本発明は、主として歯周病（歯肉炎、歯周炎）、インプラント周囲疾患（インプラント周囲粘膜炎、インプラント周囲炎）の検査等のために歯肉溝に滲出、滞留する生体液である歯肉溝滲出液またはインプラント周囲溝滲出液を検体として採取する方法及び採取する器具に関する。The present invention relates to a method and instrument for collecting gingival crevicular fluid or peri-implant crevicular fluid, which is a biological fluid that seeps into and accumulates in the gingival sulcus, as a specimen, primarily for testing for periodontal disease (gingivitis, periodontitis) and peri-implant disease (peri-implant mucositis, peri-implantitis).
現在、一般歯科診療所などでの歯周疾病の検査、診断、または歯周治療後の効果の判定には様々な臨床パラメーターが用いられており、歯周ポケット（歯肉溝）検査、歯の動揺度検査、およびエックス線検査などがある。標準的な診断方法としては形態計測学的な手法のプロービングデプス（ＰＤ）がある。これは、歯周ポケットにプローブと呼ばれる器具を挿入し、その深さを測ることにより、歯周組織の破壊の程度を評価する方法である。Currently, general dental clinics and other facilities use a variety of clinical parameters to examine and diagnose periodontal disease, or to assess the effectiveness of periodontal treatment, including periodontal pocket (gingival sulcus) examinations, tooth mobility tests, and X-ray examinations. The standard diagnostic method is the morphometric technique of probing depth (PD). This involves inserting an instrument called a probe into the periodontal pocket and measuring its depth to assess the degree of destruction of the periodontal tissue.
しかしながら、プローブによる検査は歯周病により既に歯周組織が破壊された程度を知るものであり、検査時点での炎症の程度による疾病活動度を知ることはできない。さらに計測に熟練を要する、歯周組織に損傷を与える可能性がある、目視評価のため判定が主観的であり不確実でばらつきが生じるという問題点も指摘されている。However, probe testing only reveals the extent to which periodontal tissue has already been destroyed by periodontal disease, and does not reveal the degree of disease activity, which is based on the level of inflammation at the time of testing. Furthermore, problems have been pointed out, such as the need for skilled measurement, the possibility of damaging periodontal tissue, and the fact that the assessment is subjective, uncertain, and subjective, resulting in variability, as it is a visual evaluation.
このため、前記診断方法に加え、歯周疾患の早期診断や進行を予測する客観的な指標として、細菌学的検査や生化学的検査に関する手法が数多く提案され、プローブを使用しない非侵襲な検査として臨床的に応用される試みがなされている。For this reason, in addition to the diagnostic methods mentioned above, numerous bacteriological and biochemical testing techniques have been proposed as objective indicators for early diagnosis and predicting the progression of periodontal disease, and attempts are being made to apply them clinically as non-invasive tests that do not use probes.
細菌学的検査では、歯周病はその発症、進行に歯周病原細菌が大きく関与している感染症であることから、細菌叢と細菌数を把握することで、リスク因子の特定や診断、治療効果の判定など必要な情報を得ることがある。例えば、唾液に含まれる歯周病原性細菌が放出する酵素であるALP （アルカリフォスファターゼ）やトリプシン様酵素であるぺプチダーゼ を特異的に検出する手法について考案され実用化もされている。（ 特許文献１、非許文献１）。In bacteriological testing, since periodontal disease is an infectious disease in which periodontal pathogens play a major role in its onset and progression, understanding the bacterial flora and bacterial count can provide necessary information for identifying risk factors, making a diagnosis, and assessing the effectiveness of treatment. For example, methods have been devised and put into practical use to specifically detect ALP (alkaline phosphatase), an enzyme released by periodontal pathogenic bacteria in saliva, and peptidase, a trypsin-like enzyme. (Patent Document 1, Non-Patent Document 1)
生化学的手法については、主に歯肉溝に漏出する滲出液（歯肉溝滲出液）や唾液中 に含まれる特定の蛋白質や酵素を歯周疾患マーカーの検査試料として検査および診断に用いるものが数多く提案され、進行状態を知ることができる。例えば、歯肉溝滲出液や唾液中のヘモグロビン量またはカルシウム結合性蛋白質であるカルプロテクチン量を測定する診断キット（特許文献２、３）、歯または肉結合組織を構成する主成分であるコラーゲンを分解する酵素であるプロテアーゼの一種であるMMP（マトリックスメタロプロテアーゼ）が歯周疾患の進行度に関係していることを利用した診断キットも考案されている（特許文献４）。A number of biochemical methods have been proposed that use specific proteins and enzymes contained in the exudate that leaks into the gingival crevicular fluid (gingival crevicular fluid) or saliva as test samples for periodontal disease markers for testing and diagnosis, allowing the progression of the disease to be determined. For example, diagnostic kits have been devised that measure the amount of hemoglobin or the amount of calprotectin, a calcium-binding protein, in gingival crevicular fluid or saliva (Patent Documents 2 and 3), and a diagnostic kit has also been devised that utilizes the fact that MMP (matrix metalloproteinase), a type of protease that breaks down collagen, the main component of tooth or muscle connective tissue, is related to the progression of periodontal disease (Patent Document 4).
従来、検査試料として利用する唾液、歯肉溝滲出液は、歯科医師あるいは歯科衛生士が、主として吸収性の紙などで構成される薄片状に成型した材料（製品名ペリオペーパー）、あるいは根管治療などに用いられる紙を爪楊枝状としてペーパーポイントを採取器具とし、一端をピンセットで摘んで歯肉溝に挿入もしくは歯肉溝近傍に押し当てることにより採取されている 。Traditionally, saliva and gingival crevicular fluid used as test samples have been collected by dentists or dental hygienists using a collection tool made from a thin, absorbent material such as periodontal paper (product name: periodontal paper), or a toothpick-shaped paper point made from paper used in root canal treatment, by pinching one end with tweezers and inserting it into or pressing it near the gingival sulcus.
また、インプラント周囲疾患の場合も同じくインプラント体と歯肉の間隙溝に滞留する滲出液（インプラント周囲溝滲出液）を検査試料として利用、採取されている。In the case of peri-implant disease, the exudate that accumulates in the gap between the implant body and the gums (peri-implant crevice exudate) is also used and collected as a test sample.
このような唾液、歯肉溝滲出液を採取する器具が開示されており、特許文献５に記載の発明は毛細管を備え、その先端部に扁平な形状を有する挿入部と基端から延出し毛細管と連通する生体液保持部とを備えた形状、特許文献６に記載の発明はブラシ状の毛束を備えた形状、また、特許文献７に記載の発明は筒状体を有し、その壁部の一部が厚さ方向に薄い壁が複数重ねられた形状の採取器具が考案されている。Devices for collecting such saliva and gingival crevicular fluid have been disclosed. The invention described in Patent Document 5 is a device equipped with a capillary tube, an insertion section with a flat shape at the tip, and a biological fluid holding section that extends from the base end and communicates with the capillary tube. The invention described in Patent Document 6 is a device equipped with a brush-like bristle bundle. The invention described in Patent Document 7 is a collection device with a cylindrical body, part of whose wall is made up of multiple thin walls stacked in the thickness direction.
しかしながら、従来の薄片状に成型した材料のペリオペーパー、爪楊枝状のペーパーポイントをピンセットで摘んで歯肉溝滲出液を採取する場合において、目的とする採取部位の歯肉溝へ近接する際に、歯牙や口腔内粘膜などの別部位に採取器具が当たる等して変形する、または意図せず唾液を吸い取ってしまい目的とする検体液を吸収する能力が低下する等の問題があった。However, when collecting gingival crevicular fluid using conventional periodontal paper, which is made from thin, molded material, or toothpick-shaped paper points held with tweezers, there are problems such as the collection tool hitting other parts of the body, such as teeth or the oral mucosa, and becoming deformed when approaching the gingival sulcus of the intended collection site, or unintentionally sucking up saliva, reducing its ability to absorb the intended sample fluid.
また、生体液採取部は紙製の材質であるため、コシが足りず強度が不足していた。このため歯肉溝に挿入するのが難しく、更に生体液に接触すると瞬時に軟化し目的とする採取部位に固定し難いことがあり、経験の乏しい者は採取器具を新しいものに交換して採取し直す場合も多く効率が悪かった。Furthermore, because the biological fluid collection part is made of paper, it lacks stiffness and strength. This makes it difficult to insert into the gingival sulcus, and when it comes into contact with biological fluid it instantly softens, making it difficult to secure in the desired collection area. Those with little experience often have to replace the collection tool with a new one and start collecting again, which is inefficient.
また、インプラント周囲疾患の場合はインプラント周囲溝滲出液を検査試料として適切に採取する必要があるが、インプラント体の種類や様式、特にアバットメント（連結部位）または上部構造体（人工歯）の形状によっては、採取器具が目的部位の近傍まで到達する前に、生体液採取部がコシ折れする、またはアバットメントの形状によっては目的部位近傍に固定できないためインプラント周囲溝滲出液の採取がし難い場合があった。Furthermore, in the case of peri-implant disease, it is necessary to properly collect peri-implant crevicular exudate as a test sample, but depending on the type and style of implant body, and particularly the shape of the abutment (connection part) or superstructure (artificial tooth), the biological fluid collection part may break before the collection tool reaches the vicinity of the target site, or depending on the shape of the abutment, it may not be possible to fix it near the target site, making it difficult to collect peri-implant crevicular exudate.
特許文献６、７に記載の採取器具は、上記採取器具と比較して生体液を採取し易い構造や仕組みとなっているが、素材の構造が複雑であり製造コストがかかる、また同様に採取部位に固定し難いという課題があった。The collection devices described in Patent Documents 6 and 7 have structures and mechanisms that make it easier to collect biological fluids compared to the above-mentioned collection devices, but they have issues such as the complex structure of the material, which increases manufacturing costs, and similarly makes it difficult to fix them to the collection site.
そこで本発明は、以上のことを鑑み、簡易な構造であっても目的部位の歯肉溝から歯肉溝滲出液またはインプラント周囲溝滲出液を一回の採取で確実かつ容易に採取するための採取器具を提供する。In view of the above, the present invention provides a collection device that has a simple structure but can reliably and easily collect gingival crevicular fluid or peri-implant crevicular fluid from the gingival sulcus of the target area in a single collection.
本発明は、歯肉溝滲出液またはインプラント周囲溝滲出液を採取する為の検体採取器具であって、
平面板状の滲出液採取部、滲出液採取部を保持する把持部、平面板状の支持部を有し、
滲出液採取部は、滲出液を吸収かつ保持できる素材であり、略長方形体であり、略長方形体の長辺端部付近に把持部を有し、滲出液採取部の長辺他端部は滲出液吸収端であり、
把持部は、疎水性の素材であり、滲出液採取部である平面板状の両面に設けられ、略長方形体の長辺端部の先端から長辺他端部方向に有し且つ長辺他端部と長辺端部の中央付近を超えず、
支持部は、疎水性の弾性を有する素材であり、略長方形体であり、略長方形体の長辺端部に把持部を介して滲出液採取部が着脱可能に接着されており、長辺他端部は滲出液吸収部を支える吸収支持端であり、
支持部と滲出液採取部のそれぞれの面が対抗し近接しており、
滲出液採取部の長辺端部と支持部の略長方形体の長辺端部は同一方向に保持される様に接着されており、
滲出液採取部の長辺他端部に比べ、支持部の略長方形体の長辺他端部が他端部方向に突出している検体採取器具である。
好ましくは、支持部の略長方形体の短辺は滲出液採取部の略長方形体の短辺に比べ0.5～2.0倍であり、
支持部の長辺他端部の先端部分は滲出液採取部の長辺他端部の先端から0～5.0ｍｍ長く突出している、ことを特徴とする検体採取器具である。The present invention provides a specimen collection device for collecting gingival crevicular fluid or peri-implant crevicular fluid, comprising:
The device has a flat exudate collection part, a grip part for holding the exudate collection part, and a flat support part,
the exudate collection portion is made of a material capable of absorbing and retaining exudate, is a substantially rectangular body, has a grip portion near one end of a long side of the substantially rectangular body, and the other end of the long side of the exudate collection portion is an exudate absorption end;
The gripping portion is made of a hydrophobic material and is provided on both sides of the flat plate-like exudate collection portion, and extends from the tip of the long side end of the approximately rectangular body toward the other long side end, but does not extend beyond the center between the other long side end and the long side end.
the support part is made of a hydrophobic elastic material and has a substantially rectangular shape, the exudate collection part is detachably attached to one end of a long side of the substantially rectangular shape via a grip part, and the other end of the long side is an absorbent support end that supports the exudate absorption part;
The surfaces of the support part and exudate collection part are opposite and close to each other,
The long side end of the exudate collection part and the long side end of the approximately rectangular body of the support part are bonded together so as to be held in the same direction,
This is a specimen collection device in which the other end of the long side of the approximately rectangular support part protrudes in the direction of the other end, compared to the other end of the long side of the exudate collection part.
Preferably, the short side of the substantially rectangular shape of the support part is 0.5 to 2.0 times the short side of the substantially rectangular shape of the exudate collection part,
This is a specimen collection device characterized in that the tip of the other end of the long side of the support part protrudes 0 to 5.0 mm beyond the tip of the other end of the long side of the exudate collection part.
本発明は、簡易な構造であっても目的部位の歯肉溝から歯肉溝滲出液またはインプラント周囲溝滲出液を一回の採取で確実かつ容易に採取するための採取器具を提供することができる。The present invention provides a collection device that has a simple structure and can reliably and easily collect gingival crevicular fluid or peri-implant crevicular fluid from the gingival sulcus of the target area in a single collection.
１０ 検体採取器具
２０ 支持部
20a 支持部短辺
20ｂ 支持部突出部
30 生体液採取部
30a 生体液採取部短辺
４０ 把持部
５０ 粘着剤
６０a 天然歯牙
６０b 人工歯
７０ 歯肉
８０ 歯肉溝
８０a 歯肉溝滲出液
８０b インプラント周囲溝滲出液
９０ インプラント体10 Sample collection tool 20 Support part
20a Short side of support part
20b Support part protrusion
30 Biological fluid collection section
30a Biological fluid collection portion Short side 40 Grip portion 50 Adhesive 60a Natural tooth 60b Artificial tooth 70 Gum 80 Gingival sulcus 80a Gingival crevicular fluid 80b Peri-implant crevicular fluid 90 Implant body
検体採取器具とは歯肉溝滲出液またはインプラント周囲溝滲出液を採取する器具である。
検体採取器具は平面板状の滲出液採取部、滲出液採取部を保持する把持部、平面板状の支持部を有している。The specimen collection tool is a tool used to collect gingival crevicular fluid or peri-implant crevicular fluid.
The specimen collection device has a flat-plate-shaped exudate collection portion, a grip portion for holding the exudate collection portion, and a flat-plate-shaped support portion.
滲出液採取部とは平面板状であって、滲出液を吸収かつ保持できる素材であり、略長方形体であり、略長方形体である。滲出液採取部の長辺端部付近に把持部を有する。The exudate collection portion is a flat, plate-like material that can absorb and retain exudate, and is roughly rectangular in shape. It has a grip portion near the long edge of the exudate collection portion.
把持部は、疎水性の素材であり、滲出液採取部である平面板状の両面に設けられ、略長方形体の長辺端部の先端から長辺他端部方向に有し且つ長辺他端部と長辺端部の中央付近を超えない。
The gripping portion is made of a hydrophobic material and is provided on both sides of the flat plate-like exudate collection portion, extending from the tip of the long side end of the approximately rectangular body toward the other long side end, but not extending beyond the center between the other long side end and the long side end.
支持部は、疎水性の弾性を有する素材であり、略長方形体であり、略長方形体の長辺端部に把持部を介して着滲出液採取部が着脱可能に接着されており、長辺他端部は滲出液吸収部を支える吸収支持端である。The support part is made of a hydrophobic, elastic material and is roughly rectangular. The exudate collection part is removably attached to the long edge of the roughly rectangular body via a grip, and the other long edge is an absorbent support end that supports the exudate absorption part.
支持部と滲出液採取部のそれぞれの面が対抗し近接している。
滲出液採取部の長辺端部と支持部の略長方形体の長辺端部は同一方向に保持される様に接着されている。滲出液採取部の長辺他端部に比べ、支持部の略長方形体の長辺他端部が他端部方向に突出している。The surfaces of the support portion and the exudate collection portion face each other and are adjacent to each other.
The long side end of the exudate collection portion and the long side end of the approximately rectangular support portion are bonded together so that they are held in the same direction. Compared to the other long side end of the exudate collection portion, the other long side end of the approximately rectangular support portion protrudes toward the other end.
支持部の略長方形体の短辺は滲出液採取部の略長方形体の短辺に比べ0.5～2.0倍であり、好ましくは0.7～1.5倍である。
支持部の長辺他端部の先端部分は滲出液採取部の長辺他端部の先端から0～5.0ｍｍ長く突出している。The shorter side of the approximately rectangular support portion is 0.5 to 2.0 times, preferably 0.7 to 1.5 times, the shorter side of the approximately rectangular exudate collection portion.
The tip of the other long side end of the support part protrudes 0 to 5.0 mm beyond the tip of the other long side end of the exudate collection part.
実施形態に係わる検体採取器具（１０）の全体構成を説明する。図１ 又は図２に示すように、検体採取器具（１０）は、扁平な板状の支持部（２０）を有し、前記支持部（２０）の表面上に接着剤（５０）で保持された生体液採取部（３０）及び把持部（４０）から構成される。The overall configuration of the specimen collection device (10) according to this embodiment will now be described. As shown in Figures 1 and 2, the specimen collection device (10) has a flat, plate-shaped support portion (20), and is composed of a biological fluid collection portion (30) and a grip portion (40) that are held on the surface of the support portion (20) with adhesive (50).
本発明の検体採取器具は、例えば図４に示したように、天然歯牙（６０a）と歯肉（７０）との間隙に形成された目的部位の歯肉溝（８０）へ、支持部短辺（２０a）を挿入し近傍に固定することで外れることがなく確実に歯肉溝滲出液（８０a）を生体液採取部（３０）が吸収し採取することができる。
さらに、例えば図５に示したように、人工歯（６０ｂ）またはインプラント体（９０）と歯肉（７０）との間隙に形成された目的部位の歯肉溝（８０）へ、支持部短辺（２０a）を挿入し近傍に固定することで外れることがなく確実にインプラント周囲溝滲出液（８０ｂ）を生体液採取部（３０）が吸収し採取することができる。As shown in Figure 4, for example, the specimen collection device of the present invention can be secured in the vicinity of the gingival sulcus (80) of the target area formed in the gap between the natural tooth (60a) and the gum (70) by inserting the short side (20a) of the support part into the gingival sulcus (80) and fixing it therein, so that the biological fluid collection part (30) can reliably absorb and collect the gingival crevicular fluid (80a) without it coming off.
Furthermore, as shown in Figure 5, for example, by inserting the short side (20a) of the support part into the gingival sulcus (80) of the target area formed in the gap between the artificial tooth (60b) or implant body (90) and the gums (70) and fixing it in the vicinity, the biological fluid collection part (30) can reliably absorb and collect the peri-implant sulcus exudate (80b) without coming off.
なお、（２０）支持部および生体液採取部（３０）は、図４に示したように目的部位の歯肉溝（８０）へ重なり合うように一体にて挿入されても何ら問題はない。
さらに、検体採取後において生体液採取部（３０）は支持部（２０）から分離して用いることができ、検体の抽出処理時にて邪魔にならないよう使用することができる。It should be noted that there is no problem if the support part (20) and the biological fluid collection part (30) are inserted as a unit so that they overlap each other into the gingival sulcus (80) at the target site as shown in FIG.
Furthermore, after the specimen has been collected, the biological fluid collection section (30) can be separated from the support section (20) and used without getting in the way during the specimen extraction process.
支持部（２０）の表面の一部には粘着剤（５０）がコーティングされ、前記粘着剤（５０）が把持部（４０）を保持且つ脱着することができる。Part of the surface of the support portion (20) is coated with an adhesive (50), which allows the grip portion (40) to be held and detached.
なお、支持部（２０）の素材は弾性を有する樹脂であれば特に限定されるものではなく、例えばポリエチレン、ポリプロピレン、ポリエチレンテレフタレート、ポリブチレンテレフタレート、ポリスチレン、ポリメタクリル酸メチル、セルロースプロピオネート、ポリアクリレート、ポリカーボネート、ポリオキシメチレン、アクリロニトリル、ポリアミド等の樹脂を単独でまたは２ 種以上混合して使用できる。The material of the support portion (20) is not particularly limited as long as it is an elastic resin, and examples of resins that can be used include polyethylene, polypropylene, polyethylene terephthalate, polybutylene terephthalate, polystyrene, polymethyl methacrylate, cellulose propionate, polyacrylate, polycarbonate, polyoxymethylene, acrylonitrile, and polyamide, either alone or in combination of two or more.
生体液採取部（３０）は生体液を吸収かつ保持できる素材であれば特に限定されるものではなく、例えば、紙、和紙、パルプ紙、濾紙に用いられるセルロース、ガラス繊維、不織布の繊維等を使用できる。The biological fluid collection section (30) is not particularly limited as long as it is made of a material that can absorb and retain biological fluids. For example, paper, Japanese paper, pulp paper, cellulose used in filter paper, glass fiber, nonwoven fabric fibers, etc. can be used.
把持部（４０）は水分等の液体を吸収し難い疎水性の素材であれば特に限定されるものではなく、例えばポリビニルアルコール、ポリ酢酸ビニル、ポリビニルピロリドン、ブチラール樹脂等が使用できる。またピンセット等で摘まむことができる強度であるのが好ましい。The gripping portion (40) is not particularly limited as long as it is made of a hydrophobic material that does not easily absorb liquids such as water. For example, polyvinyl alcohol, polyvinyl acetate, polyvinylpyrrolidone, butyral resin, etc. can be used. It is also preferable that the gripping portion (40) is strong enough to be held with tweezers, etc.
粘着剤（５０）は把持部（４０）保持可能な粘着能力があり且つ少ない力を加えると脱離可能とする素材であれば特に限定されるものではなく、例えば、アクリル系、ウレタン系、酢酸ビニル系、シリコーン系、フッ素系等の合成樹脂にて覆うことができる。The adhesive (50) is not particularly limited as long as it has the adhesive ability to hold the gripping portion (40) and can be released with the application of a small amount of force. For example, it can be covered with a synthetic resin such as an acrylic, urethane, vinyl acetate, silicone, or fluorine-based resin.
支持部（２０）は、歯肉溝もしくはインプラント周囲溝に挿入され、検体採取器具（１０）を近傍に固定又は維持する役割を有する。従って、歯肉溝もしくはインプラント周囲溝への挿入に適した支持部（２０）の一端の短辺（２０a）寸法（W1）は、好ましくは生体液採取部（３０）の短辺（３０a）寸法（W2）の0.5倍より大きく2倍以下が適当で、より好ましくは0.7倍より大きく1.5倍以下が適当である。The support portion (20) is inserted into the gingival sulcus or peri-implant sulcus and serves to fix or maintain the specimen collection device (10) in the vicinity. Therefore, the dimension (W1) of the short side (20a) of one end of the support portion (20) suitable for insertion into the gingival sulcus or peri-implant sulcus is preferably more than 0.5 times and less than 2 times the dimension (W2) of the short side (30a) of the biological fluid collection portion (30), and more preferably more than 0.7 times and less than 1.5 times.
また、上記と同様に歯肉溝もしくはインプラント周囲溝への挿入に適した支持部（２０）の支持部突出部（２０ｂ）の長さ（T1）は、好ましくは生体液採取部短辺（３０a）から0ｍｍ以上５ｍｍ以下、より好ましくは0.2ｍｍ以上３ｍｍ以下長く突出しているのが適当である。Furthermore, as described above, the length (T1) of the support portion protrusion (20b) of the support portion (20) suitable for insertion into the gingival sulcus or peri-implant sulcus preferably protrudes from the short side (30a) of the biological fluid collection portion by 0 mm or more and 5 mm or less, more preferably by 0.2 mm or more and 3 mm or less.
本発明は歯肉溝滲出液またはインプラント周囲溝滲出液を採取する器具であり、産業上利用することができる。
The present invention is an instrument for collecting gingival crevicular fluid or peri-implant crevicular fluid, and can be used industrially.
| Application Number | Priority Date | Filing Date | Title |
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| JP2021126541AJP7742691B2 (en) | 2021-08-02 | 2021-08-02 | Specimen collection equipment for dental disease testing |
| Application Number | Priority Date | Filing Date | Title |
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| JP2021126541AJP7742691B2 (en) | 2021-08-02 | 2021-08-02 | Specimen collection equipment for dental disease testing |
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| JP2023021589A JP2023021589A (en) | 2023-02-14 |
| JP7742691B2true JP7742691B2 (en) | 2025-09-22 |
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| JP2021126541AActiveJP7742691B2 (en) | 2021-08-02 | 2021-08-02 | Specimen collection equipment for dental disease testing |
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