【発明の詳細な説明】[Detailed description of the invention]本−Ｊ＾明は養毛・育毛料に関し、更に詳しくは血行促
）炸剤及び炭酸ガスを配合した養毛・育毛料に１）１１
する。従来より養毛・育毛料には血行促進作用を有する合成又
ｔま天然物抽出エキス等が適用されているが、少量の添
加では充分な効果が得られず、また多量に配合するとあ
る程度効果が得られるものの適用部位に不快な刺激感を
与え、さらに連続使用すると皮膚炎を起こす等の欠点が
あった。一方炭酸ガスは血管拡張作用を有することが知られてお
り、臨床的にも炭酸ガス浴としてυノ・ビリチージョン
などに使用されている。そこで、本発明者は、炭酸ガスを養毛・育毛料に配合す
ることに着目し種々研究を行なった結果、養毛・育毛料
に血行促進剤と炭酸ガスを併用すれば頭皮における血流
の増加及び血流増加の持続をはかることができ頭髪の脱
毛の減少及び頭髪の成長を促進できることを見出し、本
発明を完成した。すなわち、本発明は血行促進剤を含有する養毛・育毛料
に炭酸ガスを配合して耐圧容器に密封した養毛・育毛料
を提供するものである。本発明に使用される血行促進剤としては、合成又は天然
成分である、酢酸（Ｉｇ−α−トコフェロール、シカプ
リル酸ピリドキシン、ビオチン、ニコチン酸及びその誘
導体、塩酸トラゾリン、グリチルレチン酸グリセリル、
ヒノキチオール、センプリ抽出物、ニンニク抽出物、当
帰抽出物、用鳥抽出物、陳皮抽出物、カミラン抽出物及
び薄荷葉抽出物などが挙げられるが、これらのうち酢酸
ｄＪ−α−トコフェロール、センブリ抽出物、当帰抽出
物及び用弯抽出物が特に好ましいうこの血行促進剤は水
又は水−低級アルコール等の溶媒に配合して使用される
う血行促進剤は本発明の養毛・育毛剤中に０．００１〜
５重量％（以下単にチで示す）配合するのが好ましいっ
ｏ、ｏｏｉｓ以下では充分な効果が得られず、また５％
以上配合すると頭皮に不快な刺激感を与え好ましくない
。ところで、炭酸ガスは、これが溶解している溶液のＩ）
Ｈが酸性の場合にはＣＯ２分子として存在し、血管拡張
作用を示すことが知られている。従って、本発明の養毛
・育毛料の液性はｐＨ７以下、特にｐＨ４，、５〜６．
５に調整するのが好ましい。なお、養毛・育毛料のｐｆ
（は炭酸ガスが圧入され、これが養毛・育毛料中に溶は
込むと更に酸性度が強くなるが、最終ｐＨが上記範囲に
なるように調節すればよい。このｐｆ（調節剤としては
、例えばクエン酸、慟石酸、乳酸等の有機酸又はこれら
の塩、あるいはリン酸又はその塩が好適に使用されろう
炭酸ガスを養毛・育毛料に配合するには、養毛・育毛料
を耐圧容器に入れ、これに高圧ガスを封入する方法、耐
圧容器に炭酸水素す） ＩＪウム等の炭酸塩を含ませた
養毛・育毛料を入れ、これにｐｆ（調節剤を加えて炭酸
ガスを発生させ、直ちに密封する方法、あるいはドライ
アイスペレットを容器内に入れて密封する方法等が採用
されるが、就中特に高圧ガスを封入する方法が好ましい
。このようにするとき、炭酸ガスの一部は養毛・ａ毛料中
に溶解して配合され、また一部は容器中に気体として存
在するつ本発明に、おいては炭酸ガスが養毛・育毛料中
に溶けて配合されていることが重装であり、この配合量
は炭酸ガス製置が６０ｐ ｐｒｎ以上であることが好ま
しく、これより少ないと充分な血管拡張作用を期待でき
ず、本発明の効果は得られない、炭酸ガスの配合量の調
節は、炭酸ガスの注入（圧入）量によって行うことがで
き、一般には容器中の圧力が３５℃の温度で１．２〜８
ｋｇ／ｃｄ（ゲージ圧）になるようにするのが好ましい
・ま７′ξ、本発明でｉ重用される耐圧容器は、調製後
団用さ、ＪＬるまで上記圧力に耐えて養毛・ａ毛科をＶ
？Ｆ 、ＪＡｆ状７ｉ！１で１１１持できるものである
ことが必要であり、例えばアルミ、ブリキ等の金属容器
、アセタール糸ＩＪ脂、ポリカーボネート系樹脂等の合
成樹＋＋ｈ容器及びガラス容器が用いられる。一方吐出ノズルはその径が小さいと充填液は霧状に、太
さいと泡状又は液状に噴射されろう噴射形態は、また缶
内圧によっても異なるが、一般にエアゾールｌＪｆ’（
’ｉ３容器の吐出ノズルの径は０．３ ＩｒＩＮ以下で
あり、これ全本発明の養毛・育毛料に適用した。１＜）
合、霧状に噴霧されて炭酸ガスがすぐ飛散してしまうの
で充分な効果が１けられない。本発明の効果をより高め
るためには、養毛・育毛１ｉ）中の炭酸ガスの１′消留
時間を長くする必要があり、本発明柔毛・育毛料を頭髪
に付着することなく、頭皮に直接１ｉ！ｌ状又は液状で
塗布１，７、頭皮上で発泡させるのが好−ドしいうこの
ため、吐出ノズルの径ヲ０．３〜１．５ｒ・１、長さを
１〜１５Ｃｒｎにすることが好ましい。更に１史用に伴
なう缶内圧の減少による炭酸ガスの溶解、殴の減少を防
ぎ、又噴射状態を一定に１呆つために、容器中に炭酸ガ
スのミニｙ１５ンベを内蔵し、使用時圧力が低下した場
合に、新たをこ炭酸ガスを供給する特開昭５７−１５３
７５２号のようなエアゾール噴射装置と組み合わせるこ
とが好まし℃・。斯くすれば、使用当初から使用終了まで炭酸ガス濃度を
一定に維持することができる。本発明の養毛・育毛料には上記必須成分のｉｔ力・に、
通常の化粧料に使用される油性基剤、エモリエント剤、
ゲル化剤、各種乳化剤、香料、ノくラヒドロキシ安息香
酸エステル等の防腐剤、ブチルヒドロキシアニソール等
の酸化防止剤、染料等の着色剤、メントール等の清涼剤
、ヒノキチオール等の殺菌剤、プロピレングリコール等
の湿潤剤を添加配合することができる。叙上の如く、本発明の養毛・育毛料は、血行促進剤と炭
酸ガスを含有しているため、短時間で珀This book is about hair nourishing and hair growing products, and in more detail, it is about hair nourishing and hair growing products that contain explosives (promoting blood circulation) and carbon dioxide.
do. Conventionally, synthetic or natural product extracts that have blood circulation promoting effects have been used in hair nourishing and restoring products, but adding them in small amounts does not provide sufficient effects, and adding large amounts may not be effective to some extent. The resulting product has disadvantages such as giving an unpleasant irritation to the application site and causing dermatitis when used continuously. On the other hand, carbon dioxide gas is known to have a vasodilatory effect, and is clinically used as a carbon dioxide bath for virility. Therefore, the inventor of the present invention focused on incorporating carbon dioxide gas into hair nourishing and hair growth products, and as a result of conducting various studies, found that if a blood circulation promoter and carbon dioxide gas are used together in hair growth products, blood flow in the scalp can be improved. The present invention was completed based on the discovery that it is possible to reduce hair loss and promote hair growth by increasing and sustaining the increase in blood flow. That is, the present invention provides a hair nourishing and hair growing agent containing a blood circulation promoter, mixed with carbon dioxide gas, and sealed in a pressure-resistant container. The blood circulation promoter used in the present invention includes synthetic or natural ingredients such as acetic acid (Ig-α-tocopherol, pyridoxine caprilate, biotin, nicotinic acid and its derivatives, tolazoline hydrochloride, glyceryl glycyrrhetinate,
Examples include hinokitiol, senpuri extract, garlic extract, toki extract, chotori extract, chinpi extract, kamilan extract, and mink leaf extract, among which dJ-α-tocopherol acetate, japonica japonica extract, etc. Among the peritoneal blood circulation promoters, which are particularly preferably porcine extracts, pharyngeal extracts, and pharyngeal extracts, are those used by blending them in water or a solvent such as water-lower alcohol. 0.001～
It is preferable to incorporate 5% by weight (hereinafter simply indicated by ``chi''). If the content is less than oois, sufficient effect cannot be obtained,
Containing any of the above ingredients gives an unpleasant irritation to the scalp, which is undesirable. By the way, carbon dioxide gas is I) of the solution in which it is dissolved.
It is known that when H is acidic, it exists as CO2 molecules and exhibits a vasodilatory effect. Therefore, the liquid quality of the hair nourishing/growth agent of the present invention is pH 7 or lower, particularly pH 4.5 to 6.
It is preferable to adjust it to 5. In addition, the pf of hair growth/hair growth fee
(When carbon dioxide gas is pressurized and dissolved in the hair nourishing/growth agent, the acidity becomes even stronger, but the final pH should be adjusted to the above range.This pf (adjusting agent) For example, organic acids such as citric acid, chloric acid, lactic acid, or salts thereof, or phosphoric acid or salts thereof are preferably used.To incorporate carbon dioxide into a hair nourishing/hair growing agent, the hair nourishing/hair growing agent should be mixed with carbon dioxide. A method of putting hydrogen carbonate in a pressure-resistant container and filling it with high-pressure gas.Put a hair growth agent containing carbonate such as IJum, and add PF (regulator and add carbon dioxide gas). Methods such as generating carbon dioxide and immediately sealing the container, or placing dry ice pellets in a container and sealing the container, etc., are adopted, but the method of enclosing high-pressure gas is particularly preferred. A part of the carbon dioxide gas is dissolved and blended into the hair nourishing/a-hair product, and a part is present as a gas in the container.In the present invention, carbon dioxide gas is dissolved and blended into the hair nourishing/hair growing product. It is preferable that the amount of carbon dioxide gas is 60 pprn or more.If it is less than this, sufficient vasodilatory effect cannot be expected and the effect of the present invention cannot be obtained. The amount of gas blended can be adjusted by changing the amount of carbon dioxide gas injected (injected), and generally the pressure in the container is 1.2 to 8 at a temperature of 35°C.
kg/cd (gauge pressure).Preferably, the pressure-resistant container used in the present invention is used after preparation, and is able to withstand the above pressure until hair growth and a. V for the hair department
? F, JAf type 7i! For example, metal containers such as aluminum or tin, synthetic resin containers such as acetal thread IJ resin, polycarbonate resin containers, and glass containers are used. On the other hand, if the diameter of the discharge nozzle is small, the filling liquid will be sprayed in the form of a mist, and if the diameter is large, the liquid will be sprayed in the form of foam or liquid.The spray form also varies depending on the internal pressure of the can, but generally the aerosol lJf' (
The diameter of the discharge nozzle of the 'i3 container was 0.3 IrIN or less, and this was all applied to the hair nourishing and hair growth composition of the present invention. 1<)
In this case, it is sprayed in a mist and the carbon dioxide gas immediately scatters, resulting in insufficient effectiveness. In order to further enhance the effects of the present invention, it is necessary to lengthen the 1' disappearance time of carbon dioxide gas during hair growth and growth 1i). Directly to 1i! For this reason, it is preferable to apply it in l-form or liquid form and foam it on the scalp, so the diameter of the discharge nozzle should be 0.3 to 1.5 r·1 and the length should be 1 to 15 cr. preferable. Furthermore, in order to prevent the dissolution of carbon dioxide gas and decrease in blowing due to the decrease in the internal pressure of the can due to one cycle of use, and to maintain a constant jetting condition, a mini carbon dioxide gas tank is built into the container and used. JP-A-57-153 that supplies fresh carbon dioxide gas when the pressure decreases
It is preferable to combine it with an aerosol injection device such as No. 752. In this way, the carbon dioxide concentration can be maintained constant from the beginning of use until the end of use. The hair nourishing/hair growing agent of the present invention has the above-mentioned essential ingredients,
Oil bases and emollients used in regular cosmetics,
Gelling agents, various emulsifiers, fragrances, preservatives such as nokura hydroxybenzoic acid ester, antioxidants such as butylhydroxyanisole, coloring agents such as dyes, cooling agents such as menthol, disinfectants such as hinokitiol, propylene glycol A wetting agent such as the following may be added and blended. As mentioned above, the hair nourishing and restoring agent of the present invention contains a blood circulation promoter and carbon dioxide gas, so it can quickly heal hair.
【流を増加させ
、かつ、ある程度まで血流増加を持続→−ることかでき
、優れた養毛・育毛効果及び脱毛抑止効果を示す。また
、炭酸ガスを併用することにより１トリδに性の強い血
行促進剤の配合量を少なくできるので、連続使用が可能
となり、上記効果をより高めることができる。更に、炭
酸ガスの発泡効果により頭皮に快適な刺激感及びマツサ
ージ効果を与えることができ、また養毛・育毛料自体の
ｐ Ｊ−１が弱酸性であるので皮膚のＩ）Ｈに近くなり
、皮Ｉａに好ましい影響を与えることができる。次に実施ｆ１を挙げ本発明を説明する。８：、−′５例１ｃ３ｉｔマウス（＄）の休止期にある背部皮膚の毛を皮
膚を傷つけないように刈り、次期成長期毛の成長をＦ、
ｉ察した。皮膚表面上に毛の成長を認めた部位のｉｈｉ
積を経口的に測定し、その刈上部の面積に対する割合（
「）をめた。結果を第１表に示す。■下金臼９’ｒ １表に示す如く、加齢とともに毛の成長開始の
遅れる部位の面積が増加した。実施例１生後１０８日のＣ３Ｈマウス（Ｓ）の休止期に１ある背
部皮膚の毛を皮膚を傷つけないように刈って７群に分け
、その刈上部に下記第２表に示す組成の養毛・育毛料を
連日塗布し、次期成長を観察した。皮膚表面上に毛の成長を認めた部位の面積を経口的に測
定し、その刈上部の面積に対する割合（ｒ）をめた。結
果を第３表に示す。以下余白〔拮 果〕第３．ｆｆ′・を】ヒ ｉ！ｌ５ＩＱｊ乏に同じ。第３表に示す如く、炭酸ガスを含有する本発明養毛・Ｙ
′ｆ毛４′４Ｆを使用することにより、毛の成長開始の
早期化が認められたつ参考例２家系的に男性型脱毛症になる素因を有すると思われる３
０〜４０才の男性を対象に、頭頂部毛髪の毛周期分布を
測定し、まだ、；で・１照として同年代の正常人及び既
に本脱毛症の認められた者の毛周期分布を測定して比較
検討した。結果を第４表に示す。第４表＊ 平均値。第４表より、脱毛症及び脱毛症の素因のある者に、ｊ６
いては、休止期の状態にある毛髪の割合が正常人のそれ
に比べ多いことが明らかとなった。実施例２男性ＡＩ！脱毛症の素因を有し、休止助手が増加してい
る者及び現在脱毛症が進行している者に、下ｆ！ｆイ３
５表に示す組成の養毛・育毛料を連日１年間使用しても
らい、使用前及び使用後の休止期系率を６１ηべ／こ。結果を第６表に示す。〔組 成〕第５表〔５吉 °待 〕第６表４１３６表に示す如く、炭酸ガスを含有する本発明−１
Ｏ毛・育毛料の使用により、休止期系率のイ・ｋ少が認
められた。以下余白[It can increase blood flow and maintain the increase in blood flow to a certain extent, and exhibits excellent hair nourishing and hair growth effects and hair loss prevention effects. In addition, by using carbon dioxide gas in combination, the amount of the blood circulation promoter that is strong against δ can be reduced, so continuous use is possible, and the above effects can be further enhanced. Furthermore, the bubbling effect of carbon dioxide gas can provide a comfortable stimulation and pine surge effect to the scalp, and since the pJ-1 of the hair growth agent itself is weakly acidic, it is close to the I)H of the skin. It is possible to have a favorable influence on the skin Ia. Next, the present invention will be described with reference to implementation f1. 8:, -'5 Example 1 The hair on the dorsal skin in the resting phase of c3it mice ($) was clipped without damaging the skin, and the growth of the next anagen hair was inhibited by F,
I guessed it. ihi of areas where hair growth is observed on the skin surface
Orally measure the product and calculate its ratio to the area of the cut area (
). The results are shown in Table 1. ■ Lower metal mill 9'r As shown in Table 1, the area of the area where the start of hair growth is delayed increases with age. Example 1 108 days after birth During the resting phase of C3H mice (S), one hair on the dorsal skin was shaved without damaging the skin, divided into 7 groups, and a hair growth agent with the composition shown in Table 2 below was applied to the shaved area every day. The next growth was observed. The area of the area where hair growth was observed on the skin surface was orally measured, and the ratio (r) to the area of the cut area was determined. The results are shown in Table 3. Margin [Part 3.ff'] is the same as i!l5IQj deficiency.As shown in Table 3, the hair growth agent of the present invention containing carbon dioxide gas
By using 'f hair 4' 4F, the start of hair growth was observed to be earlier.Reference example 2: A patient who seems to have a family predisposition to androgenetic alopecia 3
We measured the hair cycle distribution on the top of the scalp in men aged 0 to 40 years old, and also measured the hair cycle distribution in normal people of the same age and those who were already confirmed to have this alopecia. A comparative study was conducted. The results are shown in Table 4. Table 4 * Average values. From Table 4, j6
It was revealed that the proportion of hair in the resting phase was higher than that of normal people. Example 2 Male AI! The following f! f-3
The hair nourishing/hair growth product with the composition shown in Table 5 was used every day for one year, and the telogen rate before and after use was 61η b/c. The results are shown in Table 6. [Composition] Table 5 [5 luck] As shown in Table 6, Table 4136, the present invention-1 containing carbon dioxide gas
A decrease in the rate of telogen phase was observed due to the use of hair growth products. Margin below