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JPS57183738A - Aromatic carboxylic acid derivative - Google Patents

Aromatic carboxylic acid derivative

Info

Publication number
JPS57183738A
JPS57183738AJP6777881AJP6777881AJPS57183738AJP S57183738 AJPS57183738 AJP S57183738AJP 6777881 AJP6777881 AJP 6777881AJP 6777881 AJP6777881 AJP 6777881AJP S57183738 AJPS57183738 AJP S57183738A
Authority
JP
Japan
Prior art keywords
alkyl
substituted
formula
carboxylic acid
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6777881A
Other languages
Japanese (ja)
Inventor
Noriyoshi Inukai
Shinichi Tsukamoto
Kenji Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co LtdfiledCriticalYamanouchi Pharmaceutical Co Ltd
Priority to JP6777881ApriorityCriticalpatent/JPS57183738A/en
Publication of JPS57183738ApublicationCriticalpatent/JPS57183738A/en
Pendinglegal-statusCriticalCurrent

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Abstract

NEW MATERIAL:A compound of formulaI[R1 is formula II(R3,R4 are H, lower alkyl, CF3), 6W10C alkyl, mono- or di-lower alkylaminolower alkyl, pyridyl; R2 is hydroxyl, lower alkoxy, which may be substituted with, e.g., OH, CN, morpholino), lower alkylamino, aromatic amino; A is CH, N; B is N (R5) (R5 is H, lower alkyl, aromatic group, which may be substituted), O; where when R2 is hydroxyl or lower alkoxy and B is NH, BR1 and OR2 are not in the ortho- position]or its salt.
EXAMPLE: N-(m-Trifluoromethylphenyl)anthranylic 3-morpholinopropyl ester.
USE: An adenolytic accelerator used as a thrombolytic agent.
PREPARATION: The acid component of formulaIb and the alcohol component of formula IV (R6 is lower alkyl, which may be substituted with, e.g., a morpholino group) are esterified by a usual method to give the compound of formula Ic.
COPYRIGHT: (C)1982,JPO&Japio
JP6777881A1981-05-061981-05-06Aromatic carboxylic acid derivativePendingJPS57183738A (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
JP6777881AJPS57183738A (en)1981-05-061981-05-06Aromatic carboxylic acid derivative

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
JP6777881AJPS57183738A (en)1981-05-061981-05-06Aromatic carboxylic acid derivative

Publications (1)

Publication NumberPublication Date
JPS57183738Atrue JPS57183738A (en)1982-11-12

Family

ID=13354747

Family Applications (1)

Application NumberTitlePriority DateFiling Date
JP6777881APendingJPS57183738A (en)1981-05-061981-05-06Aromatic carboxylic acid derivative

Country Status (1)

CountryLink
JP (1)JPS57183738A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP0825184A1 (en)*1993-03-291998-02-25Zeneca LimitedHeterocyclic derivatives as platelet aggregation inhibitors
WO2008029199A1 (en)*2006-09-032008-03-13Techfields Biochem Co. LtdPositively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate
JP2015120703A (en)*2015-01-052015-07-02テックフィールズ インコーポレイテッド NSAIA prodrug with very fast skin and membrane permeation rate and novel pharmaceutical use thereof
US9371284B2 (en)2007-06-042016-06-21Techfields Pharma Co., Ltd.Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
JP2017105853A (en)*2017-03-222017-06-15テックフィールズ インコーポレイテッドNsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine
US9872846B2 (en)2006-07-092018-01-23Techfields Pharma Co., Ltd.High penetration compositions and uses thereof
JP2020147604A (en)*2020-06-172020-09-17テックフィールズ インコーポレイテッドNsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine
US11135153B2 (en)2006-07-092021-10-05Techfields Pharma Co., Ltd.High penetration composition and uses thereof
US11541029B2 (en)2008-12-042023-01-03Techfields Pharma Co., Ltd.High penetration compositions and their applications
US11813256B2 (en)2012-01-182023-11-14Techfields Pharma Co., Ltd.High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions

Cited By (13)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP0825184A1 (en)*1993-03-291998-02-25Zeneca LimitedHeterocyclic derivatives as platelet aggregation inhibitors
US9872846B2 (en)2006-07-092018-01-23Techfields Pharma Co., Ltd.High penetration compositions and uses thereof
US11135153B2 (en)2006-07-092021-10-05Techfields Pharma Co., Ltd.High penetration composition and uses thereof
WO2008029199A1 (en)*2006-09-032008-03-13Techfields Biochem Co. LtdPositively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate
US10233198B2 (en)2007-06-042019-03-19Techfields Pharma Co., Ltd.Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
US9371284B2 (en)2007-06-042016-06-21Techfields Pharma Co., Ltd.Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
US11541029B2 (en)2008-12-042023-01-03Techfields Pharma Co., Ltd.High penetration compositions and their applications
US11813256B2 (en)2012-01-182023-11-14Techfields Pharma Co., Ltd.High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions
US11857545B2 (en)2012-01-182024-01-02Techfields Pharma Co., Ltd.High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
JP2015120703A (en)*2015-01-052015-07-02テックフィールズ インコーポレイテッド NSAIA prodrug with very fast skin and membrane permeation rate and novel pharmaceutical use thereof
JP2017105853A (en)*2017-03-222017-06-15テックフィールズ インコーポレイテッドNsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine
JP2020147604A (en)*2020-06-172020-09-17テックフィールズ インコーポレイテッドNsaia prodrug having very fast skin- and film-infiltration rate, and new use thereof as medicine
JP2024026659A (en)*2020-06-172024-02-28テックフィールズ インコーポレイテッド NSAIA prodrugs with very fast skin and membrane permeation rates and their novel pharmaceutical uses

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