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MX344701B - Pyrrole derivatives used as modulators of alpha7 nachr. - Google Patents

Pyrrole derivatives used as modulators of alpha7 nachr.

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Publication number
MX344701B
MX344701BMX2013008947AMX2013008947AMX344701BMX 344701 BMX344701 BMX 344701BMX 2013008947 AMX2013008947 AMX 2013008947AMX 2013008947 AMX2013008947 AMX 2013008947AMX 344701 BMX344701 BMX 344701B
Authority
MX
Mexico
Prior art keywords
pyrrole derivatives
nicotinic acetylcholine
acetylcholine receptors
modulators
subtype
Prior art date
Application number
MX2013008947A
Other languages
Spanish (es)
Other versions
MX2013008947A (en
Inventor
Neelima Sinha
Gourhari Jana
Navnath Popat Karche
Shridhar Keshav Adurkar
Girish Dhanraj Hatnapure
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin LtdfiledCriticalLupin Ltd
Publication of MX2013008947ApublicationCriticalpatent/MX2013008947A/en
Publication of MX344701BpublicationCriticalpatent/MX344701B/en

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Abstract

The present invention is related to pyrrole derivatives of formula I as the modulators of nicotinic acetylcholine receptors particularly the a7 subtype. The invention includes pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically acceptable salts, polymorphs, solvates, optical isomers, clathrates, co-crystals, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them. Owing to the modulatory activity of the pyrrole derivatives on the nicotinic acetylcholine receptors, the invention finds application in the prophylaxis and therapy of disorders encompassing the involvement of cholinergic transmission in the central and peripheral nervous system. The invention relates to the ability of pyrrole derivatives to modulate the cholinergic transmission and efficacy of the endogenous neurotransmitter ACh thorough the nicotinic acetylcholine receptors particularly the a7 subtype.
MX2013008947A2011-02-032012-01-31Pyrrole derivatives used as modulators of alpha7 nachr.MX344701B (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
IN151KO20112011-02-03
PCT/IB2012/050442WO2012104782A1 (en)2011-02-032012-01-31Pyrrole derivatives used as modulators of alpha7 nachr

Publications (2)

Publication NumberPublication Date
MX2013008947A MX2013008947A (en)2014-01-08
MX344701Btrue MX344701B (en)2017-01-03

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ID=45787252

Family Applications (1)

Application NumberTitlePriority DateFiling Date
MX2013008947AMX344701B (en)2011-02-032012-01-31Pyrrole derivatives used as modulators of alpha7 nachr.

Country Status (11)

CountryLink
US (1)US20130310419A1 (en)
EP (1)EP2670744B1 (en)
JP (1)JP5865397B2 (en)
KR (1)KR20140041442A (en)
CN (1)CN103443092B (en)
AU (1)AU2012213086B2 (en)
BR (1)BR112013019893A2 (en)
CA (1)CA2825519A1 (en)
MX (1)MX344701B (en)
SG (1)SG192078A1 (en)
WO (1)WO2012104782A1 (en)

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SG193387A1 (en)*2011-03-312013-10-30Lupin LtdPyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
IN2014MN01756A (en)2012-03-062015-07-03Lupin Ltd
US20150299178A1 (en)2012-11-122015-10-22Lupin LimitedThiazole Derivatives as Alpha 7 NACHR Modulators
WO2014111839A1 (en)2013-01-162014-07-24Lupin LimitedPyrrole derivatives as alpha 7 nachr modulators
WO2014141091A1 (en)2013-03-132014-09-18Lupin LimitedPyrrole derivatives as alpha 7 nachr modulators
TW201446243A (en)2013-06-032014-12-16Lupin Ltd4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide as alpha 7 nAChR modulator
US9504680B2 (en)2013-06-172016-11-29Lupin LimitedPyrrole derivatives as alpha 7 nAChR modulators
GB2516045A (en)*2013-07-092015-01-14Neuro Bio LtdNeurodegenerative disorders
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Also Published As

Publication numberPublication date
MX2013008947A (en)2014-01-08
NZ613467A (en)2015-03-27
WO2012104782A1 (en)2012-08-09
CN103443092A (en)2013-12-11
EP2670744A1 (en)2013-12-11
SG192078A1 (en)2013-08-30
CN103443092B (en)2015-11-25
CA2825519A1 (en)2012-09-08
KR20140041442A (en)2014-04-04
AU2012213086A1 (en)2013-08-22
BR112013019893A2 (en)2016-10-11
EP2670744B1 (en)2015-05-27
AU2012213086B2 (en)2016-05-05
JP2014504632A (en)2014-02-24
JP5865397B2 (en)2016-02-17
US20130310419A1 (en)2013-11-21

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