【発明の詳細な説明】Ｕ産業上の利用分野コ本発明は、整腸用組成物に関する。更に詳しくは、般食
品、健康食品、機能性食品などの食品素材をはじめ、医
薬、飼料分野において使用され得る乳酸菌及びビフィズ
ス菌の増殖作用による整腸機能、体調維持機能をもっ組
成物に関する。DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a composition for intestinal regulation. More specifically, the present invention relates to a composition having intestinal regulation function and physical condition maintenance function due to the growth action of lactic acid bacteria and bifidobacteria, which can be used in food materials such as general foods, health foods, and functional foods, as well as in the pharmaceutical and feed fields.
７従来の技術］オリゴ糖は、腸内において乳酸菌及びビフィズス菌を増
殖させる機能をもち、便通を良くする整腸作用を有し、
しかも大腸内で癌が発生するのを抑制する作用を呈する
ので、従来より種々の健康食品なとに使用されつつある
（食品と開発２４ Ｆ２（（１９８９） Ｐ、６０〜６
７）。7. Prior art] Oligosaccharides have the function of proliferating lactic acid bacteria and bifidobacteria in the intestine, and have an intestinal regulation effect that improves bowel movement.
Moreover, since it exhibits the effect of suppressing the development of cancer in the large intestine, it has been used in various health foods (Food and Development 24 F2 ((1989) P, 60-6
7).
又、ユッカもその抽出物や破砕品は、腸内に生息して（
・るビフィズス菌を増殖させ、整腸作用を有する。In addition, yucca extracts and crushed products live in the intestines (
- Propagates Bifidobacterium and has an intestinal regulating effect.
発明か解決しようとする課題］しかしなから、十分な整腸作用を発揮させるにめには、
それぞれを単独で用いる場合、多量のオリゴ糖、ユッカ
を使用しなければならず、少量を摂取するだけでこれら
の作用を充分に発揮する整腸用組成物について研究かす
すめられているが、未だかかる整腸組成物は見出されて
いないのが現状である。[Invention or problem to be solved] However, in order to exert sufficient intestinal regulation effect,
When using each alone, large amounts of oligosaccharide and yucca must be used, and research is being conducted on compositions for intestinal regulation that can sufficiently exert these effects by ingesting small amounts, but there are still no studies yet. At present, no such intestinal regulation composition has been found.
［課題を解決しようとするｆめの手段］そこで、本発明
者等は前記従来技術に鑑みて、少量使用するだけで優れ
た整腸作用なとを発揮する整腸用組成物をうるべく鋭意
研究を重ねたところ、驚くべきことにオリゴ糖とユッカ
とを併用しに組成物が乳酸菌やビフィズス菌増殖作用に
著しい効果を発揮すること、つまりユッカ及びオリゴ糖
を単独使用する場合から全く予想出来なかった著しく大
きな相乗効果を得ることを見出し、本発明を完成するに
至った。[Fth Means for Solving the Problem] Therefore, in view of the above-mentioned prior art, the present inventors have worked diligently to create a composition for intestinal regulation that exhibits an excellent intestinal regulation effect even when used in a small amount. As a result of repeated research, we surprisingly found that a composition using oligosaccharides and yucca in combination exerts a remarkable effect on the growth of lactic acid bacteria and bifidobacteria, which was completely unexpected from the case of using yucca and oligosaccharides alone. They discovered that a significantly greater synergistic effect could be obtained, and completed the present invention.
即ち、本発明はユッカとイソマルトオリゴ糖、ガラクト
オリゴ糖、フラクトオリゴ糖から選ばれるオリゴ糖とか
配合されてなる整腸用組成物に関する。That is, the present invention relates to an intestinal regulation composition containing yucca and an oligosaccharide selected from isomaltooligosaccharides, galactooligosaccharides, and fructooligosaccharides.
前記の如く本発明はユッカとオリゴ糖を併用した場合に
は、それぞれ単独で用いｆコ場合に比べて、格段優れ１
こ整腸作用が呈されるという知見に基ついてなされたも
のである。As mentioned above, the present invention shows that when yucca and oligosaccharide are used together, it is much better than when each is used alone.
This was done based on the knowledge that it has an intestinal regulating effect.
尚、本明細書にいう整腸作用とは、腸内のビフィズス菌
の増殖か促進されることによる排便促進や腸内の有害・
菌の抑制、腸内フローラの正常化、腸管内圧の正常化、
便量の増加による大腸内の有害物質の希釈及び腸壁に付
着している油状汚物を除去することによる吸収作用の正
常化なとの作用をいう。In addition, the intestinal regulation effect referred to in this specification refers to the promotion of defecation by promoting the growth of bifidobacteria in the intestine, and the prevention of harmful and harmful substances in the intestine.
Suppression of bacteria, normalization of intestinal flora, normalization of intestinal pressure,
This refers to the effect of diluting harmful substances in the large intestine due to increased stool volume and normalizing absorption by removing oily dirt adhering to the intestinal wall.
本発明の整腸用組成物は前記のような整腸作用を有する
ので便秘の予防などのために好適に使用しうるしのであ
り、ヒト及び動物の排泄物の臭気抑制効果かあり、更に
成人病をも予防しうるちのである。The composition for regulating the intestines of the present invention has the above-mentioned effect on regulating the intestines, so it can be suitably used for the prevention of constipation, etc. It also has the effect of suppressing the odor of human and animal excreta, and furthermore, it has the effect of suppressing the odor of human and animal excreta. It also prevents.
本発明に用いられるオリゴ糖とは、例えばビフィズス菌
の増殖促進物質として用いられているフラクトオリゴ糖
、ガラクトオリゴ糖、イソマルトオリゴ糖の３って、こ
れらはいずれも生体に安全であることか確認されている
オリゴ糖である。ｅＪｌ これらのオリゴ糖は単独で、
又は２種以上を組合わせて用いてもよい。また、かかろ
オリゴ糖の形状については、特に限定はなく、例えば粒
子状、粉末状、顆粒状、液状など任意の形で用いられう
る。The oligosaccharides used in the present invention include, for example, fructooligosaccharides, galactooligosaccharides, and isomalto-oligosaccharides, which are used as growth-promoting substances for bifidobacteria, all of which have been confirmed to be safe for living organisms. It is an oligosaccharide. eJl These oligosaccharides alone,
Alternatively, two or more types may be used in combination. Further, there is no particular limitation on the shape of the oligosaccharide, and it may be used in any form, such as particulate, powder, granule, or liquid.
本発明に用いられるユッカは、非アルコール性飲料やア
イスクリームなどの添加剤として用いられているもので
あり、これも生体に安全であることか確認されている。The yucca used in the present invention is used as an additive for non-alcoholic drinks, ice cream, etc., and it has been confirmed that it is safe for living organisms.
又、ユッカ又はその抽出物には、有害バクテリアの毒素
が要因であるといわれる関節炎やリューマチに効能かあ
り、又、飼料に添加すると家畜の成長を促進し、牛肉や
牛乳の産出量を増加させる効果かあるといわれている。In addition, yucca or its extracts are effective against arthritis and rheumatism, which are said to be caused by harmful bacterial toxins, and when added to feed, it promotes the growth of livestock and increases the production of beef and milk. It is said to be effective.
本発明においてユッカは、ユッカのすべての部分、即ち
、花、種子、種子莢、果実、葉、茎、及び根を用いるこ
とができ、常法（こより乾燥して得られる粉末や抽出液
などとして用いられろ。In the present invention, all parts of Yucca can be used, such as flowers, seeds, seed pods, fruits, leaves, stems, and roots. Be used.
前記のユッカの抽出物をうる方法としては、例えば前記
ユッカを沸騰水により煮沸する方法、アルコールなどの
有機溶媒で抽出する方法、ユッカを単に圧搾する方法な
とが挙げられるか、本発明はこれらの方法のみ限定され
るものではない。Examples of methods for obtaining the yucca extract include boiling the yucca with boiling water, extracting it with an organic solvent such as alcohol, and simply pressing the yucca. The method is not limited to the above method.
面記ユッカとオリゴ糖は、その混合比（ユッカ、オリゴ
糖１重量基準、以下同様）力（１：９〜９：１、好まし
くは１５〜５：ｌ、特に好ましくは２：４〜４２となる
ように調整される。前記混合比が９，１をこえる場合及
びＩ・９未満である場合のいずれも目的とする整腸作用
が相乗的に発揮されにくくなる傾向がある。Yucca and oligosaccharide have a mixing ratio (based on 1 weight of yucca and oligosaccharide, the same applies hereinafter) of 1:9 to 9:1, preferably 15 to 5:1, particularly preferably 2:4 to 42. When the mixing ratio exceeds 9.1 and when it is less than I.9, it tends to be difficult to synergistically exhibit the desired intestinal regulation effect.
かくして得られる本発明の整腸用組成物の使用量は、成
人に対して通常１日あたり０．２〜１０ｇである。The amount of the intestinal regulation composition of the present invention thus obtained is usually 0.2 to 10 g per day for adults.
本発明の組成物の形態は水溶液、水懸濁液、水飴状、乾
燥固型、粉末状又はカプセル等任意の形で用いられる。The composition of the present invention can be used in any form such as an aqueous solution, aqueous suspension, starch syrup, dry solid, powder, or capsule.
本発明の整腸用組成物は、そのままの状態で使用されて
もよいが、更に例えば、ヨーグルト、豆乳、牛乳なとの
飲物やビスケットなどの菓子類などの食物に混合されて
使用されてもよい。整腸用組成物を食物に混合する場合
には、該整腸用組成物の食物中における自存率は０１〜
２０重量％、なかんつく０２〜１０重量％となるように
調整されるのか好ましい。本発明の整腸組成物には、更
に薬理学的に許容しうる、例えば保存剤、ソルビン酸、
デヒドロ酢酸などの添加剤か適宜配合されても良い。The intestinal regulation composition of the present invention may be used as it is, or may be mixed with foods such as yogurt, soy milk, milk drinks, and confectionery such as biscuits. good. When the intestinal regulation composition is mixed with food, the survival rate of the intestinal regulation composition in the food is 01 to 0.
It is preferable to adjust the content to 20% by weight, particularly 02 to 10% by weight. The intestinal regulation composition of the present invention further includes pharmacologically acceptable agents, such as preservatives, sorbic acid,
Additives such as dehydroacetic acid may be added as appropriate.
３作 用本発明のユッカとオリゴ糖との組成物は、極ぬで優れた
整腸機能をもつ。3. Effects The composition of yucca and oligosaccharide of the present invention has an extremely excellent intestinal regulation function.
二実施例次に実施例を挙げて本発明の整腸用組成物を更に具体的
に説明する。Second Example Next, the composition for intestinal regulation of the present invention will be explained in more detail with reference to Examples.
実施例１〜２、対照例１〜８乳酸菌培養の培地（ペプトン５９／ｃ、イーストエキス
５９／ａ、硫酸マクネンウム・７水和物１ｙ／ρを混合
溶解し、水酸化ナトリウム水溶液でＰＨ７に調整して製
造）及びビフィズス菌培養の培＠（カザミノ酸８ｇ、Ｑ
、イーストエキス４．８９／ρ、ポリペプトン３．２９
／ｌ！、Ｌ−システィン０．４ｇ／（１、食塩ｒ 、
５９＃、ノニオンイオン性界面活性剤であるアトラスパ
ウダー社製の商品名Ｔｗｅｅｎ８０（ポリオキノエチレ
ンソルヒタンモノオレート系）１．０１？／Ｑをそれぞ
れ混合溶解し、水酸化ナトリウム水溶液でＰＨ７に調整
して製造）の２つの培地を準備しｆコ。Examples 1-2, Control Examples 1-8 Lactic acid bacteria culture medium (mixed and dissolved peptone 59/c, yeast extract 59/a, macanenium sulfate heptahydrate 1y/ρ, adjusted to pH 7 with aqueous sodium hydroxide solution) ) and Bifidobacterium culture medium @ (casamino acids 8g, Q
, yeast extract 4.89/ρ, polypeptone 3.29
/l! , L-cysteine 0.4g/(1, salt r,
59#, a nonionic ionic surfactant manufactured by Atlas Powder under the trade name Tween 80 (polyoquinoethylene solhitane monooleate type) 1.01? /Q were mixed and dissolved respectively, and the pH was adjusted to 7 with an aqueous sodium hydroxide solution to prepare two media.
次にそれぞれの培地にユッカとオリゴ糖を１：１の割合
て２９／ｇ加え基本培地とし１こ。尚、対照例はユッカ
及びオリゴ糖を単独で加えた。Next, 29/g of yucca and oligosaccharide were added to each medium at a ratio of 1:1 to form a basic medium. In addition, in the control example, yucca and oligosaccharide were added alone.
上記基本培地を滅菌した後、一定量の菌懸濁液（乳酸菌
二うクトバチリウス ブレビ゛ス（Ｌａｃｔｏｂａｃｉ
ｌｌｕｓ ｂｒｅｖｉｓ） ｊ及びビフィズス菌［ビ
フィドバクテリウム ブレへ（ｂｉｆｉｄｏ ｂｕｃｔ
ｅｒｉｕｍ ｂｒｅｖｅ）コを植え、乳酸菌培養培地は
３０℃で４８時門静置培養し、ビフィズス菌培養培地は
３７°Ｃて９６時間嫌気培養した。培養後、顕微鏡にて
生育した菌数を測定した。この結果を第１表に示す。After sterilizing the above basic medium, a certain amount of bacterial suspension (Lactobacillus dilactobacillus brevis) was added.
llus brevis) j and bifidobacteria [bifidobacterium brevis]
erium breve), the lactic acid bacteria culture medium was incubated at 30°C for 48 hours, and the bifidobacteria culture medium was anaerobically cultured at 37°C for 96 hours. After culturing, the number of grown bacteria was measured using a microscope. The results are shown in Table 1.
実施例３〜８実施例１，２においてユッカとオリゴ糖の混合比を変更
した以外は、同じ条件下で実験を行った。この結果を第
３表及び第４表に示す。Examples 3 to 8 Experiments were conducted under the same conditions as in Examples 1 and 2, except that the mixing ratio of yucca and oligosaccharide was changed. The results are shown in Tables 3 and 4.
第 １ 表尚、初発の菌数は３ＸＩＯ’個で有る。Table 1The initial bacterial count was 3XIO'.
第２表尚、初発の菌数は５ｘｌＯ’個で有る。Table 2The initial bacterial count was 5xlO'.
第３表手続補正書平成２年６月７日第４表事件の表示平成２年特許願第１１６６３７号２ 発明の名称整腸用組成物一効 果ｊ本願の二ツカとオリゴ糖からなる組成物は、乳酸菌やビ
フィズス菌等に対して優れた増殖作用を発揮するので、
整腸用組成物として有効である。Table 3 Procedural Amendment June 7, 1990 Table 4 Case Description 1990 Patent Application No. 116637 2 Name of Invention Composition for Intestinal Regulation - Effects j Composition consisting of Futatsuka and oligosaccharide of the present application The substance exhibits an excellent growth effect on lactic acid bacteria and bifidobacteria, so
It is effective as a composition for intestinal regulation.
３ 補正をする者事件との関係 特許出願人3 Person making the amendmentRelationship to the incident: Patent applicant
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2116637AJPH0416163A (en) | 1990-05-02 | 1990-05-02 | Intestine-controlling composition |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2116637AJPH0416163A (en) | 1990-05-02 | 1990-05-02 | Intestine-controlling composition |
| Publication Number | Publication Date |
|---|---|
| JPH0416163Atrue JPH0416163A (en) | 1992-01-21 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2116637APendingJPH0416163A (en) | 1990-05-02 | 1990-05-02 | Intestine-controlling composition |
| Country | Link |
|---|---|
| JP (1) | JPH0416163A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997029763A1 (en)* | 1996-02-14 | 1997-08-21 | The Procter & Gamble Company | Urogenital and intestinal disorder compositions comprising a substance derived from plant species of the ericaceae family and a lactic acid bacteria growth factor |
| KR20030069231A (en)* | 2002-02-02 | 2003-08-27 | 비앤아이티(주) | The improvement product of intestianl function by means of constipation type |
| US6891079B2 (en) | 2001-12-20 | 2005-05-10 | Kimberly-Clark Worldwide, Inc. | Wipe |
| WO2005092122A1 (en)* | 2004-03-26 | 2005-10-06 | Nihon Medicine Co., Ltd. | Composition comprising yucca extract, quillaia extract and lactic acid bacterium and food and drink containing the composition |
| US7154018B2 (en) | 2001-12-20 | 2006-12-26 | Kimberly-Clark Worldwide, Inc. | Absorbent article |
| FR2891439A1 (en)* | 2005-10-05 | 2007-04-06 | Physcience Soc Par Actions Sim | Food complement useful to increase in the weight of feces and the volume of intestinal gas comprises a passive laxative agent and an active laxative agent |
| US7485110B2 (en) | 2001-12-20 | 2009-02-03 | Kimberly Clark Worldwide, Inc. | Wipe comprising a pathogen selective antimicrobial |
| CN108785366A (en)* | 2018-08-15 | 2018-11-13 | 通化特立杰尔医药技术推广服务有限公司 | A kind of composition to relax bowel and its application |
| US10681922B2 (en) | 2003-12-01 | 2020-06-16 | Mars, Incorporated | Methods of enhancing the gastrointestinal health of a companion animal |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997029763A1 (en)* | 1996-02-14 | 1997-08-21 | The Procter & Gamble Company | Urogenital and intestinal disorder compositions comprising a substance derived from plant species of the ericaceae family and a lactic acid bacteria growth factor |
| US6891079B2 (en) | 2001-12-20 | 2005-05-10 | Kimberly-Clark Worldwide, Inc. | Wipe |
| US7154018B2 (en) | 2001-12-20 | 2006-12-26 | Kimberly-Clark Worldwide, Inc. | Absorbent article |
| US7485110B2 (en) | 2001-12-20 | 2009-02-03 | Kimberly Clark Worldwide, Inc. | Wipe comprising a pathogen selective antimicrobial |
| KR20030069231A (en)* | 2002-02-02 | 2003-08-27 | 비앤아이티(주) | The improvement product of intestianl function by means of constipation type |
| US10681922B2 (en) | 2003-12-01 | 2020-06-16 | Mars, Incorporated | Methods of enhancing the gastrointestinal health of a companion animal |
| WO2005092122A1 (en)* | 2004-03-26 | 2005-10-06 | Nihon Medicine Co., Ltd. | Composition comprising yucca extract, quillaia extract and lactic acid bacterium and food and drink containing the composition |
| FR2891439A1 (en)* | 2005-10-05 | 2007-04-06 | Physcience Soc Par Actions Sim | Food complement useful to increase in the weight of feces and the volume of intestinal gas comprises a passive laxative agent and an active laxative agent |
| CN108785366A (en)* | 2018-08-15 | 2018-11-13 | 通化特立杰尔医药技术推广服务有限公司 | A kind of composition to relax bowel and its application |
| Publication | Publication Date | Title |
|---|---|---|
| DE60032599T2 (en) | BACTERIENSTAMM, PROCESSED PLANT EXTRACTS AND PROBIOTIC PREPARATIONS FOR HUMAN AND AUTHENTIC USE | |
| DE69600525T2 (en) | Lyophilized food composition containing live bakery | |
| DE69833691T2 (en) | BACTERIENSTAMM OF THE LACTOBACILLUS PARACASEI TYPE, UNTERART PARACASEI, COMPOSITIONS CONTAINING THEREOF FOR USE IN FOODSTUFFS AND PRODUCTS THEREOF | |
| DE60012524T2 (en) | METHOD FOR PRODUCING A MILK PRODUCT WITH IMMUNOSTIMULATING EFFECT AND ITS USE | |
| DE69517721T2 (en) | Lactic acid bacteria of the genus Lactobacillus | |
| JP3789303B2 (en) | New species of microorganisms and their use | |
| DE60011061T2 (en) | DIARRHOA PREVENTIVE LACTOBACILLUS PARACASEI STRAIN | |
| DE69031285T2 (en) | Bacterial growth-promoting substance containing pullulan with or without dextran | |
| DE68928846T2 (en) | Bottle spa powder composition | |
| DK2549994T3 (en) | Use of D-phagomin as an inhibitor of bacterial adhesion to epithelial cells | |
| EP1965809A2 (en) | Novel compositions to improve gut health and animal performance and methods of making the same | |
| EP1952703B1 (en) | Product including living probiotic micro organisms | |
| CN106417989A (en) | Probiotic composition for aquatic animal feed, preparation method and application thereof | |
| EP4164411A1 (en) | Use of an activated pectin-containing citrus fiber for producing products | |
| DE60035355T2 (en) | IMMUNO-REINFORCING CONNECTIONS | |
| KR101467698B1 (en) | Anti-microbial composition comprising cynanchi wilfordii radix extract and the use thereof | |
| JPH0416163A (en) | Intestine-controlling composition | |
| JPS62104552A (en) | Feed composition | |
| JP2005013211A (en) | Lactic acid bacteria-containing food composition | |
| KR102856473B1 (en) | Prebiotics comprising Pear Extract, Synbiotics Compositions comprising the Same and Uses thereof | |
| KR20080004515A (en) | Blood pressure lowering agents obtained by lactic acid bacteria culture | |
| US5164183A (en) | Growth promoter for bifidobacterium species and method of using the same | |
| US20080193597A1 (en) | Food supplement comprising spirulina and a plant-based product of the aloe genus, and the cosmetic use thereof | |
| CN104012858A (en) | Healthcare and fresh-keeping steamed bread with mantis shrimps and preparation method of healthcare and fresh-keeping steamed bread with mantis shrimps | |
| JP4315496B2 (en) | Hydrogen sulfide production inhibitor from sulfate-reducing bacteria and hydrogen sulfide production inhibitor composition containing the same |