| WO2012129373A2              (en) | 2011-03-23 | 2012-09-27 | Pioneer Hi-Bred International, Inc. | Methods for producing a complex transgenic trait locus | 
| EP3613852A3              (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity | 
| US20150225734A1              (en) | 2012-06-19 | 2015-08-13 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses | 
| EP4397760A3              (en) | 2012-10-23 | 2024-10-09 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof | 
| KR102186281B1              (ko) | 2013-04-16 | 2020-12-03 | 리제너론 파마슈티칼스 인코포레이티드 | 랫트 게놈의 표적화된 변형 | 
| EP3008186B1              (en) | 2013-06-14 | 2018-11-28 | Cellectis | Methods for non-transgenic genome editing in plants | 
| US20150044192A1              (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease | 
| US9359599B2              (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof | 
| CN120574876A              (zh) | 2013-08-22 | 2025-09-02 | 纳幕尔杜邦公司 | 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法 | 
| US9526784B2              (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases | 
| US9228207B2              (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers | 
| US9322037B2              (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof | 
| US10584358B2              (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri | 
| JP2016536021A              (ja) | 2013-11-07 | 2016-11-24 | エディタス・メディシン,インコーポレイテッド | CRISPR関連方法および支配gRNAのある組成物 | 
| JP6174811B2              (ja) | 2013-12-11 | 2017-08-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ゲノムの標的改変のための方法及び組成物 | 
| US11053481B2              (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains | 
| US10787654B2              (en) | 2014-01-24 | 2020-09-29 | North Carolina State University | Methods and compositions for sequence guiding Cas9 targeting | 
| CN106232803A              (zh) | 2014-02-27 | 2016-12-14 | 孟山都技术公司 | 用于定点基因组修饰的组合物和方法 | 
| JP2017512481A              (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーNorth Carolina State University | Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物 | 
| US11584936B2              (en)* | 2014-06-12 | 2023-02-21 | King Abdullah University Of Science And Technology | Targeted viral-mediated plant genome editing using CRISPR /Cas9 | 
| CN106687594A              (zh) | 2014-07-11 | 2017-05-17 | 纳幕尔杜邦公司 | 用于产生对草甘膦除草剂具有抗性的植物的组合物和方法 | 
| EP3177718B1              (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins | 
| US10513711B2              (en) | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease | 
| WO2016033298A1              (en) | 2014-08-28 | 2016-03-03 | North Carolina State University | Novel cas9 proteins and guiding features for dna targeting and genome editing | 
| EP3628739B1              (en) | 2014-09-12 | 2024-05-01 | Corteva Agriscience LLC | Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use | 
| AU2015343307B2              (en) | 2014-11-06 | 2021-05-20 | Iff Us Holding, Llc | Peptide-mediated delivery of RNA-guided endonuclease into cells | 
| AU2015349692B2              (en) | 2014-11-21 | 2021-10-28 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide RNAs | 
| EP4400584A3              (en) | 2014-12-03 | 2024-10-16 | Agilent Technologies, Inc. | Guide rna with chemical modifications | 
| EP3229586B1              (en) | 2014-12-10 | 2025-07-30 | Regents of the University of Minnesota | Genetically modified cells, tissues, and organs for treating disease | 
| CA2971425A1              (en) | 2014-12-16 | 2016-06-23 | Pioneer Hi-Bred International, Inc. | Restoration of male fertility in wheat | 
| JP2017538427A              (ja) | 2014-12-18 | 2017-12-28 | インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド | Crispr系組成物及び使用方法 | 
| US20180179523A1              (en)* | 2014-12-18 | 2018-06-28 | Integrated Dna Technologies, Inc. | Crispr-based compositions and methods of use | 
| DK3252162T5              (da) | 2015-01-27 | 2024-10-07 | Inst Genetics & Developmental Biology Cas | Fremgangsmåde til foretagelse af stedsspecifik modifikation på hel plante via transient genekspression | 
| HUE063813T2              (hu) | 2015-01-28 | 2024-02-28 | Caribou Biosciences Inc | CRISPR hibrid DNS/RNS polinukleotidok és alkalmazási eljárások | 
| BR112017016762A2              (pt) | 2015-02-04 | 2018-04-10 | Du Pont | polinucleotídeo heterólogo, polipeptídeo heterólogo, complexo polipeptídico, preparação de anticorpo, cassete de expressão, célula hospedeira, célula transformada, método de identificação de compostos, método de rastreamento de compostos de teste, método de geração de uma variante, método de seleção de suscetibilidade alterada, método de alteração da suscetibilidade de um inseto, kit para rastreamento de populações de insetos, método para isolamento | 
| SG11201706767RA              (en) | 2015-02-23 | 2017-09-28 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies | 
| US12129471B2              (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies | 
| EP3262176A1              (en)* | 2015-02-25 | 2018-01-03 | Pioneer Hi-Bred International, Inc. | Composition and methods for regulated expression of a guide rna/cas endonuclease complex | 
| EA038896B1              (ru) | 2015-03-16 | 2021-11-03 | Институт Генетики И Биологии Развития Академии Наук Китая | Способ осуществления сайт-направленной модификации растительных геномов с использованием ненаследуемых материалов | 
| EP3270685B1              (en)* | 2015-03-19 | 2023-07-19 | Pioneer Hi-Bred International, Inc. | Methods and compositions for accelerated trait introgression | 
| WO2016160389A1              (en) | 2015-03-27 | 2016-10-06 | E I Du Pont De Nemours And Company | Soybean u6 small nuclear rna gene promoters and their use in constitutive expression of small rna genes in plants | 
| EP3280803B1              (en)* | 2015-04-06 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation | 
| WO2016186946A1              (en) | 2015-05-15 | 2016-11-24 | Pioneer Hi-Bred International, Inc. | Rapid characterization of cas endonuclease systems, pam sequences and guide rna elements | 
| DE102015014252A1              (de) | 2015-11-05 | 2017-05-11 | Kws Saat Se | Verfahren und Konstrukte zur gezielten Nukleinsäure Editierung in Pflanzen | 
| EP3095870A1              (en)* | 2015-05-19 | 2016-11-23 | Kws Saat Se | Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom | 
| DE102015006335A1              (de) | 2015-05-19 | 2016-11-24 | Kws Saat Se | Verfahren und Konstrukte zur gezielten Nukleinsäure Editierung in Pflanzen | 
| KR102451796B1              (ko) | 2015-05-29 | 2022-10-06 | 노쓰 캐롤라이나 스테이트 유니버시티 | 크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법 | 
| WO2016196887A1              (en) | 2015-06-03 | 2016-12-08 | Board Of Regents Of The University Of Nebraska | Dna editing using single-stranded dna | 
| DK3307872T3              (da) | 2015-06-15 | 2023-10-23 | Univ North Carolina State | Fremgangsmåder og sammensætninger til effektiv indgivelse af nukleinsyrer og rna-baserede antimikrober | 
| WO2016210393A1              (en)* | 2015-06-26 | 2016-12-29 | Pioneer Hi-Bred International, Inc. | Gos2 regulatory elements and use thereof | 
| EP3313989B1              (en)* | 2015-06-29 | 2024-12-25 | Ionis Pharmaceuticals, Inc. | Modified crispr rna and modified single crispr rna and uses thereof | 
| WO2017004279A2              (en)* | 2015-06-29 | 2017-01-05 | Massachusetts Institute Of Technology | Compositions comprising nucleic acids and methods of using the same | 
| EP3328399B1              (en) | 2015-07-31 | 2023-12-27 | Regents of the University of Minnesota | Modified cells and methods of therapy | 
| US9580727B1              (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides | 
| WO2017028768A1              (en) | 2015-08-14 | 2017-02-23 | Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences | Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution | 
| AU2016315655A1              (en) | 2015-08-28 | 2018-02-01 | E. I. Du Pont De Nemours And Company | Ochrobactrum-mediated transformation of plants | 
| IL241462A0              (en) | 2015-09-10 | 2015-11-30 | Yeda Res & Dev | Heterologous engineering of betalain pigments in plants | 
| WO2017053729A1              (en) | 2015-09-25 | 2017-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Nuclease-mediated genome editing of primary cells and enrichment thereof | 
| EP3356533A1              (en) | 2015-09-28 | 2018-08-08 | North Carolina State University | Methods and compositions for sequence specific antimicrobials | 
| EP3356535A1              (en)* | 2015-09-30 | 2018-08-08 | Pioneer Hi-Bred International, Inc. | Plant epsp synthases and methods of use | 
| MX390143B              (es)* | 2015-10-02 | 2025-03-04 | Monsanto Technology Llc | Secuencias recombinantes de cromosoma b de maíz y sus usos | 
| WO2017062855A1              (en)* | 2015-10-09 | 2017-04-13 | Monsanto Technology Llc | Novel rna-guided nucleases and uses thereof | 
| EP3362560B1              (en) | 2015-10-12 | 2022-08-10 | DuPont US Holding, LLC | Protected dna templates for gene modification and increased homologous recombination in cells and methods of use | 
| US20190075749A1              (en) | 2015-10-16 | 2019-03-14 | Pioneer Hi-Bred International, Inc. | Generating maize plants with enhanced resistance to northern leaf blight | 
| KR20180069832A              (ko) | 2015-10-20 | 2018-06-25 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 유도 cas 시스템을 통한 비기능성 유전자 산물에 대한 기능 회복 및 이용 방법 | 
| EP3159407A1              (en)* | 2015-10-23 | 2017-04-26 | Silence Therapeutics (London) Ltd | Guide rnas, methods and uses | 
| US9677090B2              (en) | 2015-10-23 | 2017-06-13 | Caribou Biosciences, Inc. | Engineered nucleic-acid targeting nucleic acids | 
| SG10202104041PA              (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof | 
| ES2942309T3              (es) | 2015-11-04 | 2023-05-31 | Vertex Pharma | Materiales y métodos para el tratamiento de hemoglobinopatías | 
| SG11201803144WA              (en)* | 2015-11-04 | 2018-05-30 | Fate Therapeutics Inc | Genomic engineering of pluripotent cells | 
| WO2017079026A1              (en) | 2015-11-06 | 2017-05-11 | E. I. Du Pont De Nemours And Company | Generation of complex trait loci in soybean and methods of use | 
| WO2017095698A1              (en) | 2015-11-30 | 2017-06-08 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof | 
| CN106811479B              (zh)* | 2015-11-30 | 2019-10-25 | 中国农业科学院作物科学研究所 | 利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用 | 
| WO2017096237A1              (en)* | 2015-12-02 | 2017-06-08 | Ceres, Inc. | Methods for genetic modification of plants | 
| CN109310784B              (zh) | 2015-12-07 | 2022-08-19 | 阿克生物公司 | 用于制备和使用指导核酸的方法和组合物 | 
| JP6888906B2              (ja)* | 2015-12-11 | 2021-06-18 | 株式会社豊田中央研究所 | 生物体のゲノムの改変方法及びその利用 | 
| WO2017100158A1              (en) | 2015-12-11 | 2017-06-15 | Danisco Us Inc. | Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects | 
| EP3390631B1              (en) | 2015-12-18 | 2020-04-08 | Danisco US Inc. | Methods and compositions for t-rna based guide rna expression | 
| US11761007B2              (en)* | 2015-12-18 | 2023-09-19 | The Scripps Research Institute | Production of unnatural nucleotides using a CRISPR/Cas9 system | 
| WO2017112620A1              (en) | 2015-12-22 | 2017-06-29 | North Carolina State University | Methods and compositions for delivery of crispr based antimicrobials | 
| WO2017112006A1              (en) | 2015-12-22 | 2017-06-29 | Pioneer Hi-Bred International, Inc. | Tissue-preferred promoters and methods of use | 
| EP3402885A4              (en) | 2016-01-11 | 2019-07-03 | The Board of Trustees of the Leland Stanford Junior University | CHIMERIC PROTEINS AND METHOD FOR REGULATING GENE EXPRESSION | 
| CN108463229B              (zh) | 2016-01-11 | 2023-10-17 | 斯坦福大学托管董事会 | 嵌合蛋白和免疫治疗方法 | 
| WO2017123772A1              (en)* | 2016-01-12 | 2017-07-20 | Regents Of The University Of Minnesota | Glyphosate tolerant plants having modified 5-enolpyruvylshikimate-3-phosphate synthase gene regulation | 
| US11136589B2              (en) | 2016-01-26 | 2021-10-05 | Pioneer Hi-Bred International, Inc. | Waxy corn | 
| CA3014036A1              (en)* | 2016-02-09 | 2017-08-17 | Cibus Us Llc | Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair | 
| EP3426780A1              (en) | 2016-03-11 | 2019-01-16 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use | 
| CA3010628A1              (en) | 2016-03-11 | 2017-09-14 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use | 
| WO2017155715A1              (en) | 2016-03-11 | 2017-09-14 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use | 
| CN107312821A              (zh)* | 2016-04-25 | 2017-11-03 | 中国检验检疫科学研究院 | 用于转基因大米m12品系特异性基因成分精准定量检测的引物探针、试剂盒及方法 | 
| CA3025523A1              (en) | 2016-05-27 | 2017-11-30 | Aadigen, Llc | Peptides and nanoparticles for intracellular delivery of genome-editing molecules | 
| WO2017207589A1              (en) | 2016-06-01 | 2017-12-07 | Kws Saat Se | Hybrid nucleic acid sequences for genome engineering | 
| US10767175B2              (en)* | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs | 
| WO2017218185A1              (en) | 2016-06-14 | 2017-12-21 | Pioneer Hi-Bred International, Inc. | Use of cpf1 endonuclease for plant genome modifications | 
| WO2017222773A1              (en) | 2016-06-20 | 2017-12-28 | Pioneer Hi-Bred International, Inc. | Novel cas systems and methods of use | 
| CA3029271A1              (en)* | 2016-06-28 | 2018-01-04 | Cellectis | Altering expression of gene products in plants through targeted insertion of nucleic acid sequences | 
| WO2018027078A1              (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof | 
| WO2018031683A1              (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof | 
| WO2018039438A1              (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing | 
| CN106350536B              (zh)* | 2016-08-28 | 2021-02-12 | 浙江大学 | 一种植物杂交体系及其应用 | 
| IL247752A0              (en)* | 2016-09-11 | 2016-11-30 | Yeda Res & Dev | Compositions and methods for modulating gene expression for site-directed mutagenesis | 
| CN109936977A              (zh)* | 2016-09-14 | 2019-06-25 | 孟山都技术公司 | 用于通过单倍体诱导来进行基因组编辑的方法和组合物 | 
| US20190225974A1              (en) | 2016-09-23 | 2019-07-25 | BASF Agricultural Solutions Seed US LLC | Targeted genome optimization in plants | 
| JP2019533996A              (ja) | 2016-10-07 | 2019-11-28 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | S.ピオゲネスcas9変異遺伝子及びこれによってコードされるポリペプチド | 
| US11242542B2              (en) | 2016-10-07 | 2022-02-08 | Integrated Dna Technologies, Inc. | S. pyogenes Cas9 mutant genes and polypeptides encoded by same | 
| UA128281C2              (uk) | 2016-10-13 | 2024-05-29 | Піонір Хай-Бред Інтернешнл, Інк. | Одержання маїсу, стійкого до північної плямистості листя | 
| EP3526320A1              (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors | 
| GB2605540B              (en) | 2016-10-18 | 2022-12-21 | Univ Minnesota | Tumor infiltrating lymphocytes and methods of therapy | 
| WO2018081728A1              (en)* | 2016-10-31 | 2018-05-03 | Emendobio Inc. | Compositions for genome editing | 
| CA3042259A1              (en) | 2016-11-04 | 2018-05-11 | Flagship Pioneering Innovations V. Inc. | Novel plant cells, plants, and seeds | 
| CA3043774A1              (en)* | 2016-11-14 | 2018-05-17 | Caixia Gao | A method for base editing in plants | 
| KR20190082318A              (ko) | 2016-11-22 | 2019-07-09 | 인티그레이티드 디엔에이 테크놀로지스 아이엔씨. | Crispr/cpf1 시스템 및 방법 | 
| US11236348B2              (en) | 2016-11-29 | 2022-02-01 | Pioneer Hi-Bred International, Inc. | Transcriptional terminators for gene expression in plants | 
| US9816093B1              (en) | 2016-12-06 | 2017-11-14 | Caribou Biosciences, Inc. | Engineered nucleic acid-targeting nucleic acids | 
| CN108165573B              (zh)* | 2016-12-07 | 2022-01-14 | 中国科学院分子植物科学卓越创新中心 | 叶绿体基因组编辑方法 | 
| JP7696694B2              (ja)* | 2016-12-08 | 2025-06-23 | インテリア セラピューティクス,インコーポレイテッド | 修飾されたガイドrna | 
| CA3042939A1              (en)* | 2016-12-08 | 2018-06-14 | Syngenta Participations Ag | Methods for improving transformation frequency | 
| US11293022B2              (en) | 2016-12-12 | 2022-04-05 | Integrated Dna Technologies, Inc. | Genome editing enhancement | 
| CA3047415A1              (en)* | 2016-12-22 | 2018-06-28 | Intellia Therapeutics, Inc. | Compositions and methods for treating alpha-1 antitrypsin deficiency | 
| AU2017379402B2              (en)* | 2016-12-22 | 2022-03-10 | Toolgen Incorporated | Oleic acid-enriched plant body having genetically modified FAD2 and production method therefor | 
| WO2018119225A1              (en)* | 2016-12-22 | 2018-06-28 | Monsanto Technology Llc | Genome editing-based crop engineering and production of brachytic plants | 
| US10745677B2              (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection | 
| CN106834341B              (zh)* | 2016-12-30 | 2020-06-16 | 中国农业大学 | 一种基因定点突变载体及其构建方法和应用 | 
| US11859219B1              (en) | 2016-12-30 | 2024-01-02 | Flagship Pioneering Innovations V, Inc. | Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA | 
| WO2018131034A1              (en)* | 2017-01-11 | 2018-07-19 | Yeda Research And Development Co. Ltd. | Targeted recombination between homologous chromosomes and uses thereof | 
| SG11201906795SA              (en) | 2017-01-28 | 2019-08-27 | Inari Agriculture Inc | Novel plant cells, plants, and seeds | 
| TW201839136A              (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 | 
| BR112019018200B1              (pt) | 2017-03-03 | 2024-02-20 | Pioneer Hi-Bred International, Inc | Método para medir a quantidade de um sucrosil-oligossacarídeo,método para medir estaquiose, método para processar sementes de soja geneticamente modificadas | 
| CN107066944B              (zh)* | 2017-03-06 | 2019-11-05 | 北京数码视讯科技股份有限公司 | 一种手指指根的定位方法及装置 | 
| EP3592381A1              (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine | 
| EP3592853A1              (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing | 
| JP2020510439A              (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 | 
| WO2018176009A1              (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins | 
| CA3058377A1              (en)* | 2017-03-30 | 2018-10-04 | Pioneer Hi-Bred International, Inc. | Improved plant epsp synthases and methods of use | 
| EP3601610A1              (en)* | 2017-03-30 | 2020-02-05 | Pioneer Hi-Bred International, Inc. | Methods of identifying and characterizing gene editing variations in nucleic acids | 
| WO2018183878A1              (en) | 2017-03-31 | 2018-10-04 | Pioneer Hi-Bred International, Inc. | Expression modulating elements and use thereof | 
| WO2018197520A1              (en) | 2017-04-24 | 2018-11-01 | Dupont Nutrition Biosciences Aps | Methods and compositions of anti-crispr proteins for use in plants | 
| EP3619305A1              (en) | 2017-05-03 | 2020-03-11 | KWS SAAT SE & Co. KGaA | Use of crispr-cas endonucleases for plant genome engineering | 
| EP3635118A4              (en)* | 2017-05-05 | 2021-01-27 | Institute Of Genetics And Developmental Biology Chinese Academy of Sciences | PROCESSES FOR ISOLATING CELLS WITHOUT USING TRANSGENIC MARKER SEQUENCES | 
| EA201992637A1              (ru)* | 2017-05-11 | 2020-03-17 | Институте Оф Генетисс Анд Девелопментал Биологй, Чинесе Асадемй Оф Ссиенсес | Создание гена, устойчивого к гербицидам, и его применение | 
| WO2018209320A1              (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation | 
| US20200199604A1              (en)* | 2017-05-17 | 2020-06-25 | Cold Spring Harbor Laboratory | Compositions and methods for generating weak alleles in plants | 
| GB201708662D0              (en) | 2017-05-31 | 2017-07-12 | Tropic Biosciences Uk Ltd | Compositions and methods for increasing shelf-life of banana | 
| GB201708665D0              (en) | 2017-05-31 | 2017-07-12 | Tropic Biosciences Uk Ltd | Compositions and methods for increasing extractability of solids from coffee beans | 
| EP3630973A1              (en) | 2017-05-31 | 2020-04-08 | Tropic Biosciences UK Limited | Methods of selecting cells comprising genome editing events | 
| WO2018224861A1              (en) | 2017-06-07 | 2018-12-13 | International Rice Research Institute | Increasing hybrid seed production through higher outcrossing rate in cytoplasmic male sterile gramineae plants and related materials and methods | 
| WO2018237197A2              (en)* | 2017-06-21 | 2018-12-27 | Noble Research Institute, Llc | Crispr-mediated selective gene disruption in plants | 
| US11756183B2              (en) | 2017-06-23 | 2023-09-12 | Cornell University | RNA molecules, methods of producing circular RNA, and treatment methods | 
| WO2019006418A2              (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY | 
| WO2019014564A1              (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES | 
| CN111801345A              (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 | 
| CA3073662A1              (en) | 2017-08-22 | 2019-02-28 | Napigen, Inc. | Organelle genome modification using polynucleotide guided endonuclease | 
| WO2019139645A2              (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam | 
| US20200199609A1              (en)* | 2017-09-14 | 2020-06-25 | Pioneer Hi-Bred International, Inc. | Compositions and methods for stature modification in plants | 
| CN111344403B              (zh)* | 2017-09-15 | 2025-05-06 | 利兰斯坦福初级大学董事会 | 遗传工程细胞的多元性产生和条形码编制 | 
| EP3684914B1              (en)* | 2017-09-18 | 2024-05-29 | Futuragene Israel Ltd. | Tissue-specific expression control of della polypeptides | 
| US20200270604A1              (en) | 2017-09-19 | 2020-08-27 | Tropic Biosciences UK Limited | Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells | 
| CN111373046A              (zh) | 2017-09-25 | 2020-07-03 | 先锋国际良种公司 | 组织偏好性启动子和使用方法 | 
| US11603536B2              (en) | 2017-09-29 | 2023-03-14 | Inari Agriculture Technology, Inc. | Methods for efficient maize genome editing | 
| BR112020007343A2              (pt) | 2017-10-13 | 2020-10-06 | Pioneer Hi-Bred International, Inc. | método para gerar um embrião de planta haploide, micrósporo embriogênico, embrioide ou tecido embriogênico, célula vegetal compreendendo um cassete de expressão, população de células vegetais | 
| CA3082251A1              (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors | 
| WO2019084306A1              (en)* | 2017-10-26 | 2019-05-02 | University Of Florida Research Foundation, Inc. | METHOD FOR REDUCING GENOMIC COMPLEXITY AND DETECTING POLYMORPHISMS | 
| US11274311B2              (en) | 2017-11-16 | 2022-03-15 | Corteva Agriscience Llc | Plant promoter for transgene expression | 
| KR20250133448A              (ko) | 2017-12-05 | 2025-09-05 | 버텍스 파마슈티칼스 인코포레이티드 | Crispr-cas9 변형된 cd34+ 인간 조혈 줄기 및 전구 세포 및 이의 용도 | 
| EP3724214A4              (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING | 
| JP7384801B2              (ja) | 2017-12-15 | 2023-11-21 | ダニスコ・ユーエス・インク | Cas9変異体及び使用方法 | 
| KR102339365B1              (ko)* | 2017-12-22 | 2021-12-17 | (주)지플러스 생명과학 | 키메라 게놈 조작 분자 및 방법 | 
| MY202687A              (en) | 2017-12-23 | 2024-05-15 | Uwell Biopharma Inc | Pharmaceutical chimeric receptor composition and method thereof | 
| CA3084365A1              (en) | 2017-12-27 | 2019-07-04 | Pioneer Hi-Bred International, Inc. | Transformation of dicot plants | 
| CN109971763A              (zh)* | 2017-12-28 | 2019-07-05 | 未名生物农业集团有限公司 | 花期调控基因cmp1和相关的载体及其应用 | 
| EP3734741A4              (en)* | 2017-12-28 | 2021-12-08 | Hitachi Zosen Corporation | FULLY SOLID BATTERY, ITS MANUFACTURING PROCESS AND PROCESSING DEVICE | 
| US11634722B2              (en) | 2018-01-22 | 2023-04-25 | Inari Agriculture Technology, Inc. | Plant gene editing systems, methods, and compositions | 
| US20240318171A1              (en)* | 2018-01-26 | 2024-09-26 | Integrated Dna Technologies, Inc. | Crispr-based compositions and methods of use | 
| US11802288B1              (en) | 2018-01-29 | 2023-10-31 | Inari Agriculture Technology, Inc. | Methods for efficient soybean genome editing | 
| US11220694B1              (en) | 2018-01-29 | 2022-01-11 | Inari Agriculture, Inc. | Rice cells and rice plants | 
| US11926835B1              (en) | 2018-01-29 | 2024-03-12 | Inari Agriculture Technology, Inc. | Methods for efficient tomato genome editing | 
| WO2019150196A1              (en) | 2018-02-05 | 2019-08-08 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies | 
| US11268077B2              (en) | 2018-02-05 | 2022-03-08 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies | 
| WO2019161251A1              (en)* | 2018-02-15 | 2019-08-22 | The Broad Institute, Inc. | Cell data recorders and uses thereof | 
| US20210105962A1              (en)* | 2018-02-22 | 2021-04-15 | Elsoms Developments Ltd | Methods and compositions relating to maintainer lines | 
| EP3755792A4              (en) | 2018-02-23 | 2021-12-08 | Pioneer Hi-Bred International, Inc. | NEW CASE ORTHOLOGISTS9 | 
| WO2019173125A1              (en) | 2018-03-09 | 2019-09-12 | Pioneer Hi-Bred International, Inc. | Compositions and methods for modification of fatty acids in soybean | 
| US20210062203A1              (en)* | 2018-03-12 | 2021-03-04 | Pioneer Hi-Bred International, Inc. | Methods for plant transformation | 
| JP7550648B2              (ja)* | 2018-03-19 | 2024-09-13 | クリスパー セラピューティクス アーゲー | 新規rnaプログラム可能エンドヌクレアーゼ系およびその使用 | 
| WO2019182884A1              (en) | 2018-03-23 | 2019-09-26 | Pioneer Hi-Bred International, Inc. | Methods of identifying, selecting, and producing disease resistant crops | 
| CN110396523B              (zh)* | 2018-04-23 | 2023-06-09 | 中国科学院分子植物科学卓越创新中心 | 一种重复片段介导的植物定点重组方法 | 
| WO2019205919A1              (zh)* | 2018-04-28 | 2019-10-31 | 青岛清原化合物有限公司 | 一种生物突变体库的构建方法 | 
| CA3097209A1              (en)* | 2018-05-07 | 2019-11-14 | Pioneer Hi-Bred International, Inc. | Methods and compositions for homology directed repair of double strand breaks in plant cell genomes | 
| WO2019213910A1              (en)* | 2018-05-10 | 2019-11-14 | Syngenta Participations Ag | Methods and compositions for targeted editing of polynucleotides | 
| JP2021523745A              (ja) | 2018-05-16 | 2021-09-09 | シンテゴ コーポレイション | ガイドrna設計および使用のための方法およびシステム | 
| CN108642077A              (zh)* | 2018-05-18 | 2018-10-12 | 江苏省农业科学院 | 基于CRISPR/Cas9基因编辑技术选育绿豆不育突变体的方法及专用gRNA | 
| BR112020023702A2              (pt)* | 2018-05-21 | 2021-02-17 | Pioneer Hi-Bred International, Inc. | modificação de glutamina sintetase para melhorar o rendimento em plantas | 
| US12157760B2              (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof | 
| EP3802887A2              (en)* | 2018-05-25 | 2021-04-14 | Pioneer Hi-Bred International, Inc. | Systems and methods for improved breeding by modulating recombination rates | 
| EP3802811A4              (en)* | 2018-05-29 | 2022-07-13 | Monsanto Technology LLC | TRANSGENIC PLANTS WITH ADVANCED CHARACTERISTICS | 
| EP3575402A1              (en)* | 2018-06-01 | 2019-12-04 | Algentech SAS | Gene targeting | 
| US11866719B1              (en) | 2018-06-04 | 2024-01-09 | Inari Agriculture Technology, Inc. | Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants | 
| WO2020006112A1              (en) | 2018-06-26 | 2020-01-02 | Regents Of The University Of Minnesota | Delivery of developmental regulators to plants for the induction of meristematic tissue with genetic alterations | 
| EP3833747A1              (en) | 2018-06-28 | 2021-06-16 | Pioneer Hi-Bred International, Inc. | Methods for selecting transformed plants | 
| WO2020005667A1              (en) | 2018-06-29 | 2020-01-02 | Pioneer Hi-Bred International, Inc. | Compositions and methods for editing an endogenous nac gene in plants | 
| CA3104856A1              (en) | 2018-06-29 | 2020-01-02 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto | 
| CN112638494B              (zh)* | 2018-06-30 | 2022-01-21 | 因思科瑞普特公司 | 用于改进活细胞中编辑序列的检测的仪器、模块和方法 | 
| BR112021002792A2              (pt) | 2018-08-13 | 2021-06-29 | Pioneer Hi-Bred International, Inc. | novos receptores de toxinas inseticidas e métodos de uso | 
| EP3844263A4              (en)* | 2018-08-30 | 2022-05-25 | Inscripta, Inc. | ENHANCED DETECTION OF NUCLEASE-EDITED SEQUENCES IN AUTOMATED MODULES AND INSTRUMENTS | 
| US11459551B1              (en) | 2018-08-31 | 2022-10-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing | 
| CN109136258A              (zh)* | 2018-09-06 | 2019-01-04 | 先正达参股股份有限公司 | 小麦中基因编辑效率的优化 | 
| CA3110093A1              (en) | 2018-09-14 | 2020-03-19 | Pioneer Hi-Bred International, Inc. | Fertility restoration in plants | 
| KR20210060561A              (ko)* | 2018-09-20 | 2021-05-26 | 사노피 | 인트론-기반 범용 클로닝 방법 및 조성물 | 
| US10711267B2              (en) | 2018-10-01 | 2020-07-14 | North Carolina State University | Recombinant type I CRISPR-Cas system | 
| WO2020072253A1              (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for screening for variant cells | 
| WO2020072254A1              (en) | 2018-10-01 | 2020-04-09 | North Carolina State University | Recombinant type i crispr-cas system and uses thereof for killing target cells | 
| US12264313B2              (en) | 2018-10-01 | 2025-04-01 | North Carolina State University | Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression | 
| WO2020072418A1              (en)* | 2018-10-02 | 2020-04-09 | Monsanto Technology Llc | Compositions and methods for transferring biomolecules to wounded cells | 
| EP3866583A1              (en) | 2018-10-16 | 2021-08-25 | Pioneer Hi-Bred International, Inc. | Genome edited fine mapping and causal gene identification | 
| US11407995B1              (en) | 2018-10-26 | 2022-08-09 | Inari Agriculture Technology, Inc. | RNA-guided nucleases and DNA binding proteins | 
| US12281338B2              (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof | 
| KR20210084557A              (ko) | 2018-10-31 | 2021-07-07 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 오크로박트럼-매개 유전자 편집을 위한 조성물 및 방법 | 
| EP3874050A1              (en) | 2018-10-31 | 2021-09-08 | Pioneer Hi-Bred International, Inc. | Compositions and methods for ochrobactrum-mediated plant transformation | 
| JP2022505440A              (ja)* | 2018-11-01 | 2022-01-14 | キージーン ナムローゼ フェンノートシャップ | 植物細胞におけるCRISPR/Casゲノム編集のためのデュアルガイドRNA | 
| US11434477B1              (en) | 2018-11-02 | 2022-09-06 | Inari Agriculture Technology, Inc. | RNA-guided nucleases and DNA binding proteins | 
| US11518999B1              (en) | 2018-11-09 | 2022-12-06 | Inari Agriculture Technology, Inc. | Plant transformation | 
| EP3890473A4              (en)* | 2018-12-04 | 2022-09-07 | Syngenta Crop Protection AG | GEN TURN OFF VIA GENO EDITING | 
| EP3896155A4              (en)* | 2018-12-12 | 2022-08-17 | Kyushu University, National University Corporation | Production method for genome-edited cells | 
| US10934536B2              (en) | 2018-12-14 | 2021-03-02 | Pioneer Hi-Bred International, Inc. | CRISPR-CAS systems for genome editing | 
| US12351837B2              (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof | 
| US11453885B1              (en) | 2019-02-19 | 2022-09-27 | Inari Agriculture Technology, Inc. | Plant transformation | 
| AU2020239058B2              (en)* | 2019-03-11 | 2024-02-01 | Colorado State University Research Foundation | Herbicide tolerant plants and production and detection of same | 
| GB201903519D0              (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest | 
| GB201903520D0              (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells | 
| GB201903521D0              (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | No title | 
| WO2020191246A1              (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences | 
| US12031149B2              (en)* | 2019-03-27 | 2024-07-09 | Emendobio Inc. | Compositions and methods for promoting gene editing of CXCR4 gene | 
| EP3947425A1              (en) | 2019-03-27 | 2022-02-09 | Pioneer Hi-Bred International, Inc. | Plant explant transformation | 
| WO2020206202A1              (en) | 2019-04-05 | 2020-10-08 | Danisco Us Inc | Methods for integrating a donor dna sequence into the genome of bacillus using linear recombinant dna constructs and compositions thereof | 
| JP2022526414A              (ja) | 2019-04-05 | 2022-05-24 | ダニスコ・ユーエス・インク | 二重環状組換えDNAコンストラクトを使用するバチルス(Bacillus)のゲノムへのポリヌクレオチド組込みのための方法及びその組成物 | 
| JP2022529771A              (ja)* | 2019-04-24 | 2022-06-24 | オレゴン ヘルス アンド サイエンス ユニヴァーシティ | プロモーター配列及び関連製品並びにそれらの使用 | 
| US11692197B2              (en) | 2019-05-06 | 2023-07-04 | Inari Agriculture Technology, Inc. | Delivery of biological molecules to plant cells | 
| CN110241121B              (zh)* | 2019-05-21 | 2022-03-29 | 南京农业大学 | 大豆E3泛素连接酶GmNLA1编码基因的应用 | 
| JP2022537722A              (ja)* | 2019-06-19 | 2022-08-29 | ベターシーズ リミテッド | 遺伝子編集を介してカンナビス(Cannabis:大麻)の収量を増加させるための方法 | 
| BR112021026220A2              (pt) | 2019-06-25 | 2022-02-15 | Inari Agriculture Tech Inc | Edição aprimorada do genoma por reparo dependente de homologia | 
| WO2021003410A1              (en)* | 2019-07-03 | 2021-01-07 | Napigen, Inc. | Organelle genome modification | 
| US20210047651A1              (en)* | 2019-07-12 | 2021-02-18 | The Regents Of The University Of California | Compositions and methods for targeted insertion of selectable marker-free dna sequence in plants | 
| US11746354B2              (en) | 2019-07-19 | 2023-09-05 | Inari Agriculture Technology, Inc. | Homology dependent repair genome editing | 
| CN110358767B              (zh)* | 2019-07-30 | 2021-06-08 | 湖北大学 | 一种基于CRISPR-Cas12a系统的运动发酵单胞菌基因组编辑方法及其应用 | 
| CN115244176A              (zh)* | 2019-08-19 | 2022-10-25 | 钟明宏 | 向导rna-cas蛋白复合物的缀合物 | 
| EP3798301A1              (en)* | 2019-09-25 | 2021-03-31 | KWS SAAT SE & Co. KGaA | Promoter repression | 
| WO2021072328A1              (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna | 
| CA3158555A1              (en) | 2019-10-23 | 2021-04-29 | Pairwise Plants Services, Inc. | Compositions and methods for rna-templated editing in plants | 
| KR20220110748A              (ko) | 2019-11-05 | 2022-08-09 | 페어와이즈 플랜츠 서비시즈, 인크. | 대립유전자의 rna-코딩된 dna-대체를 위한 조성물 및 방법 | 
| CN112779266A              (zh)* | 2019-11-06 | 2021-05-11 | 青岛清原化合物有限公司 | 在生物体内创制新基因的方法及应用 | 
| AU2019474716A1              (en) | 2019-11-19 | 2022-07-07 | Protalix Ltd. | Removal of constructs from transformed cells | 
| US12031140B2              (en)* | 2019-11-25 | 2024-07-09 | Syngenta Crop Protection Ag | Glycine regulatory elements and uses thereof | 
| EP4069830A4              (en)* | 2019-12-02 | 2024-10-02 | Regents of the University of California | Engineering circular guide rnas | 
| CA3162915A1              (en) | 2019-12-17 | 2021-06-24 | Pioneer Hi-Bred International, Inc. | Reduced stature maize and mads-box transcription factors | 
| CN111057713A              (zh)* | 2019-12-18 | 2020-04-24 | 广东省微生物研究所(广东省微生物分析检测中心) | 一种适用于埃德菌FS110的CRISPR/Cas9载体及其构建方法和应用 | 
| BR112022013772A2              (pt)* | 2020-01-09 | 2022-10-11 | Pioneer Hi Bred Int | Troca de genes em duas etapas | 
| US12157892B2              (en)* | 2020-01-22 | 2024-12-03 | Pioneer Hi-Bred International, Inc. | Dominant CRISPR inverted-repeat alleles to down-regulate gene expression in heterozygous plants | 
| CN115066175A              (zh)* | 2020-02-12 | 2022-09-16 | 先锋国际良种公司 | Cas介导的体细胞植物组织中的同源定向修复 | 
| EP4110905A4              (en) | 2020-02-24 | 2024-03-27 | Pioneer Hi-Bred International, Inc. | Intra-genomic homologous recombination | 
| AU2021226415A1              (en) | 2020-02-28 | 2022-09-15 | Pioneer Hi-Bred International, Inc. | Sorghum doubled haploid production system | 
| WO2021183874A1              (en)* | 2020-03-13 | 2021-09-16 | Pairwise Plants Services, Inc. | Methods of introducing variation into plants and products produced therefrom | 
| EP4125338A4              (en) | 2020-03-30 | 2024-05-01 | Inari Agriculture Technology, Inc. | Improved polynucleotides for expression of rna-guided nucleases and dna binding proteins in soybean | 
| CN115362370A              (zh) | 2020-04-02 | 2022-11-18 | 先锋国际良种公司 | 新颖的杀昆虫毒素受体和使用方法 | 
| WO2021211227A1              (en) | 2020-04-15 | 2021-10-21 | Pioneer Hi-Bred International, Inc. | Plant pathogen effector and disease resistance gene identification, compositions, and methods of use | 
| TW202208626A              (zh)* | 2020-04-24 | 2022-03-01 | 美商生命編輯公司 | Rna引導核酸酶及其活性片段與變體,以及使用方法 | 
| AU2021267940A1              (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence | 
| JP2023526035A              (ja)* | 2020-05-13 | 2023-06-20 | ヌンヘムス ビー.ブイ. | 標的突然変異生成によって変異体植物を得るための方法 | 
| JP2023528434A              (ja)* | 2020-06-03 | 2023-07-04 | パイオニア ハイ-ブレッド インターナショナル, インコーポレイテッド | トウモロコシイベントdp-915635-4及びその検出方法 | 
| CN111778274A              (zh)* | 2020-06-09 | 2020-10-16 | 新疆生产建设兵团第六师农业科学研究所 | 一种通过基因编辑提高番茄耐贮藏性的方法 | 
| WO2021252238A1              (en) | 2020-06-12 | 2021-12-16 | Pioneer Hi-Bred International, Inc. | Alteration of seed composition in plants | 
| EP4168561A4              (en) | 2020-07-20 | 2024-08-21 | Flagship Pioneering, Inc. | VIROID-DERIVED POLYNUCLEOTIDES FOR PLANT MODIFICATIONS | 
| US11242534B1              (en) | 2020-07-31 | 2022-02-08 | Inari Agriculture Technology, Inc. | INHT31 transgenic soybean | 
| US11369073B2              (en) | 2020-07-31 | 2022-06-28 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize | 
| US20240011043A1              (en) | 2020-07-31 | 2024-01-11 | Inari Agriculture Technology, Inc. | Generation of plants with improved transgenic loci by genome editing | 
| US11214811B1              (en) | 2020-07-31 | 2022-01-04 | Inari Agriculture Technology, Inc. | INIR6 transgenic maize | 
| US11326177B2              (en) | 2020-07-31 | 2022-05-10 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize | 
| US11359210B2              (en) | 2020-07-31 | 2022-06-14 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize | 
| WO2022031720A1              (en)* | 2020-08-03 | 2022-02-10 | Arcadia Biosciences, Inc. | Dna constructs containing rna polymerase iii promoters from cannabis, and methods of their use | 
| WO2022038536A1              (en) | 2020-08-18 | 2022-02-24 | International Rice Research Institute | Methods of increasing outcrossing rates in gramineae | 
| US20220056470A1              (en) | 2020-08-18 | 2022-02-24 | Pioneer Hi-Bred International, Inc. | Multiple disease resistance genes and genomic stacks thereof | 
| JP2023541418A              (ja)* | 2020-09-10 | 2023-10-02 | モンサント テクノロジー エルエルシー | 減数分裂及び生殖系列プロモーターを使用する遺伝子編集及び部位特異的組込み事象の増加 | 
| KR102579767B1              (ko)* | 2020-09-21 | 2023-09-18 | 서울대학교산학협력단 | eIF4E1 유전자 교정에 의해 포티바이러스 저항성이 증가된 유전체 교정 토마토 식물체의 제조방법 및 상기 방법에 의해 제조된 포티바이러스 저항성이 증가된 유전체 교정 토마토 식물체 | 
| US11198885B1              (en) | 2020-09-28 | 2021-12-14 | Inari Agriculture Technology, Inc. | Genetic regulatory element | 
| US11976291B2              (en) | 2020-09-28 | 2024-05-07 | Inari Agriculture Technology, Inc. | Genetically enhanced maize plants | 
| US12188031B2              (en) | 2020-09-28 | 2025-01-07 | Inari Agriculture Technology, Inc. | Genetic regulatory element | 
| IL301914A              (en) | 2020-10-05 | 2023-06-01 | Protalix Ltd | Dicer-like knock-out plant cells | 
| JP2023545493A              (ja)* | 2020-10-14 | 2023-10-30 | パイオニア ハイ-ブレッド インターナショナル, インコーポレイテッド | ゲノム編集の改善のための操作されたCasエンドヌクレアーゼバリアント | 
| CN112481259B              (zh)* | 2020-11-24 | 2022-09-16 | 南昌大学 | 两种甘薯U6基因启动子IbU6的克隆与应用 | 
| US20220185978A1              (en)* | 2020-12-11 | 2022-06-16 | Celanese International Corporation | Foam Formed From Cellulose Ester Composition | 
| WO2022233271A1              (en)* | 2021-05-02 | 2022-11-10 | Qingdao Kingagroot Chemical Compound Co., Ltd. | Method for generating new gene in organism and use thereof | 
| JP2024524924A              (ja) | 2021-07-02 | 2024-07-09 | トロピック バイオサイエンシーズ ユーケー リミテッド | バナナ果実における褐変の遅延又は防止 | 
| GB202109586D0              (en) | 2021-07-02 | 2021-08-18 | Tropic Biosciences Uk Ltd | Method for editing banana genes | 
| GB202112865D0              (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to black sigatoka disease in banana | 
| GB202112866D0              (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to fusarium wilt in a banana | 
| CN117957317A              (zh) | 2021-09-10 | 2024-04-30 | 安捷伦科技有限公司 | 用于先导编辑的具有化学修饰的指导rna | 
| MX2024005239A              (es) | 2021-11-01 | 2024-07-22 | Flagship Pioneering Innovations Vii Llc | Polinucleotidos para modificar organismos. | 
| WO2023102393A1              (en) | 2021-11-30 | 2023-06-08 | Pioneer Hi-Bred International, Inc. | High efficiency large scale chromosomal genome manipulation | 
| US20250230452A1              (en) | 2022-01-20 | 2025-07-17 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms | 
| EP4490299A1              (en)* | 2022-03-07 | 2025-01-15 | Inedita Bio, Inc. | Methods and compositions for intron mediated- expression of regulatory elements for trait development | 
| CN114836446B              (zh)* | 2022-04-26 | 2023-12-19 | 上海交通大学 | 一种抗草甘膦的植物及其制法 | 
| WO2024005863A1              (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing | 
| WO2024006802A1              (en) | 2022-06-30 | 2024-01-04 | Pioneer Hi-Bred International, Inc. | Artificial intelligence-mediated methods and systems for genome editing | 
| WO2024005864A1              (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing | 
| EP4299739A1              (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing | 
| EP4299733A1              (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing | 
| WO2024020360A1              (en) | 2022-07-18 | 2024-01-25 | Pairwise Plants Services, Inc. | Mustard green plants named 'pwrg-1', 'pwrg-2,' and 'pwsgc' | 
| CN119630800A              (zh)* | 2022-07-27 | 2025-03-14 | 先锋国际良种公司 | 指导rna捕获的基因组编辑 | 
| EP4562168A1              (en) | 2022-07-28 | 2025-06-04 | Institut Pasteur | Hsc70-4 in host-induced and spray-induced gene silencing | 
| WO2024036190A2              (en) | 2022-08-09 | 2024-02-15 | Pioneer Hi-Bred International, Inc. | Guide polynucleotide multiplexing | 
| WO2024118876A1              (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system | 
| EP4627078A1              (en) | 2022-12-01 | 2025-10-08 | Danisco US Inc. | Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system | 
| EP4627077A1              (en) | 2022-12-01 | 2025-10-08 | Danisco US Inc. | Iterative multiplex genome engineering in microbial cells using a selection marker swapping system | 
| WO2024123786A1              (en) | 2022-12-06 | 2024-06-13 | Pioneer Hi-Bred International, Inc. | Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants | 
| CN120731217A              (zh) | 2022-12-21 | 2025-09-30 | 唐纳德丹福斯植物科学中心 | 抗微生物肽及其修饰 | 
| CN115762641B              (zh)* | 2023-01-10 | 2023-04-07 | 天津极智基因科技有限公司 | 一种指纹图谱构建方法及系统 | 
| WO2024196921A1              (en) | 2023-03-20 | 2024-09-26 | Pioneer Hi-Bred International, Inc. | Cas polypeptides with altered pam recognition | 
| WO2024218295A1              (en) | 2023-04-21 | 2024-10-24 | Vib Vzw | Allelic combinations in crops for yield increase | 
| AR132588A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de tymovirales artificiales | 
| AR132591A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de secoviridae artificiales | 
| WO2024229395A1              (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Partitiviral satellite rna amplification systems for plants | 
| WO2024229347A1              (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial tombusviridae satellite rnas | 
| WO2024229385A1              (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial ghabrivirales satellite rnas | 
| AR132587A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de martellivirales artificiales | 
| AR132585A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Sistemas de amplificación de arn satélite endornavirales para plantas | 
| AR132586A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de amalgavirus artificiales | 
| AR132589A1              (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de solemoviridae artificiales | 
| US20240382622A1              (en) | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression | 
| WO2025021702A1              (en) | 2023-07-21 | 2025-01-30 | Alia Therapeutics S.R.L. | Cas9 orthologue nuclease and uses thereof | 
| WO2025038723A1              (en) | 2023-08-14 | 2025-02-20 | The Texas A&M University System | Corn endotype-derived polypeptides capable of metabolizing fumonisin | 
| WO2025059184A1              (en) | 2023-09-12 | 2025-03-20 | Pioneer Hi-Bred International, Inc. | Methods and compositions for generating genome-edited paternal doubled haploids | 
| WO2025076141A1              (en) | 2023-10-03 | 2025-04-10 | Inari Agriculture Technology, Inc. | Viral delivery of grna to the scion | 
| WO2025132372A1              (en) | 2023-12-21 | 2025-06-26 | Technische Universität München | Plant sensor twa1 as molecular thermogenetic control switch and for improvement of thermotolerance and modifying of senescence | 
| WO2025168705A1              (en) | 2024-02-08 | 2025-08-14 | Vib Vzw | Means and methods for the production of saponins with endosomal escape-enhancing properties | 
| WO2025184759A1              (en) | 2024-03-04 | 2025-09-12 | Pioneer Hi-Bred International, Inc. | Maize plants comprising resistance to gray leaf spot and compositions and methods for selecting and producing the same | 
| CN119842730A              (zh)* | 2024-12-20 | 2025-04-18 | 中国科学院遗传与发育生物学研究所 | 一种调控大豆根瘤共生固氮的基因GmPMT及其应用 |