【０００１】[0001]
【産業上の利用分野】本発明は、血液浄化療法で使用さ
れる透析装置又は透析液供給装置の消毒方法に関するも
のである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for disinfecting a dialysis machine or a dialysate supply system used in blood purification therapy.
【０００２】[0002]
【従来の技術】医療用装置特に透析装置の液流路は、透
析治療後の体液老廃物で汚染されこれが病原菌感染の原
因となる。これら液流路の大部分はディスポーザルとし
て治療終了ごとに取り替えることもできないため、透析
終了ごとに該液流路を消毒して再度使用することにな
る。2. Description of the Related Art The liquid flow path of a medical device, particularly a dialysis device, is contaminated with body fluid waste products after dialysis treatment, which causes infection of pathogenic bacteria. Since most of these liquid flow paths cannot be replaced as a disposable after each treatment, the liquid flow paths must be disinfected and used again after each dialysis.
【０００３】従来の液流路消毒方法は薬液を使用すると
か、熱湯を使用する方法である。薬液を使用する方法と
しては、次亜塩素酸系消毒薬を水で数百ｐｐｍ濃度に希
釈し、液流路内をこの液で満たし一昼夜放置する方法、
また、数千から数十万ｐｐｍで数時間から数十分間にわ
たり液流路内に薬液を流し消毒する方法が行われてい
る。その他の薬液を用いることもあるがいずれも液流路
内に薬液を流す方法である。熱湯を使用する方法は摂氏
数十度の熱水を液流路内に流す方法である。The conventional liquid flow path disinfection method is to use a chemical solution or hot water. As a method of using a chemical solution, a method of diluting a hypochlorous acid-based disinfectant with water to a concentration of several hundred ppm and filling the liquid flow path with this solution and leaving it for a whole day and night,
In addition, a method of sterilizing by flowing a chemical solution in a liquid flow path for several hours to several tens of minutes at several thousands to several hundreds of thousands ppm is used. Although other chemicals may be used, they are all methods of flowing the chemicals into the liquid flow path. The method of using hot water is a method of flowing hot water of several tens of degrees Celsius into the liquid flow path.
【０００４】[0004]
【発明が解決しようとする課題】しかしこれらの消毒方
法では、次の問題があった。次亜塩素酸系及びその他消
毒薬液は薬剤濃度の高い消毒薬液を使用する必要がある
こと、消毒後の廃液は、下水に直接流すことが出来ない
ので廃液処理槽を通すが、消毒薬液の濃度が濃いほどこ
の廃液処理の負担が大きいことが問題であった。However, these disinfection methods have the following problems. Hypochlorite-based and other disinfectant solutions must use a high disinfectant solution, and the waste solution after disinfection cannot be passed directly to sewage, so it passes through the waste solution treatment tank, but the disinfectant solution concentration The higher the concentration, the greater the burden of waste liquid treatment, which was a problem.
【０００５】また、熱湯の消毒方法は液流路内に熱水が
流れるため、液流路に耐熱性のよい材料を使用せねばな
らないことや耐圧性機構を液流路にもたせねばならない
必要があった。このため液流路の材質は金属を採用する
ことになるが、これは装置の重量が増加すること、装置
の製造原価が高くなることにつながる。そして金属材料
を使用すると消毒中に手が接触して火傷をする心配も大
きかった。Further, in the method of disinfecting hot water, since hot water flows in the liquid flow path, it is necessary to use a material having good heat resistance in the liquid flow path and to provide a pressure resistant mechanism also in the liquid flow path. there were. For this reason, a metal is used as the material of the liquid flow path, but this leads to an increase in the weight of the device and an increase in the manufacturing cost of the device. Also, when using a metal material, there was a great concern that the hand might come into contact with the hand during the disinfection, resulting in burns.
【０００６】本発明は、かかる課題を解決するために、
薬剤濃度の低い消毒薬液を使用しながらも従来通りの消
毒効果が得られる方法を提供する。In order to solve such problems, the present invention provides
Provided is a method for obtaining a conventional disinfecting effect while using an antiseptic solution having a low drug concentration.
【０００７】[0007]
【課題を解決するための手段】本発明は、透析膜を介し
て血液などの体液を透析液に接触させて浄化するように
した浄化器に対して透析液を流入させる透析液流入路
と、該透析器から流出する透析液を導く透析液流出路と
を備え、該透析液流路を通じて前記透析液としての電解
質溶液を供給しかつ流通させる透析装置を塩化ナトリウ
ム水溶液の電解によって得られる電解水で洗浄する場合
において、該電解水のｐＨが４〜６であることを特徴と
する透析装置の消毒方法を要旨とする。DISCLOSURE OF THE INVENTION The present invention provides a dialysate inflow passage through which a dialysate flows into a purifier designed to bring a body fluid such as blood into contact with a dialysate through a dialysis membrane for purification. A dialysis device provided with a dialysate outflow passage for guiding a dialysate flowing out from the dialyzer, and supplying and circulating an electrolyte solution as the dialysate through the dialysate flow path is electrolyzed water obtained by electrolysis of an aqueous sodium chloride solution. The method of disinfecting a dialysis device is characterized in that the electrolyzed water has a pH of 4 to 6 when washed with.
【０００８】本発明において用いられる透析装置又は透
析液供給装置は公知のものである。The dialysis device or dialysate supply device used in the present invention is known.
【０００９】本発明において、塩化ナトリウム水溶液の
電解によって得られる電解水とは次のような公知の方法
で準備する。 （１）０．０５〜３％程度の濃度の塩化ナトリウム水を
アノード（例：チタン基板に白金及びイリジウムをコー
ティングした電極等）とカソード（耐蝕性のものが好
適）を配した電解槽中で電解に付す方法（特開平２−１
１１７０８号公報に開示）。 （２）塩化ナトリウムを添加した水と塩酸を添加した水
とを混合し、これを無隔膜電解槽で電気分解することで
次亜塩素酸含有水を製造し、陰極室側の電解水を有効に
利用する（特開平５−２３７４７８号公報に開示）。In the present invention, electrolyzed water obtained by electrolysis of an aqueous sodium chloride solution is prepared by the following known method. (1) In an electrolytic cell in which an aqueous solution of sodium chloride having a concentration of about 0.05 to 3% is arranged as an anode (eg, an electrode in which a titanium substrate is coated with platinum and iridium) and a cathode (preferably a corrosion resistant one). Method of subjecting to electrolysis (Japanese Patent Laid-Open No. 2-1
Disclosed in JP 11708). (2) Water containing sodium chloride and water containing hydrochloric acid are mixed, and electrolyzed in a diaphragmless electrolytic cell to produce hypochlorous acid-containing water, and electrolyzed water on the cathode chamber side is effectively used. (Disclosed in Japanese Patent Laid-Open No. 5-237478).
【００１０】本発明において、塩化ナトリウム水溶液と
は上記（２）のように、純粋の塩化ナトリウム水溶液で
なくてもよい。In the present invention, the aqueous sodium chloride solution does not have to be a pure aqueous sodium chloride solution as described in (2) above.
【００１１】[0011]
【作用】本発明は、透析装置又は透析液供給装置を電解
水で洗浄する場合において、該電解水のｐＨが４〜６で
あり、この結果、有効塩素濃度がわずか５〜１５０ｐｐ
ｍで消毒の効果が顕著に現れることを特徴とする透析液
供給装置の消毒方法である。ここでｐＨが４未満である
と装置の液流路が仮にステンレスであったとしても腐食
する心配がある。また、ｐＨが６を超えると消毒の効果
が少なくなるという問題がある。有効塩素濃度も５ｐｐ
ｍ未満であると消毒の効果が少なくなるが、逆に有効塩
素濃度が１５０ｐｐｍを超えると消毒効果は良くても廃
液処理がしにくくなるので好ましくない。但し、液流路
において消毒水の滞留時間が極端に短いときは適宜１５
０〜３００ｐｐｍで消毒しても構わない。According to the present invention, when the dialyzer or dialysate feeder is washed with electrolyzed water, the electrolyzed water has a pH of 4 to 6, and as a result, the effective chlorine concentration is only 5 to 150 pp.
m is a disinfection method for a dialysate supply device, in which the disinfection effect remarkably appears. If the pH is less than 4 here, there is a risk of corrosion even if the liquid flow path of the apparatus is made of stainless steel. Further, if the pH exceeds 6, there is a problem that the effect of disinfection decreases. Effective chlorine concentration is 5pp
If it is less than m, the disinfecting effect is reduced, but conversely, if the effective chlorine concentration exceeds 150 ppm, the disinfecting effect is good but the waste liquid treatment becomes difficult, which is not preferable. However, when the retention time of the disinfecting water in the liquid flow path is extremely short, it is appropriately 15
It may be disinfected at 0 to 300 ppm.
【００１２】[0012]
【発明の効果】本発明によれば、透析装置の消毒方法と
して、市販の次亜塩素酸ナトリウムの濃厚液を消毒液と
して準備する必要なく、塩化ナトリウムを含む電解水を
消毒に用いる結果、次亜塩素酸塩の希薄な液であっても
消毒液として用いることができる。これにより、消毒後
の廃液中に含まれる塩素濃度も低下し廃液処理槽の負荷
も低減できる。According to the present invention, as a method for disinfecting a dialysis apparatus, it is not necessary to prepare a commercially available concentrated solution of sodium hypochlorite as an antiseptic solution, and as a result of using electrolytic water containing sodium chloride for disinfection, Even a dilute solution of chlorite can be used as an antiseptic solution. As a result, the concentration of chlorine contained in the waste liquid after disinfection can be reduced and the load on the waste liquid treatment tank can be reduced.
【００１３】[0013]
【実施例】次亜塩素酸を発生させる消毒装置をを用い
て、濃度０．１％の塩化ナトリウム水を１５００ｍｌ／
分の流量で電解槽に送り、電解電流１２アンペアで電解
し、有効塩素（殺菌水中に残留する遊離塩素のことを言
う。）濃度が５０ｐｐｍの消毒水を得た。この消毒水１
０ｍｌと３８万個／ｍｌの大腸菌を含む菌液０．１ｍｌ
とを混合し、２５℃で１０分間接触させた後、混合液中
の残菌数を測定した結果、大腸菌の数は２６０個／ｍｌ
であった。[Example] Using a disinfection device that generates hypochlorous acid, 1500 ml / 0.1 ml of 0.1% concentration of sodium chloride water was used.
It was sent to an electrolytic cell at a flow rate of a minute and electrolyzed at an electrolytic current of 12 amps to obtain disinfecting water having a concentration of available chlorine (which means free chlorine remaining in sterilized water) of 50 ppm. This disinfection water 1
0.1 ml of bacterial solution containing 0 ml and 380,000 cells / ml of E. coli
After mixing with and contacting them at 25 ° C for 10 minutes, the number of remaining bacteria in the mixed solution was measured, and as a result, the number of E. coli was 260 cells / ml
Met.
【００１４】比較例１として市販の次亜塩素酸ナトリウ
ムの濃厚液であって、有効塩素濃度が３００ｐｐｍの消
毒水で上記と同様の殺菌効果を測定した結果、大腸菌の
数は２７０個／ｍｌであった。As Comparative Example 1, a commercially available concentrated solution of sodium hypochlorite was used, and the same bactericidal effect was measured with disinfecting water having an effective chlorine concentration of 300 ppm. As a result, the number of E. coli was 270 cells / ml. there were.
【００１５】比較例２として市販の次亜塩素酸ナトリウ
ムの濃厚液であって、有効塩素濃度が５０ｐｐｍの消毒
水で上記と同様の殺菌効果を測定した結果、大腸菌の数
は１３４０個／ｍｌであった。As Comparative Example 2, a commercially available concentrated solution of sodium hypochlorite was used, and the same bactericidal effect was measured with disinfecting water having an effective chlorine concentration of 50 ppm. As a result, the number of E. coli was 1340 / ml. there were.
【００１６】以下、本発明の消毒方法による装置の実施
例を図面に従って説明する。図１は本発明の透析装置の
消毒方法を実施する装置例の構成図である。図は、透析
装置２に消毒装置１を連結したものである。Embodiments of the apparatus according to the disinfection method of the present invention will be described below with reference to the drawings. FIG. 1 is a block diagram of an example of an apparatus for carrying out the dialysis apparatus disinfection method of the present invention. In the figure, the dialysis device 2 is connected to the disinfection device 1.
【００１７】透析装置２は血液を浄化する浄化器を取り
付け、透析液の原液を水で３５倍程度に希釈する攪拌装
置も付けられ、それらの操作部からなる。透析治療にあ
たり必要な透析液の量は一例として５００ｍｌ／分の流
量で４時間となる。The dialysis device 2 is equipped with a purifier for purifying blood, and is also equipped with a stirring device for diluting a stock solution of dialysate with water about 35 times, and is composed of their operating parts. For example, the amount of dialysate required for dialysis treatment is 4 hours at a flow rate of 500 ml / min.
【００１８】治療中の透析液の供給は本発明の消毒装置
１においてはバイパス経路で供給する。すなわち、消毒
装置１の電源ブレーカー５をＯＦＦにし、透析用の水は
水入り口３よりまず消毒装置１へ流入し、減圧弁４で指
定の圧力まで減圧され、ノーマルオープン（ＮＯ）タイ
プの二方電磁弁６へ導かれ、自閉式カプラ７よりカプラ
８を通して透析装置２へ送り込む。The supply of dialysate during treatment is supplied by the bypass route in the disinfection device 1 of the present invention. That is, the power breaker 5 of the disinfection device 1 is turned off, and the dialysis water first flows into the disinfection device 1 through the water inlet 3 and is decompressed to a specified pressure by the pressure reducing valve 4, which is a normally open (NO) type two way. It is guided to the solenoid valve 6 and sent from the self-closing coupler 7 to the dialysis device 2 through the coupler 8.
【００１９】透析治療が終了して、透析装置２の流路を
消毒するときは、消毒装置１を作動させて自閉式カプラ
７とカプラ８を離し、自閉式カプラ９へカプラ８を接続
する。そして電源ブレーカー５をＯＮにすると電源ラン
プ１０が点灯し、ノーマルクローズ（ＮＣ）タイプの二
方電磁弁１１が開くとともに二方電磁弁６が閉じる。When the dialysis treatment is completed and the flow path of the dialysis device 2 is to be disinfected, the disinfection device 1 is operated to separate the self-closing coupler 7 from the coupler 8, and the coupler 8 is connected to the self-closing coupler 9. When the power breaker 5 is turned on, the power lamp 10 is turned on, the normally closed (NC) type two-way solenoid valve 11 is opened, and the two-way solenoid valve 6 is closed.
【００２０】透析装置２の消毒を開始するために、以下
の手順で消毒装置１で次亜塩素酸を発生した消毒液を作
り、それを透析装置２へ供給する。In order to start the disinfection of the dialysis device 2, the disinfecting device 1 produces a disinfectant solution containing hypochlorous acid by the following procedure, and the disinfecting liquid is supplied to the dialysis device 2.
【００２１】水入り口３より流入した水は減圧弁４・二
方電磁弁１１・フロースイッチ付き流量計１２を通り攪
拌槽１３へ流入する。これと同時に電解質溶液１４は送
液ポンプ１７によりコネクターオス１５・コネクターメ
ス１６・逆止弁１８を通り水との混合部１９へ導かれ攪
拌槽１３へ流入し水と均一に混合される。混合後の希釈
された電解質溶液を反応槽２０へ通すと電解により次亜
塩素酸を含んだ溶液が作成される。電解水のｐＨが４〜
６であり、かつ、有効塩素濃度が５〜１５０ｐｐｍの消
毒水を得るには、濃度０．０３〜０．３％の塩化ナトリ
ウム水を５００〜３０００ｍｌ／分の流量で電解槽に送
り、電解電流１２アンペアで電解すればよい。消毒水は
流量計２１を通り透析装置２へ供給され、透析装置の液
流路消毒が行われる。この場合の液量は約７５０ｍｌ／
分である。Water flowing from the water inlet 3 flows into the stirring tank 13 through the pressure reducing valve 4, the two-way solenoid valve 11 and the flow meter 12 with a flow switch. At the same time, the electrolyte solution 14 is guided by the liquid feed pump 17 through the connector male 15, the connector female 16, and the check valve 18 to the mixing section 19 with water, flows into the stirring tank 13, and is uniformly mixed with water. When the diluted electrolyte solution after mixing is passed through the reaction tank 20, electrolysis produces a solution containing hypochlorous acid. PH of electrolyzed water is 4 ~
In order to obtain disinfecting water having an effective chlorine concentration of 5 to 150 ppm, sodium chloride water having a concentration of 0.03 to 0.3% is sent to the electrolytic cell at a flow rate of 500 to 3000 ml / min to generate an electrolytic current. Electrolyze at 12 amps. The disinfecting water is supplied to the dialyzer 2 through the flow meter 21, and the liquid flow path disinfection of the dialyzer is performed. The liquid volume in this case is about 750 ml /
Minutes.
【００２２】安全機構として、透析装置２の信号出力端
子部２３より、カプラ、準備、開始信号を出力し、消毒
装置１の信号入力端子部２４より電源／制御部２５に信
号を入れ、これとフロースイッチ付き流量計の出力信号
があることを電源／制御部２５が確認した上で反応槽２
０へ電流が流れ次亜塩素酸が発生するよう制御が行われ
る。また、目視できるように反応槽が作動すると反応槽
動作ランプ２２が点灯する。As a safety mechanism, a coupler, a preparation, and a start signal are output from the signal output terminal section 23 of the dialysis machine 2, and a signal is input from the signal input terminal section 24 of the disinfection system 1 to the power supply / control section 25. After confirming that there is an output signal from the flowmeter with a flow switch, the power supply / control unit 25 confirms that the reaction tank 2
Control is performed so that current flows to 0 and hypochlorous acid is generated. Further, when the reaction tank operates so that it can be visually observed, the reaction tank operation lamp 22 is turned on.
【００２３】以上に実施例を挙げて本発明を説明した
が、本発明は上記実施例に限定されるものではなく、そ
の要旨を変更しない範囲で種々変更可能である。例え
ば、上記実施例においては、消毒装置を透析装置へ取り
付け動作させていたが、透析装置でなく、これを透析液
供給装置などとすることも可能である。Although the present invention has been described with reference to the embodiments, the present invention is not limited to the above embodiments, and various modifications can be made without departing from the scope of the invention. For example, in the above embodiment, the disinfecting device was attached to the dialysis device and operated, but it is also possible to use this as a dialysate supply device instead of the dialysis device.
【図１】本発明の透析液供給装置の消毒方法を実施する
装置例の構成図。FIG. 1 is a configuration diagram of an example of a device for implementing a disinfection method for a dialysate supply device of the present invention.
１ 消毒装置 ２ 透析装置 ３ 消毒装置水入り口 ４ 減圧弁 ５ 電源ブレーカー ６ 二方電磁弁（ＮＯ） ７ 自閉式カプラ ８ カプラ ９ 自閉式カプラ １０ 電源ランプ １１ 二方電磁弁（ＮＣ） １２ フロースイッチ付き流量計 １３ 攪拌槽 １４ 電解質溶液 １５ コネクターオス １６ コネクターメス １７ 送液ポンプ １８ 逆止弁 １９ 混合部 ２０ 反応槽 ２１ 流量計 ２２ 反応槽動作ランプ ２３ 信号出力端子部 ２４ 信号入力端子部 ２５ 電源／制御部 1 Disinfection device 2 Dialysis device 3 Disinfection device Water inlet 4 Pressure reducing valve 5 Power breaker 6 Two-way solenoid valve (NO) 7 Self-closing coupler 8 Coupler 9 Self-closing coupler 10 Power lamp 11 Two-way solenoid valve (NC) 12 With flow switch Flowmeter 13 Stirring tank 14 Electrolyte solution 15 Connector male 16 Connector female 17 Liquid feed pump 18 Check valve 19 Mixing section 20 Reaction tank 21 Flowmeter 22 Reaction tank operation lamp 23 Signal output terminal section 24 Signal input terminal section 25 Power supply / control Department
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6215050AJPH0871147A (en) | 1994-09-08 | 1994-09-08 | Method for disinfecting dialysis device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6215050AJPH0871147A (en) | 1994-09-08 | 1994-09-08 | Method for disinfecting dialysis device |
| Publication Number | Publication Date |
|---|---|
| JPH0871147Atrue JPH0871147A (en) | 1996-03-19 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6215050APendingJPH0871147A (en) | 1994-09-08 | 1994-09-08 | Method for disinfecting dialysis device |
| Country | Link |
|---|---|
| JP (1) | JPH0871147A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10127760A (en)* | 1996-10-02 | 1998-05-19 | Fresenius Medical Care Deutsche Gmbh | Disinfecting method and device for medical apparatus |
| JP2001353214A (en)* | 2000-06-14 | 2001-12-25 | Toray Medical Co Ltd | Dialysis system |
| JP2009142436A (en)* | 2007-12-13 | 2009-07-02 | Tsutomu Sanaka | Aqueous solution for dialysis |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10127760A (en)* | 1996-10-02 | 1998-05-19 | Fresenius Medical Care Deutsche Gmbh | Disinfecting method and device for medical apparatus |
| JP2001353214A (en)* | 2000-06-14 | 2001-12-25 | Toray Medical Co Ltd | Dialysis system |
| JP2009142436A (en)* | 2007-12-13 | 2009-07-02 | Tsutomu Sanaka | Aqueous solution for dialysis |
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