| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694693P | 2012-08-29 | 2012-08-29 | |
| PCT/US2013/057214WO2014036219A2 (en) | 2012-08-29 | 2013-08-29 | Methods and compositions for treatment of a genetic condition |
| Publication Number | Publication Date |
|---|---|
| IN2015DN01480Atrue IN2015DN01480A (en) | 2015-07-03 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1480DEN2015IN2015DN01480A (en) | 2012-08-29 | 2013-08-29 |
| Country | Link |
|---|---|
| US (4) | US9963715B2 (en) |
| EP (1) | EP2890780B8 (en) |
| JP (4) | JP2015533786A (en) |
| KR (3) | KR102474010B1 (en) |
| CN (1) | CN104704110B (en) |
| AU (1) | AU2013308770B2 (en) |
| CA (2) | CA3171494A1 (en) |
| CL (1) | CL2015000450A1 (en) |
| DK (1) | DK2890780T3 (en) |
| EA (1) | EA039384B1 (en) |
| ES (1) | ES2812599T3 (en) |
| HR (1) | HRP20201443T1 (en) |
| HU (1) | HUE050516T2 (en) |
| IL (1) | IL237050B (en) |
| IN (1) | IN2015DN01480A (en) |
| LT (1) | LT2890780T (en) |
| MX (1) | MX367081B (en) |
| PH (3) | PH12021551661A1 (en) |
| PL (1) | PL2890780T3 (en) |
| PT (1) | PT2890780T (en) |
| RS (1) | RS60838B1 (en) |
| SG (2) | SG10201701601WA (en) |
| SI (1) | SI2890780T1 (en) |
| UA (1) | UA118957C2 (en) |
| WO (1) | WO2014036219A2 (en) |
| ZA (1) | ZA201500900B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| BR112014020625A2 (en)* | 2012-02-24 | 2017-07-04 | Hutchinson Fred Cancer Res | polynucleotide, polypeptide, composition, cell, and stem cell edited by genome |
| FI3597749T3 (en) | 2012-05-25 | 2023-10-09 | Univ California | METHODS AND COMPOSITIONS FOR RNA-DIRECTED MODIFICATION OF TARGET DNA AND RNA-DIRECTED MODULATION OF TRANSCRIPTION |
| EP4397760A3 (en)* | 2012-10-23 | 2024-10-09 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| ES2714154T3 (en) | 2012-12-06 | 2019-05-27 | Sigma Aldrich Co Llc | Modification and regulation of the genome based on CRISPR |
| JP6491113B2 (en) | 2013-02-25 | 2019-03-27 | サンガモ セラピューティクス, インコーポレイテッド | Methods and compositions for enhancing nuclease-mediated gene disruption |
| BR112015022061B8 (en) | 2013-03-14 | 2023-12-26 | Caribou Biosciences Inc | Genetically engineered single-stranded guide nucleic acid targeting nucleic acid, polynucleotide, method for cleaving a target nucleic acid and for ligating a target nucleic acid, composition and kit |
| EP4286517A3 (en) | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Therapeutic uses of genome editing with crispr/cas systems |
| CA2910489A1 (en)* | 2013-05-15 | 2014-11-20 | Sangamo Biosciences, Inc. | Methods and compositions for treatment of a genetic condition |
| AU2014274840B2 (en)* | 2013-06-05 | 2020-03-12 | Duke University | RNA-guided gene editing and gene regulation |
| EP3019595A4 (en) | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF GENOME EDITING WITH CRISPR / CAS SYSTEMS | |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| WO2015031619A1 (en)* | 2013-08-28 | 2015-03-05 | Sangamo Biosciences, Inc. | Compositions for linking dna-binding domains and cleavage domains |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| JP2016536021A (en) | 2013-11-07 | 2016-11-24 | エディタス・メディシン,インコーポレイテッド | CRISPR-related methods and compositions with governing gRNA |
| DK3068881T3 (en)* | 2013-11-13 | 2019-04-15 | Childrens Medical Center | NUCLEASE-MEDIATED REGULATION OF GENEPRESSION |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| EP3102673B1 (en)* | 2014-02-03 | 2020-04-15 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a beta thalessemia |
| AU2015218576B2 (en) | 2014-02-24 | 2020-02-27 | Sangamo Therapeutics, Inc. | Methods and compositions for nuclease-mediated targeted integration |
| EP3114227B1 (en) | 2014-03-05 | 2021-07-21 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa |
| US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
| ES2745769T3 (en) | 2014-03-10 | 2020-03-03 | Editas Medicine Inc | CRISPR / CAS related procedures and compositions for treating Leber 10 congenital amaurosis (LCA10) |
| US11339437B2 (en) | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
| JP6594891B2 (en) | 2014-03-18 | 2019-10-23 | サンガモ セラピューティクス, インコーポレイテッド | Methods and compositions for modulating zinc finger protein expression |
| EP3981876A1 (en)* | 2014-03-26 | 2022-04-13 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
| EP3122181A4 (en)* | 2014-03-26 | 2018-04-25 | The Brigham and Women's Hospital, Inc. | Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells |
| WO2015148860A1 (en)* | 2014-03-26 | 2015-10-01 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating beta-thalassemia |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| GB2544001A (en) | 2014-08-27 | 2017-05-03 | Caribou Biosciences Inc | Methods for increasing Cas9-mediated engineering efficiency |
| SI3194570T1 (en)* | 2014-09-16 | 2022-01-31 | Sangamo Therapeutics, Inc. | Nuclease-mediated methods and compositions for genomic engineering and hematopoietic stem cell correction |
| EP3215623A4 (en) | 2014-11-06 | 2018-09-26 | President and Fellows of Harvard College | Cells lacking b2m surface expression and methods for allogeneic administration of such cells |
| US20170355958A1 (en)* | 2014-11-24 | 2017-12-14 | Children's Medical Center Corporation | Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells |
| WO2016094880A1 (en)* | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs) |
| US12129471B2 (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| SG11201706767RA (en)* | 2015-02-23 | 2017-09-28 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies |
| EP3910641B1 (en) | 2015-04-13 | 2022-10-05 | Invitae Corporation | Methods, systems and processes of identifying genetic variation in highly similar genes |
| SG11201708653RA (en) | 2015-04-24 | 2017-11-29 | Editas Medicine Inc | Evaluation of cas9 molecule/guide rna molecule complexes |
| US10179918B2 (en) | 2015-05-07 | 2019-01-15 | Sangamo Therapeutics, Inc. | Methods and compositions for increasing transgene activity |
| WO2016183041A2 (en) | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| BR112017024115A2 (en) | 2015-05-12 | 2018-08-07 | Sangamo Therapeutics Inc | nuclease-mediated gene expression regulation |
| US9957501B2 (en) | 2015-06-18 | 2018-05-01 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
| US10676735B2 (en)* | 2015-07-22 | 2020-06-09 | Duke University | High-throughput screening of regulatory element function with epigenome editing technologies |
| KR102803519B1 (en)* | 2015-09-23 | 2025-05-08 | 상가모 테라퓨틱스, 인코포레이티드 | HTT REPRESSOR AND ITS USES |
| KR20180069832A (en)* | 2015-10-20 | 2018-06-25 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | Functional Recovery and Utilization of Non-Functional Gene Products by Induction CAS System |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| PE20181206A1 (en) | 2015-10-28 | 2018-07-23 | Sangamo Therapeutics Inc | SPECIFIC LIVER CONSTRUCTIONS, FACTOR VIII EXPRESSION CASSETTES AND METHODS OF USE OF THESE |
| ES2942309T3 (en) | 2015-11-04 | 2023-05-31 | Vertex Pharma | Materials and methods for the treatment of hemoglobinopathies |
| ES2905558T3 (en) | 2015-11-13 | 2022-04-11 | Avellino Lab Usa Inc | Procedures for the treatment of corneal dystrophies |
| EA201891212A1 (en) | 2015-12-18 | 2019-01-31 | Сангамо Терапьютикс, Инк. | ADDRESS DISORGANIZATION OF GKGS CELL RECEPTOR |
| US20190249172A1 (en) | 2016-02-18 | 2019-08-15 | The Regents Of The University Of California | Methods and compositions for gene editing in stem cells |
| EP3430142A1 (en)* | 2016-03-14 | 2019-01-23 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating beta hemoglobinopathies |
| WO2017165862A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency |
| WO2018026976A1 (en) | 2016-08-02 | 2018-02-08 | Editas Medicine, Inc. | Compositions and methods for treating cep290 associated disease |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| JP2019524149A (en) | 2016-08-20 | 2019-09-05 | アベリノ ラボ ユーエスエー インコーポレイテッドAvellino Lab USA, Inc. | Single-stranded guide RNA, CRISPR / Cas9 system, and methods of use thereof |
| WO2020225754A1 (en) | 2019-05-06 | 2020-11-12 | Mcmullen Tara | Crispr gene editing for autosomal dominant diseases |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240144493A (en) | 2016-08-24 | 2024-10-02 | 상가모 테라퓨틱스, 인코포레이티드 | Engineered target specific nucleases |
| CN110325635B (en)* | 2016-08-24 | 2023-12-26 | 桑格摩生物治疗股份有限公司 | Regulation of gene expression using engineered nucleases |
| US10960085B2 (en) | 2016-09-07 | 2021-03-30 | Sangamo Therapeutics, Inc. | Modulation of liver genes |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018071663A1 (en)* | 2016-10-14 | 2018-04-19 | Emendobio Inc. | Rna compositions for genome editing |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| TWI758316B (en)* | 2017-01-09 | 2022-03-21 | 美商聖加莫治療股份有限公司 | Regulation of gene expression using engineered nucleases |
| TW201839136A (en) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | Composition and method for treating hemochromatosis |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| JP2020510439A (en) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Base-editing factor from cytosine to guanine |
| WO2018170184A1 (en) | 2017-03-14 | 2018-09-20 | Editas Medicine, Inc. | Systems and methods for the treatment of hemoglobinopathies |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018200597A1 (en) | 2017-04-24 | 2018-11-01 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Homology directed repair compositions for the treatment of hemoglobinopathies |
| WO2018209158A2 (en) | 2017-05-10 | 2018-11-15 | Editas Medicine, Inc. | Crispr/rna-guided nuclease systems and methods |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| MX2020000676A (en)* | 2017-07-18 | 2021-05-14 | Csl Behring Gene Therapy Inc | Compositions and methods for treating beta-hemoglobinopathies. |
| CN111801345A (en) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | Methods and compositions using an evolved base editor for Phage Assisted Continuous Evolution (PACE) |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| MA50849A (en) | 2017-10-26 | 2020-09-02 | Vertex Pharma | SUBSTANCES AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES |
| WO2019094725A2 (en)* | 2017-11-09 | 2019-05-16 | Sangamo Therapeutics, Inc. | Genetic modification of cytokine inducible sh2-containing protein (cish) gene |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND PROCEDURES FOR PREDICTING REPAIR RESULTS IN GENE ENGINEERING |
| EP3511412A1 (en) | 2018-01-12 | 2019-07-17 | Genethon | Genetically engineered hematopoietic stem cell as a platform for systemic protein expression |
| US11268077B2 (en) | 2018-02-05 | 2022-03-08 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
| RU2020129448A (en)* | 2018-02-08 | 2022-03-09 | Сангамо Терапьютикс, Инк. | DESIGNED TARGET-SPECIFIC NUCLEASE |
| CN111954548A (en) | 2018-02-21 | 2020-11-17 | 亚克安娜生命科学有限公司 | Fluid delivery system and method |
| KR20200132924A (en) | 2018-03-14 | 2020-11-25 | 에디타스 메디신, 인코포레이티드 | Systems and methods for the treatment of hemoglobinosis |
| WO2019217942A1 (en) | 2018-05-11 | 2019-11-14 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| AU2019327386A1 (en) | 2018-08-27 | 2021-03-18 | Alcyone Therapeutics, Inc. | Fluid delivery systems and methods |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191246A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| BR112021019448A2 (en) | 2019-04-02 | 2021-11-30 | Sangamo Therapeutics Inc | Methods for treating beta-thalassemia |
| WO2020208223A1 (en)* | 2019-04-12 | 2020-10-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Correction of βeta-thalassemia phenotype by genetically engineered hematopoietic stem cell |
| CN112391410B (en)* | 2020-02-17 | 2024-04-02 | 华东师范大学 | sgRNA and application thereof in repairing abnormal splicing of introns |
| CA3145687A1 (en)* | 2019-08-01 | 2021-02-04 | Tippi MACKENZIE | Compositions and methods for treating alpha thalassemia |
| WO2021026336A2 (en)* | 2019-08-07 | 2021-02-11 | I Altius Institute For Biomedical Sciences | Compositions and methods for modulation of gene expression |
| CA3147643A1 (en)* | 2019-09-23 | 2021-04-01 | Omega Therapeutics, Inc. | Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (hnf4.alpha.) gene expression |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| EP4045649A4 (en)* | 2019-10-15 | 2023-11-22 | Altius Institute For Biomedical Sciences | Dna binding proteins for displacing endogenous transcription factors bound to gene regulatory regions |
| US20250263752A1 (en) | 2020-04-21 | 2025-08-21 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
| WO2021216623A1 (en) | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
| AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| TW202342498A (en) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | Modified paramyxoviridae fusion glycoproteins |
| EP4448775A1 (en) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modified paramyxoviridae attachment glycoproteins |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| EP4472646A1 (en) | 2022-02-01 | 2024-12-11 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| EP4473097A1 (en) | 2022-02-02 | 2024-12-11 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
| WO2024064838A1 (en) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
| EP4602174A1 (en) | 2022-10-13 | 2025-08-20 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
| EP4627096A1 (en) | 2022-12-02 | 2025-10-08 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024220560A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Engineered protein g fusogens and related lipid particles and methods thereof |
| WO2024220598A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Lentiviral vectors with two or more genomes |
| WO2024220574A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Universal protein g fusogens and adapter systems thereof and related lipid particles and uses |
| WO2024243340A1 (en) | 2023-05-23 | 2024-11-28 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| US20250230470A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
| WO2025153530A1 (en) | 2024-01-16 | 2025-07-24 | Novo Nordisk A/S | Albumin-targeted endonucleases, compositions, and methods of use |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US789538A (en) | 1904-11-11 | 1905-05-09 | Colin E Ham | Dumb-bell. |
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| EP0770129B1 (en) | 1994-01-18 | 2005-11-23 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| CA2186118C (en) | 1994-03-23 | 2010-10-19 | Richard W. Hanson | Compacted nucleic acids and their delivery to cells |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| EP2022856B1 (en) | 1994-08-20 | 2011-09-14 | Gendaq Limited | Improvements in or relating to binding proteins for recognition of DNA |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB2338237B (en) | 1997-02-18 | 2001-02-28 | Actinova Ltd | In vitro peptide or protein expression library |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| DE69942334D1 (en) | 1998-03-02 | 2010-06-17 | Massachusetts Inst Technology | POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS |
| CO5070700A1 (en) | 1998-06-05 | 2001-08-28 | Basf Ag | NOVELTY GENES OF (ADP-RIBOSA) POLYMERASE |
| US6140815A (en) | 1998-06-17 | 2000-10-31 | Dover Instrument Corporation | High stability spin stand platform |
| US6532231B1 (en) | 1998-08-29 | 2003-03-11 | Lucent Technologies Inc. | Arrangement for changing the destination of single link, single destination data messages |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6534261B1 (en)* | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| CA2361191A1 (en) | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
| US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| IL150069A0 (en) | 1999-12-06 | 2002-12-01 | Sangamo Biosciences Inc | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| DE60143192D1 (en) | 2000-02-08 | 2010-11-18 | Sangamo Biosciences Inc | CELLS FOR THE DISCOVERY OF MEDICAMENTS |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| JP2002060786A (en) | 2000-08-23 | 2002-02-26 | Kao Corp | Bactericidal antifouling agent for hard surfaces |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| JP2005500061A (en) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Zinc finger binding domain for CNN |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| AU2003251286B2 (en) | 2002-01-23 | 2007-08-16 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| EP2368982A3 (en) | 2002-03-21 | 2011-10-12 | Sangamo BioSciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
| WO2004037977A2 (en) | 2002-09-05 | 2004-05-06 | California Institute Of Thechnology | Use of chimeric nucleases to stimulate gene targeting |
| DK2927318T3 (en) | 2003-08-08 | 2020-08-03 | Sangamo Therapeutics Inc | Method and compositions for targeted cleavage and recombination |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| CA2562193A1 (en) | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Treatment of neuropathic pain with zinc finger proteins |
| WO2005099771A2 (en) | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Methods and compositions for treating neuropathic and neurodegenerative conditions |
| EP1789095A2 (en) | 2004-09-16 | 2007-05-30 | Sangamo Biosciences Inc. | Compositions and methods for protein production |
| CA2599004C (en)* | 2005-02-28 | 2015-05-26 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
| EP1877583A2 (en) | 2005-05-05 | 2008-01-16 | Arizona Board of Regents on behalf of the Unversity of Arizona | Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences |
| AU2006272634B2 (en)* | 2005-07-26 | 2013-01-24 | Sangamo Therapeutics, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| ES2384440T3 (en) | 2005-10-18 | 2012-07-04 | Precision Biosciences | Rationally designed meganucleases with sequence specificity and altered DNA binding affinity |
| DE602007005634D1 (en) | 2006-05-25 | 2010-05-12 | Sangamo Biosciences Inc | VARIANT FOKI CREVICE HOLLAND DOMAINS |
| JP5551432B2 (en) | 2006-05-25 | 2014-07-16 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Methods and compositions for gene inactivation |
| DE602008003684D1 (en) | 2007-04-26 | 2011-01-05 | Sangamo Biosciences Inc | TARGETED INTEGRATION IN THE PPP1R12C POSITION |
| US8790345B2 (en) | 2007-08-21 | 2014-07-29 | Zimmer, Inc. | Titanium alloy with oxidized zirconium for a prosthetic implant |
| CA2700231C (en) | 2007-09-27 | 2018-09-18 | Sangamo Biosciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| EP2597155B1 (en) | 2007-10-25 | 2016-11-23 | Sangamo BioSciences, Inc. | Methods and compositions for targeted integration |
| BE1018531A4 (en) | 2007-10-31 | 2011-03-01 | Gielen Cornelis | THE USE OF NON-PATHOGENIC BACTERIA IN TRACE FORM OR IN SLEEPING FOR REMOVAL OF HOUSEHOLDING EJECTS AND ORGANIC ALLERGY MATERIALS OF ALL TEXTILE TYPES. |
| DE102007056956B4 (en) | 2007-11-27 | 2009-10-29 | Moosbauer, Peter, Dipl.-Ing.(FH) | Circuit for controlling the power supply of a consumer and method for operating a circuit |
| JP2011518555A (en) | 2008-04-14 | 2011-06-30 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Linear donor constructs for targeted integration |
| JP2011521643A (en) | 2008-05-28 | 2011-07-28 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Composition for linking a DNA binding domain and a cleavage domain |
| AU2009283194B2 (en) | 2008-08-22 | 2014-10-16 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted single-stranded cleavage and targeted integration |
| WO2010030963A2 (en) | 2008-09-15 | 2010-03-18 | Children's Medical Center Corporation | Modulation of bcl11a for treatment of hemoglobinopathies |
| SG172760A1 (en) | 2008-12-04 | 2011-08-29 | Sangamo Biosciences Inc | Genome editing in rats using zinc-finger nucleases |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| EP3156504B1 (en) | 2009-08-11 | 2018-10-31 | Sangamo Therapeutics, Inc. | Organisms homozygous for targeted modification |
| SG181601A1 (en) | 2009-12-10 | 2012-07-30 | Univ Minnesota | Tal effector-mediated dna modification |
| CN106086047B (en) | 2010-01-22 | 2021-07-06 | 陶氏益农公司 | Targeted genome engineering |
| EP2615106B1 (en)* | 2010-02-08 | 2018-04-25 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
| JP2013518602A (en) | 2010-02-09 | 2013-05-23 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Targeted genome modification by partially single-stranded donor molecules |
| HRP20200254T1 (en) | 2010-05-03 | 2020-05-29 | Sangamo Therapeutics, Inc. | PREPARATIONS FOR CONNECTING ZINC FINGER MODULE |
| EP2571512B1 (en) | 2010-05-17 | 2017-08-23 | Sangamo BioSciences, Inc. | Novel dna-binding proteins and uses thereof |
| US20140127814A1 (en) | 2010-08-10 | 2014-05-08 | Srinivasan Chandrasegaran | Generation and use of pluripotent stem cells |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| WO2012073047A2 (en) | 2010-12-03 | 2012-06-07 | Genome Research Limited | Compositions and methods |
| KR102061557B1 (en) | 2011-09-21 | 2020-01-03 | 상가모 테라퓨틱스, 인코포레이티드 | Methods and compositions for refulation of transgene expression |
| JP6188703B2 (en) | 2011-10-27 | 2017-08-30 | サンガモ セラピューティクス, インコーポレイテッド | Methods and compositions for modifying the HPRT locus |
| BR112014020625A2 (en)* | 2012-02-24 | 2017-07-04 | Hutchinson Fred Cancer Res | polynucleotide, polypeptide, composition, cell, and stem cell edited by genome |
| EP2847338B1 (en) | 2012-05-07 | 2018-09-19 | Sangamo Therapeutics, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
| CA2910489A1 (en) | 2013-05-15 | 2014-11-20 | Sangamo Biosciences, Inc. | Methods and compositions for treatment of a genetic condition |
| Publication | Publication Date | Title |
|---|---|---|
| PH12019502292A1 (en) | Methods and compositions for treatment of a genetic condition | |
| IN2014CN02639A (en) | ||
| IL230836A (en) | Multi-part sterilant system | |
| IN2012DE03088A (en) | ||
| SMT202200337T1 (en) | Terminally modified rna | |
| AU2013225816A8 (en) | Compositions and methods for treating Type III Gaucher Disease | |
| SG11201407089SA (en) | Cyclosporine-containing, non-irritative nanoemulsion opthalmic composition | |
| MX2015002487A (en) | Process for the preparation of teneligliptin. | |
| PT2708607T (en) | Genetic markers for myb28 | |
| GB201423420D0 (en) | Blackhoe loader | |
| IN2015DN03815A (en) | ||
| GB2505638B (en) | Continuous culture | |
| GB201103407D0 (en) | Genetic association | |
| GB2491544A (en) | Perpetum mobile | |
| MX2012013246A (en) | Dust supressant composition. | |
| GB201212331D0 (en) | Elaectric pruner | |
| UA79072U (en) | (4-tert-butylperoxy-4-methylpentyl)methacrylate | |
| AU338012S (en) | Dinosaur costume | |
| AU348528S (en) | A food mould | |
| IN2011KO00551A (en) | ||
| UA78206U (en) | Technique for esophagogastroplasty with ileocecal segment | |
| GB201222429D0 (en) | Nolan | |
| GB201300551D0 (en) | Multi-part push-pulls | |
| IN2012DE01204A (en) | "shikhar technology" | |
| GB201201144D0 (en) | Distributed versioning |