Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21704492 | 1992-08-14 | ||
JP5192586AJP2777530B2 (ja) | 1992-08-14 | 1993-08-03 | 物理吸着型高分子ミセル医薬 |
Publication Number | Publication Date |
---|---|
KR940003548Utrue KR940003548U (ko) | 1994-02-21 |
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR2019930004566UKR940003548U (ko) | 1992-08-14 | 1993-03-24 | 세탁물 건조기 |
KR1019930015734AKR960009407B1 (ko) | 1992-08-14 | 1993-08-14 | 물리포착형 중합체 미셀 약제 |
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930015734AKR960009407B1 (ko) | 1992-08-14 | 1993-08-14 | 물리포착형 중합체 미셀 약제 |
Country | Link |
---|---|
US (2) | US5449513A (ko) |
EP (1) | EP0583955B1 (ko) |
JP (1) | JP2777530B2 (ko) |
KR (2) | KR940003548U (ko) |
AU (1) | AU668967B2 (ko) |
CA (1) | CA2104045C (ko) |
DE (1) | DE69327490T2 (ko) |
ES (1) | ES2141135T3 (ko) |
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153193A (en)* | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
US6277410B1 (en) | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
US6093391A (en)* | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
US5716981A (en)* | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
DK1159974T3 (da) | 1993-07-19 | 2007-11-26 | Angiotech Pharm Inc | Antiangiogene sammensætninger indeholdende taxol og en ikke-bionedbrydelig bærer og deres anvendelse |
US5686110A (en)* | 1994-06-02 | 1997-11-11 | Enzon, Inc. | Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance |
US5567410A (en)* | 1994-06-24 | 1996-10-22 | The General Hospital Corporation | Composotions and methods for radiographic imaging |
US6353055B1 (en)* | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
JP2690276B2 (ja)* | 1995-01-10 | 1997-12-10 | 科学技術振興事業団 | 静電結合型高分子ミセル薬物担体とその薬剤 |
AU4574202A (en)* | 1995-01-10 | 2002-07-18 | Research Development Corporation Of Japan | Electrostatic bonding type macromolecular micelle drug carrier and drug carried thereon |
JPH11510837A (ja) | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
EP0844269B1 (en)* | 1995-08-10 | 2002-10-23 | Kazunori Kataoka | Block copolymer having functional groups at both ends |
US5770627A (en)* | 1995-08-16 | 1998-06-23 | University Of Washington | Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto |
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
BR9606674B1 (pt)* | 1995-09-29 | 2010-08-10 | novo derivado de composto de antraciclina e preparação farmacêutica contendo o mesmo. | |
EP0897929B1 (en) | 1996-05-09 | 2004-03-24 | Nippon Suisan Kaisha, Ltd. | Chitin derivatives having carboxylated lower alkyl groups as hydrophilic substituents and hydrophobic substituents, high-molecular micellar supports comprising the derivatives, and micellar aqueous composition thereof |
EP1616563A3 (en)* | 1996-05-24 | 2006-01-25 | Angiotech Pharmaceuticals, Inc. | Perivascular administration of anti-angiogenic factors for treating or preventing vascular diseases |
DE19634477C2 (de)* | 1996-06-05 | 2002-10-17 | Forschungszentrum Juelich Gmbh | Verfahren zur Herstellung von hydrophob-hydrophilen AB-Blockcopolymeren und AB-Blockcopolymer |
US6054492A (en)* | 1996-09-09 | 2000-04-25 | Supratek Pharma Inc. | Fluorinated copolymeric pharmaceutical adjuncts |
CA2291622C (en) | 1997-06-06 | 2007-09-04 | Anna Gutowska | Reversible geling co-polymer and method of making |
WO1998056348A1 (en)* | 1997-06-13 | 1998-12-17 | University Of Nebraska Board Of Regents | Compositions for delivery of biological agents and methods for the preparation thereof |
JP2002504123A (ja)* | 1997-06-13 | 2002-02-05 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 生物学的物質をデリバリーするための組成物およびその製法 |
US6060235A (en)* | 1997-09-19 | 2000-05-09 | Geltex Pharmaceuticals, Inc. | Antiviral polymers comprising acid functional groups and hydrophobic groups |
GB9721367D0 (en) | 1997-10-09 | 1997-12-10 | Univ Liverpool | Delivery system |
FR2774096B1 (fr)* | 1998-01-29 | 2000-04-07 | Virsol | Nouveaux copolymeres tensioactifs a base de methylidene malonate |
US20120088848A1 (en)* | 1998-03-19 | 2012-04-12 | Deming Timothy J | Methods and compositions for controlled polypeptide synthesis |
US20040254635A1 (en) | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US7208011B2 (en) | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
DE19814739A1 (de)* | 1998-04-02 | 1999-10-07 | Basf Ag | Verwendung von Polyalkylenoxid-haltigen Pfropfpolymerisaten als Solubilisatoren |
US20040228794A1 (en)* | 1998-04-10 | 2004-11-18 | Battelle Memorial Institute | Therapeutic agent carrier compositions |
US7087244B2 (en)* | 2000-09-28 | 2006-08-08 | Battelle Memorial Institute | Thermogelling oligopeptide polymers |
US6841617B2 (en)* | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
FR2778100B1 (fr) | 1998-04-29 | 2001-05-04 | Virsol | Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant |
US5939453A (en)* | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
US6293967B1 (en) | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US20040234472A1 (en) | 2001-04-20 | 2004-11-25 | Jackson John K. | Micellar drug delivery systems for hydrophobic drugs |
US6365191B1 (en)* | 1999-02-17 | 2002-04-02 | Dabur Research Foundation | Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof |
US6290673B1 (en) | 1999-05-20 | 2001-09-18 | Conor Medsystems, Inc. | Expandable medical device delivery system and method |
KR100360827B1 (ko) | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법 |
AU7599900A (en)* | 1999-09-23 | 2001-04-24 | Dabur Research Foundation | Formulations of paclitaxel entrapped into nanoparticles of polymeric micelles |
FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
JP3523821B2 (ja)* | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
US7256180B2 (en) | 2000-04-28 | 2007-08-14 | Supratek Pharma Inc. | Compositions and methods for inducing activation of dendritic cells |
ES2390066T3 (es)* | 2000-05-12 | 2012-11-06 | Samyang Biopharmaceuticals Corporation | Procedimiento para la preparación de micelas poliméricas mediante separación de fase de un copolímero en bloque |
US7217770B2 (en)* | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
FR2814952B1 (fr)* | 2000-10-06 | 2004-01-02 | Flamel Tech Sa | Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation |
US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
GB2369297B (en)* | 2000-09-18 | 2005-04-27 | Univ Delhi | A sustained release and long residing opthalmic formulation and the process of preparing the same |
US6579519B2 (en)* | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
AU2001292235A1 (en)* | 2000-09-26 | 2002-04-08 | Center For Advanced Science And Technology Incubation, Ltd. | Polymeric micelle containing cisplatin enclosed therein and use thereof |
FR2814951B1 (fr)* | 2000-10-06 | 2003-01-17 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation |
AU2001294634B2 (en) | 2000-10-16 | 2006-07-06 | Innovational Holdings, Llc | Expandable medical device for delivery of beneficial agent |
US6764507B2 (en) | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
KR100418916B1 (ko)* | 2000-11-28 | 2004-02-14 | 한국과학기술원 | 생분해성 고분자와 항암제의 접합체를 이용한 서방형미셀제제의 제조방법 |
US20040073294A1 (en) | 2002-09-20 | 2004-04-15 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
US6964680B2 (en) | 2001-02-05 | 2005-11-15 | Conor Medsystems, Inc. | Expandable medical device with tapered hinge |
US20030157170A1 (en)* | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
CA2440935A1 (en)* | 2001-03-13 | 2002-09-19 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
FR2822834B1 (fr)* | 2001-04-02 | 2005-02-25 | Flamel Tech Sa | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
US7094810B2 (en)* | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
US6939564B2 (en)* | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
WO2003002096A1 (en)* | 2001-06-28 | 2003-01-09 | Wisconsin Alumni Research Foundation | Methods and compositions for polyene antibiotics with reduced toxicity |
JP4063510B2 (ja)* | 2001-07-13 | 2008-03-19 | ナノキャリア株式会社 | 薬物含有高分子ミセルの凍結乾燥用組成物およびその凍結乾燥製剤 |
US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
KR100774366B1 (ko) | 2001-09-10 | 2007-11-08 | 주식회사 중외제약 | 파클리탁셀 주사제 조성물 |
US6592899B2 (en) | 2001-10-03 | 2003-07-15 | Macromed Incorporated | PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
FR2830447B1 (fr)* | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
DE60222007T2 (de)* | 2001-10-18 | 2008-05-15 | Samyang Corp. | Polymermicellenzusammensetzung mit verbesserter stabilität |
EP1572933A4 (en) | 2002-02-13 | 2007-09-05 | Univ Duke | MODULATION OF THE IMMUNE RESPONSE BY POLYPEPTIDES AS AN ANSWER TO NONPEPTIDIC BINDING STRENGTH |
US6780324B2 (en) | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
US20040010060A1 (en)* | 2002-03-20 | 2004-01-15 | Mathieu Joanicot | Vesicles comprising an amphiphilic di-block copolymer and a hydrophobic compound |
US20040005351A1 (en)* | 2002-03-29 | 2004-01-08 | Kwon Glen S. | Polymeric micelle formulations of hydrophobic compounds and methods |
DE60325709D1 (de) | 2002-04-09 | 2009-02-26 | Flamel Tech Sa | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
BR0309093A (pt)* | 2002-04-09 | 2005-02-09 | Flamel Tech Sa | Formulação farmacêutica oral sob a forma de suspensão aquosa de microcápsulas permitindo a liberação modificada de amoxicilina |
FR2838964B1 (fr)* | 2002-04-26 | 2004-07-09 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et leur mode de preparation |
JP2003342168A (ja)* | 2002-05-24 | 2003-12-03 | Nano Career Kk | 注射用薬物含有ポリマーミセル製剤の製造方法 |
JP2004010479A (ja)* | 2002-06-03 | 2004-01-15 | Japan Science & Technology Corp | ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法 |
FR2840614B1 (fr)* | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
JP2004018494A (ja)* | 2002-06-19 | 2004-01-22 | Japan Science & Technology Corp | ブロック共重合体−薬剤複合体の製造法 |
FR2843117B1 (fr)* | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
US20040034336A1 (en)* | 2002-08-08 | 2004-02-19 | Neal Scott | Charged liposomes/micelles with encapsulted medical compounds |
KR100502840B1 (ko)* | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | 약물 담지능력이 우수한 블록 공중합체 미셀 조성물 |
AU2003279770A1 (en)* | 2002-10-01 | 2004-04-23 | Novartis Vaccines And Diagnostics, Inc. | Anti-cancer and anti-infectious disease compositions and methods for using same |
WO2004034992A2 (en)* | 2002-10-15 | 2004-04-29 | Wisconsin Alumni Research Foundation | Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles |
US7045589B2 (en)* | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
CA2508751A1 (fr)* | 2002-12-04 | 2004-07-22 | Flamel Technologies | Polyaminoacides fonctionnalises par au moins un groupement (oligo)aminoacide et leurs applications notamment therapeutiques |
PL1604687T3 (pl)* | 2003-03-20 | 2011-04-29 | Nippon Kayaku Kk | Preparat micelarny zawierający słabo rozpuszczalny w wodzie lek przeciwnowotworowy oraz nowy kopolimer blokowy |
WO2004087214A1 (en) | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device with beneficial agent concentration gradient |
US7517342B2 (en)* | 2003-04-29 | 2009-04-14 | Boston Scientific Scimed, Inc. | Polymer coated device for electrically medicated drug delivery |
FR2855521B1 (fr) | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
WO2004105799A1 (ja)* | 2003-05-29 | 2004-12-09 | Toudai Tlo, Ltd. | 安定化高分子ミセル |
US7169179B2 (en) | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
WO2005018607A1 (ja)* | 2003-08-20 | 2005-03-03 | Ajinomoto Co., Inc. | 溶解性を改善した医薬品製剤 |
US7785653B2 (en) | 2003-09-22 | 2010-08-31 | Innovational Holdings Llc | Method and apparatus for loading a beneficial agent into an expandable medical device |
FR2860516B1 (fr)* | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
US7311901B2 (en)* | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
FR2862536B1 (fr)* | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
US20050226932A1 (en)* | 2004-04-09 | 2005-10-13 | Samyang Corporation | Pharmaceutical formulations for itraconazole |
FR2873703B1 (fr)* | 2004-07-30 | 2006-12-08 | Flamel Technologies Sa | Polyaminoacides branches, fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
FR2873704B1 (fr)* | 2004-07-30 | 2006-12-08 | Flamel Technologies Sa | Polyaminoacides fonctionnalises par des greffons hydrophobes portant une charge anionique et leurs applications notamment therapeutiques |
EP1792927B1 (en)* | 2004-09-22 | 2013-03-06 | Nippon Kayaku Kabushiki Kaisha | Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
WO2006057429A1 (ja)* | 2004-11-24 | 2006-06-01 | Nanocarrier Co., Ltd. | ブロックコポリマーのモーフォロジ-の変化方法 |
WO2006033641A1 (en)* | 2004-12-22 | 2006-03-30 | Merlin Md Pte Ltd | A medical device |
AU2006204067B2 (en)* | 2005-01-04 | 2011-07-07 | Intezyne Technologies, Incorporated | Synthesis of hybrid block copolymers and uses thereof |
FR2881140B1 (fr)* | 2005-01-27 | 2007-04-06 | Flamel Technologies Sa | Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
EP1848460A4 (en)* | 2005-02-11 | 2008-03-12 | Intezyne Technologies Inc | SYNTHESIS OF HOMOPOLYMERS AND COPOLYMERS SEQUENCES |
EP1848410A4 (en)* | 2005-02-17 | 2011-11-09 | Medivas Llc | COMPOSITIONS FOR DISPENSING POLYMER PARTICLES AND APPLICATION METHOD THEREFOR |
AU2006221448B2 (en)* | 2005-03-09 | 2012-03-15 | Toray Industries, Inc. | Microparticle and pharmaceutical composition |
WO2006098496A1 (ja)* | 2005-03-18 | 2006-09-21 | The University Of Tokyo | ジアミノシクロヘキサン白金(ii)とブロック共重合体との配位化合物及びそれを含有する抗がん剤 |
JP4610391B2 (ja)* | 2005-03-30 | 2011-01-12 | ピアス株式会社 | カチオン型高分子ミセル薬物担体を配合した皮膚外用剤、化粧料 |
WO2006105123A2 (en)* | 2005-03-31 | 2006-10-05 | Ap Pharma, Inc. | Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions |
ATE440117T1 (de) | 2005-04-01 | 2009-09-15 | Intezyne Technologies Inc | Polymermicellen für die arzneistoffzufuhr |
US20060224095A1 (en)* | 2005-04-05 | 2006-10-05 | University Of New Hampshire | Biocompatible polymeric vesicles self assembled from triblock copolymers |
AU2006238072A1 (en)* | 2005-04-18 | 2006-10-26 | Hiroshi Maeda | Polymeric pharmaceutical agent for treatment of cancer and process for production of the same |
EP1926780B1 (en) | 2005-09-22 | 2013-08-14 | Medivas, LLC | Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
CN101331173A (zh) | 2005-10-05 | 2008-12-24 | 东京Cro株式会社 | 生物相容性嵌段共聚物、其用途和制造方法 |
FR2892725B1 (fr)* | 2005-10-31 | 2011-03-04 | Flamel Tech Sa | Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques |
KR20080074207A (ko)* | 2005-12-05 | 2008-08-12 | 닛토덴코 가부시키가이샤 | 폴리글루타메이트-아미노산 콘쥬게이트 및 이의 제조 방법 |
US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
MX2008008423A (es) | 2005-12-28 | 2008-09-23 | Dabur Pharma Ltd | Polimero no toxico, no biodegradable, biocompatible, util para composiciones farmaceuticas con nanoparticulas. |
KR20080106254A (ko) | 2006-03-28 | 2008-12-04 | 니폰 가야꾸 가부시끼가이샤 | 탁산류의 고분자 결합체 |
JP2009534309A (ja) | 2006-03-31 | 2009-09-24 | マサチューセッツ インスティテュート オブ テクノロジー | 治療剤の標的化送達のためのシステム |
JPWO2007126110A1 (ja)* | 2006-04-24 | 2009-09-17 | ナノキャリア株式会社 | 低分子薬物内包ポリマーミセルの製造方法 |
EP2019691B1 (en)* | 2006-05-15 | 2020-08-12 | Massachusetts Institute of Technology | Polymers for functional particles |
US8940332B2 (en) | 2006-05-18 | 2015-01-27 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
WO2007136134A1 (ja)* | 2006-05-23 | 2007-11-29 | Nanocarrier Co., Ltd. | 疎水性薬物内包ポリマーミセルの製造方法 |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
US8147868B2 (en) | 2006-07-18 | 2012-04-03 | Nanocarrier Co., Ltd. | Physiologically active polypeptide- or protein-encapsulating polymer micelles, and method for production of the same |
EP2050792B1 (en)* | 2006-08-09 | 2013-11-20 | DIC Corporation | Metal nanoparticle dispersion and production process of the same |
WO2008035229A2 (en)* | 2006-09-22 | 2008-03-27 | Labopharm, Inc. | Compositions and methods for ph targeted drug delivery |
WO2008056596A1 (en) | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US20080181852A1 (en)* | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
JP2008214324A (ja)* | 2007-02-28 | 2008-09-18 | Hokkaido Univ | ミセル封入リポソーム |
EP2144600A4 (en) | 2007-04-04 | 2011-03-16 | Massachusetts Inst Technology | POLY (AMINIC ACID) TARGET MOLECULES |
EP2144631A2 (en)* | 2007-04-10 | 2010-01-20 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
DE602008003183D1 (de)* | 2007-04-30 | 2010-12-09 | Intezyne Technologies Inc | Hybride blockcopolymer-mizellen mit gemischter stereochemie zur verkapselung hydrophober stoffe |
FR2915748B1 (fr) | 2007-05-03 | 2012-10-19 | Flamel Tech Sa | Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques |
EP2155254B1 (en)* | 2007-05-09 | 2012-11-28 | Nitto Denko Corporation | Polymers conjugated with platinum drugs |
EP2155253A2 (en)* | 2007-05-09 | 2010-02-24 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
US8197828B2 (en)* | 2007-05-09 | 2012-06-12 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
WO2008151019A1 (en)* | 2007-05-30 | 2008-12-11 | University Of Florida Research Foundation, Inc. | Extended release of bioactive molecules from silicone hydrogels |
US8075909B2 (en)* | 2007-09-04 | 2011-12-13 | University Of Florida Research Foundation, Incorporated | Contact lens based bioactive agent delivery system |
USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
ES2627292T3 (es) | 2007-10-12 | 2017-07-27 | Massachusetts Institute Of Technology | Nanotecnología de vacunas |
WO2009111271A1 (en)* | 2008-03-06 | 2009-09-11 | Nitto Denko Corporation | Polymer paclitaxel conjugates and methods for treating cancer |
WO2009116509A1 (ja) | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
US20110200525A1 (en)* | 2008-10-09 | 2011-08-18 | Patz Jr Edward F | Vhh antibody fragments for use in the detection and treatment of cancer |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
WO2010127154A1 (en)* | 2009-04-30 | 2010-11-04 | Intezyne Technologies, Incorporated | Polymers for polynucleotide encapsulation |
EP2424359A4 (en) | 2009-04-30 | 2014-01-15 | Intezyne Technologies Inc | POLYMIC MICELLES WITH ANTHRACYCLINES FOR THE TREATMENT OF CANCER |
WO2010127159A2 (en)* | 2009-04-30 | 2010-11-04 | Intezyne Technologies, Incorporated | Polymeric micelles for polynucleotide encapsulation |
KR20120094546A (ko)* | 2009-05-04 | 2012-08-24 | 인터자인 테크놀로지스, 인코포레이티드 | 종양 치료를 위한 sn―38을 함유하는 폴리머 미셀 |
US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
CA2768651C (en)* | 2009-08-31 | 2017-05-16 | Nanocarrier Co., Ltd. | Particulate composition and pharmaceutical composition containing the same |
WO2011043980A1 (en) | 2009-10-07 | 2011-04-14 | Sanford Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
JP4829351B2 (ja)* | 2010-02-05 | 2011-12-07 | ナノキャリア株式会社 | 易崩壊型ポリマーミセル組成物 |
JP4653242B1 (ja) | 2010-02-12 | 2011-03-16 | ナノキャリア株式会社 | 粒子状医薬組成物 |
WO2011127405A1 (en) | 2010-04-08 | 2011-10-13 | Sanford-Burnham Medical Research Institute | Methods and compositions for enhanced delivery of compounds |
EP2591792B1 (en) | 2010-07-09 | 2016-12-21 | The University of Tokyo | Composition for nucleic acid delivery, carrier composition, pharmaceutical composition using the composition for nucleic acid delivery or the carrier composition, and method for delivering nucleic acid |
AU2011297045B2 (en) | 2010-09-02 | 2014-12-18 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug-block-copolymer composite and pharmaceutical product containing same |
CA2816997A1 (en) | 2010-11-17 | 2012-05-24 | Nippon Kayaku Kabushiki Kaisha | Novel polymer derivative of cytidine metabolic antagonist |
CA2819635A1 (en) | 2010-12-01 | 2012-06-07 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
EA201390874A1 (ru) | 2010-12-14 | 2013-12-30 | Нэшнл Юниверсити Оф Сингапур | Моноклональное антитело человека со специфичностью к белку e вируса денге серотипа 1 и его применение |
WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
ES2992024T3 (es) | 2011-06-23 | 2024-12-05 | Dsm Ip Assets Bv | Nuevos copolímeros de poliesteramida biodegradables para la administración de fármacos |
US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
PT2754682T (pt) | 2011-09-11 | 2017-08-29 | Nippon Kayaku Kk | Método para o fabrico de copolímero de bloco |
WO2013124867A1 (en) | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules |
US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
US20130259921A1 (en)* | 2012-03-30 | 2013-10-03 | Abbott Cardiovascular Systems Inc. | Treatment Of Diabetic Patients With A Stent And An Adjunctive Drug Formulation |
US10172796B2 (en) | 2012-12-03 | 2019-01-08 | Manli International Ltd. | Use of umirolimus and its derivatives for treating cancer |
WO2014141289A1 (en) | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | Photo - chemo composition on the basis of microcapsules with a core -shell structure |
PL230602B1 (pl) | 2013-04-04 | 2018-11-30 | Centrum Badan Molekularnych I Makromolekularnych Polskiej Akademii Nauk | Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie |
PL223918B1 (pl) | 2013-05-28 | 2016-11-30 | Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk | 3-Arylo-2-fosforylo podstawione 1-indanony i sposób ich wytwarzania |
JP6106103B2 (ja) | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法、並びにこれに用いる新規なアセタール基含有アルコール化合物及びそのアルカリ金属塩 |
JP6106104B2 (ja) | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法 |
US11135316B2 (en) | 2014-01-31 | 2021-10-05 | Washington University | Imaging and treatment of pathophysiologic conditions by Cerenkov radiation |
CN103976978A (zh)* | 2014-04-30 | 2014-08-13 | 成都市绿科华通科技有限公司 | 聚吡咯型高分子药物载体胶束 |
CN103980487A (zh)* | 2014-05-06 | 2014-08-13 | 成都市绿科华通科技有限公司 | 一种可降解多孔聚乙二醇的制备方法 |
US9974870B2 (en) | 2014-06-09 | 2018-05-22 | Washington University | Compositions and methods for treatment and imaging using nanoparticles |
AU2015292498B2 (en) | 2014-07-23 | 2020-11-05 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72) |
EP3172222A4 (en) | 2014-07-24 | 2018-03-21 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
JP6463229B2 (ja) | 2014-12-04 | 2019-01-30 | 信越化学工業株式会社 | 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法、並びにこれに用いる重合開始剤及びその原料となるアルコール化合物 |
US9708350B2 (en) | 2014-12-04 | 2017-07-18 | Shin-Etsu Chemical Co., Ltd. | Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator |
US10377775B2 (en) | 2014-12-04 | 2019-08-13 | Shin-Etsu Chemical Co., Ltd. | Method for producing polyalkylene glycol derivative having amino group at end |
JP6460937B2 (ja) | 2014-12-04 | 2019-01-30 | 信越化学工業株式会社 | 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法 |
PT3230463T (pt) | 2014-12-09 | 2022-08-30 | Sweetwater Energy Inc | Pré-tratamento rápido |
AU2015366355B2 (en) | 2014-12-18 | 2020-05-28 | Dsm Ip Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
JP6150957B2 (ja)* | 2015-02-27 | 2017-06-28 | ナノキャリア株式会社 | ポリマーミセル担体組成物およびポリマーミセル組成物 |
WO2016137007A1 (ja)* | 2015-02-27 | 2016-09-01 | ナノキャリア株式会社 | 高分子処理剤 |
EP3313447A2 (en) | 2015-06-25 | 2018-05-02 | Sanford Burnham Prebys Medical Discovery Institute | Compositions for delivery to and treatment of atherosclerotic plaques |
US20200190101A1 (en) | 2015-11-18 | 2020-06-18 | Nippon Kayaku Kabushiki Kaisha | Composition Containing Novel Glutamic Acid Derivative And Block Copolymer, And Use Thereof |
JP2019513151A (ja) | 2016-03-08 | 2019-05-23 | ロス ガトス ファーマスーティカルズ, インク.Los Gatos Pharmaceuticals, Inc. | カンプトテシン誘導体及びその使用 |
US10064855B2 (en) | 2016-03-08 | 2018-09-04 | Los Gatos Pharmaceuticals, Inc. | Composite nanoparticles and uses thereof |
EP3495406A4 (en)* | 2016-08-02 | 2020-04-01 | Nippon Kayaku Kabushiki Kaisha | ACTIVE TARGETING TYPE POLYMER DERIVATIVE, COMPOSITION CONTAINING SAID POLYMER DERIVATIVE, AND USES OF SAID POLYMER DERIVATIVE AND COMPOSITION THEREOF |
US11821047B2 (en) | 2017-02-16 | 2023-11-21 | Apalta Patent OÜ | High pressure zone formation for pretreatment |
WO2018204392A1 (en) | 2017-05-02 | 2018-11-08 | Stanford Burnham Prebys Medical Discovery Institute | Tumor associated monocyte/macrophage binding peptide and methods of use thereof |
JP6848743B2 (ja) | 2017-07-24 | 2021-03-24 | 信越化学工業株式会社 | ポリアルキレングリコール誘導体の製造方法及び精製方法 |
CA3127985A1 (en) | 2019-02-04 | 2020-08-13 | University Of Tartu | Bi-specific extracellular matrix binding peptides and methods of use thereof |
US11788091B2 (en) | 2019-08-21 | 2023-10-17 | University Of Virginia Patent Foundation | Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth |
AU2020412611A1 (en) | 2019-12-22 | 2022-07-14 | Apalta Patents OÜ | Methods of making specialized lignin and lignin products from biomass |
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63213126A (ja)* | 1987-02-27 | 1988-09-06 | Nec Corp | 光デイスク装置 |
JP2517760B2 (ja)* | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
GB2240547A (en)* | 1990-01-31 | 1991-08-07 | Ciba Geigy Ag | New compositions |
US5219564A (en)* | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
US5143731A (en)* | 1990-08-07 | 1992-09-01 | Mediventures Incorporated | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
US5124151A (en)* | 1990-08-07 | 1992-06-23 | Mediventures Inc. | Drug delivery by injection with thermo-irreversible gels |
CA2087125A1 (en)* | 1992-01-23 | 1993-07-24 | Mridula Nair | Chemically fixed micelles |
Publication number | Publication date |
---|---|
CA2104045C (en) | 1997-02-04 |
JPH06107565A (ja) | 1994-04-19 |
DE69327490D1 (de) | 2000-02-10 |
AU668967B2 (en) | 1996-05-23 |
US5449513A (en) | 1995-09-12 |
ES2141135T3 (es) | 2000-03-16 |
CA2104045A1 (en) | 1994-02-15 |
DE69327490T2 (de) | 2008-10-09 |
EP0583955A3 (en) | 1996-06-12 |
KR960009407B1 (ko) | 1996-07-19 |
US5510103A (en) | 1996-04-23 |
EP0583955A2 (en) | 1994-02-23 |
AU4452393A (en) | 1994-03-10 |
JP2777530B2 (ja) | 1998-07-16 |
KR940003548A (ko) | 1994-03-12 |
EP0583955B1 (en) | 2000-01-05 |
Publication | Publication Date | Title |
---|---|---|
KR940003548U (ko) | 세탁물 건조기 | |
DE69305472D1 (de) | Händetrockner | |
FI931629L (fi) | Torkningsdel | |
ITPN920052A0 (it) | Asciugabiancheria perfezionata | |
KR930025679U (ko) | 세탁 건조기 | |
KR940016003U (ko) | 의류건조기 | |
DE69303990D1 (de) | Energiesparender Wäschetrockner | |
KR940010147U (ko) | 세탁물 건조기 | |
KR940016792U (ko) | 회전식 건조기 | |
KR940015932U (ko) | 세탁기의 건조장치 | |
KR950018965U (ko) | 의류건조대 | |
KR940015993U (ko) | 의류 건조기 | |
KR920009576U (ko) | 세탁물 건조장치 | |
KR940027278U (ko) | 회전드럼식 건조기 | |
KR940010102U (ko) | 세탁기의 건조장치 | |
ITMI930668A0 (it) | Asciugatrice per biancheria | |
KR940003547U (ko) | 세탁물 건조기 | |
BR7300680U (pt) | Secador de roupas | |
BR7301375U (pt) | Secadora de roupas | |
ITPN920016A0 (it) | Asciugabiancheria perfezionata | |
BR7001215U (pt) | Secadora de roupas | |
KR950023386U (ko) | 세탁물 건조기 | |
KR950033348U (ko) | 세탁물 건조대 | |
KR950023317U (ko) | 세탁물 건조망 | |
KR940012691U (ko) | 의류건조기용 주름형성기구 |
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
UA0108 | Application for utility model registration | Comment text:Application for Utility Model Registration Patent event code:UA01011R08D Patent event date:19930324 | |
UA0201 | Request for examination | Patent event date:19930324 Patent event code:UA02012R01D Comment text:Request for Examination of Application | |
UG1501 | Laying open of application | ||
E902 | Notification of reason for refusal | ||
UE0902 | Notice of grounds for rejection | Comment text:Notification of reason for refusal Patent event code:UE09021S01D Patent event date:19950926 | |
E601 | Decision to refuse application | ||
UE0601 | Decision on rejection of utility model registration | Comment text:Decision to Refuse Application Patent event code:UE06011S01D Patent event date:19951130 |