| US3022291A (en)* | | 1962-02-20 | | cuhno |
| US3416530A (en) | 1966-03-02 | 1968-12-17 | Richard A. Ness | Eyeball medication dispensing tablet |
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| BE764656A (en)* | 1970-03-25 | 1971-09-22 | Fujisawa Pharmaceutical Co | NEW QUATERNARY AMMONIUM SALTS AND THEIR APPLICATION TO THE REGULATION OF PLANT GROWTH |
| US3828777A (en) | 1971-11-08 | 1974-08-13 | Alza Corp | Microporous ocular device |
| BE802469A (en)* | 1972-07-20 | 1974-01-18 | Wilkinson Sword Ltd | IMPROVEMENTS MADE AND / OR RELATING TO COMPOUNDS EXERCISING A PHYSIOLOGICAL REFRIGERANT EFFECT AND COMPOSITIONS CONTAINING THEM |
| US3832253A (en) | 1973-03-21 | 1974-08-27 | Baxter Laboratories Inc | Method of making an inflatable balloon catheter |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US4244890A (en) | 1977-12-14 | 1981-01-13 | Scm Corporation | Cyclic terpenoid amines, their preparation and uses |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| DE2830764A1 (en) | 1978-07-13 | 1980-01-31 | Basf Ag | ACETANILIDE |
| US4300557A (en) | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
| EP0052322B1 (en) | 1980-11-10 | 1985-03-27 | Gersonde, Klaus, Prof. Dr. | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3218121A1 (en) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Pharmaceutical compositions for tumour treatment |
| US4667014A (en) | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| EP0102324A3 (en) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipids and surfactants in an aqueous medium |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| CA1200416A (en) | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| ATE59966T1 (en) | 1983-09-26 | 1991-02-15 | Ehrenfeld Udo | MEDICATION AND PRODUCT FOR THE DIAGNOSIS AND THERAPY OF TUMORS AND FOR THE TREATMENT OF WEAKNESSES IN THE CELLULAR AND HUMORAL IMMUNE DEFENSE. |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| EP0177742B1 (en) | 1984-09-12 | 1990-03-07 | Firmenich Sa | Nitrogen compounds, their preparation and their use as starting products for the preparation of decalin ketones |
| US5147647A (en) | 1986-10-02 | 1992-09-15 | Sohrab Darougar | Ocular insert for the fornix |
| US5322691A (en) | 1986-10-02 | 1994-06-21 | Sohrab Darougar | Ocular insert with anchoring protrusions |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US4894388A (en) | 1988-12-22 | 1990-01-16 | Monsanto Company | Glycosidase inhibitors and use thereof |
| DE3905050A1 (en) | 1989-02-18 | 1990-08-30 | Lohmann Therapie Syst Lts | THERAPEUTIC SYSTEM FOR DELAYED AND CONTROLLED TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION OF ACTIVE SUBSTANCES (II) |
| US4946450A (en) | 1989-04-18 | 1990-08-07 | Biosource Genetics Corporation | Glucan/collagen therapeutic eye shields |
| US5103008A (en) | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US5043273A (en) | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| JPH04167172A (en) | 1990-10-31 | 1992-06-15 | Nec Corp | Vector processor |
| US5290892A (en) | 1990-11-07 | 1994-03-01 | Nestle S.A. | Flexible intraocular lenses made from high refractive index polymers |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5679666A (en) | 1991-11-22 | 1997-10-21 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids |
| US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| US5178635A (en) | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
| FR2690846B1 (en) | 1992-05-05 | 1995-07-07 | Aiache Jean Marc | GALENIC FORM FOR EYE ADMINISTRATION AND METHOD OF PREPARATION. |
| US5672659A (en) | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5455351A (en) | 1993-12-13 | 1995-10-03 | Abbott Laboratories | Retroviral protease inhibiting piperazine compounds |
| US5516522A (en) | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| WO1995024929A2 (en) | 1994-03-15 | 1995-09-21 | Brown University Research Foundation | Polymeric gene delivery system |
| US5710165A (en) | 1994-07-06 | 1998-01-20 | Synthelabo | Use of polyamine antagonists for the treatment of glaucoma |
| US5844102A (en) | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
| US5595760A (en) | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| AUPM897594A0 (en) | 1994-10-25 | 1994-11-17 | Daratech Pty Ltd | Controlled release container |
| ATE232089T1 (en) | 1994-11-10 | 2003-02-15 | Univ Kentucky Res Found | CONTROLLED RELEASE IMPLANTABLE REFILLABLE DEVICE FOR ADMINISTERING DRUGS IMMEDIATELY TO AN INTERNAL PART OF THE BODY |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5743274A (en) | 1996-03-18 | 1998-04-28 | Peyman; Gholam A. | Macular bandage for use in the treatment of subretinal neovascular members |
| US5824073A (en) | 1996-03-18 | 1998-10-20 | Peyman; Gholam A. | Macular indentor for use in the treatment of subretinal neovascular membranes |
| US5904144A (en) | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| AU734905B2 (en) | 1996-04-10 | 2001-06-28 | Regents Of The University Of California, The | Correction of genetic defects using chemical chaperones |
| US6270954B1 (en) | 1996-04-10 | 2001-08-07 | The Regents Of The University Of California | Correction of genetic defects using chemical chaperones |
| AU6319196A (en)* | 1996-07-05 | 1998-02-02 | Shionogi & Co., Ltd. | P/q type calcium channel antagonist |
| DE19638486A1 (en) | 1996-09-20 | 1998-03-26 | Basf Ag | Hetaroyl derivatives |
| DE69827138T2 (en) | 1997-08-11 | 2006-02-23 | Allergan, Inc., Irvine | Sterile retinoid-containing biodegradable implant with improved biocompatibility and process for its preparation |
| US5902598A (en) | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
| US6146366A (en) | 1998-11-03 | 2000-11-14 | Ras Holding Corp | Device for the treatment of macular degeneration and other eye disorders |
| US6492333B1 (en) | 1999-04-09 | 2002-12-10 | Osteoscreen, Inc. | Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors |
| US6562836B1 (en) | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| US6416777B1 (en) | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| NZ519183A (en)* | 1999-12-03 | 2005-02-25 | Ono Pharmaceutical Co | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient |
| US6656912B2 (en) | 2000-01-20 | 2003-12-02 | Washington University In St. Louis | Methods to treat α1-antitrypsin deficiency |
| EP1181277A4 (en) | 2000-03-31 | 2005-08-10 | Univ Michigan State | PROCESS FOR THE PREPARATION OF 1,5-DIDEOXY-1,5-IMINO-HEXITOLES FROM OXIMES OR IMINES |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US6818203B2 (en)* | 2000-08-11 | 2004-11-16 | Schering Aktiengesellschaft | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses |
| CA2432203C (en) | 2001-01-03 | 2008-03-25 | Michael J. Brubaker | Sustained release drug delivery devices with multiple agents |
| GB0118752D0 (en) | 2001-08-01 | 2001-09-26 | Pfizer Ltd | Process for the production of quinazolines |
| EP1430042A2 (en) | 2001-09-25 | 2004-06-23 | SmithKline Beecham Corporation | Bicyclic heterocycles as rxr ligands |
| US6976584B2 (en) | 2002-06-26 | 2005-12-20 | Bausch & Lomb Incorporated | Package for surgical implant |
| US20040131648A1 (en)* | 2002-10-24 | 2004-07-08 | The Procter & Gamble Company | Nuclear hormone receptor compounds, products and methods employing same |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| BRPI0407001A (en) | 2003-01-31 | 2006-01-10 | Sinai School Medicine | Method for increasing the stability of a purified protein, use of a site-specific active binding protein, method for increasing the production of a recombinant protein and pharmaceutical composition |
| EP2327400A3 (en) | 2003-03-14 | 2011-10-19 | University of Washington | Retinoid Replacements and Opsin Agonists and Methods for the Use Thereof |
| WO2004108867A2 (en) | 2003-06-02 | 2004-12-16 | Flexitral, Inc. | Cyclohexene carboamides and carbothioamides |
| CL2004001996A1 (en) | 2003-08-08 | 2005-05-06 | Eyetech Pharmaceuticals Inc | ANTI-VEGF APTAMEROS (VASCULAR ENDOTELIAL GROWTH FACTOR) WITH 5'-5 'OR 3'-3' INVERTED NUCLEOTIDIC BLOCK, COMPOSITION CONTAINING IT, USEFUL FOR NEOVASCULARIZATION DISORDERS. |
| NZ550340A (en) | 2004-03-17 | 2010-08-27 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle using a retinoid |
| KR20140140616A (en) | 2004-06-18 | 2014-12-09 | 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 | Retinal derivatives and methods for the use thereof for the treatment of visual disorders |
| MXPA06014978A (en) | 2004-06-23 | 2007-04-25 | Sirion Therapeutics Inc | Methods and compositions for treating ophthalmic conditions with retinyl derivatives. |
| WO2006033734A2 (en) | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| WO2006039551A2 (en) | 2004-09-30 | 2006-04-13 | The Regents Of The University Of California | Local administration of retinoids to treat deficiencies in dark adaptation |
| US8946444B2 (en) | 2004-11-23 | 2015-02-03 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control |
| CA2642927A1 (en) | 2005-02-24 | 2006-08-31 | University Of Washington | Methods for treatment of retinal degenerative disease |
| GB0506133D0 (en)* | 2005-03-24 | 2005-05-04 | Sterix Ltd | Compound |
| KR20080072721A (en) | 2005-11-30 | 2008-08-06 | 이노텍 파마슈티컬스 코포레이션 | Purine derivatives and methods of use thereof |
| AU2007277033A1 (en)* | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating or preventing ophthalmic disease |
| AU2007277035A1 (en) | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating or preventing ophthalmic light toxicity |
| AU2007277032A1 (en) | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Opsin stabilizing compounds and methods of use |
| JP5592265B2 (en) | 2007-11-01 | 2014-09-17 | アキュセラ インコーポレイテッド | Amine derivative compounds for the treatment of eye diseases and disorders |
| US8642660B2 (en)* | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US20110015442A1 (en) | 2008-03-17 | 2011-01-20 | Toshiya Takahashi | Sulfone compound and method for producing the same |
| AU2009308483C1 (en) | 2008-10-22 | 2014-01-23 | Acucela, Inc. | Compounds for treating ophthalmic diseases and disorders |
| WO2010074746A1 (en) | 2008-12-23 | 2010-07-01 | Bikam Pharmaceuticals, Inc. | Methods of use for opsin binding ligands |
| IN2012DN00352A (en) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| WO2012174064A1 (en) | 2011-06-14 | 2012-12-20 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |