【発明の詳細な説明】〔産業上の利用分野〕本発明は生体内の組織を破砕、吸引するための生体組織
超音波破砕装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a biological tissue ultrasonic disruption device for disrupting and suctioning tissue within a living body.
一般にこの種の超音波破砕装置は例えば特願昭６０−２
１０５０２号に示されるごとく超音波振動子を内蔵した
把持部と超音波振動を組織に伝えるための挿入部からな
る。そしてシースを通して体腔内に挿入した挿入部の先
端を組織に当てながら超音波振動を伝達させることによ
り破砕、吸引を行なうようになっている。Generally, this type of ultrasonic crushing device is used, for example, in Japanese Patent Application No. 60-2.
As shown in No. 10502, it consists of a grasping part containing an ultrasonic vibrator and an insertion part for transmitting ultrasonic vibrations to tissue. The distal end of the insertion section inserted into the body cavity through the sheath is applied to the tissue while transmitting ultrasonic vibrations to perform crushing and suction.
この挿入部の先端部がまっすぐか又は先端に行くにした
がい先細りで発振振幅を大きくとるようになっていた。The distal end of this insertion portion is either straight or tapers toward the distal end to increase the oscillation amplitude.
このように従来の超音波破砕装置は挿入部の先端がまっ
すぐか又は先細りになり中心部が吸引孔であるため厚さ
が薄（なっていると組織に押し付けた時組織を穿孔した
り、組織内の血管を切断してしまう危険があった。In this way, conventional ultrasonic disruption devices have a straight or tapered tip and a suction hole in the center, so they are thin (if they are thin, they may perforate the tissue when pressed against the tissue). There was a risk of severing an internal blood vessel.
本発明はこのような問題点に着目してなされたもので、
超音波破砕装置の挿入部の先端部端面をｍ織への接触面
を大きくすることにより破砕能力を向上させ、組織に対
する穿孔。The present invention was made by focusing on these problems.
By increasing the contact surface of the distal end of the insertion section of the ultrasonic crushing device to the m weave, the crushing ability is improved and the tissue is perforated.
および血管への損傷等を防止することを目的とする。and to prevent damage to blood vessels.
この装置では超音波振動子４を内蔵している把持部２と
、この把持部２からホーン６を介して振動を伝達する挿
入部３とよりなり、この挿入部３の先端部の端面を組織
に対して広く接触されるように鈍的な形状３１に形成さ
れている。This device consists of a gripping part 2 containing an ultrasonic transducer 4, and an insertion part 3 that transmits vibrations from the gripping part 2 through a horn 6. It is formed into a blunt shape 31 so that it can be widely contacted.
この装置ではシース内に超音波振動を組織に伝える挿入
部寺を挿通した状態で生体組織に挿入し、挿入部会の先
端部にある鈍的な形状３１の部分を組織に押し当てるこ
とにより把持部会の超音波振動子４からの振動で組織を
破砕吸引させる。In this device, the insertion section that transmits ultrasonic vibrations to the tissue is inserted into the sheath and inserted into the living tissue, and the grasping section is moved by pressing the blunt-shaped portion 31 at the tip of the insertion section against the tissue. The tissue is crushed and suctioned by the vibration from the ultrasonic transducer 4.
第１図ないし第２図は本発明の第１実施例を示すもので
ある。第１図は生体組織超音波破砕装置の構造を示す一
部断面にした図で、生体組織超音波破砕装置１は操作者
が手で把持する把持部２と生体内に挿入される挿入部３
とからなる。上記把持部２は超音波振動子４を内蔵する
ための円筒状の外装ケース５と超音波振動子４の前端に
配置された円錐形状のホーン６を収納するための円錐筒
状をした前側カバー７とからなる。上記外装ケース５の
前側開口端部の外周には雄ねじ８が形成されており、こ
の雄ねじ８は前側カバー７の後端開口部の内周に形成さ
れた雌ねじ９と螺合されて外装ケース５と前側カバー７
とが一体化さるようになっている。又外装ケース５の内
部空間にはランジュバン型の超音波振動子４が収納され
ており、この超音波振動子４は圧電素子１０． を極板
１１．前側金属ブロック１２゜後側金属ブロック１３か
ら構成されている。そして圧電素子１０．電極板１１は
前側金属ブロック１２と後側金属ブロック１３に挾まれ
ている。1 and 2 show a first embodiment of the present invention. FIG. 1 is a partially cross-sectional view showing the structure of a living tissue ultrasonic disruption device, in which the living tissue ultrasound disruption device 1 includes a grip part 2 that is held by an operator's hand, and an insertion part 3 that is inserted into a living body.
It consists of The gripping section 2 includes a cylindrical exterior case 5 for housing the ultrasonic transducer 4 and a conical front cover for accommodating the conical horn 6 disposed at the front end of the ultrasonic transducer 4. It consists of 7. A male thread 8 is formed on the outer periphery of the front opening end of the exterior case 5, and this male thread 8 is screwed together with a female thread 9 formed on the inner periphery of the rear end opening of the front cover 7 to complete the exterior case 5. and front cover 7
are now integrated. Further, a Langevin-type ultrasonic transducer 4 is housed in the interior space of the outer case 5, and this ultrasonic transducer 4 includes a piezoelectric element 10. The electrode plate 11. It is composed of a front metal block 12 degrees and a rear metal block 13. and piezoelectric element 10. The electrode plate 11 is sandwiched between a front metal block 12 and a rear metal block 13.
これらの中心軸には中空を有するボルト部１４が貫通さ
れている。このボルト部１４の前端は、前側金属ブロッ
ク１２の前端に配置されたホーン６の後端部とまたボル
ト部１４の後端は後側金属ブロック１３の後端に配置さ
れたナツト１５との螺合により前側金属ブロック１２．
圧電素子１０．電極板１１．後側金属ブロック１３がそ
れぞれ挾まれて固定されている。さらに外装ケース５の
中間内周には周溝部１６が形成され、この周溝部１６と
超音波振動子４の後側金属ブロック１３の後方との間で
０リング１７により支持されており、一方前側金属ブロ
ック１２のフランジ部１８と前側カバー７の内周突出部
の間に挾まれ、さらにホーン６の後方の外周部との間に
位置された０リング１９によりそれぞれ超音波振動子４
が支持されるようになっている。超音波振動子４の一方
の電極はリード線２０を介し、又他方の電極とのリード
線２１とともに外装ケース５の外部にケーブル２２とし
て引出されて図示しない超音波電源部に接続されるよう
になっている。一方前側カバー７内に収納され上記超音
波振動子４に接続されたホーン６の前側の小径先端部２
３は前方に延び出しており、その先端外周には雄ねじ２
４が形成されている。又ホーン６の中心部には接続孔２
５が設けられ、この接続孔２５に挿入部３を有する金属
製のパイプ２６の基部が嵌合されるようになっており、
上記パイプ２６の基部寄りに形成されたフランジ部２７
をホーン６の小径先端部２３の端面に密接させ、リング
ナツト２８でホーン６の雄ねじ２４に締付けることによ
り固定されている。このようにバイ１２６は上記リング
ナツト２８を介して超音波振動子４のホーン６に着脱自
在となっている。上記前側カバー７の先端開口部には内
周に周溝部２９が形成され、この周溝部２９とホーン６
の小径先端部２３との間に０リング３０が嵌着されるこ
とで液密的に密閉されている。上記のパイプ２６の先端
は第２図で示すように生体組織に接触して接触面積を大
きくするように先端端面が直角ではなくＲ掻上の面取り
がされた鈍的な形状３１を形成している。さらにこのパ
イプ２６内には組織を破砕したものを吸引するための吸
引孔３２が設けられ、この吸引孔３２はパイプ２６がホ
ーン６に嵌合された時接続孔２５に接続されさらにボル
ト部１４内の中空部を貫通して外チューブ３５が接続さ
れることで図には示してない吸引タンクを介して吸引ポ
ンプに連結されている。又外装ケース５の後端開口部に
は周溝部３６が形成され、パイプ材３４の間でＯＵフグ
３フにより支持されている。A hollow bolt portion 14 passes through these central axes. The front end of this bolt portion 14 is connected to the rear end portion of the horn 6 disposed at the front end of the front metal block 12, and the rear end of the bolt portion 14 is threaded to a nut 15 disposed at the rear end of the rear metal block 13. Depending on the case, the front metal block 12.
Piezoelectric element 10. Electrode plate 11. The rear metal blocks 13 are respectively sandwiched and fixed. Further, a circumferential groove 16 is formed on the intermediate inner circumference of the exterior case 5, and is supported by an O-ring 17 between this circumferential groove 16 and the rear of the rear metal block 13 of the ultrasonic transducer 4, while the front The ultrasonic transducers 4 are connected to each other by O-rings 19 which are sandwiched between the flange portion 18 of the metal block 12 and the inner peripheral protrusion of the front cover 7, and further positioned between the rear outer peripheral portion of the horn 6.
is now supported. One electrode of the ultrasonic transducer 4 is pulled out as a cable 22 to the outside of the exterior case 5 together with a lead wire 21 connected to the other electrode via a lead wire 20 and connected to an ultrasonic power source (not shown). It has become. On the other hand, the small diameter tip 2 on the front side of the horn 6 housed in the front cover 7 and connected to the ultrasonic transducer 4
3 extends forward, and there is a male screw 2 on the outer periphery of the tip.
4 is formed. Also, there is a connection hole 2 in the center of the horn 6.
5 is provided, and the base of a metal pipe 26 having an insertion portion 3 is fitted into this connection hole 25,
A flange portion 27 formed near the base of the pipe 26
is brought into close contact with the end face of the small-diameter tip 23 of the horn 6, and is fixed by tightening the male thread 24 of the horn 6 with a ring nut 28. In this way, the bi 126 is detachably attached to the horn 6 of the ultrasonic transducer 4 via the ring nut 28. A circumferential groove 29 is formed on the inner periphery of the front end opening of the front cover 7, and this circumferential groove 29 and the horn 6
An O-ring 30 is fitted between the small-diameter tip 23 of the holder and the small-diameter tip 23 of the holder to provide a liquid-tight seal. As shown in FIG. 2, the tip of the pipe 26 has an obtuse shape 31 with an R-shaped chamfer instead of a right angle so as to contact the living tissue and increase the contact area. There is. Furthermore, a suction hole 32 for suctioning the crushed tissue is provided in this pipe 26, and this suction hole 32 is connected to the connecting hole 25 when the pipe 26 is fitted to the horn 6, and is connected to the bolt part 14. The outer tube 35 is connected to the suction pump through a suction tank (not shown) by passing through the inner hollow part. Further, a circumferential groove portion 36 is formed at the rear end opening of the exterior case 5, and is supported by the OU puffer 3 between the pipe members 34.
ここで超音波破砕装置の作用について説明すると体腔内
にシースを挿入後、そのシース内に超音波破砕装置１の
パイプ２６を導入し、生体組織にパイプ２６の先端の鈍
的な形状３１を押し当てるそしてまず超音波振動を与え
るために電源部から駆動電圧を圧電素子１０に印加バー
７！ネキ内のホーン６で増幅されるとともに挿入部３のパ
イプ２６に伝わる。そこで超音波振動しているパイプ２
６の鈍的な形状３１をした先端から生体組織例えば前立
腺等にその振動が伝わり前立腺を破砕させる。この破砕
された破片は図示しない吸引ポンプにより吸引チューブ
３５を介して挿入部３のパイプ２６にある吸引孔３２を
通じて吸引され、対外に排出される。Here, the action of the ultrasonic disruption device will be explained. After inserting the sheath into the body cavity, the pipe 26 of the ultrasonic disruption device 1 is introduced into the sheath, and the blunt shape 31 of the tip of the pipe 26 is pushed into the living tissue. First, a driving voltage is applied from the power supply section to the piezoelectric element 10 to give ultrasonic vibration to the bar 7! It is amplified by the horn 6 inside the neck and transmitted to the pipe 26 of the insertion section 3. Pipe 2 is vibrating ultrasonically there.
The vibration is transmitted from the blunt-shaped tip 31 of 6 to a living tissue such as the prostate gland, thereby crushing the prostate gland. The crushed pieces are sucked by a suction pump (not shown) through a suction tube 35 through a suction hole 32 in the pipe 26 of the insertion section 3, and are discharged to the outside.
上記の様に超音波破砕装置の挿入部先端を鈍的な形状に
して生体組織に当てることによりＵ織への接触面積を大
きくとれるとともに先端が丸くなっているので生体組織
に穿孔させたり、生体内にある血管等を損傷することな
く破砕することができるものである。As mentioned above, by making the tip of the insertion part of the ultrasonic crushing device blunt and applying it to the living tissue, it is possible to increase the contact area with the U-weave, and since the tip is rounded, it is possible to make a hole in the living tissue or to insert it into the living tissue. It is capable of crushing blood vessels within the body without damaging them.
第３図は第２実施例を示すものであるが超音波破砕装置
の挿入部の先端部の形状が第１実施例に比べ外径を太く
した形状３８にし、端面ば丸味を持たせた鈍的な形状３
１にしたものである。他の構成は第１実施例と同様であ
るので省略する。この場合は先端の面積が第１実施例よ
りさらに広くなっているのでより振動伝達が有効に働く
ものである。FIG. 3 shows the second embodiment, in which the tip of the insertion part of the ultrasonic crushing device has a shape 38 with a larger outer diameter than the first embodiment, and the end surface is a blunt one with a rounded shape. shape 3
It is set to 1. The other configurations are the same as those in the first embodiment, and will therefore be omitted. In this case, since the area of the tip is wider than that of the first embodiment, vibration transmission works more effectively.
第４図は第３実例であるが第２実施例と逆にパイプ２６
の先端の内径を狭くした形状３９にしたもので他の構成
は第２実施例と同様であるので省略する。第３実施例は
パイプ２６の先端を狭くしたので吸引孔３２に入る破砕
した組織は詰ることなく吸引できるものである。FIG. 4 shows the third example, but the pipe 26 is opposite to the second example.
The other configuration is the same as that of the second embodiment, and therefore will not be described here. In the third embodiment, the tip of the pipe 26 is narrowed, so that the crushed tissue entering the suction hole 32 can be suctioned without clogging.
第５図は第４実施例を示すものでパイプ２６の先端の下
側をさらに伸ばして丸くして組織に当たる面積を広くし
た形状４０にするとともに先端面を鈍的な形状３１に形
成したものである。FIG. 5 shows a fourth embodiment, in which the lower side of the tip of the pipe 26 is further extended and rounded to have a shape 40 that widens the area that contacts the tissue, and the tip surface is formed into a blunt shape 31. be.
第６図、第７図は第５．第６実施例でそれぞれパイプ２
Ｇの先端を丸めたもので第６図は外側に丸めた鈍的な形
状４１、第７図は内側に丸めた鈍的な形状４２にしたも
のである。他の構成効果は第１実施例と同様であるので
省略する。Figures 6 and 7 are 5. In the sixth embodiment, each pipe 2
The tip of the G is rounded, and FIG. 6 shows an outwardly rounded blunt shape 41, and FIG. 7 shows an inwardly rounded blunt shape 42. Other structural effects are the same as those in the first embodiment, so their description will be omitted.
第８図ないし第９図は第７実施例を示すもので超音波破
砕装置の挿入部３のパイプ２６の先端部の形状が第１実
施例ないし第６実施例と異なるものですなわち第８図は
挿入部３のパイプ２６に接続された先端部に略樋状をし
た破砕子４３を設けたものである。この破砕子４３の先
端面４４には中央部に挿入部３のパイプ２６に貫通する
吸引孔３２を配置したものである。8 to 9 show a seventh embodiment, in which the shape of the tip of the pipe 26 of the insertion section 3 of the ultrasonic crushing device is different from the first to sixth embodiments, that is, FIG. In this example, a substantially gutter-shaped crusher 43 is provided at the tip end connected to the pipe 26 of the insertion portion 3. A suction hole 32 that penetrates the pipe 26 of the insertion section 3 is arranged in the center of the distal end surface 44 of the crusher 43.
第９図は破砕子４３をシース４５に光学視管４６ととも
に配列された状態図を示している。他の構成は第１実施
例と同様であるので省略する。FIG. 9 shows a state diagram in which the fragmentation element 43 is arranged in the sheath 45 together with the optical viewing tube 46. The other configurations are the same as those in the first embodiment, and will therefore be omitted.
この構成においては体腔内の組織に挿入部３の略樋状を
した破砕子４３を押し当てるためにはまずシース４５を
挿入後シース４５の内周の上側に光学視管４６を挿入し
、下側の内壁面には先端に破砕子４３を有する超音波破
砕装置の挿入部３を挿入する。次に光学視管４６で観察
しながら組織に破砕子４３の先端面４４を接触させ、手
元側で超音波振動を印加することにより挿入部３の先端
面４４に振動を伝えることで組織が破砕され、さらに破
砕された破片を吸引ポンプを作動させることで先端面４
４の吸引孔３２から吸引されるものである。In this configuration, in order to press the roughly gutter-shaped fragmentation element 43 of the insertion section 3 against the tissue within the body cavity, the sheath 45 is first inserted, the optical viewing tube 46 is inserted above the inner periphery of the sheath 45, and the optical viewing tube 46 is inserted downward. An insertion section 3 of an ultrasonic crushing device having a crusher 43 at the tip is inserted into the inner wall surface of the side. Next, while observing with the optical viewing tube 46, the distal end surface 44 of the disruptor 43 is brought into contact with the tissue, and ultrasonic vibration is applied on the proximal side to transmit the vibration to the distal end surface 44 of the insertion section 3, thereby disrupting the tissue. The distal end surface 4 is further crushed by activating the suction pump to remove the crushed fragments.
The air is sucked through the suction hole 32 of No. 4.
このように挿入部３の破砕子４３の先端面４４が組織と
接触する接触面積が上記の実施例よりも太き（なるので
それだけ組織の破砕能力が大となるものである。In this way, the contact area where the distal end surface 44 of the crusher 43 of the insertion section 3 comes into contact with the tissue is larger than in the above embodiment (therefore, the ability to crush the tissue is increased accordingly).
第１０図は第８実施例を示すもので、超音波４コ破砕装置の挿入部先端を扁平形状した破砕子４７をパイ
プ２６の先端に設けたものである。他の構成効果は第７
実施例と同様であるので省略する。FIG. 10 shows an eighth embodiment, in which a crusher 47 with a flattened tip of the insertion part of a four-piece ultrasonic crusher is provided at the tip of a pipe 26. The other compositional effect is the seventh
Since this is the same as the embodiment, the description will be omitted.
第１１図は第９実施例を示すものである。超音波破砕装
置の挿入部３のパイプ２６の先端に円筒状をなした破砕
子４８を設け、この破砕子４８の先端面４９は光学視管
４６の挿入部５０を挿通さ廿る挿通口５１が設けられ、
さらに下側には吸引孔３２が配置され、パイプ２６内に
連通している。この先端部の破砕子４８には光学視管４
６を挿入した状態でシース内を前後動できる。FIG. 11 shows a ninth embodiment. A cylindrical fragment 48 is provided at the tip of the pipe 26 of the insertion section 3 of the ultrasonic fragmentation device, and the distal end surface 49 of the fragment 48 has an insertion port 51 through which the insertion section 50 of the optical viewing tube 46 is inserted. is established,
A suction hole 32 is arranged further below and communicates with the inside of the pipe 26. An optical viewing tube 4 is attached to the crusher 48 at the tip.
6 can be moved back and forth within the sheath with it inserted.
このように超音波破砕装置の挿入部３の先端面を組織と
接触する面接を第７実施例、第８実施例より大きくした
ので振動による破砕効果がより向上させることができる
。As described above, since the surface area of the distal end surface of the insertion section 3 of the ultrasonic crushing device that contacts the tissue is made larger than that of the seventh and eighth embodiments, the crushing effect due to vibration can be further improved.
又第７実施例ないし第９実施例では挿入部の先端面が平
面になっているが特に平面にする必要なく角部に丸味を
もたせて純的な形状としてもよい。このように丸味をも
たせることで正常組織に対する損傷を防ぐこともできる
。Further, in the seventh to ninth embodiments, the distal end surface of the insertion portion is flat, but there is no need to make it flat, and the corners may be rounded to have a pure shape. This roundness can also prevent damage to normal tissue.
本発明は生体組織超音波破砕装置の挿入部の先端を組織
に対して接触する面積を大にしかつ角部に丸味をもたせ
たので正常組織への穿孔や血管等の損傷を防止すること
ができるものである。The present invention increases the contact area of the tip of the insertion section of the biological tissue ultrasonic disruption device with the tissue and has rounded corners, making it possible to prevent perforation of normal tissue and damage to blood vessels, etc. It is something.
第１図本発明の第１実施例による生体組織超音波破砕装
置の一部断面にした全体図。第２図は第１図の挿入部先
端の拡大断面図、第３図、第４図は第２実施例、第３実
施例の挿入部先部の拡大断面図、第５図は第４実施例の
挿入部先端の拡大断面図、第６図ないし第７図は第５実
施例、第６実施例の挿入先端の拡大断面図、第８図は第
７実施例による破砕子の斜視図、第９図は第８図をシー
スに挿入した時の断面図、第１０図ないし第１１図は第
８実施例ないし第９実施例を示す斜視図である。FIG. 1 is an overall partially sectional view of a biological tissue ultrasonic disruption device according to a first embodiment of the present invention. Figure 2 is an enlarged sectional view of the tip of the insertion tube in Figure 1, Figures 3 and 4 are enlarged sectional views of the tip of the insertion tube of the second and third embodiments, and Figure 5 is the fourth embodiment. FIGS. 6 and 7 are enlarged sectional views of the insertion tips of the fifth and sixth embodiments; FIG. 8 is a perspective view of the shredder according to the seventh embodiment; FIG. 9 is a sectional view of FIG. 8 inserted into the sheath, and FIGS. 10 and 11 are perspective views showing the eighth to ninth embodiments.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61054086AJPS62211057A (en) | 1986-03-12 | 1986-03-12 | Ultrasonic vibration treatment apparatus |
| JP61054085AJPS62211056A (en) | 1986-03-12 | 1986-03-12 | Tissue incision apparatus |
| JP1986040902UJPS62152705U (en) | 1986-03-12 | 1986-03-20 | |
| JP61067916AJPS62224341A (en) | 1986-03-12 | 1986-03-26 | Apparatus for freeze destruction of living body tissue |
| JP61067704AJPS62224342A (en) | 1986-03-12 | 1986-03-26 | Apparatus for ultrasonic grinding of living body tissue |
| DE19873707921DE3707921A1 (en) | 1986-03-12 | 1987-03-12 | Medical treatment device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61054086AJPS62211057A (en) | 1986-03-12 | 1986-03-12 | Ultrasonic vibration treatment apparatus |
| JP61054085AJPS62211056A (en) | 1986-03-12 | 1986-03-12 | Tissue incision apparatus |
| JP1986040902UJPS62152705U (en) | 1986-03-12 | 1986-03-20 | |
| JP61067916AJPS62224341A (en) | 1986-03-12 | 1986-03-26 | Apparatus for freeze destruction of living body tissue |
| JP61067704AJPS62224342A (en) | 1986-03-12 | 1986-03-26 | Apparatus for ultrasonic grinding of living body tissue |
| Publication Number | Publication Date |
|---|---|
| JPS62224342Atrue JPS62224342A (en) | 1987-10-02 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61054085APendingJPS62211056A (en) | 1986-03-12 | 1986-03-12 | Tissue incision apparatus |
| JP61054086APendingJPS62211057A (en) | 1986-03-12 | 1986-03-12 | Ultrasonic vibration treatment apparatus |
| JP1986040902UPendingJPS62152705U (en) | 1986-03-12 | 1986-03-20 | |
| JP61067704APendingJPS62224342A (en) | 1986-03-12 | 1986-03-26 | Apparatus for ultrasonic grinding of living body tissue |
| JP61067916APendingJPS62224341A (en) | 1986-03-12 | 1986-03-26 | Apparatus for freeze destruction of living body tissue |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61054085APendingJPS62211056A (en) | 1986-03-12 | 1986-03-12 | Tissue incision apparatus |
| JP61054086APendingJPS62211057A (en) | 1986-03-12 | 1986-03-12 | Ultrasonic vibration treatment apparatus |
| JP1986040902UPendingJPS62152705U (en) | 1986-03-12 | 1986-03-20 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61067916APendingJPS62224341A (en) | 1986-03-12 | 1986-03-26 | Apparatus for freeze destruction of living body tissue |
| Country | Link |
|---|---|
| JP (5) | JPS62211056A (en) |
| DE (1) | DE3707921A1 (en) |
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| JPS62211057A (en) | 1987-09-17 |
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