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IN2015DN01151A - - Google Patents

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Publication number
IN2015DN01151A
IN2015DN01151AIN1151DEN2015AIN2015DN01151AIN 2015DN01151 AIN2015DN01151 AIN 2015DN01151AIN 1151DEN2015 AIN1151DEN2015 AIN 1151DEN2015AIN 2015DN01151 AIN2015DN01151 AIN 2015DN01151A
Authority
IN
India
Prior art keywords
pyridinone derivatives
pharmaceutical compositions
tissue transglutaminase
pyridinone
derivatives
Prior art date
Application number
Inventor
Christian Büchold
Uwe Gerlach
Martin Hils
Ralf Pasternack
Johannes Weber
Original Assignee
Zedira Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zedira GmbhfiledCriticalZedira Gmbh
Publication of IN2015DN01151ApublicationCriticalpatent/IN2015DN01151A/en

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Abstract

The invention relates to pyridinone derivatives of general formula (I) as inhibitors for tissue transglutaminase to methods for producing the pyridinone derivatives to pharmaceutical compositions containing said pyridinone derivatives and to the use of said pharmaceutical compositions to prevent and treat diseases associated with tissue transglutaminase.
IN1151DEN20152012-07-172015-02-12IN2015DN01151A (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
EP12176776.8AEP2687511A1 (en)2012-07-172012-07-17Pyridinone derivatives as tissue transglutaminase inhibitors
US201261741871P2012-07-302012-07-30
PCT/EP2013/064789WO2014012858A1 (en)2012-07-172013-07-12Pyridinone derivatives as tissue transglutaminase inhibitors

Publications (1)

Publication NumberPublication Date
IN2015DN01151Atrue IN2015DN01151A (en)2015-06-26

Family

ID=46516598

Family Applications (1)

Application NumberTitlePriority DateFiling Date
IN1151DEN2015IN2015DN01151A (en)2012-07-172015-02-12

Country Status (20)

CountryLink
US (1)US9434763B2 (en)
EP (2)EP2687511A1 (en)
JP (1)JP6236445B2 (en)
CN (1)CN104603109B (en)
AU (1)AU2013292149B2 (en)
CA (1)CA2878796C (en)
CY (1)CY1116775T1 (en)
DK (1)DK2797892T3 (en)
ES (1)ES2543956T3 (en)
HR (1)HRP20150829T1 (en)
HU (1)HUE027051T2 (en)
IL (1)IL236707B (en)
IN (1)IN2015DN01151A (en)
PL (1)PL2797892T3 (en)
PT (1)PT2797892E (en)
RS (1)RS54153B1 (en)
RU (1)RU2652987C2 (en)
SI (1)SI2797892T1 (en)
SM (1)SMT201500208B (en)
WO (1)WO2014012858A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US10526326B2 (en)2015-08-052020-01-07Ratiopharm GmbhCrystalline form and acetic acid adducts of palbociclib
WO2019201432A1 (en)*2018-04-172019-10-24Zedira GmbhInhibitors of blood coagulation factor xiii
TWI825144B (en)*2018-08-102023-12-11美商思達利醫藥公司Transglutaminase 2 (tg2) inhibitors
TWI762939B (en)*2019-05-312022-05-01大陸商海思科醫藥集團股份有限公司 BTK inhibitor cyclic derivatives, preparation method and pharmaceutical application thereof
HRP20231072T1 (en)*2020-04-242023-12-22Dr. Falk Pharma GmbhSystemic formulation of a pyridinone derivate for coeliac disease
PH12022552790A1 (en)*2020-04-242024-03-25Dr Falk Pharma GmbhSystemic Formulation of a Pyridinone Derivate for TG2-related Diseases
EP3900706A1 (en)*2020-04-242021-10-27Dr. Falk Pharma GmbhSystemic formulation of a pyridinone derivate for coeliac disease
EP3900707A1 (en)*2020-04-242021-10-27Dr. Falk Pharma GmbhSystemic formulation of a pyridinone derivate for tg2-related diseases
FI4192813T3 (en)2021-06-302024-11-07Zedira Gmbh TRANSGLUTAMINASE INHIBITORS
JP2024528557A (en)2021-06-302024-07-30ゼディラ ゲーエムべーハー Transglutaminase Inhibitors
WO2023110138A1 (en)*2021-12-172023-06-22Zedira GmbhInhibitors of transglutaminases
CN117561240A (en)*2021-06-302024-02-13策迪拉有限公司Inhibitors of transglutaminase
AU2022303109A1 (en)2021-06-302023-12-14Zedira GmbhInhibitors of transglutaminases
WO2023072368A1 (en)*2021-10-252023-05-04Dr. Falk Pharma GmbhOral formulation of a pyridinone derivate and use thereof in prophylaxis and/or treatment of intestinal fibrosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5021440A (en)*1989-07-311991-06-04Merck & Co., Inc.Imidazole compounds and their use as transglutaminase inhibitors
AU743735B2 (en)*1996-10-112002-02-07Millennium Pharmaceuticals, Inc.Selective factor Xa inhibitors
AR032318A1 (en)*2000-04-132003-11-05Pharmacia Corp HALOGENATED DERIVATIVE COMPOUND OF HEPTENOIC ACID 2-AMINO-5,6; PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT AS AN INHIBITOR OF NITRICAL SYNTHEASE OXIDE
WO2003096984A2 (en)*2002-05-142003-11-27The Board Of Trustees Of The Leland Stanford Junior UniversityDrug therapy for celiac sprue
US7265093B2 (en)*2002-05-142007-09-04The Board Of Trustees Of The Leland Stanford Junior UniversityDrug therapy for Celiac Sprue
PE20050159A1 (en)*2003-05-272005-04-19Vertex Pharma DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS
WO2006018164A2 (en)2004-08-112006-02-23N-Zyme Biotec GmbhFluorescence-based kinetic determination of transglutaminase activity
DE102006052755A1 (en)*2006-11-082008-05-15N-Zyme Biotec GmbhNew peptide derivatives and peptidomimetics are transglutaminase inhibitors useful for the treatment or prophylaxis of e.g. celiac disease, fibrosis, thrombosis, neurodegenerative disorders, Huntington's chorea and Parkinson disease
JP2013180955A (en)*2012-02-292013-09-12Toray Ind IncTissue transglutaminase inhibitor, chalcone derivative, and pharmaceutical application thereof

Also Published As

Publication numberPublication date
IL236707A0 (en)2015-02-26
US20150203535A1 (en)2015-07-23
CA2878796C (en)2018-10-23
SI2797892T1 (en)2015-09-30
US9434763B2 (en)2016-09-06
IL236707B (en)2018-12-31
CN104603109A (en)2015-05-06
AU2013292149B2 (en)2016-11-24
CY1116775T1 (en)2017-03-15
JP2015529645A (en)2015-10-08
ES2543956T3 (en)2015-08-26
EP2797892A1 (en)2014-11-05
HRP20150829T1 (en)2015-09-11
RS54153B1 (en)2015-12-31
RU2015104969A (en)2016-09-10
SMT201500208B (en)2015-10-30
EP2797892B1 (en)2015-05-27
PT2797892E (en)2015-09-18
CA2878796A1 (en)2014-01-23
CN104603109B (en)2017-07-28
JP6236445B2 (en)2017-11-22
EP2687511A1 (en)2014-01-22
RU2652987C2 (en)2018-05-04
WO2014012858A1 (en)2014-01-23
HUE027051T2 (en)2016-08-29
DK2797892T3 (en)2015-07-20
PL2797892T3 (en)2015-10-30
AU2013292149A1 (en)2015-02-05

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