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JPS55153713A - Pharmaceutical preparation of ribosome containing active substance - Google Patents

Pharmaceutical preparation of ribosome containing active substance

Info

Publication number
JPS55153713A
JPS55153713AJP5428379AJP5428379AJPS55153713AJP S55153713 AJPS55153713 AJP S55153713AJP 5428379 AJP5428379 AJP 5428379AJP 5428379 AJP5428379 AJP 5428379AJP S55153713 AJPS55153713 AJP S55153713A
Authority
JP
Japan
Prior art keywords
active substance
ribosome
wall membrane
pharmaceutical preparation
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5428379A
Other languages
Japanese (ja)
Other versions
JPH0240644B2 (en
Inventor
Takatoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha CorpfiledCriticalKureha Corp
Priority to JP5428379ApriorityCriticalpatent/JPS55153713A/en
Priority to CA000351077Aprioritypatent/CA1143656A/en
Priority to GB8014793Aprioritypatent/GB2050287B/en
Priority to DE19803016976prioritypatent/DE3016976A1/en
Priority to FR8009985Aprioritypatent/FR2455458A1/en
Publication of JPS55153713ApublicationCriticalpatent/JPS55153713A/en
Publication of JPH0240644B2publicationCriticalpatent/JPH0240644B2/ja
Grantedlegal-statusCriticalCurrent

Links

Classifications

Landscapes

Abstract

PURPOSE: The title rebosome pharmaceutical preparation having a high strength of wall membrane and improved prolonged release of an active substance, containing an active substance in its vacuole, obtained by forming the wall membrane wherein a specific amount of oily substance molecules exist in the bimolecular layer of phospholipid.
CONSTITUTION: A wall membrane, wherein 3W20wt%, preferably 5W15wt% of oily substance molecules existin the bimolecular layer of phosphlipid, e.g., Lecithin, is formed and contains an active substance in its vacuole. The oily substance is one compound selected from the group consisting of mineral oil, wax, triglyceride, or their mixture. The ribosome has a complex emulsion form of water in oil in water type (W/O/O type), and more improved retention ability of the active substance than conventional phospholipid micell type emulsion. The ribosome is suitable as a protective for a drug unstable in the living body or one having side effect and useful as a medicine.
COPYRIGHT: (C)1980,JPO&Japio
JP5428379A1979-05-021979-05-02Pharmaceutical preparation of ribosome containing active substanceGrantedJPS55153713A (en)

Priority Applications (5)

Application NumberPriority DateFiling DateTitle
JP5428379AJPS55153713A (en)1979-05-021979-05-02Pharmaceutical preparation of ribosome containing active substance
CA000351077ACA1143656A (en)1979-05-021980-05-01Liposome including active substance
GB8014793AGB2050287B (en)1979-05-021980-05-02Liposomes containing physiologically active substances
DE19803016976DE3016976A1 (en)1979-05-021980-05-02 LIPOSOME CONTAINING AN ACTIVE SUBSTANCE AND METHOD FOR THE PRODUCTION THEREOF
FR8009985AFR2455458A1 (en)1979-05-021980-05-05 LIPOSOMES CONTAINING AN ACTIVE SUBSTANCE, IN PARTICULAR AN ACTIVE INGREDIENT OF A MEDICINAL PRODUCT

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
JP5428379AJPS55153713A (en)1979-05-021979-05-02Pharmaceutical preparation of ribosome containing active substance

Publications (2)

Publication NumberPublication Date
JPS55153713Atrue JPS55153713A (en)1980-11-29
JPH0240644B2 JPH0240644B2 (en)1990-09-12

Family

ID=12966226

Family Applications (1)

Application NumberTitlePriority DateFiling Date
JP5428379AGrantedJPS55153713A (en)1979-05-021979-05-02Pharmaceutical preparation of ribosome containing active substance

Country Status (5)

CountryLink
JP (1)JPS55153713A (en)
CA (1)CA1143656A (en)
DE (1)DE3016976A1 (en)
FR (1)FR2455458A1 (en)
GB (1)GB2050287B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS60152410A (en)*1984-01-231985-08-10Pola Chem Ind IncExternal preparation for skin
JPS60243022A (en)*1984-04-091985-12-03サンド・アクチエンゲゼルシヤフトImprovement on interleukin therapy
JPS61100518A (en)*1984-10-221986-05-19Ono Pharmaceut Co LtdLyophilized ribosome pharmaceutical preparation comprising dimyristoylphosphatidylcholine as main component
WO2005053643A1 (en)*2003-12-012005-06-16Mitsubishi Pharma CorporationLiposome
JP2015514683A (en)*2012-02-162015-05-21ブライトサイド イノベーションズ,インコーポレイティド Food nutritional composition and method of use
WO2017057418A1 (en)*2015-09-282017-04-06小林製薬株式会社Liposome

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NO177774C (en)*1987-01-271995-11-22Vestar Inc Process for the preparation of a composition suitable for administration of a substantially water-insoluble active ingredient
US5723147A (en)*1987-02-231998-03-03Depotech CorporationMultivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5811119A (en)*1987-05-191998-09-22Board Of Regents, The University Of TexasFormulation and use of carotenoids in treatment of cancer
US5925375A (en)*1987-05-221999-07-20The Liposome Company, Inc.Therapeutic use of multilamellar liposomal prostaglandin formulations
US5811118A (en)*1987-05-221998-09-22The Liposome Company, Inc.Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations
US5262168A (en)*1987-05-221993-11-16The Liposome Company, Inc.Prostaglandin-lipid formulations
WO1988009170A1 (en)*1987-05-221988-12-01The Liposome Company, Inc.Prostaglandin-lipid formulations
SE457933B (en)*1987-07-061989-02-13Larsson Kare PHARMACEUTICAL COMPOSITION INCLUDING A WATER DISPERSED MIXTURE OF LIPIDS, MONOGLYCERIDES AND PHOSPHATIDYLCOLINE AND ITS APPLICATION FOR THE PREPARATION OF A GASTRONIN TESTINALLY EFFECTIVE COMPOSITION
US5807572A (en)*1988-02-181998-09-15Depotech CorporationMultivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5422120A (en)*1988-05-301995-06-06Depotech CorporationHeterovesicular liposomes
GB8822857D0 (en)*1988-09-291988-11-02Patralan LtdPharmaceutical formulations
FR2649610B1 (en)*1989-07-131994-06-03Dior Christian Parfums COSMETIC OR PHARMACEUTICAL AND PARTICULARLY DERMATOLOGICAL COMPOSITION CONTAINING AMPC OR ITS LIPOSOME DERIVATIVES
DE4005711C1 (en)*1990-02-231991-06-13A. Nattermann & Cie Gmbh, 5000 Koeln, De
DE4108902A1 (en)*1990-08-061992-02-13Nattermann A & CieAq. liposome systems
US5556637A (en)*1990-08-061996-09-17A. Nattermann & Cie. GmbhWater containing liposome system
DE4107152C2 (en)*1991-03-061994-03-24Gregor Cevc Preparations for non-invasive administration of antidiabetics
DE4107153A1 (en)*1991-03-061992-09-10Gregor CevcCompsns. for application of active agents
US6165500A (en)*1990-08-242000-12-26Idea AgPreparation for the application of agents in mini-droplets
WO1995001163A1 (en)*1992-01-031995-01-12Corbiere JeromeNovel pharmaceutical peptide preparations for general delivery
FR2685868B1 (en)*1992-01-031995-06-23Corbiere Jerome NOVEL PHARMACEUTICAL PREPARATIONS BASED ON PEPTIDES FOR THE GENERAL ROUTE.
ES2128417T3 (en)*1992-01-161999-05-16Univ Texas FORMULATION AND USE OF CAROTENOIDS IN THE TREATMENT OF CANCER.
IL101241A (en)*1992-03-161997-11-20Yissum Res Dev CoPharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
US5989587A (en)*1992-10-231999-11-23National Research Council Of CanadaFormation of stable liposomes from lipid extracts of archaeobacteria (archaeu)
JPH0657741U (en)*1993-01-221994-08-12株式会社村上開明堂 Mirror device with monitoring function
US5455044A (en)*1993-05-141995-10-03Depotech CorporationMethod for treating neurological disorders
US5853755A (en)*1993-07-281998-12-29Pharmaderm Laboratories Ltd.Biphasic multilamellar lipid vesicles
IL107471A (en)*1993-11-021997-09-30Yissum Res Dev CoPharmaceutical preparation comprising a self- emulsifying formulation and process for its production
RO116341B1 (en)*1993-11-162001-01-30Depotech Corp La JoliaMultivesicle liposome and process for producing the same
US5840328A (en)*1994-01-111998-11-24The Liposome Company, Inc.Treatment using arachidonic acid metabolite and particulate formulations
WO1996004891A1 (en)*1994-08-081996-02-22Board Of Regents, The University Of Texas SystemFormulation and use of carotenoids in treatment of cancer
US5993850A (en)*1994-09-131999-11-30Skyepharma Inc.Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US5965160A (en)*1995-04-241999-10-12Yissum Research Development Company Of The Hebrew University Of JerusalemSelf-emulsifiable formulation producing an oil-in-water emulsion
US5931809A (en)*1995-07-141999-08-03Depotech CorporationEpidural administration of therapeutic compounds with sustained rate of release
IL117773A (en)*1996-04-022000-10-31Pharmos LtdSolid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
US5997899A (en)1996-10-011999-12-07Skyepharma Inc.Method for producing liposomes with increased percent of compound encapsulated
WO1999002139A1 (en)*1997-07-101999-01-21Keith BakerMethods for universally distributing therapeutic agents to the brain
US6306432B1 (en)1997-09-082001-10-23Chiron CorporationHigh and low load formulations of IGF-I in multivesicular liposomes
ES2343767T3 (en)1997-09-182010-08-09Pacira Pharmaceuticals, Inc. LIPOSOMIC ANESTHETIC COMPOSITIONS OF SUSTAINED LIBERATION.
WO1999025319A1 (en)1997-11-141999-05-27Depotech CorporationProduction of multivesicular liposomes
KR100638150B1 (en)1998-12-232006-10-26이데아 악티엔게젤샤프트 Improved formulations for local non-invasive use in vivo
PT1031347E (en)1999-01-272002-09-30Idea Ag TRANSNATIONAL TRANSMISSION / IMMUNIZATION WITH MOST ADAPTABLE VEHICLES
EP1031346B1 (en)1999-01-272002-05-02Idea AgNoninvasive vaccination through the skin
AU5409699A (en)1999-07-052001-01-22Idea AgA method for the improvement of transport across adaptable semi-permeable barriers
US20030068361A1 (en)*2001-10-092003-04-10Rimona MargalitLiposome-encapsulated insulin formulations
US7473432B2 (en)2002-10-112009-01-06Idea AgNSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
EP2585046A4 (en)*2010-06-232013-11-06Brightside Innovations Inc CARRIER VESICLES OF LECITHIN AND METHODS OF MAKING SAME
CN110536674A (en)*2017-05-232019-12-03大江生医股份有限公司Emulsified fatty substance body composition and preparation method thereof
US11033495B1 (en)2021-01-222021-06-15Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en)2021-01-222024-11-26Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en)2021-01-222022-06-14Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en)2021-01-222022-03-22Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US12285419B2 (en)2021-10-142025-04-29Pacira Pharmaceuticals, Inc.Bupivacaine multivesicular liposome formulations and uses thereof
US12251472B1 (en)2024-05-202025-03-18Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en)2024-05-202024-12-03Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes
US12251468B1 (en)2024-05-202025-03-18Pacira Pharmaceuticals, Inc.Manufacturing of bupivacaine multivesicular liposomes

Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS49118826A (en)*1971-10-121974-11-13
JPS5186117A (en)*1975-01-271976-07-28Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
JPS5513260A (en)*1978-04-141980-01-30Little Inc AXenobiotics transfer vehicles*their production and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3060030A (en)*1960-04-041962-10-23Carl F ObenaufLecithinated product
JPS5126213A (en)*1974-08-211976-03-04Tanabe Seiyaku Co JOHOSEIBIRYUSHISEIZAINO SEIHO
GB1575343A (en)*1977-05-101980-09-17Ici LtdMethod for preparing liposome compositions containing biologically active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS49118826A (en)*1971-10-121974-11-13
JPS5186117A (en)*1975-01-271976-07-28Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
JPS5513260A (en)*1978-04-141980-01-30Little Inc AXenobiotics transfer vehicles*their production and use

Cited By (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS60152410A (en)*1984-01-231985-08-10Pola Chem Ind IncExternal preparation for skin
JPS60243022A (en)*1984-04-091985-12-03サンド・アクチエンゲゼルシヤフトImprovement on interleukin therapy
JPS61100518A (en)*1984-10-221986-05-19Ono Pharmaceut Co LtdLyophilized ribosome pharmaceutical preparation comprising dimyristoylphosphatidylcholine as main component
WO2005053643A1 (en)*2003-12-012005-06-16Mitsubishi Pharma CorporationLiposome
JP2015514683A (en)*2012-02-162015-05-21ブライトサイド イノベーションズ,インコーポレイティド Food nutritional composition and method of use
US10888572B2 (en)2012-02-162021-01-12Bio-Up Mimetic Technologies, Inc.Dietary and nutritional compositions and methods of use
WO2017057418A1 (en)*2015-09-282017-04-06小林製薬株式会社Liposome
JP2017066059A (en)*2015-09-282017-04-06小林製薬株式会社Liposome

Also Published As

Publication numberPublication date
GB2050287A (en)1981-01-07
CA1143656A (en)1983-03-29
JPH0240644B2 (en)1990-09-12
DE3016976A1 (en)1980-11-13
FR2455458A1 (en)1980-11-28
FR2455458B1 (en)1983-04-15
GB2050287B (en)1983-04-20

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