IL-15 MUTANTS ACTING AS AGONISTS/ANTAGONISTS
CA2561264A1 (en)2004-03-242005-10-06Xencor, Inc.Immunoglobulin variants outside the fc region
RU2402548C2 (en)2004-05-192010-10-27Медарекс, Инк.Chemical linkers and conjugates thereof
BRPI0510909A2 (en)2004-05-192008-12-16Medarex Inc cytotoxic drug-binder binding compound, pharmaceutical formulation, method for killing a cell and method for retarding or stopping tumor growth
EP1753783B1 (en)2004-06-032014-08-06Novimmune SAAnti-cd3 antibodies and methods of use thereof
WO2006004910A2 (en)2004-06-282006-01-12Transtarget Inc.Improved bispecific antibodies
JP2008512352A (en)2004-07-172008-04-24イムクローン システムズ インコーポレイティド Novel tetravalent bispecific antibody
CN101052653A (en)2004-09-022007-10-10健泰科生物技术公司Anti-Fc-gamma RIIB receptor antibody and uses therefor
CU23472A1 (en)2004-09-172009-12-17Ct Ingenieria Genetica Biotech ANTAGONIST PEPTIDE OF INTERLEUCINE-15
WO2006034488A2 (en)2004-09-232006-03-30Genentech, Inc.Cysteine engineered antibodies and conjugates
CA2580796C (en)2004-09-242013-03-26Amgen Inc.Modified fc molecules having peptides inserted in internal loop regions
CA2587766A1 (en)2004-11-102007-03-01Macrogenics, Inc.Engineering fc antibody regions to confer effector function
US8367805B2 (en)2004-11-122013-02-05Xencor, Inc.Fc variants with altered binding to FcRn
US8066989B2 (en)2004-11-302011-11-29Trion Pharma GmbhMethod of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
KR20070089186A (en)2004-12-132007-08-30사이토스 바이오테크놀로지 아게 IL-15 Antigen Arrays and Uses
KR20130105885A (en)2005-01-052013-09-26에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하.Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
US8716451B2 (en)2005-01-122014-05-06Kyowa Hakko Kirin Co., LtdStabilized human IgG2 and IgG3 antibodies
WO2006106905A1 (en)2005-03-312006-10-12Chugai Seiyaku Kabushiki KaishaProcess for production of polypeptide by regulation of assembly
US7714016B2 (en)2005-04-082010-05-11Medarex, Inc.Cytotoxic compounds and conjugates with cleavable substrates
US20060257361A1 (en)2005-04-122006-11-16Government Of The Us, As Represented By The Secretary, Department Of Health And Human ServicesNovel form of interleukin-15, Fc-IL-15, and methods of use
US9284375B2 (en)2005-04-152016-03-15Macrogenics, Inc.Covalent diabodies and uses thereof
EP1899364B2 (en)2005-05-172024-10-30University of ConnecticutCompositions and methods for immunomodulation in an organism
AU2006265936A1 (en)2005-07-012007-01-11Medimmune, LlcAn integrated approach for generating multidomain protein therapeutics
EP1919930B1 (en)2005-07-012016-09-14Dako Denmark A/SNew nucleic acid base pairs
EP2586798A3 (en)2005-07-252013-08-07Emergent Product Development Seattle, LLCB-cell reduction using CD37-specific and CD20-specific binding molecules
EP1919505A2 (en)2005-07-252008-05-14Trubion Pharmaceuticals, Inc.Single dose use of cd20-specific binding molecules
WO2007018431A2 (en)2005-08-052007-02-15Syntarga B.V.Triazole-containing releasable linkers and conjugates comprising the same
US7612181B2 (en)2005-08-192009-11-03Abbott LaboratoriesDual variable domain immunoglobulin and uses thereof
WO2007033230A2 (en)2005-09-122007-03-22Novimmune S.A.Anti-cd3 antibody formulations
DK1931709T3 (en)2005-10-032017-03-13Xencor Inc FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
CA2625440C (en)2005-10-112023-06-13Micromet AgCompositions comprising cross-species-specific antibodies and uses thereof
KR20080073293A (en)2005-10-142008-08-08메디뮨 엘엘씨 Cell display of antibody library
WO2007047829A2 (en)2005-10-192007-04-26Laboratoires Serono S.A.Novel heterodimeric proteins and uses thereof
EP1777294A1 (en)2005-10-202007-04-25Institut National De La Sante Et De La Recherche Medicale (Inserm)IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
TW200732350A (en)2005-10-212007-09-01Amgen IncMethods for generating monovalent IgG
CA2627190A1 (en)2005-11-102007-05-24Medarex, Inc.Duocarmycin derivatives as novel cytotoxic compounds and conjugates
CA2627446A1 (en)2005-11-212007-05-31Laboratoires Serono S.A.Compositions and methods of producing hybrid antigen binding molecules and uses thereof
CN101426521A (en)2005-12-212009-05-06医疗免疫有限责任公司EPHA2 BiTE molecules and uses thereof
JP5709356B2 (en)*2006-01-132015-04-30アメリカ合衆国 Codon optimized IL-15 and IL-15R-α genes for expression in mammalian cells
KR20080114709A (en)2006-02-022008-12-31신타가 비.브이. Water Soluble CC-1065 Analogues and Their Conjugates
EP1820513A1 (en)2006-02-152007-08-22Trion Pharma GmbhDestruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
EP1829895A1 (en)2006-03-032007-09-05f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H.Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
AU2007227292B2 (en)2006-03-172012-04-12Biogen Ma Inc.Stabilized polypeptide compositions
EP1999154B1 (en)2006-03-242012-10-24Merck Patent GmbHEngineered heterodimeric protein domains
EP2009101B1 (en)2006-03-312017-10-25Chugai Seiyaku Kabushiki KaishaAntibody modification method for purifying bispecific antibody
EP2006381B1 (en)2006-03-312016-02-03Chugai Seiyaku Kabushiki KaishaMethod for controlling blood pharmacokinetics of antibodies
CA2647282A1 (en)2006-04-052007-10-11Pfizer Products Inc.Ctla4 antibody combination therapy
CN101437847A (en)2006-05-082009-05-20菲洛根有限公司Antibody-targeted cytokines for therapy
EP2035456A1 (en)2006-06-222009-03-18Novo Nordisk A/SProduction of bispecific antibodies
AT503861B1 (en)2006-07-052008-06-15F Star Biotech Forsch & Entw METHOD FOR MANIPULATING T-CELL RECEPTORS
AT503902B1 (en)2006-07-052008-06-15F Star Biotech Forsch & Entw METHOD FOR MANIPULATING IMMUNE LOBULINS
AT503889B1 (en)2006-07-052011-12-15Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
AU2007303572A1 (en)2006-10-022008-04-10Sea Lane Biotechnologies, LlcDesign and construction of diverse synthetic peptide and polypeptide libraries
JP5779350B2 (en)2007-03-272015-09-16シー レーン バイオテクノロジーズ, エルエルシー Constructs and libraries containing antibody surrogate light chain sequences
EP1975178A1 (en)2007-03-302008-10-01f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H.Transcytotic modular antibody
KR101589759B1 (en)2007-04-032016-01-29암젠 리서치 (뮌헨) 게엠베하 Species specific CD3-epsilon binding domain
MX2009010611A (en)2007-04-032010-03-26Micromet AgCross-species-specific bispecific binders.
WO2008124858A2 (en)2007-04-112008-10-23F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H.Targeted receptor
WO2008137475A2 (en)2007-05-012008-11-13Research Development FoundationImmunoglobulin fc libraries
PT2769984T (en)2007-05-112017-10-05Altor Bioscience Corp MOLECULES OF FUSION AND VARIANTS OF IL-15
KR20100021601A (en)2007-05-142010-02-25바이오겐 아이덱 엠에이 인코포레이티드Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
EP3392273A1 (en)2007-05-302018-10-24Xencor, Inc.Methods and compositions for inhibiting cd32b expressing cells
EP4119579A1 (en)2007-05-312023-01-18Genmab A/SStable igg4 antibodies
JP2010531137A (en)2007-06-122010-09-24ワイス・エルエルシー Anti-CD20 therapeutic compositions and methods
CN101802006B (en)2007-06-262013-08-14F-星生物技术研究与开发有限公司 display binder
NZ582330A (en)2007-06-272012-05-25Marinepolymer Tech IncCOMPLEXES OF IL-15 AND IL-15Ra (RECEPTOR ALPHA) AND USES THEREOF
WO2009017823A2 (en)2007-08-012009-02-05The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of HealthA fold-back diabody diphtheria toxin immunotoxin and methods of use
EP2173739B1 (en)2007-08-012013-07-31Syntarga B.V.Substituted cc-1065 analogs and their conjugates
CN101842116A (en)2007-08-282010-09-22比奥根艾迪克Ma公司Compositions binding multiple epitopes of IGF-1R
EP2033657A1 (en)2007-09-042009-03-11Trion Pharma GmbhIntraoperative trifunctional antibody application for prophylatic intraperitonal tumour cell dissemination
MX2010002683A (en)2007-09-142010-03-26Amgen Inc POPULATIONS OF HOMOGENEO ANTIBODIES.
JP5334319B2 (en)2007-09-262013-11-06中外製薬株式会社 Method for modifying isoelectric point of antibody by amino acid substitution of CDR
EP2535349A1 (en)2007-09-262012-12-19UCB Pharma S.A.Dual specificity antibody fusions
ES2566957T3 (en)2007-09-262016-04-18Chugai Seiyaku Kabushiki Kaisha Constant region of modified antibody
AU2008345242B2 (en)2007-10-312014-02-27Xencor, Inc.Fc variants with altered binding to FcRn
PL2235064T3 (en)2008-01-072016-06-30Amgen IncMethod for making antibody fc-heterodimeric molecules using electrostatic steering effects
WO2009106096A1 (en)2008-02-272009-09-03Fresenius Biotech GmbhTreatment of resistant tumors with trifunctional antibodies
RU2531754C2 (en)2008-04-112014-10-27ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,USImmunotherapeutic agent combined with cd37, and its combination with bifunctional chemotherapeutic agent
EP2280997A2 (en)2008-04-182011-02-09Xencor, Inc.Human equivalent monoclonal antibodies engineered from nonhuman variable regions
JP5624535B2 (en)2008-05-022014-11-12シアトル ジェネティクス,インコーポレーテッド Methods and compositions for preparing antibodies and antibody derivatives having low core fucosylation
RU2010153580A (en)2008-06-032012-07-20Эбботт Лэборетриз (Us) IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION
WO2010017103A2 (en)2008-08-042010-02-11The United States Of America, As Represented By The Secretary, Department Of Health And Human ServicFully human anti-human nkg2d monoclonal antibodies
WO2010028796A1 (en)2008-09-102010-03-18F. Hoffmann-La Roche AgTrispecific hexavalent antibodies
PL2853545T3 (en)2008-09-172016-12-30Antibody specific for IgE
US20170247470A9 (en)2008-09-172017-08-31Xencor, Inc.Rapid clearance of antigen complexes using novel antibodies
EP2342231A1 (en)2008-09-262011-07-13Roche Glycart AGBispecific anti-egfr/anti-igf-1r antibodies
JP6126782B2 (en)2008-10-012017-05-10アムゲン リサーチ (ミュンヘン) ゲーエムベーハー Cross-species specific PSMA × CD3 bispecific single chain antibody
KR101942694B1 (en)2008-10-012019-01-25암젠 리서치 (뮌헨) 게엠베하Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxcd3, igf-1rxcd3 or fapalphaxcd3 bispecific single chain antibody
WO2010037838A2 (en)2008-10-012010-04-08Micromet AgCross-species-specific single domain bispecific single chain antibody
CA2738566C (en)2008-10-012024-04-30Micromet AgBispecific single chain antibodies with specificity for high molecular weight target antigens
KR101901458B1 (en)2008-10-102018-09-21압테보 리서치 앤드 디벨롭먼트 엘엘씨TCR Complex immunotherapeutics
HUE035798T2 (en)2008-11-032018-05-28Syntarga BvCc-1065 analogs and their conjugates
US8057507B2 (en)2009-01-162011-11-15Novate Medical LimitedVascular filter
MX2011007833A (en)2009-01-232011-10-06Biogen Idec IncStabilized fc polypeptides with reduced effector function and methods of use.
JP2012519706A (en)2009-03-062012-08-30ジェネンテック, インコーポレイテッド Antibody preparation
EP2233500A1 (en)2009-03-202010-09-29LFB BiotechnologiesOptimized Fc variants
EP2414391B1 (en)2009-04-022018-11-28Roche Glycart AGMultispecific antibodies comprising full length antibodies and single chain fab fragments
PT2417156E (en)2009-04-072015-04-29Roche Glycart AgTrivalent, bispecific antibodies
AU2010233993A1 (en)2009-04-072011-09-08Roche Glycart AgBispecific anti-ErbB-1/anti-c-Met antibodies
EP2417159A1 (en)2009-04-072012-02-15Roche Glycart AGBispecific anti-erbb-3/anti-c-met antibodies
EP2241576A1 (en)2009-04-172010-10-20Trion Pharma GmbhUse of trifunctional bispecific antibodies for the treatment of tumors associated with CD133+/EpCAM+ cancer stem cells
ES2439802T3 (en)2009-05-272014-01-24F. Hoffmann-La Roche Ag Tri- or tetra-specific antibodies
KR20180017231A (en)2009-06-262018-02-20아이2 파마슈티컬스, 인크.Expression of surrogate light chains
PL2975051T3 (en)2009-06-262021-09-20Regeneron Pharmaceuticals, Inc.Readily isolated bispecific antibodies with native immunoglobulin format
WO2011008517A2 (en)2009-06-302011-01-20Research Development FoundationImmunoglobulin fc polypeptides
AU2010270844A1 (en)2009-07-082011-12-22Amgen Inc.Design of stable and aggregation free antibody Fc molecules through CH3 domain interface engineering
WO2011020047A1 (en)2009-08-142011-02-17The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesUse of il-15 to increase thymic output and to treat lymphopenia
US9493578B2 (en)2009-09-022016-11-15Xencor, Inc.Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
DE102009045006A1 (en)2009-09-252011-04-14Technische Universität Dresden Anti-CD33 antibodies and their use for immuno-targeting in the treatment of CD33-associated diseases
AU2010321720B2 (en)2009-11-232017-03-02Amgen Inc.Monomeric antibody Fc
JP2013512251A (en)2009-11-242013-04-11アンプリミューン、インコーポレーテッド Simultaneous inhibition of PD-L1 / PD-L2
EP2506871B1 (en)2009-11-302016-10-19Janssen Biotech, Inc.ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
PL2522724T3 (en)2009-12-252020-07-13Chugai Seiyaku Kabushiki KaishaPolypeptide modification method for purifying polypeptide multimers
US20130129723A1 (en)2009-12-292013-05-23Emergent Product Development Seattle, LlcHeterodimer Binding Proteins and Uses Thereof
EA022984B1 (en)2009-12-292016-04-29Эмерджент Продакт Дивелопмент Сиэтл, ЛлсRon binding constructs and methods of use thereof
US20110189178A1 (en)2010-02-042011-08-04Xencor, Inc.Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
CA2794708C (en)2010-03-292021-11-16Zymeworks Inc.Antibodies with enhanced or suppressed effector function
TWI667257B (en)2010-03-302019-08-01中外製藥股份有限公司Antibodies with modified affinity to fcrn that promote antigen clearance
KR101930964B1 (en)2010-04-202018-12-19젠맵 에이/에스Heterodimeric antibody fc-containing proteins and methods for production thereof
MX346731B (en)2010-04-232017-03-30Genentech Inc *Production of heteromultimeric proteins.
CA2797981C (en)2010-05-142019-04-23Rinat Neuroscience CorporationHeterodimeric proteins and methods for producing and purifying them
DK2580243T3 (en)2010-06-092020-01-13Genmab As ANTIBODIES AGAINST HUMAN CD38
JP2013532153A (en)2010-06-182013-08-15ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease
DK3029066T3 (en)2010-07-292019-05-20Xencor Inc ANTIBODIES WITH MODIFIED ISOELECTRIC ITEMS
ES2667100T3 (en)2010-08-022018-05-09Macrogenics, Inc. Covalent Diabodies and Their Uses
CA2807278A1 (en)2010-08-242012-03-01F. Hoffmann - La Roche AgBispecific antibodies comprising a disulfide stabilized - fv fragment
WO2012032080A1 (en)2010-09-072012-03-15F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.HStabilised human fc
CN107880136B (en)*2010-09-212021-11-12阿尔托生物科学有限公司Multimeric IL-15 soluble fusion molecules and methods of making and using the same
KR101973930B1 (en)2010-11-052019-04-29자임워크스 인코포레이티드Stable heterodimeric antibody design with mutations in the fc domain
DK2637670T4 (en)2010-11-102024-03-25Amgen Res Munich Gmbh PREVENTION OF ADVERSE EVENTS CAUSED BY SPECIFIC CD3 BINDING DOMAINS
JP5878182B2 (en)2011-02-102016-03-08ロシュ グリクアート アーゲー Mutant interleukin-2 polypeptide
US9499605B2 (en)2011-03-032016-11-22Zymeworks Inc.Multivalent heteromultimer scaffold design and constructs
EP2686682A4 (en)2011-03-112015-03-11Amgen IncMethod of correlated mutational analysis to improve therapeutic antibodies
EP2686345B1 (en)2011-03-162018-04-25Amgen Inc.Fc variants
EA201791693A1 (en)2011-03-252018-05-31Гленмарк Фармасьютикалс С.А. HETERODIMERNY IMMUNOHLOBULINS
TWI803876B (en)2011-03-282023-06-01法商賽諾菲公司Dual variable region antibody-like binding proteins having cross-over binding region orientation
SG193554A1 (en)2011-03-292013-11-29Roche Glycart AgAntibody fc variants
KR102345943B1 (en)2011-04-282021-12-31암젠 리서치 (뮌헨) 게엠베하Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects
EA201892619A1 (en)2011-04-292019-04-30Роше Гликарт Аг IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS
NZ703939A (en)2011-05-212016-01-29Macrogenics IncCd3-binding molecules capable of binding to human and non-human cd3
US9328170B2 (en)2011-05-252016-05-03Merck Sharp & Dohme Corp.Method for preparing Fc containing polypeptides having improved properties
EP2537933A1 (en)2011-06-242012-12-26Institut National de la Santé et de la Recherche Médicale (INSERM)An IL-15 and IL-15Ralpha sushi domain based immunocytokines
US9890218B2 (en)2011-06-302018-02-13Chugai Seiyaku Kabushiki KaishaHeterodimerized polypeptide
WO2013006544A1 (en)2011-07-062013-01-10Medimmune, LlcMethods for making multimeric polypeptides
CA2842860A1 (en)2011-07-282013-01-31Sea Lane Biotechnologies, LlcSur-binding proteins
WO2013022855A1 (en)2011-08-052013-02-14Xencor, Inc.Antibodies with modified isoelectric points and immunofiltering
SI2748201T1 (en)2011-08-232018-03-30Roche Glycart AgBispecific t cell activating antigen binding molecules
KR20140054268A (en)2011-08-262014-05-08메리맥 파마슈티컬즈, 인크.Tandem fc bispecific antibodies
TWI827333B (en)2011-09-302023-12-21日商中外製藥股份有限公司 Antigen-binding molecules that promote antigen disappearance
WO2013047748A1 (en)2011-09-302013-04-04中外製薬株式会社Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
JP6310394B2 (en)2011-10-102018-04-11ゼンコア インコーポレイテッド Methods for purifying antibodies
US10851178B2 (en)2011-10-102020-12-01Xencor, Inc.Heterodimeric human IgG1 polypeptides with isoelectric point modifications
AU2012325232B2 (en)2011-10-202017-08-31Esbatech - A Novartis Company LlcStable multiple antigen-binding antibody
RU2681885C2 (en)2011-10-312019-03-13Чугаи Сейяку Кабусики КайсяAntigen-binding molecule having regulated conjugation between heavy-chain and light-chain
KR102052774B1 (en)2011-11-042019-12-04자임워크스 인코포레이티드Stable heterodimeric antibody design with mutations in the fc domain
WO2013096828A1 (en)2011-12-222013-06-27Sea Lane Biotechnologies, LlcSurrogate binding proteins
AU2013211059B8 (en)2012-01-202017-12-21Centre Hospitalier Regional Universitaire De MontpellierTargeted mutant alpha-helical bundle cytokines
CN104244980B (en)2012-02-242017-11-10中外制药株式会社Antigen binding molecules that promote antigen elimination via Fc γ IIB
CN114163530B (en)2012-04-202025-04-29美勒斯公司 Methods and means for producing immunoglobulin-like molecules
JPWO2013180201A1 (en)2012-05-302016-01-21中外製薬株式会社 Antigen-binding molecules that eliminate associated antigens
WO2014004586A1 (en)2012-06-252014-01-03Zymeworks Inc.Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
AU2013289883B2 (en)2012-07-132018-11-01Zymeworks Bc Inc.Bispecific asymmetric heterodimers comprising anti-CD3 constructs
CN104640561A (en)2012-07-232015-05-20酵活有限公司 Immunoglobulin constructs comprising selective pairing of light and heavy chains
JOP20200236A1 (en)2012-09-212017-06-16Regeneron PharmaAnti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
US10087250B2 (en)2012-10-082018-10-02Roche Glycart AgFc-free antibodies comprising two fab-fragments and methods of use
CN104271602B (en)2012-11-212020-08-21武汉友芝友生物制药有限公司Bispecific antibodies
EP2934577A1 (en)2012-12-192015-10-28Adimab, LLCMultivalent antibody analogs, and methods of their preparation and use
DK2943511T3 (en)*2013-01-142019-10-21Xencor Inc NEW HETERODIMERIC PROTEINS
US10968276B2 (en)2013-03-122021-04-06Xencor, Inc.Optimized anti-CD3 variable regions
US10487155B2 (en)2013-01-142019-11-26Xencor, Inc.Heterodimeric proteins
US10131710B2 (en)2013-01-142018-11-20Xencor, Inc.Optimized antibody variable regions
US9605084B2 (en)2013-03-152017-03-28Xencor, Inc.Heterodimeric proteins
US9701759B2 (en)2013-01-142017-07-11Xencor, Inc.Heterodimeric proteins
WO2014113510A1 (en)2013-01-152014-07-24Xencor, Inc.Rapid clearance of antigen complexes using novel antibodies
AU2014249243C1 (en)2013-03-132019-08-08Imaginab, Inc.Antigen binding constructs to CD8
US10858417B2 (en)2013-03-152020-12-08Xencor, Inc.Heterodimeric proteins
US10519242B2 (en)2013-03-152019-12-31Xencor, Inc.Targeting regulatory T cells with heterodimeric proteins
US10106624B2 (en)2013-03-152018-10-23Xencor, Inc.Heterodimeric proteins
KR102211176B1 (en)*2013-03-152021-02-01젠코어 인코포레이티드Heterodimeric proteins
US10544187B2 (en)2013-03-152020-01-28Xencor, Inc.Targeting regulatory T cells with heterodimeric proteins
KR102539359B1 (en)2013-04-192023-06-02싸이튠 파마Cytokine derived treatment with reduced vascular leak syndrome
WO2014209804A1 (en)2013-06-242014-12-31Biomed Valley Discoveries, Inc.Bispecific antibodies
JP6474797B2 (en)2013-06-272019-02-27アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Interleukin 15 (IL-15) antagonists and their use for the treatment of autoimmune and inflammatory diseases
CN105593059B (en)2013-07-192018-07-31萤火虫医疗公司 Devices for mobility aids and infusion management
SI3030262T1 (en)2013-08-082020-03-31Cytune Pharma Combined pharmaceutical composition
BR112016002614B8 (en)2013-08-082023-11-07Hopitaux Paris Assist Publique Immunocytokine and pharmaceutical composition
EP2839842A1 (en)2013-08-232015-02-25MacroGenics, Inc.Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
EA036577B1 (en)2013-11-042020-11-25Икнос Сайенсиз СаProduction of t cell retargeting hetero-dimeric immunoglobulins
RS60443B1 (en)2013-12-172020-07-31Genentech IncAnti-cd3 antibodies and methods of use
RU2016128726A (en)2013-12-172018-01-23Дженентек, Инк. METHODS FOR TREATING MALIGNANT TUMORS USING PD-1 BINDING ANTAGONISTS AND ANTIBODIES AGAINST CD20
JP6706578B2 (en)2013-12-302020-06-10エピムアブ バイオセラピューティクス インコーポレイテッド Tandem Fab immunoglobulins and uses thereof
EP3093295B1 (en)2014-01-082020-05-27Shanghai Hengrui Pharmaceutical Co., Ltd.Il-15 heterogeneous dimer protein and uses thereof
EP2915569A1 (en)2014-03-032015-09-09Cytune PharmaIL-15/IL-15Ralpha based conjugates purification method
TWI754319B (en)2014-03-192022-02-01美商再生元醫藥公司Methods and antibody compositions for tumor treatment
BR112016022385A2 (en)2014-03-282018-06-19Xencor, Inc specific antibodies that bind to cd38 and cd3
WO2015168379A2 (en)2014-04-302015-11-05President And Fellows Of Harvard CollegeCombination vaccine devices and methods of killing cancer cells
ES2890079T3 (en)2014-05-292022-01-17Macrogenics Inc Trispecific binding molecules and methods of using same
US20150351275A1 (en)2014-05-302015-12-03Johanson Manufacturing CorporationThin-Film Radio Frequency Power Terminator
WO2015195163A1 (en)*2014-06-202015-12-23R-Pharm Overseas, Inc.Pd-l1 antagonist fully human antibody
US9925247B2 (en)2014-06-302018-03-27Altor Bioscience CorporationIL-15-based molecules and methods of use thereof
WO2016014984A1 (en)2014-07-242016-01-28Xencor, Inc.Rapid clearance of antigen complexes using novel antibodies
RU2020117196A (en)2014-08-192020-10-15Новартис Аг CHIMERIC ANTIGENIC RECEPTOR (CAR) AGAINST CD123 FOR USE IN THE TREATMENT OF MALIGNANT TUMORS
JO3663B1 (en)2014-08-192020-08-27Merck Sharp & DohmeAnti-lag3 antibodies and antigen-binding fragments
US9763705B2 (en)2014-10-032017-09-19Globus Medical, Inc.Orthopedic stabilization devices and methods for installation thereof
JP2017536098A (en)2014-10-142017-12-07アルモ・バイオサイエンシーズ・インコーポレイテッド Interleukin-15 composition and use thereof
RU2017119185A (en)2014-11-052018-12-05Дженентек, Инк. ANTIBODIES AGAINST FGFR2 / 3 AND WAYS OF THEIR APPLICATION
MY192999A (en)2014-11-202022-09-20Hoffmann La RocheCombination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists
US20160176969A1 (en)2014-11-262016-06-23Xencor, Inc.Heterodimeric antibodies including binding to cd8
US10259887B2 (en)2014-11-262019-04-16Xencor, Inc.Heterodimeric antibodies that bind CD3 and tumor antigens
ES2886523T3 (en)*2014-11-262021-12-20Xencor Inc Heterodimeric antibodies that bind to CD3 and CD20
EA037065B1 (en)2014-11-262021-02-01Ксенкор, Инк.Heterodimeric antibodies that bind cd3 and cd38
AU2015366795B2 (en)2014-12-192020-12-17Jiangsu Hengrui Medicine Co., Ltd.Interleukin 15 protein complex and use thereof
EP3237446B1 (en)2014-12-222021-05-05PD-1 Acquisition Group, LLCAnti-pd-1 antibodies
WO2016105450A2 (en)2014-12-222016-06-30Xencor, Inc.Trispecific antibodies
WO2016141387A1 (en)*2015-03-052016-09-09Xencor, Inc.Modulation of t cells with bispecific antibodies and fc fusions
EP3064507A1 (en)2015-03-062016-09-07Deutsches Krebsforschungszentrum Stiftung des öffentlichen RechtsFusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof
MX390190B (en)2015-05-082025-03-20Xencor Inc HETERODIMERIC ANTIBODIES THAT BIND TO CD3 AND TUMOR ANTIGENS.
TWI762879B (en)2015-07-302022-05-01美商宏觀基因股份有限公司Pd-1-binding molecules and methods of use thereof
KR20180125435A (en)2015-09-252018-11-23알토 바이오사이언스 코포레이션 Interleukin-15 superagens that significantly improve graft-versus-tumor activity
SMT202300304T1 (en)2015-12-222023-11-13Regeneron PharmaCombination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer
EP3464370A1 (en)2016-06-012019-04-10Xencor, Inc.Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma
US20170349660A1 (en)2016-06-012017-12-07Xencor. Inc.Bispecific antibodies that bind cd123 and cd3
EP3252078A1 (en)2016-06-022017-12-06F. Hoffmann-La Roche AGType ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
RU2018145961A (en)2016-06-072020-07-14Макродженикс, Инк. COMBINATION THERAPY
HUE068801T2 (en)2016-06-142025-01-28Xencor IncBispecific checkpoint inhibitor antibodies
US20190256454A1 (en)2016-07-052019-08-22Novartis AgNew process for early sacubitril intermediates
US10793632B2 (en)2016-08-302020-10-06Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
MY203000A (en)2016-10-142024-06-01Xencor IncIl15/il15r� heterodimeric fc-fusion proteins
EP4613776A2 (en)2016-10-212025-09-10Altor BioScience CorporationMultimeric il-15-based molecules
CN110214153B (en)2016-11-182024-03-29法国施维雅药厂anti-PD-1 antibodies and compositions
WO2019006472A1 (en)2017-06-302019-01-03Xencor, Inc.Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains
US10981992B2 (en)2017-11-082021-04-20Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
EP3749363A1 (en)2018-02-082020-12-16Amgen Inc.Low ph pharmaceutical antibody formulation
JP2021516045A (en)2018-02-282021-07-01ファイザー・インク IL-15 variant and its use
JP2021521784A (en)*2018-04-182021-08-30ゼンコア インコーポレイテッド PD-1 targeted heterodimer fusion proteins containing IL-15 / IL-15RaFc fusion proteins and PD-1 antigen binding domains and their use
IL310398A (en)*2018-04-182024-03-01Xencor IncIl-15/il-15rα heterodimeric fc fusion proteins and uses thereof
EP3864047A2 (en)2018-10-122021-08-18Xencor, Inc.Pd-1 targeted il-15/il-15ralpha fc fusion proteins and uses in combination therapies thereof
WO2020132646A1 (en)2018-12-202020-06-25Xencor, Inc.Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
US20220135682A1 (en)2019-03-112022-05-05Jounce Therapeutics, Inc.Anti-ICOS Antibodies for the Treatment of Cancer
TW202128757A (en)*2019-10-112021-08-01美商建南德克公司Pd-1 targeted il-15/il-15ralpha fc fusion proteins with improved properties

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