【０００１】[0001]
【産業上の利用分野】本発明は皮膚面に貼付する貼付剤
に関し、詳しくは貼付操作時の取扱性が良好で、しかも
貼付後にはその吸湿性によって柔軟性を発現する吸湿性
貼付剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch to be applied to the skin surface, and more particularly to a moisture-absorbing patch which exhibits good handleability at the time of applying operation and exhibits flexibility due to its hygroscopicity after application.
【０００２】[0002]
【従来の技術】皮膚面に貼付して使用する貼付剤として
は、各種用途に使用されているが、貼付面が皮膚面であ
るために、その開発に当たっては粘着性、密着性、皮膚
追従性、皮膚無刺激性など種々の特性を満足する必要が
ある。特に、これらの貼付剤は比較的長時間にわたって
貼付する場合があり、皮膚面への貼付後の違和感や皮膚
に対する刺激性を発現しないものが重要な要求特性とな
る。2. Description of the Related Art Patches used by being adhered to the skin surface are used for various purposes. However, since the adhered surface is the skin surface, the adhesive, adhesiveness, and skin-following properties must be used in the development. It is necessary to satisfy various characteristics such as non-irritating properties of the skin. In particular, these patches may be applied for a relatively long period of time, and those that do not exhibit discomfort or irritation to the skin after application to the skin surface are important required characteristics.
【０００３】このような要求に応じるものとしては、従
来から支持体の厚みをできるだけ薄くして支持体のエッ
ジ部による刺激性を低減し、皮膚追従性を付与した貼付
剤が提案されている。しかしながら、支持体の厚みを薄
くした場合、上記要求特性は満足できるものの貼付位自
体に自己支持性がなくなるために貼付時の取扱性が悪く
なり、貼付後の貼付剤に皺を生じたり、また貼付時に粘
着面同士がくっついて綺麗に貼付できないという問題を
有するものである。In order to meet such a demand, a patch has been proposed in which the thickness of the support is reduced as much as possible to reduce the irritation caused by the edge portion of the support and to provide skin followability. However, when the thickness of the support is reduced, the above-mentioned required properties can be satisfied, but the self-supporting property is lost in the application position itself, so that the handling property at the time of application becomes poor, and the patch after application becomes wrinkled, or At the time of sticking, there is a problem that the sticky surfaces are stuck together and cannot be stuck neatly.
【０００４】そこで、上記問題を解決する方法として、
貼付剤の粘着剤表面に通常貼着されているセパレータに
複数の分割線（背切り）を設ける方法や、支持体背面に
自己支持性の台紙を仮着する方法などが提案されてい
る。前者の方法は、例えば特開昭５９−１４１９４３号
公報に開示さており、中央部と左右両端部に分割された
セパレータの中央部のみを先ず剥離して粘着剤面を露出
させ、次いで、両端部を把持しながら露出した粘着剤面
を適用皮膚面に貼付し、そののち左右両端部のセパレー
タを徐々に剥離除去するというものである。この方法で
は貼付操作時の自己支持性は維持できるが、露出した粘
着剤面が折曲して接着するおそれが依然として解決でき
ないものである。Therefore, as a method for solving the above problem,
There have been proposed a method of providing a plurality of dividing lines (slits) on a separator usually adhered to the surface of the adhesive of a patch, and a method of temporarily attaching a self-supporting backing paper to the back surface of a support. The former method is disclosed in, for example, JP-A-59-141943, in which only the center portion of a separator divided into a center portion and left and right end portions is first peeled to expose an adhesive surface, and then both end portions are separated. While holding the adhesive, the exposed adhesive surface is adhered to the applied skin surface, and then the separators on both left and right ends are gradually peeled off. This method can maintain the self-supporting property at the time of the sticking operation, but still cannot solve the possibility that the exposed pressure-sensitive adhesive surface is bent and adhered.
【０００５】一方、後者の方法は、特開昭５５−３２５
５３号公報や実開昭５６−５７２３５号公報、実開昭５
６−１５８２１５号公報、特開昭６４−１６７１９号公
報など多く提案されており、貼付操作性に優れた方法で
ある。しかしながら、この方法では自己支持性の台紙を
仮着する際の接着力の調整が不充分であると、貼付前に
台紙が剥離してしまったり、また、貼付後台紙を剥離す
る際に貼付剤自体も剥離してしまうことがあり、仮着接
着力の調整には充分に注意をはらう必要がある。On the other hand, the latter method is disclosed in Japanese Unexamined Patent Publication No. 55-325.
No. 53, Japanese Utility Model Publication No. 56-57235, Japanese Utility Model Application Publication No.
Many methods have been proposed, such as JP-A-6-158215 and JP-A-64-16719, which are excellent in sticking operability. However, in this method, if the adjustment of the adhesive force at the time of temporarily attaching the self-supporting backing paper is insufficient, the backing paper may be peeled off before pasting, or when the backing paper is peeled off after pasting. The film itself may be peeled off, and it is necessary to pay sufficient attention to the adjustment of the temporary adhesion force.
【０００６】特に、薬物投与量を厳格に制御して体内に
経皮吸収させる薬物含有の貼付剤においては、貼付時の
皮膚刺激性の低減や貼付面積の一定化などの点から、上
記問題は重要な解決課題であり、これらの問題を解決す
る技術の提供が望まれているのが実情である。[0006] In particular, in the case of a patch containing a drug which is percutaneously absorbed into the body by strictly controlling the dose of the drug, the above-mentioned problems are pointed out from the viewpoint of reducing skin irritation at the time of application and keeping the applied area constant. This is an important problem to be solved, and the fact is that provision of a technology to solve these problems is desired.
【０００７】[0007]
【発明が解決しようとする課題】そこで、本発明者らは
厚みの薄い貼付剤であっても自己支持性を維持して貼付
操作性に優れ、しかも、貼付後には柔軟性を発揮して皮
膚面の動きにも追従できて皮膚に対する刺激性を有しな
い貼付剤を得るべく鋭意検討を重ねた。その結果、常態
における人体皮膚面からの水分蒸散量が２５０〜５００
ｇ／ｍ2・２４ｈであることに着目し、特定の吸湿性を
有する支持体を用いるか、もしくは特定の性質を有する
吸湿性層を形成して吸湿前後の貼付剤全体の剛軟度を調
整すると、上記課題が解決できることを見い出し、本発
明を解決するに至った。Therefore, the present inventors have maintained the self-supporting property even with a thin patch, and have excellent sticking operability, and have exhibited flexibility after sticking, thereby exhibiting flexibility. Intensive studies were conducted to obtain a patch which can follow the movement of the surface and has no irritation to the skin. As a result, the amount of water transpiration from the human skin surface in a normal state is 250 to 500.
g / m2 · 24h, using a support having specific hygroscopicity, or forming a hygroscopic layer with specific properties to adjust the overall softness of the patch before and after moisture absorption Then, they found that the above problem could be solved, and came to solve the present invention.
【０００８】[0008]
【課題を解決するための手段】即ち、本発明は支持体の
片面に粘着剤層を形成してなる貼付剤であって、カンチ
レバー法による剛軟度測定において２０℃，６５％ＲＨ
条件下での剛軟度が５０ｍｍ以上で、かつ４０℃，９０
％ＲＨ条件下で６０分間放置後の剛軟度が２５ｍｍ以下
の吸湿性を有することを特徴とする吸湿性貼付剤を提供
するものである。That is, the present invention relates to a patch comprising a support having an adhesive layer formed on one surface thereof, wherein the patch is measured at 20 ° C. and 65% RH by a cantilever method.
The softness under the conditions is 50 mm or more and 40 ° C, 90
It is intended to provide a moisture-absorbing patch characterized in that it has a moisture-absorbing property having a stiffness after standing for 60 minutes under% RH conditions of 25 mm or less.
【０００９】本発明の吸湿性貼付剤は支持体の片面に粘
着剤層を有するものであって、用いる粘着剤とは粘着剤
自体に皮膚刺激性を有しない医療用途の粘着剤であれ
ば、アクリル系粘着剤、天然ゴム系粘着剤、合成ゴム系
粘着剤、ビニルエーテル系粘着剤、シリコーン系粘着剤
などを問わず用いることができる。好ましくは本発明の
貼付剤を皮膚面に貼付したのち、皮膚面から蒸散してく
る水分（湿気）を吸収しやすい透湿性の粘着剤を用い
る。このように粘着剤に透湿性を付与するには親水性モ
ノマーを共重合したアクリル系の粘着剤や低級アルキル
ビニルエーテル系の粘着剤など粘着剤自体に透湿性を有
するものを用いたり、粘着剤層に親水性ポリマーや親水
性の添加剤を配合したり、さらには粘着剤層に穿孔処理
や多孔質化処理を施したり、筋塗りなどのパターン塗工
することによって行うことができる。The adhesive patch of the present invention has a pressure-sensitive adhesive layer on one side of a support, and the pressure-sensitive adhesive used is a pressure-sensitive adhesive for medical use which does not have skin irritation itself. An acrylic adhesive, a natural rubber adhesive, a synthetic rubber adhesive, a vinyl ether adhesive, a silicone adhesive, or the like can be used. Preferably, after applying the patch of the present invention to the skin surface, a moisture-permeable adhesive that easily absorbs water (moisture) evaporating from the skin surface is used. In order to impart moisture permeability to the adhesive in this manner, an adhesive having a moisture permeability to the adhesive itself, such as an acrylic adhesive or a lower alkyl vinyl ether adhesive obtained by copolymerizing a hydrophilic monomer, or an adhesive layer is used. Can be carried out by blending a hydrophilic polymer or a hydrophilic additive into the adhesive layer, further subjecting the pressure-sensitive adhesive layer to a perforation treatment or a porous treatment, or applying a pattern coating such as streaking.
【００１０】上記粘着剤を片面に支持する支持体として
は、従来から用いられている支持体材料である紙、プラ
スチック材料などからなるフィルム、不織布、織布、編
布、およびこれらと金属層との積層体などを用いる場合
と、吸水率が１％以上の親水性高分子材料からなるフィ
ルム、不織布、織布、編布、およびこれらと金属層との
積層体などを支持体として用いる場合とがある。The support for supporting the pressure-sensitive adhesive on one side may be a film, a non-woven fabric, a woven fabric, a knitted fabric, or a nonwoven fabric, a woven fabric, or a knitted fabric, which is a conventionally used support material, such as paper or plastic material. And a case where a film, a nonwoven fabric, a woven fabric, a knitted fabric, and a laminate of these and a metal layer made of a hydrophilic polymer material having a water absorption of 1% or more are used as a support. There is.
【００１１】前者の支持体を用いる場合は支持体の厚み
はできるだけ薄いことが好ましく、通常、２〜１００μ
ｍ、好ましくは２〜２０μｍ程度の厚みとし、吸湿によ
る剛軟度の調整を行うために、粘着剤層表面、粘着剤層
中、粘着剤層と支持体との界面のいずれかに吸水率が１
％以上、好ましくは５％以上の親水性高分子層を形成し
て貼付剤全体に自己支持性と吸湿性を付与する必要があ
る。なお、本明細書における吸水率とは、２３℃で２４
時間放置後の吸水率をいう。吸水率が１％に満たない場
合は、充分な吸湿性を付与することできないために、貼
付時に自己支持性を有するが貼付後に柔軟性を充分に発
現することができず、満足する皮膚刺激性の低減効果を
得ることができないことがある。親水性高分子層は粘着
剤層全面もしくは部分的に形成することができ、部分的
に形成する場合には自己支持性を付与するために、粘着
剤層に額縁状や、格子状、亀甲状などの網目状、筋状な
どのパターン状に形成する。このようにパターン状に形
成することによって、表面に凹凸部ができ自己支持性を
さらに良好にする。When the former support is used, the thickness of the support is preferably as thin as possible.
m, preferably a thickness of about 2 to 20 μm, in order to adjust the stiffness by moisture absorption, the surface of the pressure-sensitive adhesive layer, in the pressure-sensitive adhesive layer, the water absorption rate at any of the interface between the pressure-sensitive adhesive layer and the support 1
%, Preferably 5% or more, of the hydrophilic polymer layer to impart self-supporting properties and hygroscopicity to the entire patch. In addition, the water absorption in this specification is 24 ° C at 23 ° C.
Water absorption after standing for a time. If the water absorption is less than 1%, sufficient hygroscopicity cannot be imparted, so that it has self-supporting properties at the time of application, but cannot exhibit sufficient flexibility after application, and has satisfactory skin irritation. May not be able to achieve the effect of reduction. The hydrophilic polymer layer can be formed entirely or partially on the pressure-sensitive adhesive layer. When partially formed, the pressure-sensitive adhesive layer has a frame shape, a lattice shape, or a turtle-shape to impart self-supporting property. It is formed in a pattern such as a mesh or streak. By forming a pattern in this manner, an uneven portion is formed on the surface, and the self-supporting property is further improved.
【００１２】一方、後者のように親水性高分子材料から
なる支持体を用いる場合は、その厚みを薄くする必要は
特になく、２０〜５００μｍ程度の厚みで充分である。
また、この場合に用いる親水性高分子層は上記と同様、
吸水率を１％以上の性質を有するものを採用して、自己
支持性と吸湿性を付与する。On the other hand, when using a support made of a hydrophilic polymer material as in the latter case, it is not particularly necessary to reduce the thickness, and a thickness of about 20 to 500 μm is sufficient.
In addition, the hydrophilic polymer layer used in this case is similar to the above,
A material having a water absorption of 1% or more is employed to provide self-supporting property and hygroscopicity.
【００１３】上記親水性高分子としては、具体的にはア
ラビアゴム、ポリエチレングリコール、ポリビニルアル
コール、ポリビニルホルマール、ポリビニルブチラー
ル、セロハン、ポリペプチド、各種セルロースエステ
ル、ポリ酢酸ビニル、ポリアミドなどが挙げられ、吸湿
性をさらに高めるために各種界面活性剤や保湿剤などを
添加することもできる。このような物質としてはグリセ
リン、ポリオキシエチレンアルキルアリルエーテル、脂
肪酸グリセリンエステル、蔗糖脂肪酸エステル、ステア
リン酸ポリオキシル、レシチン、ラノリン、セタノー
ル、ラウリル硫酸ナトリウムなどが挙げられ、１〜５０
重量％、好ましくは２〜１０重量％を親水性高分子から
なる支持体中もしくは親水性高分子層中に含有させる。Specific examples of the above hydrophilic polymer include gum arabic, polyethylene glycol, polyvinyl alcohol, polyvinyl formal, polyvinyl butyral, cellophane, polypeptide, various cellulose esters, polyvinyl acetate, polyamide and the like. In order to further enhance the properties, various surfactants and humectants may be added. Examples of such substances include glycerin, polyoxyethylene alkyl allyl ether, fatty acid glycerin ester, sucrose fatty acid ester, polyoxyl stearate, lecithin, lanolin, cetanol, sodium lauryl sulfate and the like.
% By weight, preferably 2 to 10% by weight, is contained in a support made of a hydrophilic polymer or in a hydrophilic polymer layer.
【００１４】以上のような構造からなる本発明の吸湿性
貼付剤は、皮膚面に貼付後に皮膚面から蒸散する水分に
よってその剛軟度が変化して柔軟性を発現する。本発明
における剛軟度はＪＩＳＬ−１０９６に準ずるカンチレ
バー法によって測定し、２０℃，６５％ＲＨ条件下での
剛軟度が５０ｍｍ以上で、かつ４０℃，９０％ＲＨ条件
下で６０分間放置後の剛軟度が２５ｍｍ以下の値を有す
るものである。つまり、乾燥条件下では上記剛軟度が５
０ｍｍ以上の比較的剛性を有する貼付剤であるために、
貼付操作時には自己支持性を有し、取扱性が良好なもの
となる。また、吸湿後は上記剛軟度が２５ｍｍ以下に変
化し柔軟性が増すので、皮膚面に対して追従性を有する
ようになり、皮膚刺激性が低減されるのである。The moisture-absorbing patch of the present invention having the above-mentioned structure exhibits flexibility by changing its bristles due to moisture evaporating from the skin after being applied to the skin. The bending resistance according to the present invention is measured by a cantilever method according to JISL-1096, and the bending resistance under a condition of 20 ° C. and 65% RH is 50 mm or more, and after standing at 40 ° C. and a condition of 90% RH for 60 minutes. Has a value of 25 mm or less. That is, under the dry condition, the above softness is 5
Because it is a patch with a relative rigidity of 0 mm or more,
It has a self-supporting property during the sticking operation, and has good handleability. Further, after moisture absorption, the above-mentioned softness changes to 25 mm or less and the flexibility increases, so that the skin has a following property and the skin irritation is reduced.
【００１５】上記剛軟度が５０ｍｍ以下では貼付剤全体
に充分な自己支持性を付与できない場合があり、また、
２５ｍｍ以上では貼付後、皮膚面から水分によって充分
に吸湿しない場合や、たとえ吸湿しても充分な柔軟性を
発現しないことがあり好ましくない。[0015] If the above softness is 50 mm or less, it may not be possible to impart sufficient self-supporting properties to the entire patch.
When the thickness is 25 mm or more, it is not preferable because moisture is not sufficiently absorbed from the skin surface after application, or sufficient flexibility may not be exhibited even if moisture is absorbed.
【００１６】本発明の貼付剤における上記粘着剤層には
薬物を含有させて各種疾患の治療または予防を行う経皮
吸収用の貼付剤とすることができる。このような薬物と
しては経皮吸収されて薬理効果を発揮するものであれ
ば、局所性薬物や全身性薬物のいずれを用いてもよく、
具体的にはコルチコステロイド類、鎮痛消炎剤、催眠鎮
静剤、精神安定剤、抗高血圧剤、降圧利尿剤、抗生物
質、麻酔剤、抗菌剤、抗真菌剤、ビタミン剤、冠血管拡
張剤、抗ヒスタミン剤、鎮咳剤、性ホルモン、抗鬱剤、
脳循環改善剤、制吐剤、抗腫瘍剤、生体医薬などの薬物
が使用できる。なお、これらの薬物は必要により２種類
以上を併用して含有させることができる。The adhesive layer of the adhesive patch of the present invention can be used as a patch for transdermal absorption for treating or preventing various diseases by containing a drug. As such a drug, any of a topical drug or a systemic drug may be used as long as it exerts a pharmacological effect by transdermal absorption,
Specifically, corticosteroids, analgesics and anti-inflammatory agents, hypnotics and sedatives, tranquilizers, antihypertensives, antihypertensive diuretics, antibiotics, anesthetics, antibacterials, antifungals, vitamins, coronary vasodilators, Antihistamines, antitussives, sex hormones, antidepressants,
Drugs such as a cerebral circulation improving agent, an antiemetic, an antitumor agent, and a biopharmaceutical can be used. These drugs can be used in combination of two or more if necessary.
【００１７】これらの薬物の含有量は薬物種や投与目的
に応じて適宜設定することができるが、通常、粘着剤層
中に１〜４０重量％、好ましくは２〜３０重量％程度含
有させる。含有量が１重量％に満たない場合は治療に有
効な量の薬物放出が期待できず、また、４０重量％を超
えると治療効果に限界が生じると共に経済的に不利とな
る。なお、コルチコステロイド類の場合は１重量％以下
の含有量で充分に効果を発揮するものである。The content of these drugs can be appropriately set according to the kind of the drug and the purpose of administration, but is usually contained in the pressure-sensitive adhesive layer in an amount of 1 to 40% by weight, preferably about 2 to 30% by weight. If the content is less than 1% by weight, release of a therapeutically effective amount of the drug cannot be expected, and if it exceeds 40% by weight, the therapeutic effect is limited and economically disadvantageous. In the case of corticosteroids, a content of 1% by weight or less exerts a sufficient effect.
【００１８】本発明の吸湿性貼付剤は使用するまでは大
気中の湿分によって吸湿しないことが、貼付時の取扱性
のために好ましく、防湿性のフィルムからなる包装材料
などによって、密封包装しておくことが好ましい。It is preferable that the moisture-absorbing patch of the present invention does not absorb moisture due to atmospheric moisture until it is used, because of the ease of handling at the time of sticking, and it is sealed and packaged with a packaging material made of a moisture-proof film. It is preferable to keep it.
【００１９】また、本発明の吸湿性貼付剤は各種絆創
膏、創傷被覆材、刺青テープの如き装飾用テープ、経皮
吸収用テープ製剤などの各種用途に用いることができ
る。The hygroscopic patch of the present invention can be used for various applications such as various adhesive plasters, wound dressings, decorative tapes such as tattoo tapes, and transdermal absorption tape preparations.
【００２０】[0020]
【発明の効果】本発明の吸湿性貼付剤は吸水性のある親
水性高分子からなる支持体もしくは該親水性高分子層を
有することによって、貼付前後における貼付剤全体の剛
軟性を特定値に調整しており、その結果、皮膚面への貼
付操作時の取扱性が良好であり、しかも貼付後には柔軟
な貼付剤となるので、皮膚に対する違和感や皮膚刺激性
を低減できるという効果を発揮するものである。The hygroscopic patch of the present invention has a specific value of the rigidity of the entire patch before and after the application by having a support made of a hydrophilic polymer having water absorbency or having the hydrophilic polymer layer. As a result, the handleability at the time of sticking operation on the skin surface is good, and since it becomes a flexible patch after sticking, it has the effect of reducing discomfort to the skin and skin irritation. Things.
【００２１】[0021]
【実施例】以下に本発明の実施例を示し、さらに具体的
に説明する。なお、以下において、部および％は重量部
および重量％を意味する。EXAMPLES Examples of the present invention will be shown below, and will be described more specifically. In the following, parts and% mean parts by weight and% by weight, respectively.
【００２２】実施例１ アクリル酸２−エチルヘキシル９７部およびアクリル酸
３部を酢酸エチル中にて共重合し、重合反応終了後、こ
の溶液に塩化ナトリウム１００部を添加、分散させて粘
着剤溶液を調製した。この粘着剤溶液をセパレータ上
に、乾燥後の厚みが４０μｍとなるように塗布、乾燥
し、温水中に浸漬して粘着剤層中に分散する塩化ナトリ
ウムを溶解除去した。次に、塩化ナトリウムを溶解除去
した粘着剤層を乾燥させて多孔質性の粘着剤層を形成し
た。Example 1 97 parts of 2-ethylhexyl acrylate and 3 parts of acrylic acid were copolymerized in ethyl acetate. After the completion of the polymerization reaction, 100 parts of sodium chloride was added to the solution and dispersed to obtain an adhesive solution. Prepared. This adhesive solution was applied on a separator so that the thickness after drying was 40 μm, dried, and immersed in warm water to dissolve and remove sodium chloride dispersed in the adhesive layer. Next, the pressure-sensitive adhesive layer from which sodium chloride was dissolved and removed was dried to form a porous pressure-sensitive adhesive layer.
【００２３】次いで、この粘着剤層を支持体としてポリ
オキシエチレンラウリルエーテルを５％含有する厚み２
００μｍのエチレン／酢酸ビニル共重合体製フィルム
（吸水率２％）の片面に転写、積層して本発明の吸湿性
貼付剤を作製した。Next, the pressure-sensitive adhesive layer was used as a support, and the thickness 2 containing 5% of polyoxyethylene lauryl ether was used.
A hygroscopic patch of the present invention was prepared by transferring and laminating on one side of a 00 μm ethylene / vinyl acetate copolymer film (water absorption 2%).
【００２４】実施例２ アクリル酸２−エチルヘキシルエステル４５部、アクリ
ル酸２−メトキシエチルエステル３０部、酢酸ビニル２
５部を酢酸エチル中にて共重合して得られたアクリル系
粘着剤溶液をセパレータ上に、乾燥後の厚みが２０μｍ
となるように塗布乾燥して粘着剤層を形成した。Example 2 45 parts of 2-ethylhexyl acrylate, 30 parts of 2-methoxyethyl acrylate, 2 parts of vinyl acetate
An acrylic pressure-sensitive adhesive solution obtained by copolymerizing 5 parts in ethyl acetate was placed on a separator and dried to a thickness of 20 μm.
And dried to form an adhesive layer.
【００２５】次いで、支持体としての５μｍの極薄ポリ
エチレンテレフタレートフィルムの片面に、ポリビニル
アルコール（重合度約１０００、鹸化度約９０％）の水
溶液を、乾燥後の厚みが５０μｍとなるように筋状（３
ｍｍ幅、３ｍｍピッチ）に塗布、乾燥して親水性高分子
層を形成し、この上に上記にて形成した粘着剤層を転
写、積層して本発明の吸湿性貼付剤を作製した。Next, an aqueous solution of polyvinyl alcohol (degree of polymerization: about 1000, degree of saponification: about 90%) was applied on one side of a 5 μm ultra-thin polyethylene terephthalate film as a support, so that the thickness after drying became 50 μm. (3
(a width of 3 mm, a pitch of 3 mm) and dried to form a hydrophilic polymer layer, and the pressure-sensitive adhesive layer formed above was transferred and laminated thereon to prepare a hygroscopic patch of the present invention.
【００２６】実施例３ ポリイソブチレン（分子量９９万）２５部と、ポリイソ
ブチレン（分子量４万）２５部と、ポリブテン（分子量
１２６０）５０部とを、トルエンに溶解して粘着剤溶液
とし、これをセパレータ上に、乾燥後の厚みが４０μｍ
となるように塗布乾燥して粘着剤層を形成した。Example 3 25 parts of polyisobutylene (molecular weight: 990,000), 25 parts of polyisobutylene (molecular weight: 40,000), and 50 parts of polybutene (molecular weight: 1260) were dissolved in toluene to form an adhesive solution. The thickness after drying is 40 μm on the separator.
And dried to form an adhesive layer.
【００２７】次いで、この粘着剤層を支持体として厚み
２０μｍのポリエチレンフィルムの片面に転写、積層
し、さらに粘着剤層表面に親水性高分子層として網目状
のコラーゲンフィルム（吸水率１１４％、厚み４０μ
ｍ、網目径５ｍｍ）を全面に積層して、本発明の吸湿性
貼付剤を作製した。Next, this adhesive layer was transferred and laminated on one side of a 20 μm-thick polyethylene film as a support, and a network-like collagen film (water absorption 114%, thickness 40μ
m, a mesh diameter of 5 mm) were laminated on the entire surface to prepare a hygroscopic patch of the present invention.
【００２８】比較例１ 実施例１において支持体に界面活性剤としてのポリオキ
シエチレンラウリルエーテルを添加しなかった以外は、
実施例１と同様にして貼付剤を作製した。なお、このと
きの支持体の吸水率は０．１％であった。Comparative Example 1 In Example 1, except that polyoxyethylene lauryl ether as a surfactant was not added to the support,
A patch was prepared in the same manner as in Example 1. At this time, the water absorption of the support was 0.1%.
【００２９】比較例２および３ 実施例２および３において、親水性高分子層を形成しな
かった以外は、各実施例と同様にして貼付剤を作製し、
比較例２および比較例３とした。Comparative Examples 2 and 3 Patches were prepared in the same manner as in Examples 2 and 3, except that the hydrophilic polymer layer was not formed.
Comparative Examples 2 and 3 were provided.
【００３０】上記各実施例および各比較例にて得た貼付
剤の剛軟性を下記方法によって測定し、その結果を表１
に示す。また、各貼付剤を５ｃｍ×７ｃｍの大きさに裁
断し、これをボランティアの胸部皮膚面に貼付し、その
際の取扱性、貼付後の貼付感、および皮膚無刺激性を下
記方法によって測定し、その結果を表１に示す。The bristles of the patches obtained in each of the above Examples and Comparative Examples were measured by the following method.
Shown in In addition, each patch was cut into a size of 5 cm × 7 cm, and the cut patch was stuck to the skin surface of the chest of a volunteer, and the handling property, sticking feeling after sticking, and skin irritation were measured by the following methods. Table 1 shows the results.
【００３１】〔剛軟性〕ＪＩＳＬ−１０９６に規定する
カンチレバー法に準じて、各貼付剤を３ｃｍ幅、１５ｃ
ｍ長さに裁断し、セパレータを剥離して粘着剤層面を上
にして４５度カンチレバー形試験機からの押出し距離
（ｍｍ）を測定した。なお、親水性高分子層を筋塗り形
成したものについては、筋塗り方向に押し出した。ま
た、剛軟性は２０℃，６５％ＲＨ（乾燥条件下）と、４
０℃，９０％ＲＨ，６０分間放置後（加湿条件下）に測
定した。[Rigid-softness] According to the cantilever method specified in JISL-1096, each patch was 3 cm wide and 15 cm wide.
m, the separator was peeled off, and the extruded distance (mm) from a 45-degree cantilever-type testing machine was measured with the pressure-sensitive adhesive layer surface facing upward. In addition, about what formed the hydrophilic polymer layer in the streaking, it extruded in the streaking direction. The rigidity is 20 ° C, 65% RH (dry condition) and 4%.
It was measured after leaving at 0 ° C., 90% RH for 60 minutes (humidifying conditions).
【００３２】〔取扱性〕各貼付剤からセパレータを剥離
して、皮膚面に貼付する際の取扱性を調べた。粘着剤面
同士のくっつきがなく、しかも皺が入らずに綺麗に貼付
できた場合を○、粘着剤同士のくっつきや皺が生じた
り、取扱いが極めて難しかった場合を×とした。[Handlability] The separator was peeled off from each patch, and the handleability when applied to the skin surface was examined. The case where the pressure-sensitive adhesive surfaces did not stick to each other and were able to be stuck neatly without wrinkles was evaluated as ○, and the case where the pressure-sensitive adhesives stuck or wrinkled or extremely difficult to handle was evaluated as ×.
【００３３】〔貼付感〕貼付後、柔軟性が良好で、違和
感を生じない場合を○、突っ張り感などの違和感を感じ
る場合を×とした。[Attachment Feeling] The case where, after sticking, flexibility was good and no discomfort was caused was evaluated as ○, and the case where discomfort such as tension was felt was evaluated as x.
【００３４】〔皮膚無刺激性〕貼付８時間後、各貼付剤
を皮膚面から剥離除去し、３０分経過後に貼付した皮膚
面を観察した。貼付前の状態と変化ない場合を○とし、
赤みを帯びていたり発疹、丘疹などの皮膚刺激症状が生
じている場合を×として判断した。[Skin non-irritant] 8 hours after application, each patch was peeled off from the skin surface, and after 30 minutes, the applied skin surface was observed. If there is no change from the state before pasting, it is marked as ○,
A case where the skin was reddish or a skin irritating symptom such as a rash or papule occurred was evaluated as x.
【００３５】[0035]
【表１】[Table 1]
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 9/70 A61L 15/00 - 15/64 A61F 13/02──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl.7 , DB name) A61K 9/70 A61L 15/00-15/64 A61F 13/02
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17399692AJP3240184B2 (en) | 1992-07-01 | 1992-07-01 | Hygroscopic patch |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17399692AJP3240184B2 (en) | 1992-07-01 | 1992-07-01 | Hygroscopic patch |
| Publication Number | Publication Date |
|---|---|
| JPH0616541A JPH0616541A (en) | 1994-01-25 |
| JP3240184B2true JP3240184B2 (en) | 2001-12-17 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17399692AExpired - LifetimeJP3240184B2 (en) | 1992-07-01 | 1992-07-01 | Hygroscopic patch |
| Country | Link |
|---|---|
| JP (1) | JP3240184B2 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69916424T2 (en) | 1998-12-02 | 2005-05-19 | Nichiban Co. Ltd. | PRESSURE-SENSITIVE ADHESIVE TAPE FOR FASTENING ON THE SKIN AND BASIC MATERIAL FOR ITS USE |
| JP2004034304A (en)* | 2002-06-28 | 2004-02-05 | Malay Kk | Label for body adornment |
| Publication number | Publication date |
|---|---|
| JPH0616541A (en) | 1994-01-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees | Free format text:JAPANESE INTERMEDIATE CODE: R250 | |
| FPAY | Renewal fee payment (event date is renewal date of database) | Free format text:PAYMENT UNTIL: 20121012 Year of fee payment:11 | |
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