| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| KR890002631B1 (en) | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | Composition of prolonged release of biologically active somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (en) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS. |
| PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| KR0166088B1 (en) | 1990-01-23 | 1999-01-15 | . | Cyclodextrin derivatives with increased water solubility and uses thereof |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| IT1270594B (en) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN |
| DE69632684T2 (en) | 1995-06-27 | 2005-06-09 | Takeda Pharmaceutical Co. Ltd. | PROCESS FOR PREPARING PREPARED DELETION PREPARATIONS |
| TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
| JP2909418B2 (en) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | Delayed release microsphere of drug |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6419961B1 (en) | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
| CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| DE69730093T2 (en) | 1996-10-31 | 2006-07-20 | Takeda Pharmaceutical Co. Ltd. | Preparation with delayed release |
| US6197350B1 (en) | 1996-12-20 | 2001-03-06 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
| US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| KR20070040423A (en) | 1998-03-16 | 2007-04-16 | 셀진 코포레이션 | 2- (2,6-dioxopiperidin-3-yl) isoindolin derivatives for inflammatory cytokine inhibitors, preparations thereof and uses thereof |
| US6613358B2 (en) | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
| KR19990085365A (en) | 1998-05-16 | 1999-12-06 | 허영섭 | Biodegradable polymer microspheres capable of continuously controlled controlled release and preparation method thereof |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6984522B2 (en)* | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| EP1356075A4 (en) | 2000-10-16 | 2005-04-13 | Compound Therapeutics Inc | Protein scaffolds for antibody mimics and other binding proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| JP4369662B2 (en) | 2001-04-26 | 2009-11-25 | アビディア インコーポレイテッド | Combinatorial library of monomer domains |
| GB0120441D0 (en) | 2001-08-22 | 2001-10-17 | Novartis Forschungsstiftung | Model of autoimmune disease and methods for identifying anti autoimmune disease disorders |
| US7173032B2 (en)* | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| AU2005307789A1 (en) | 2004-11-16 | 2006-05-26 | Avidia Research Institute | Protein scaffolds and uses thereof |
| AU2007249805B2 (en) | 2006-05-12 | 2013-01-10 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| US20080045485A1 (en) | 2006-08-17 | 2008-02-21 | Peter Muir | Methods of diagnosing synovial disease in a mammal by detecting bacterial DNA in synovial tissues from dogs with inflammatory knee arthritis and degenerative anterior cruciate ligament rupture |
| NZ577111A (en) | 2006-12-15 | 2012-05-25 | Abbott Lab | Novel oxadiazole compounds |
| EP3101017B1 (en) | 2007-03-20 | 2019-06-12 | Celgene Corporation | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same |
| US20100075333A1 (en)* | 2007-03-30 | 2010-03-25 | Alain Moreau | Method of determining the risk of scoliosis |
| JP5442185B2 (en)* | 2007-04-24 | 2014-03-12 | 日本メナード化粧品株式会社 | Sensitizing substance evaluation method |
| EP2269072B1 (en)* | 2008-03-31 | 2017-08-23 | Boston Medical Center Corporation | Predictive marker for topoisomerase i inhibitors |
| US20110191868A1 (en)* | 2008-04-10 | 2011-08-04 | Massachusetts Institute Of Technology | Methods for identification and use of agents targeting cancer stem cells |
| KR101692705B1 (en)* | 2008-12-05 | 2017-01-04 | 애브비 인코포레이티드 | Sulfonamide derivatives as Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| WO2010121231A1 (en) | 2009-04-18 | 2010-10-21 | Genentech, Inc. | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
| UA114856C2 (en)* | 2010-02-11 | 2017-08-10 | Селджин Корпорейшн | METHODS OF TREATMENT WITH THE APPLICATION OF ARYLMETOXISOINDOLINE DERIVATIVES |
| US9128101B2 (en)* | 2010-03-01 | 2015-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| CA2808417A1 (en) | 2010-08-18 | 2012-02-23 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| CN103492590A (en) | 2011-02-22 | 2014-01-01 | 卡里斯生命科学卢森堡控股有限责任公司 | Circulating biomarkers |
| CA2839530A1 (en)* | 2011-06-16 | 2012-12-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarker compositions and methods |
| EP3904875B1 (en) | 2012-06-29 | 2024-11-20 | Celgene Corporation | Methods for determining drug efficacy using ikzf3 (aiolos) |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| US20140343058A1 (en) | 2012-08-09 | 2014-11-20 | Celgene Corporation | Treatment of systemic lupus erythematosus |
| UA117141C2 (en) | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | COMPOSITIONS (S) -3- (4 - ((4- (MORPHOLINOMETHYL) BENZYL) OXY) -1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONE |
| JP2017522270A (en) | 2014-05-19 | 2017-08-10 | セルジーン コーポレイション | 3- (4-((4- (morpholinomethyl-benzyl) oxy) -1-oxoisoindoline-2-yl) piperidine-2,6-dione for the treatment of systemic lupus erythematosus |