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JPS6411564A - Method for lowering electric resistance of skin - Google Patents

Method for lowering electric resistance of skin

Info

Publication number
JPS6411564A
JPS6411564AJP16599187AJP16599187AJPS6411564AJP S6411564 AJPS6411564 AJP S6411564AJP 16599187 AJP16599187 AJP 16599187AJP 16599187 AJP16599187 AJP 16599187AJP S6411564 AJPS6411564 AJP S6411564A
Authority
JP
Japan
Prior art keywords
skin
voltage
electric resistance
pref
constant current
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16599187A
Other languages
Japanese (ja)
Other versions
JP2585002B2 (en
Inventor
Naoko Nakaguchi
Shigeyuki Watanabe
Susumu Sato
Mitsuo Sakakawa
Yoshiaki Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko CorpfiledCriticalNitto Denko Corp
Priority to JP62165991ApriorityCriticalpatent/JP2585002B2/en
Publication of JPS6411564ApublicationCriticalpatent/JPS6411564A/en
Application grantedgrantedCritical
Publication of JP2585002B2publicationCriticalpatent/JP2585002B2/en
Anticipated expirationlegal-statusCritical
Expired - Lifetimelegal-statusCriticalCurrent

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Abstract

PURPOSE:To increase the transmission amount of a drug without generating skin disorder in the iontophoresis of a percutaneous drug admistering method, by applying specific voltage to the skin for a specified time. CONSTITUTION:The voltage applied to the skin is 5-20V but said voltage is pref. allowed to drop in actual at the point of time when a current becomes 1mA/cm<2>. Pref. voltage lowering the electric resistance of the skin without generating skin disorder such as a burn is 7-12V and the applying time thereof is 1-60 sect and especially pref., voltage of 10V is applied for 5sec. In iontophoresis, it is necessary to allow a constant current to flow to the skin in order to obtain the effective transmission amount of a drug and the constant current is obtained by lowering the electric resistance of the skin at first and subsequently allowing voltage to drop to apply current supply voltage of 1-5V, pref., 2-3V and, by this method, a dummy constant current of 0.1-1mA/cm<2> can be allowed to flow to the electrode of iontophoresis. Since the electric resistance of the skin is lowered in spite of this low voltage, the constant current can be allowed to flow to the skin.
JP62165991A1987-07-021987-07-02 Voltage application device for transdermal drug administrationExpired - LifetimeJP2585002B2 (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
JP62165991AJP2585002B2 (en)1987-07-021987-07-02 Voltage application device for transdermal drug administration

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
JP62165991AJP2585002B2 (en)1987-07-021987-07-02 Voltage application device for transdermal drug administration

Publications (2)

Publication NumberPublication Date
JPS6411564Atrue JPS6411564A (en)1989-01-17
JP2585002B2 JP2585002B2 (en)1997-02-26

Family

ID=15822838

Family Applications (1)

Application NumberTitlePriority DateFiling Date
JP62165991AExpired - LifetimeJP2585002B2 (en)1987-07-021987-07-02 Voltage application device for transdermal drug administration

Country Status (1)

CountryLink
JP (1)JP2585002B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5700481A (en)*1995-03-171997-12-23Takeda Chemical Industries, Ltd.Transdermal drug delivery process
US5911223A (en)*1996-08-091999-06-15Massachusetts Institute Of TechnologyIntroduction of modifying agents into skin by electroporation
US5983131A (en)*1995-08-111999-11-09Massachusetts Institute Of TechnologyApparatus and method for electroporation of tissue
US6085115A (en)*1997-05-222000-07-04Massachusetts Institite Of TechnologyBiopotential measurement including electroporation of tissue surface
US6322550B2 (en)1998-04-142001-11-27Hisamitsu Pharmaceutical Co., Inc.Method for transdermal administration of GP IIb/IIIa antagonist
CN108553749A (en)*2018-05-152018-09-21咸阳张森医疗仪器有限公司A kind of iontophoresis therapeutic instrument for vaginitis

Cited By (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5700481A (en)*1995-03-171997-12-23Takeda Chemical Industries, Ltd.Transdermal drug delivery process
US5983131A (en)*1995-08-111999-11-09Massachusetts Institute Of TechnologyApparatus and method for electroporation of tissue
US5911223A (en)*1996-08-091999-06-15Massachusetts Institute Of TechnologyIntroduction of modifying agents into skin by electroporation
US6085115A (en)*1997-05-222000-07-04Massachusetts Institite Of TechnologyBiopotential measurement including electroporation of tissue surface
US6322550B2 (en)1998-04-142001-11-27Hisamitsu Pharmaceutical Co., Inc.Method for transdermal administration of GP IIb/IIIa antagonist
CN108553749A (en)*2018-05-152018-09-21咸阳张森医疗仪器有限公司A kind of iontophoresis therapeutic instrument for vaginitis

Also Published As

Publication numberPublication date
JP2585002B2 (en)1997-02-26

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