【０００１】[0001]
【発明の属する技術分野】本発明は、主に複数成分系製
剤として適用される組織接着剤の注入装置に関するもの
であり、更に詳細には高濃度のフィブリノゲン溶液に対
するトロンビン溶液の容積比を下げることによって高濃
度のフィブリンを形成させ高い閉鎖効果を得るのに適す
る組織接着剤のシリンジ固定注入装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for injecting a tissue adhesive mainly applied as a multi-component preparation, and more particularly to a method for reducing the volume ratio of a thrombin solution to a high-concentration fibrinogen solution. The present invention relates to a syringe-fixed injection device for a tissue adhesive, which is suitable for forming a high concentration of fibrin and obtaining a high closing effect.
【０００２】[0002]
【従来の技術】繊維素原（フィブリノゲン）は、いわゆ
る血液凝固カスケードの最終段階に存在する非常に重要
な役割を担う凝固因子である。フィブリノゲンは、例え
ば損傷後の血液凝固系の活性化において、トロンビンに
より、その可溶性形態から止血及び創傷治療に重要な寄
与をする不溶性のフィブリンに変換される。この血液凝
固の最終相の原理を利用した組織接着剤が開発され、外
科手術において肝臓または脾臓のような軟部器官の縫合
代用の接着剤として、または縫合補助剤として使用され
ている。同時に、幅広い臨床の現場で応用されている。
近年、２本のシリンジ体に収納されたフィブリノゲン溶
液およびトロンビン溶液を同時に射出し、無菌ガスを利
用して、射出させた２液を霧状に噴霧して混合するスプ
レー塗布法が普及し始めている。このような器具の好適
な例は、例えばＰＣＴ ＷＯ９４−０７４２０号公報に
記載されている。しかしながらこのようなスプレー塗布
法を用いても、大血管の処置や、肺のエアーリークの処
置などの強い接着・閉鎖効果が求められる症例では、組
織接着剤が十分な効果を発揮するまでにはなお克服する
べき問題が存在した。BACKGROUND OF THE INVENTION Fibrinogen is a coagulation factor that plays a very important role in the final stages of the so-called blood clotting cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes a significant contribution to hemostasis and wound healing, for example, in the activation of the blood coagulation system after injury. Tissue adhesives utilizing the principle of the final phase of blood coagulation have been developed and used in surgical operations as adhesives for suture replacement of soft organs such as liver or spleen or as suture aids. At the same time, it is applied in a wide range of clinical settings.
2. Description of the Related Art In recent years, a spray coating method in which a fibrinogen solution and a thrombin solution stored in two syringes are simultaneously ejected, and the two ejected solutions are atomized and mixed by using aseptic gas has begun to spread. . A preferred example of such a device is described, for example, in PCT WO 94-07420. However, even if such a spray coating method is used, in cases where a strong adhesive / closing effect is required, such as treatment of large blood vessels or treatment of air leak in the lungs, it is not until the tissue adhesive exerts a sufficient effect. There were still problems to overcome.
【０００３】一方組織接着剤の効果を増強する方法とし
てフィブリノゲン溶液とトロンビン溶液との混合比を変
更し、フィブリノゲン濃度を高めることが有効であるこ
とが確認された。これらの組織接着剤に適用する装置、
すなわちフィブリノゲン溶液とトロンビン溶液とを異な
る容量で同時に注入するための装置としては特開昭６１
−２９３４４３号公報、ＰＣＴ ＷＯ９７−３３６３３
号公報に図３に示される断面積の異なる２本のシリンジ
を等長の有効ストロークとするものが示されている。し
かしながら汎用のシリンジでは断面積が異なるもので有
効ストロークが等しいものはなく、この用途専用に新た
にシリンジを作製する必要があるため大量生産低価格で
あるシリンジ分野においてコストアップを免れなかっ
た。On the other hand, it has been confirmed that it is effective to increase the fibrinogen concentration by changing the mixing ratio of the fibrinogen solution and the thrombin solution as a method for enhancing the effect of the tissue adhesive. A device that applies to these tissue adhesives,
That is, as a device for simultaneously injecting a fibrinogen solution and a thrombin solution in different volumes, Japanese Patent Application Laid-Open No.
-293443, PCT WO97-33633
Japanese Patent Application Laid-Open Publication No. H11-163,087 discloses a configuration in which two syringes having different cross-sectional areas shown in FIG. 3 are used as equal-length effective strokes. However, there are no general-purpose syringes having different cross-sectional areas and the same effective stroke, and a new syringe must be manufactured specifically for this purpose. Therefore, cost increases have been unavoidable in the field of syringes that are mass-produced and inexpensive.
【０００４】[0004]
【発明が解決しようとする課題】本発明は、従来のこの
ような問題点を解決することを目的とするもので、わざ
わざ特注の専用シリンジを作製せずとも汎用の低コスト
シリンジを使用して、かつ組織接着剤の効果を最大限に
上げるために異なる容量の２液以上の薬液を常に一定の
比率で同時に注入が可能な注入装置を提供するものであ
る。SUMMARY OF THE INVENTION An object of the present invention is to solve such a conventional problem, and a general-purpose low-cost syringe can be used without specially preparing a special-purpose syringe. Another object of the present invention is to provide an injection device capable of simultaneously injecting two or more liquid medicines of different volumes at a constant ratio at the same time in order to maximize the effect of the tissue adhesive.
【０００５】[0005]
【課題を解決するための手段】即ち本発明は、少なくと
も２本以上の同じサイズのシリンジを固定し各々のシリ
ンジより同時に薬液注入を行える装置において、常に一
定の比率で異なる容量の注入が可能なシリンジ固定注入
装置であって、各々のシリンジのプランジャー移動スト
ロークおよび移動速度がお互いに異なり、かつ一定の比
率が保たれている装置であって、詳しくはバレルを固定
する本体部と、複数のシリンジのプランジャーの末端に
装着される加圧部と、本体部と複数の加圧部とを連結す
る連結板とからなり、薬液最少容量注入用シリンジ側の
本体部の後端側に連結板の回転運動の中心となる接続部
が設けられており、また加圧部には連結板の回転運動を
プランジャーに伝達するためのスライド溝が設けられて
おり、連結板において本体部の接続部と各々の加圧部と
の距離の比率が、各々のシリンジの異なる薬液注入量の
比率と同じであるように設定されているシリンジ固定注
入装置である。In other words, the present invention provides an apparatus in which at least two or more syringes of the same size are fixed and a drug solution can be simultaneously injected from each syringe, so that different volumes can always be injected at a fixed ratio. A syringe fixed injection device, wherein the plunger movement stroke and the movement speed of each syringe are different from each other, and a fixed ratio is maintained, and more specifically, a main body for fixing a barrel, and a plurality of syringes. A pressure plate attached to the end of the plunger of the syringe, and a connection plate for connecting the body portion and the plurality of pressure portions, and a connection plate on the rear end side of the body portion on the syringe side for injecting the minimum volume of the drug solution. A connecting portion that is the center of the rotational movement of the connecting plate is provided, and a sliding groove for transmitting the rotating motion of the connecting plate to the plunger is provided in the pressing portion. The ratio of the distance between the pressing portion respectively and the connecting portion of the main body portion Te is a syringe fixed injection device is set to be the same as the ratio of the different liquid medicine injection amount of each syringe.
【０００６】[0006]
【発明の実施の形態】以下、図面をもとに本発明につい
て詳細に説明する。図１は本発明の一実施例となるシリ
ンジ固定注入装置の構造を示す立体斜視図で、図２は本
発明の一実施例となるシリンジ固定注入装置の注入前と
注入後の配置を示す側面図である。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings. FIG. 1 is a three-dimensional perspective view showing the structure of a syringe fixed injection device according to one embodiment of the present invention, and FIG. 2 is a side view showing the arrangement before injection and after injection of the syringe fixed injection device according to one embodiment of the present invention. FIG.
【０００７】本発明による非等量薬液注入用のシリンジ
固定注入装置は、図１に示すように、複数の同サイズの
シリンジ（２１）のバレル（２２）を保持する本体部
（１）と、シリンジ（２１）のプランジャー（２３）の
末端に装着された複数の加圧部（２）と、本体部（１）
及び加圧部（２）双方をつなぎ止めるピン（９）、（１
０）、（１１）が付設された連結板（３）とから基本的
に構成されている。本体部（１）はシリンジ（２１）の
バレル（２２）を保持する複数のバレル受け（４）と、
バレル受け（４）の後端にはフランジ（２４）が嵌合固
定されるフランジ受け（５）が設けられており、更に薬
液最少容量注入用シリンジ側の本体部の後端側には連結
板（３）のピン（９）が挿入され回転の中心となる接続
部（６）が設けられている。加圧部（２）はプランジャ
ー（２３）の末端のフランジ部が嵌合するＵ字溝部
（７）が設けられ更に連結板（３）のピン（１０）、
（１１）がシリンジ（２１）軸に対して直角方向に移動
できるスライド溝部（８）が設けられている。連結板
（３）は前述のごとくピン（９）、（１０）、（１１）
が付設されており、本体部（１）挿入用のピン（９）と
複数の加圧部（２）挿入用のピン（１０）、（１１）と
の距離関係は目的とする薬液の注入量に比例する関係に
あり、例えば薬液の注入量の比率を１：３とする場合、
ピン（９）から（１０）の距離とピン（９）から（１
１）の距離との比率も１：３に設定されている。As shown in FIG. 1, a syringe fixing and injecting device for injecting an unequal amount of a drug solution according to the present invention comprises: a main body (1) for holding barrels (22) of a plurality of syringes (21) of the same size; A plurality of pressurizing portions (2) mounted on the ends of a plunger (23) of the syringe (21), and a main body (1)
And pins (9), (1)
Basically, it is composed of a connecting plate (3) provided with (0) and (11). A plurality of barrel receivers (4) for holding a barrel (22) of the syringe (21);
A flange receiver (5) to which a flange (24) is fitted and fixed is provided at a rear end of the barrel receiver (4), and a connecting plate is provided at a rear end side of the main body on the side of the syringe for injecting the minimum volume of a chemical solution. The connection part (6) which becomes the center of rotation by inserting the pin (9) of (3) is provided. The pressing portion (2) is provided with a U-shaped groove (7) into which the flange portion at the end of the plunger (23) is fitted, and further includes a pin (10) of the connecting plate (3),
(11) is provided with a slide groove (8) that can move in a direction perpendicular to the axis of the syringe (21). The connecting plate (3) includes the pins (9), (10), and (11) as described above.
The distance relationship between the main body (1) insertion pin (9) and the plurality of pressurizing sections (2) insertion pins (10) and (11) is determined by the injection amount of the target chemical solution. For example, when the ratio of the injection amount of the drug solution is 1: 3,
The distance from pin (9) to (10) and the distance from pin (9) to (1
The ratio with the distance of 1) is also set to 1: 3.
【０００８】本体部（１）、加圧部（２）、連結板
（３）の材質及び成形方法はプラスチック等による射出
成形等にて作製されるのが一般的であるが特に限定され
るものではない。また決められた薬液注入比率で使用す
る限りにおいては連結板（３）とピン（９）〜（１１）
を一体成形とすることがコスト的に安価となるが、注入
比率を適宜変更して使用する場合においては、ピン（１
０）、（１１）を別部品とし、連結板（３）には複数の
ピン取付部（１２）を予め設置しておけばユーザーにお
いて薬液注入比率を変更して使用することも可能となる
ため望ましい実施例の一つである。The material and molding method of the main body portion (1), the pressing portion (2), and the connecting plate (3) are generally manufactured by injection molding of plastic or the like, but are particularly limited. is not. In addition, the connection plate (3) and the pins (9) to (11) are used as long as they are used at the determined liquid injection ratio.
Is cheaper in terms of cost, but when the injection ratio is appropriately changed, the pin (1
If the pins (0) and (11) are separate parts and the connecting plate (3) is provided with a plurality of pin mounting portions (12) in advance, the user can change the liquid injection ratio and use it. This is one of the preferred embodiments.
【０００９】次に図２を用いて本発明による非等量薬液
注入用のシリンジ固定注入装置の機構を説明する。図２
（ａ）は薬液注入前の配置を示す側面図で、（ｂ）は薬
液注入後の配置を示す側面図である。取り付けられた左
右のシリンジ（１１）は容量が３ｍｌであり、３ｍｌと
１ｍｌの注入例を示している。連結板（３）は本体部
（１）の接続部（６）に嵌合したピン（９）を中心とす
る回転ができるように取り付けられており、図２（ａ）
の配置より薬液注入が開始となり、加圧部（２ａ）を加
圧することによりピン（１１）がスライド溝部（８ａ）
内を左方向に移動するとともに連結板（３）がピン
（９）を中心として回転する。そしてこの連結板（３）
の回転にともないピン（１０）が加圧部（２ｂ）のスラ
イド溝部（８ｂ）内を左方向に移動しながら加圧部（２
ｂ）を押し進め薬液注入完了時は図２（ｂ）の配置とな
る。原理的にはピン（９）→（１０）の距離をＡ、
（９）→（１１）の距離をＢとするとそれぞれの距離
Ａ：Ｂ＝１：３の場合、注入方向の距離も三角形の相似
比に等しく、必ず薬液注入方向の距離Ｃ：Ｄ＝１：３の
比率で薬液注入されることになる。Next, referring to FIG. 2, the mechanism of the syringe fixed injection device for injecting an unequal amount of drug solution according to the present invention will be described. FIG.
(A) is a side view showing the arrangement before the injection of the chemical, and (b) is a side view showing the arrangement after the injection of the chemical. The attached left and right syringes (11) have a capacity of 3 ml, and show injection examples of 3 ml and 1 ml. The connecting plate (3) is attached so as to be rotatable about the pin (9) fitted to the connecting portion (6) of the main body (1), and FIG.
Injection of the liquid medicine starts from the disposition of (1), and the pin (11) is pressed by the pressurizing section (2a) to slide the groove (8a).
And the connecting plate (3) rotates about the pin (9). And this connecting plate (3)
As the pin (10) rotates, the pin (10) moves to the left in the slide groove (8b) of the pressing section (2b) while moving to the left.
2B is pushed to complete the chemical solution injection, and the arrangement is as shown in FIG. 2B. In principle, the distance from pin (9) to (10) is A,
Assuming that the distance from (9) → (11) is B, when the respective distances A: B = 1: 3, the distance in the injection direction is also equal to the similarity ratio of the triangle, and the distance C: D = 1 in the chemical liquid injection direction always. The chemical is injected at a ratio of 3.
【００１０】[0010]
【発明の効果】以上に述べた如く、本発明による非等量
薬液注入用のシリンジ固定注入装置は複数の異なるプラ
ンジャーの進む量を常に一定の比率で進めることが可能
な機構であるため、わざわざ特注の専用シリンジを作製
せずとも汎用の低コストシリンジを使用して異なる薬液
注入を行え、特に高濃度のフィブリンを形成させ高い閉
鎖効果を得るのに適する組織接着剤の注入装置として有
用である。As described above, the syringe fixed injection device for injecting an unequal amount of a drug solution according to the present invention is a mechanism that can always advance a plurality of different plungers at a constant rate. It is possible to use a general-purpose low-cost syringe to inject different medicinal solutions without the need to create a specially-designed special-purpose syringe.It is particularly useful as a tissue adhesive injection device suitable for forming a high concentration of fibrin and obtaining a high closing effect. is there.
【図１】本発明の一実施例となる非等量薬液注入用シリ
ンジ固定注入装置の構造を示す立体斜視図である。FIG. 1 is a three-dimensional perspective view showing a structure of a syringe fixed injection device for injecting an unequal amount of a drug solution according to one embodiment of the present invention.
【図２】本発明の一実施例となる非等量薬液注入用シリ
ンジ固定注入装置の機構を示す図で（ａ）は薬液注入前
で、（ｂ）は薬液注入後のそれぞれの配置を示す側面図
である。FIG. 2 is a view showing a mechanism of a syringe fixing and injecting device for injecting an unequal amount of a drug solution according to an embodiment of the present invention, wherein (a) shows a position before the drug solution is injected, and (b) shows an arrangement after the drug solution is injected. It is a side view.
【図３】従来の非等量薬液注入用シリンジ固定注入装置
の機構を示す側面図である。FIG. 3 is a side view showing a mechanism of a conventional syringe fixed injection device for injection of a non-equivalent chemical solution.
１ 本体部 ２ 加圧部 ３ 連結板 ４ バレル受け ５ フランジ受け ６ 接続部 ７ Ｕ字溝部 ８ スライド溝部 ９ ピン（本体部取付用） 10 ピン（加圧部取付用） 11 ピン（加圧部取付用） 12 ピン取付部 21 シリンジ 22 バレル 23 プランジャー 24 フランジ DESCRIPTION OF SYMBOLS 1 Main body part 2 Pressing part 3 Connecting plate 4 Barrel receiver 5 Flange receiver 6 Connection part 7 U-shaped groove part 8 Sliding groove part 9 Pin (for mounting main part) 10 pin (for mounting pressing part) 11 pin (for mounting pressing part) 12 pin mounting part 21 syringe 22 barrel 23 plunger 24 flange
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07122199AJP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07122199AJP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
| Publication Number | Publication Date |
|---|---|
| JP2000262525Atrue JP2000262525A (en) | 2000-09-26 |
| JP3678602B2 JP3678602B2 (en) | 2005-08-03 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP07122199AExpired - Fee RelatedJP3678602B2 (en) | 1999-03-17 | 1999-03-17 | Syringe fixed injection device |
| Country | Link |
|---|---|
| JP (1) | JP3678602B2 (en) |
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