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MY105097A - Nanbv diagnostics and vaccines - Google Patents

Nanbv diagnostics and vaccines

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Publication number
MY105097A
MY105097AMYPI88001618AMYPI19881618AMY105097AMY 105097 AMY105097 AMY 105097AMY PI88001618 AMYPI88001618 AMY PI88001618AMY PI19881618 AMYPI19881618 AMY PI19881618AMY 105097 AMY105097 AMY 105097A
Authority
MY
Malaysia
Prior art keywords
sequences
hcv
virus
hepatitis
individuals
Prior art date
Application number
MYPI88001618A
Inventor
Kuo George
Houghton Micheal
Choo-Qui-Lim
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron CorpfiledCriticalChiron Corp
Publication of MY105097ApublicationCriticalpatent/MY105097A/en

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Abstract

A FAMILY OF CDNA SEQUENCES DERIVED FROM HEPATITIS C VIRUS (HCV) ARE PROVIDED. THESE SEQUENCES ENCODE ANTIGENS WHICH REACT IMMUNOLOGICALLY WITH ANTIBODIES PRESENT IN INDIVIDUALS WITH NON-A NON-B HEPATITIS (NANBH), BUT WHICH ARE ABSENT FROM INDIVIDUALS INFECTED WITH HEPATITIS A VIRUS, OR HEPATITIS B VIRUS, AND ALSO ARE ABSENT IN CONTROL INDIVIDUALS. THE HCV CDNA SEQUENCES LACK SUBSTANTIAL HOMOLOGY TO THE SEQUENCES OF HEPATITIS DELTA VIRUS (HDV) AND HBV. A COMPARISON OF THE SEQUENCES OF AMINO ACIDS ENCODED IN THE HCV CDNA WITH THE SEQUENCES OF FLAVIRUSES INDICATES THAT HVC IS A FLAVIVIRUS OR FLAVILIKE VIRUS. THE HCV CDNA SEQUENCES AND THE POLYPEPTIDES ENCODED THEREIN ARE USEFUL AS REAGENTS FOR THE DETECTION AND THERAPY OF HCV. THE REAGENTS PROVIDED IN THE INVENTION ARE ALSO USEFUL FOR THE ISOLATION OF NANBH AGENT (S), FOR THE PROPAGATION OF THESE AGENTS IN TISSUE CULTURE, AND FOR THE SCREENING OF ANTIVIRAL AGENTS FOR HCV.
MYPI88001618A1987-11-181988-12-31Nanbv diagnostics and vaccinesMY105097A (en)

Applications Claiming Priority (4)

Application NumberPriority DateFiling DateTitle
US12271487A1987-11-181987-11-18
US13988687A1987-12-301987-12-30
US16107288A1988-02-261988-02-26
US19126388A1988-05-061988-05-06

Publications (1)

Publication NumberPublication Date
MY105097Atrue MY105097A (en)1994-08-30

Family

ID=79604018

Family Applications (1)

Application NumberTitlePriority DateFiling Date
MYPI88001618AMY105097A (en)1987-11-181988-12-31Nanbv diagnostics and vaccines

Country Status (1)

CountryLink
MY (1)MY105097A (en)

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