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MX365954B - Inhibidor de quinasas reguladora de señal de apoptosis. - Google Patents

Inhibidor de quinasas reguladora de señal de apoptosis.

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Publication number
MX365954B
MX365954BMX2015009422AMX2015009422AMX365954BMX 365954 BMX365954 BMX 365954BMX 2015009422 AMX2015009422 AMX 2015009422AMX 2015009422 AMX2015009422 AMX 2015009422AMX 365954 BMX365954 BMX 365954B
Authority
MX
Mexico
Prior art keywords
apoptosis signal
kinase inhibitor
regulating kinase
compound
regulating
Prior art date
Application number
MX2015009422A
Other languages
English (en)
Inventor
Notte Gregory
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences IncfiledCriticalGilead Sciences Inc
Publication of MX365954BpublicationCriticalpatent/MX365954B/es

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Abstract

La presente invención se relaciona con un compuesto de fórmula (I): El compuesto tiene actividad inhibidora sobre la quinasa reguladora de la señal de apoptosis ("ASK 1"), y es por lo tanto útil en el tratamiento de enfermedades tales como enfermedad renal, nefropatía diabética y fibrosis renal.
MX2015009422A2012-01-272013-01-24Inhibidor de quinasas reguladora de señal de apoptosis.MX365954B (es)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US201261591710P2012-01-272012-01-27
PCT/US2013/022997WO2013112741A1 (en)2012-01-272013-01-24Apoptosis signal-regulating kinase inhibitor

Publications (1)

Publication NumberPublication Date
MX365954Btrue MX365954B (es)2019-06-20

Family

ID=47684038

Family Applications (3)

Application NumberTitlePriority DateFiling Date
MX2015009422AMX365954B (es)2012-01-272013-01-24Inhibidor de quinasas reguladora de señal de apoptosis.
MX2014009075AMX2014009075A (es)2012-01-272013-01-24Inhibidor de quinasa reguladora de señal de apoptosis.
MX2019007348AMX2019007348A (es)2012-01-272014-07-25Inhibidor de quinasa reguladora de señal de apoptosis.

Family Applications After (2)

Application NumberTitlePriority DateFiling Date
MX2014009075AMX2014009075A (es)2012-01-272013-01-24Inhibidor de quinasa reguladora de señal de apoptosis.
MX2019007348AMX2019007348A (es)2012-01-272014-07-25Inhibidor de quinasa reguladora de señal de apoptosis.

Country Status (39)

CountryLink
US (7)US8742126B2 (es)
EP (1)EP2807151B1 (es)
JP (1)JP5770950B2 (es)
KR (5)KR101582065B1 (es)
CN (2)CN109438418B (es)
AP (1)AP2014007836A0 (es)
AR (2)AR089818A1 (es)
AU (1)AU2013201586C1 (es)
BR (1)BR112014018355B1 (es)
CA (3)CA3026700C (es)
CL (1)CL2014001988A1 (es)
CO (1)CO7061073A2 (es)
CR (1)CR20140405A (es)
CY (1)CY1117201T1 (es)
DK (1)DK2807151T3 (es)
EA (1)EA024746B1 (es)
ES (1)ES2558203T3 (es)
HR (1)HRP20151399T1 (es)
HU (1)HUE028641T2 (es)
IL (3)IL233598A (es)
IN (1)IN2014DN06174A (es)
MA (1)MA35861B1 (es)
MD (1)MD4601B1 (es)
ME (1)ME02322B (es)
MX (3)MX365954B (es)
NZ (1)NZ739339A (es)
PE (1)PE20141822A1 (es)
PH (1)PH12014501697A1 (es)
PL (1)PL2807151T3 (es)
PT (1)PT2807151E (es)
RS (1)RS54492B1 (es)
SG (1)SG11201404348UA (es)
SI (1)SI2807151T1 (es)
SM (1)SMT201600047B (es)
TW (4)TWI487523B (es)
UA (1)UA112098C2 (es)
UY (1)UY34573A (es)
WO (1)WO2013112741A1 (es)
ZA (1)ZA201405260B (es)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
TWI625121B (zh)2009-07-132018-06-01基利科學股份有限公司調節細胞凋亡信號之激酶的抑制劑
PL2651417T3 (pl)2010-12-162017-08-31Calchan LimitedPochodne pirolopirymidyny hamujące ASK1
UY34573A (es)2012-01-272013-06-28Gilead Sciences IncInhibidor de la quinasa que regula la señal de la apoptosis
CA2931615A1 (en)2013-11-262015-06-04Gilead Sciences, Inc.Therapies for treating myeloproliferative disorders
AU2015206194A1 (en)2014-01-202016-07-28Gilead Sciences, Inc.Therapies for treating cancers
WO2015187499A1 (en)2014-06-032015-12-10Gilead Sciences, Inc.Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
TW201618781A (zh)2014-08-132016-06-01吉李德科學股份有限公司治療肺高血壓之方法
EP3197448B1 (en)2014-09-242019-04-24Gilead Sciences, Inc.Methods of treating liver disease
MA41252A (fr)*2014-12-232017-10-31Gilead Sciences IncFormes solides d'un inhibiteur d'ask 1
CN112225699B (zh)2014-12-232023-11-14吉利德科学公司制备ask1抑制剂的方法
TW201639573A (zh)2015-02-032016-11-16吉李德科學股份有限公司有關治療癌症之合併治療
MD3097102T2 (ro)2015-03-042018-02-28Gilead Sciences IncCompuşi de 4,6-diamino-pirido[3,2-D]pirimidină modulatori ai receptorilor de tip Toll
EP3456717B1 (en)2015-07-062021-03-17Gilead Sciences, Inc.4,6-diamino-quinoline-3-carbonitrile derivative as cancer osaka thyroid (cot) modulator for treating inflammatory disease
WO2017059224A2 (en)2015-10-012017-04-06Gilead Sciences, Inc.Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
JP2018534263A (ja)*2015-10-022018-11-22ギリアード サイエンシーズ, インコーポレイテッド癌、アレルギー性障害、自己免疫性疾患または炎症性疾患を治療するための、jak阻害物質、ask1阻害物質、brd阻害物質及び/またはmmp9阻害物質から選択される阻害物質とbtk阻害物質gs−4059の組み合わせ
AU2016370916A1 (en)2015-12-172018-06-07Gilead Sciences, Inc.Tank-binding kinase inhibitor compounds
EP3423057A1 (en)2016-03-042019-01-09Gilead Sciences, Inc.Compositions and combinations of autotaxin inhibitors
WO2017177179A1 (en)2016-04-082017-10-12Gilead Sciences, Inc.Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases
JP6730466B2 (ja)2016-06-132020-07-29アイ−エムエービー バイオファーマ ユーエス リミテッド抗pd−l1抗体およびその使用
AU2017305303B2 (en)2016-08-042020-05-28Gilead Sciences, Inc.Cobicistat for use in cancer treatments
CA3035346A1 (en)2016-09-022018-03-08Gilead Sciences, Inc.Toll like receptor modulator compounds
WO2018045150A1 (en)2016-09-022018-03-08Gilead Sciences, Inc.4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
US20180133212A1 (en)2016-11-032018-05-17Gilead Sciences, Inc.Combination of a bcl-2 inhibitor and a bromodomain inhibitor for treating cancer
US20180133203A1 (en)2016-11-112018-05-17Gilead Sciences, Inc.Methods of treating liver disease
US20180141939A1 (en)2016-11-222018-05-24Gilead Sciences, Inc.Solid forms of a bet inhibitor
AR110252A1 (es)2016-11-302019-03-13Gilead Sciences IncCompuestos heterocíclicos fusionados como inhibidores de la quinasa cam
CN109071448B (zh)*2017-01-222020-03-17福建广生堂药业股份有限公司Ask1抑制剂及其制备方法和应用
PL3572412T3 (pl)*2017-01-222021-09-27Fujian Cosunter Pharmaceutical Co., Ltd.Pochodna pirydyny jako inhibitor ask1 oraz sposób jej wytwarzania oraz zastosowanie
PL3383916T3 (pl)2017-01-242023-06-12I-Mab Biopharma Us LimitedPrzeciwciała anty-cd73 i ich zastosowania
JP2020508326A (ja)2017-02-242020-03-19ギリアド サイエンシズ, インコーポレイテッドブルトン型チロシンキナーゼの阻害剤
TWI754011B (zh)2017-02-242022-02-01美商基利科學股份有限公司布魯頓氏酪胺酸激酶之抑制劑
WO2018157277A1 (en)*2017-02-282018-09-07Eli Lilly And CompanyIsoquinolin and naphthydrin compounds
CN111094250B (zh)*2017-03-032022-11-04江苏豪森药业集团有限公司凋亡信号调节激酶抑制剂及其制备方法和应用
JOP20180017A1 (ar)2017-03-142019-01-30Gilead Sciences Incمثبط كيناز منظم لإشارة تلاشي خلايا
WO2018183342A1 (en)2017-03-282018-10-04Gilead Sciences, Inc.Methods of treating liver disease
CN110520125A (zh)2017-04-122019-11-29吉利德科学公司治疗肝病的方法
JOP20180040A1 (ar)2017-04-202019-01-30Gilead Sciences Incمثبطات pd-1/pd-l1
AU2018266911C1 (en)2017-05-122022-10-20Enanta Pharmaceuticals, Inc.Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10450301B2 (en)2017-05-252019-10-22Enanta Pharmaceuticals, Inc.Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218044A2 (en)*2017-05-252018-11-29Enanta Pharmaceuticals IncApoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218042A1 (en)*2017-05-252018-11-29Enanta Pharmaceuticals, Inc.Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10495648B2 (en)2017-06-132019-12-03Gilead Sciences, Inc.Methods of treating liver fibrosis
TW201908306A (zh)*2017-07-182019-03-01大陸商南京聖和藥業股份有限公司作為ask抑制劑的雜環化合物及其應用
US10597382B2 (en)2017-08-282020-03-24Enanta Pharmaceuticals, Inc.Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN109456308B (zh)*2017-09-062022-11-29南京圣和药业股份有限公司作为ask抑制剂的杂环化合物及其应用
US10370352B2 (en)2017-09-072019-08-06Eli Lilly And CompanyCyclobutyl-imidazolidinone compounds
WO2019047094A1 (en)*2017-09-072019-03-14Eli Lilly And Company CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS
WO2019047161A1 (en)2017-09-082019-03-14Eli Lilly And Company IMIDAZOLIDINE COMPOUNDS
EP3678662A4 (en)2017-09-082021-09-01Fronthera U.S. Pharmaceuticals LLC APOPTOSIS SIGNAL REGULATION KINASE INHIBITORS AND THEIR USES
WO2019072130A1 (zh)*2017-10-122019-04-18深圳市塔吉瑞生物医药有限公司一种1,2,4-三氮唑类化合物
CN107793400B (zh)*2017-10-312020-01-31武汉九州钰民医药科技有限公司吡啶类化合物及其在制备治疗肝脏疾病的药物中的应用
US20200340060A1 (en)2017-11-132020-10-29Gilead Sciences, Inc.Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes
KR102492187B1 (ko)2017-12-202023-01-27인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이.Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드
US11203610B2 (en)2017-12-202021-12-21Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I.2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
CN111801314B (zh)2018-01-022023-10-31西尔洛克治疗公司Ask1抑制剂化合物及其用途
EP4227302A1 (en)2018-02-132023-08-16Gilead Sciences, Inc.Pd-1/pd-l1 inhibitors
CN110294742B (zh)*2018-03-212023-01-31山东轩竹医药科技有限公司并环类ask1抑制剂及其应用
TWI833744B (zh)2018-04-062024-03-01捷克科學院有機化學與生物化學研究所3'3'-環二核苷酸
TW202005654A (zh)2018-04-062020-02-01捷克科學院有機化學與生物化學研究所2,2,─環二核苷酸
TWI818007B (zh)2018-04-062023-10-11捷克科學院有機化學與生物化學研究所2'3'-環二核苷酸
EP4537902A3 (en)*2018-04-122025-06-11Terns, Inc.Tricyclic ask1 inhibitors
CN112041311B (zh)2018-04-192023-10-03吉利德科学公司Pd-1/pd-l1抑制剂
CN110407806B (zh)*2018-04-282021-08-17深圳微芯生物科技股份有限公司甲酰胺类化合物、其制备方法及其应用
US10683289B2 (en)2018-05-022020-06-16Enanta Pharmaceuticals, Inc.Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
JP7328254B2 (ja)2018-05-022023-08-16エナンタ ファーマシューティカルズ インコーポレイテッドアポトーシスシグナル調節キナーゼ1阻害剤を含むテトラゾール及びその使用方法
TW202014193A (zh)2018-05-032020-04-16捷克科學院有機化學與生物化學研究所包含碳環核苷酸之2’3’-環二核苷酸
WO2019217780A1 (en)2018-05-112019-11-14Phosphorex, Inc.Microparticles and nanoparticles having negative surface charges
KR102551319B1 (ko)2018-05-142023-07-05길리애드 사이언시즈, 인코포레이티드Mcl-1 억제제
WO2020006429A1 (en)*2018-06-282020-01-02Hepatikos Therapeutics, LlcAsk1 isoindolin-1-one inhibitors and methods of use thereof
CA3103286C (en)2018-07-132023-05-09Gilead Sciences, Inc.Pd-1/pd-l1 inhibitors
EP3825315B1 (en)*2018-07-202022-08-31Fujian Akeylink Biotechnology Co., Ltd.Crystal form as ask1 inhibitor, preparation method therefor, and application thereof
WO2020041417A1 (en)2018-08-222020-02-27Enanta Pharmaceuticals, Inc.Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020072656A1 (en)2018-10-032020-04-09Gilead Sciences, Inc.Imidozopyrimidine derivatives
KR102298546B1 (ko)2018-10-182021-09-08에이치케이이노엔 주식회사신규한 n-(이소프로필-트리아졸릴)피리디닐)-헤테로아릴-카르복사미드 유도체 및 이의 용도
CN112955435B (zh)2018-10-242024-09-06吉利德科学公司Pd-1/pd-l1抑制剂
JP7273172B2 (ja)2018-10-312023-05-12ギリアード サイエンシーズ, インコーポレイテッドHpk1阻害活性を有する置換6-アザベンゾイミダゾール化合物
DK3873903T3 (da)2018-10-312024-04-02Gilead Sciences IncSubstituerede 6-azabenzimidazolforbindelser som hpk1-hæmmere
CN111170995A (zh)*2018-11-092020-05-19山东轩竹医药科技有限公司Ask1抑制剂及其应用
WO2020106707A1 (en)2018-11-192020-05-28Enanta Pharmaceuticals, Inc.Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN109608441A (zh)*2018-12-262019-04-12都创(上海)医药科技有限公司一种ask1抑制剂的合成工艺
SG11202107434PA (en)2019-01-152021-08-30Gilead Sciences IncFxr (nr1h4) modulating compounds
CN109813915A (zh)*2019-02-152019-05-28浠思(上海)生物技术有限公司利用htrf一步法筛选激酶抑制剂的方法
CN113439078B (zh)2019-02-192024-04-23吉利德科学公司Fxr激动剂的固体形式
AU2020231115B2 (en)2019-03-072025-02-20Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I.3'3'-cyclic dinucleotides and prodrugs thereof
WO2020178769A1 (en)2019-03-072020-09-10Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I.2'3'-cyclic dinucleotides and prodrugs thereof
US11766447B2 (en)2019-03-072023-09-26Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I.3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
US20200315972A1 (en)2019-03-112020-10-08Gilead Sciences, Inc.Formulations of a compound and uses thereof
US11466033B2 (en)2019-03-252022-10-11Enanta Pharmaceuticals, Inc.Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
TW202212339A (zh)2019-04-172022-04-01美商基利科學股份有限公司類鐸受體調節劑之固體形式
TWI751516B (zh)2019-04-172022-01-01美商基利科學股份有限公司類鐸受體調節劑之固體形式
TWI826690B (zh)2019-05-232023-12-21美商基利科學股份有限公司經取代之烯吲哚酮化物及其用途
TWI770527B (zh)2019-06-142022-07-11美商基利科學股份有限公司Cot 調節劑及其使用方法
US20220305115A1 (en)2019-06-182022-09-29Janssen Sciences Ireland Unlimited CompanyCombination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
CR20210687A (es)2019-06-252022-03-03Gilead Sciences IncPROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO
WO2020261294A1 (en)*2019-06-262020-12-30Mankind Pharma Ltd.Novel apoptosis signal-regulating kinase 1 inhibitors
AR119594A1 (es)2019-08-092021-12-29Gilead Sciences IncDerivados de tienopirimidina como inhibidores acc y usos de los mismos
EP4045083B1 (en)2019-10-182024-01-10Forty Seven, Inc.Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
JP2022552748A (ja)2019-10-312022-12-19フォーティ セブン, インコーポレイテッド抗cd47及び抗cd20による血液癌の治療
TWI778443B (zh)2019-11-122022-09-21美商基利科學股份有限公司Mcl1抑制劑
CA3158743A1 (en)2019-11-152021-05-20Gilead Sciences, Inc.Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
CN111018831B (zh)*2019-11-212022-05-31中国药科大学细胞凋亡信号调节激酶抑制剂及其应用
US20230105984A1 (en)2019-12-232023-04-06Svetlana MarukianCompositions and methods for the treatment of liver diseases and disorders
PT4081305T (pt)2019-12-242024-12-04Gilead Sciences IncCompostos moduladores da diacilglicerol quinase
CA3169451A1 (en)2020-02-142021-08-19Jounce Therapeutics, Inc.Antibodies and fusion proteins that bind to ccr8 and uses thereof
US11655237B2 (en)2020-03-302023-05-23Gilead Sciences, Inc.Solid forms of a Cot inhibitor compound
CN119390681A (zh)2020-04-022025-02-07吉利德科学公司用于制备cot抑制剂化合物的方法
CN115698009B (zh)2020-05-012025-04-08吉利德科学公司抑制cd73的2,4-二氧代嘧啶化合物
WO2021247215A1 (en)2020-06-032021-12-09Gilead Sciences, Inc.Lpa receptor antagonists and uses thereof
CN113831323B (zh)*2020-06-242025-08-29武汉人福创新药物研发中心有限公司芳杂环酰胺类化合物及其用途
CN111808079A (zh)*2020-08-052020-10-23中国药科大学吲哚类ask1小分子抑制剂及其制备方法和应用
CN114470217B (zh)*2020-11-242023-06-20深圳微芯生物科技股份有限公司预防和治疗代谢异常或炎症引起的组织损伤的药物组合物
EP4304711A1 (en)2021-03-112024-01-17Gilead Sciences, Inc.Glp-1r modulating compounds
US12410160B2 (en)2021-03-292025-09-09Gilead Sciences, Inc.KHK inhibitors
TW202302145A (zh)2021-04-142023-01-16美商基利科學股份有限公司CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
CN114246866B (zh)*2021-04-282023-09-12深圳微芯生物科技股份有限公司用于治疗慢性肾病的药物及其用途
JP7701473B2 (ja)2021-05-112025-07-01ギリアード サイエンシーズ, インコーポレイテッドLpa受容体アンタゴニスト及びそれらの使用
US20220411406A1 (en)2021-05-132022-12-29Gilead Sciences, Inc.Lpa receptor antagonists and uses thereof
WO2022245671A1 (en)2021-05-182022-11-24Gilead Sciences, Inc.Methods of using flt3l-fc fusion proteins
TW202345826A (zh)2021-06-042023-12-01美商基利科學股份有限公司治療nash之方法
TW202311256A (zh)2021-06-182023-03-16美商基利科學股份有限公司用於治療fxr誘發之搔癢之il-31調節劑
JP7654118B2 (ja)2021-06-232025-03-31ギリアード サイエンシーズ, インコーポレイテッドジアシルグリセロールキナーゼ調節化合物
JP7651018B2 (ja)2021-06-232025-03-25ギリアード サイエンシーズ, インコーポレイテッドジアシルグリセロールキナーゼ調節化合物
EP4359413A1 (en)2021-06-232024-05-01Gilead Sciences, Inc.Diacylglyercol kinase modulating compounds
WO2022271677A1 (en)2021-06-232022-12-29Gilead Sciences, Inc.Diacylglyercol kinase modulating compounds
TWI857377B (zh)2021-10-282024-10-01美商基利科學股份有限公司嗒-3(2h)-酮衍生物
EP4422756A1 (en)2021-10-292024-09-04Gilead Sciences, Inc.Cd73 compounds
US20230220106A1 (en)2021-12-082023-07-13Dragonfly Therapeutics, Inc.Antibodies targeting 5t4 and uses thereof
JP7709612B2 (ja)2021-12-082025-07-16ギリアード サイエンシーズ, インコーポレイテッドLpa受容体アンタゴニスト及びそれらの使用
US20230203202A1 (en)2021-12-082023-06-29Dragonfly Therapeutics, Inc.Proteins binding nkg2d, cd16 and 5t4
JP2024546851A (ja)2021-12-222024-12-26ギリアード サイエンシーズ, インコーポレイテッドIkarosジンクフィンガーファミリー分解剤及びその使用
EP4452415A1 (en)2021-12-222024-10-30Gilead Sciences, Inc.Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh)2022-01-282023-10-16美商基利科學股份有限公司Parp7抑制劑
PE20242225A1 (es)2022-03-172024-11-19Gilead Sciences IncDegradadores de dedos de zinc de la familia ikaros y usos de estos
US20230355796A1 (en)2022-03-242023-11-09Gilead Sciences, Inc.Combination therapy for treating trop-2 expressing cancers
TWI876305B (zh)2022-04-052025-03-11美商基利科學股份有限公司用於治療結腸直腸癌之組合療法
IL316058A (en)2022-04-212024-11-01Gilead Sciences Inc Compounds modulate KRAS G12D
EP4547657A1 (en)2022-07-012025-05-07Gilead Sciences, Inc.Cd73 compounds
US20240091351A1 (en)2022-09-212024-03-21Gilead Sciences, Inc.FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
KR20250122479A (ko)2022-12-222025-08-13길리애드 사이언시즈, 인코포레이티드Prmt5 억제제 및 이의 용도
CN115844887B (zh)*2022-12-282023-09-08中国人民解放军空军军医大学Selonsertib在制备治疗癌症的药物中的用途
WO2024215754A1 (en)2023-04-112024-10-17Gilead Sciences, Inc.Kras modulating compounds
WO2024220917A1 (en)2023-04-212024-10-24Gilead Sciences, Inc.Prmt5 inhibitors and uses thereof
WO2024236595A1 (en)*2023-05-182024-11-21Council Of Scientific And Industrial ResearchProtacs for ask1 protein degradation: preparation and use thereof
US20250042922A1 (en)2023-06-302025-02-06Gilead Sciences, Inc.Kras modulating compounds
US20250100998A1 (en)2023-07-262025-03-27Gilead Sciences, Inc.Parp7 inhibitors
US20250066328A1 (en)2023-07-262025-02-27Gilead Sciences, Inc.Parp7 inhibitors
US20250101042A1 (en)2023-09-082025-03-27Gilead Sciences, Inc.Kras g12d modulating compounds
WO2025054530A1 (en)2023-09-082025-03-13Gilead Sciences, Inc.Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250154172A1 (en)2023-11-032025-05-15Gilead Sciences, Inc.Prmt5 inhibitors and uses thereof
US20250230168A1 (en)2023-12-222025-07-17Gilead Sciences, Inc.Azaspiro wrn inhibitors

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO1998034946A1 (en)1997-02-121998-08-13Massachusetts Institute Of TechnologyDaxx, a novel fas-binding protein that activates jnk and apoptosis
US6881555B2 (en)1999-03-192005-04-19Aventis Pharmaceuticals Inc.AKT nucleic acids, polypeptides, and uses thereof
IL141984A0 (en)1999-03-192002-03-10Aventis Pharm Prod IncAkt nucleic acids, polypeptides, and uses thereof
WO2001095410A1 (en)*2000-06-072001-12-13Andelman Marc DFluid and electrical connected flow-through electrochemical cells, system and method
US20070237770A1 (en)2001-11-302007-10-11Albert LaiNovel compositions and methods in cancer
US20070167386A1 (en)2003-07-282007-07-19Osaka Industrial Promotion OrganizationRemedy for cardiac failure containing ask1 inhibitor as active ingredient and method for screening the same
US20060079494A1 (en)2004-09-272006-04-13Santi Daniel VSpecific kinase inhibitors
EP1819341A4 (en)2004-11-102011-06-29Synta Pharmaceuticals Corp IL-12 MODULATORY CONNECTIONS
EP1677113A1 (en)2004-12-292006-07-05Max-Delbrück-Centrum für Molekulare Medizin (MDC)Method for the identification of protein-protein interactions in disease related protein networks
US20070276050A1 (en)2006-02-272007-11-29Gilead Sciences, Inc.Methods for identifying ASK1 inhibitors useful for preventing and/or treating cardiovascular diseases
WO2008016131A1 (fr)2006-08-042008-02-07Takeda Pharmaceutical Company LimitedComposé hétérocyclique à cycles fusionnés
WO2008042867A2 (en)2006-09-292008-04-10Emiliem Inc.Modulators of multiple kinases
CA2671194A1 (en)2006-12-082008-06-19Asuragen, Inc.Mir-20 regulated genes and pathways as targets for therapeutic intervention
EP1942104A1 (en)*2006-12-202008-07-09sanofi-aventisHeteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US8104727B2 (en)2007-03-122012-01-31Denis JoanisseAdjustable article support
WO2009011850A2 (en)2007-07-162009-01-22Abbott LaboratoriesNovel therapeutic compounds
CN101878212A (zh)2007-08-312010-11-03默克雪兰诺有限公司三唑并吡啶化合物及其作为ask抑制剂的用途
EP2271646A1 (en)2008-03-312011-01-12Takeda Pharmaceutical Company LimitedApoptosis signal-regulating kinase 1 inhibitors
US8178555B2 (en)2008-06-242012-05-15Takeda Pharmaceutical Company LimitedApoptosis signal-regulating kinase 1 inhibitors
WO2010045470A2 (en)2008-10-152010-04-22Dana-Farber Cancer Institute, Inc.Compositions, kits, and methods for identification, assessment, prevention, and therapy of hepatic disorders
US20110294693A1 (en)2008-11-172011-12-01The George Washington UniversityCompositions and Methods for Identifying Autism Spectrum Disorders
EP2411516A1 (en)2009-03-272012-02-01Merck Sharp&Dohme Corp.RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
TWI625121B (zh)2009-07-132018-06-01基利科學股份有限公司調節細胞凋亡信號之激酶的抑制劑
WO2011041293A1 (en)2009-09-302011-04-07Takeda Pharmaceutical Company LimitedPyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
CN102834393B (zh)2010-02-032015-07-22武田药品工业株式会社细胞凋亡信号调节激酶1抑制剂
US9260417B2 (en)2010-02-082016-02-16Amitech Therapeutic Solutions, Inc.Therapeutic methods and compositions involving allosteric kinase inhibition
US8957216B2 (en)2010-03-242015-02-17Amitech Therapeutic Solutions, Inc.Heterocyclic compounds useful for kinase inhibition
PL2588475T3 (pl)*2010-07-022015-10-30Gilead Sciences IncInhibitory kinazy regulującej sygnał apoptozy
WO2012068464A2 (en)2010-11-182012-05-24University Of DelawareMethods of treating and preventing thrombotic diseases using ask1 inhibitors
PL2651417T3 (pl)2010-12-162017-08-31Calchan LimitedPochodne pirolopirymidyny hamujące ASK1
CN103492590A (zh)2011-02-222014-01-01卡里斯生命科学卢森堡控股有限责任公司循环生物标志物
JP2014526032A (ja)2011-06-072014-10-02カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル.癌に対する循環バイオマーカー
TWI549944B (zh)2011-07-012016-09-21吉李德科學股份有限公司作為離子通道調節劑之稠合雜環化合物
US8924765B2 (en)2011-07-032014-12-30Ambiq Micro, Inc.Method and apparatus for low jitter distributed clock calibration
UY34573A (es)2012-01-272013-06-28Gilead Sciences IncInhibidor de la quinasa que regula la señal de la apoptosis
CN112225699B (zh)2014-12-232023-11-14吉利德科学公司制备ask1抑制剂的方法
MA41252A (fr)2014-12-232017-10-31Gilead Sciences IncFormes solides d'un inhibiteur d'ask 1

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