Movatterモバイル変換

[0]ホーム
URL:

ME03481B - Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors - Google Patents

Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors

Info

Publication number
ME03481B
ME03481BMEP-2019-147AMEP2019147AME03481BME 03481 BME03481 BME 03481BME P2019147 AMEP2019147 AME P2019147AME 03481 BME03481 BME 03481B
Authority
ME
Montenegro
Prior art keywords
parp
adp
ribose
polymerase
inhibitors
Prior art date
Application number
MEP-2019-147A
Other languages
German (de)
French (fr)
Unknown language (me)
Inventor
Ontoria Jesus Maria Ontoria
Rita Scarpeli
Carsten Schultz-Fademrecht
Philip Jones
Original Assignee
Msd Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME03481(B)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Italia SrlfiledCriticalMsd Italia Srl
Priority claimed from EP14176452.2Aexternal-prioritypatent/EP2805945B1/en
Publication of ME03481BpublicationCriticalpatent/ME03481B/en

Links

Classifications

Landscapes

Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory discuses, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo and/or radiosensitizers for cancer treatment.
MEP-2019-147A2007-01-102008-01-08Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitorsME03481B (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
GBGB0700432.8AGB0700432D0 (en)2007-01-102007-01-10Therapeutic compounds
US92131007P2007-04-022007-04-02
EP14176452.2AEP2805945B1 (en)2007-01-102008-01-08Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors

Publications (1)

Publication NumberPublication Date
ME03481Btrue ME03481B (en)2020-01-20

Family

ID=37809722

Family Applications (1)

Application NumberTitlePriority DateFiling Date
MEP-2019-147AME03481B (en)2007-01-102008-01-08Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors

Country Status (21)

CountryLink
CN (1)CN101578279B (en)
AT (1)ATE502933T1 (en)
CR (1)CR10910A (en)
DE (1)DE602008005711D1 (en)
DK (2)DK2336120T3 (en)
ES (3)ES2362214T3 (en)
GB (1)GB0700432D0 (en)
HN (1)HN2009001260A (en)
HU (1)HUE044513T2 (en)
LT (1)LT2805945T (en)
LU (1)LUC00072I2 (en)
ME (1)ME03481B (en)
MY (1)MY147789A (en)
NI (1)NI200900135A (en)
NZ (1)NZ578256A (en)
PE (1)PE20081558A1 (en)
PT (3)PT2805945T (en)
SI (2)SI2336120T1 (en)
TW (1)TWI528961B (en)
UA (1)UA97658C2 (en)
ZA (1)ZA200903898B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN106496187A (en)*2016-09-142017-03-15陕西科技大学A kind of synthetic method for preparing PARP inhibitor Niraparib
CN106432188A (en)*2016-09-172017-02-22青岛辰达生物科技有限公司Preparation method of anti-cancer drug 2-[4-((3S)-3-Piperidinyl) phenyl]-2H-Indazole-7-Formamide
CN106432187A (en)*2016-09-172017-02-22青岛云天生物技术有限公司Chiral resolution method of 2-[4-(-3-piperidyl)phenyl]-2H-indazole-7-formamide
CN106632244A (en)*2016-09-302017-05-10陕西科技大学A novel synthetic method for preparing an anticancer medicine Niraparib
CN106467513A (en)*2016-09-302017-03-01陕西科技大学A kind of synthetic method preparing Niraparib
CN108201537A (en)*2016-12-162018-06-26苏州苏融生物医药有限公司A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof
WO2018183349A1 (en)*2017-03-272018-10-04Tesaro, Inc.Niraparib formulations
CN109081828B (en)*2017-06-142021-03-26上海时莱生物技术有限公司Poly (ADP-ribose) polymerase inhibitor, preparation method and application
CN111278433A (en)2017-09-262020-06-12特沙诺有限公司Nilaparib formulations
CN108084157A (en)*2018-02-122018-05-29安庆奇创药业有限公司A kind of synthetic method of Ni Lapani
CN108203404A (en)*2018-03-022018-06-26上海博邦医药科技有限公司(R) synthetic method of -3- Phenylpiperidines or/and the chiral intermediate of (S) -3- Phenylpiperidines and Ni Lapani
US20240016775A1 (en)2020-02-242024-01-18Fukang (Shanghai) Health Technology Co., LtdAnti-coronavirus application of poly adp ribose polymerase inhibitor
CN115611860B (en)*2021-07-132024-06-11上海博璞诺科技发展有限公司Method for synthesizing nilaparib

Also Published As

Publication numberPublication date
CN101578279B (en)2013-07-17
MY147789A (en)2013-01-31
DK2109608T3 (en)2011-07-11
SI2109608T1 (en)2011-07-29
LT2805945T (en)2019-06-25
TW200836731A (en)2008-09-16
ATE502933T1 (en)2011-04-15
ES2509115T3 (en)2014-10-17
HN2009001260A (en)2012-03-26
DK2336120T3 (en)2014-10-06
DE602008005711D1 (en)2011-05-05
UA97658C2 (en)2012-03-12
HUE044513T2 (en)2019-10-28
ES2362214T3 (en)2011-06-29
PE20081558A1 (en)2008-10-30
PT2336120E (en)2014-10-01
GB0700432D0 (en)2007-02-21
NZ578256A (en)2011-12-22
CR10910A (en)2010-01-19
CN101578279A (en)2009-11-11
ZA200903898B (en)2010-04-28
PT2109608E (en)2011-05-30
NI200900135A (en)2010-08-30
TWI528961B (en)2016-04-11
PT2805945T (en)2019-06-06
SI2336120T1 (en)2014-10-30
LUC00072I2 (en)2018-07-04
ES2728199T3 (en)2019-10-22

Similar Documents

PublicationPublication DateTitle
MX2009007200A (en)Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors.
ZA200903898B (en)Amide substituted indazoles as poly (ADP-Ribose)polymerase (PARP) inhibitors
MX2010005070A (en)Pyridazinone derivatives as parp inhibitors.
WO2007138351A3 (en)Pyridinone and pyridazinone derivatives as inhibitors of poly(adp-ribose)polymerase (parp)
MX2012002179A (en)Heterocyclic oxime compounds.
WO2008103277A3 (en)Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
ATE543811T1 (en) PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS
MX2013001204A (en)Compounds for the treatment/prevention of ocular inflammatory diseases.
WO2010045251A3 (en)Spiro-oxindole compounds and their use as therapeutic agents
MX2011011854A (en)Dihydropyrimidinones for use as bace2 inhibitors.
EA201070864A1 (en) NEW HETEROCYCLIC COMPOUNDS
WO2008017883A3 (en)4-oxo-4,5-dihydropyrrolo[1,2-a] quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
MX2012007582A (en)4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds.
WO2011147951A8 (en)Cycloamino derivatives as gpr119 agonists
MX2011013869A (en)Anthelmintic agents and their use.
GB201114389D0 (en)Novel compounds
PH12015500418A1 (en)Pyridine derivative and medicine
UA101367C2 (en)Normal;heading 1;heading 2;heading 3;HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
[8]ページ先頭
©2009-2025 Movatter.jp