| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998160542DE19860542A1 (en) | 1998-12-23 | 1998-12-23 | An enzyme fragment with hyaluronate lyase activity is derived from streptococci and used for medical applications |
| DE1998160541DE19860541A1 (en) | 1998-12-23 | 1998-12-23 | Composition for the treatment of vascular disease comprises holozyme with hyaluronate lyase activity from microbial origin |
| PCT/DE1999/004108WO2000039290A2 (en) | 1998-12-23 | 1999-12-22 | Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid |
| Publication Number | Publication Date |
|---|---|
| IL138051A0true IL138051A0 (en) | 2001-10-31 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13805199AIL138051A0 (en) | 1998-12-23 | 1999-12-22 | Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin |
| Country | Link |
|---|---|
| EP (1) | EP1056839A1 (en) |
| JP (1) | JP2002533473A (en) |
| KR (1) | KR20010041235A (en) |
| AU (1) | AU3032400A (en) |
| CA (1) | CA2318356A1 (en) |
| DE (1) | DE19982882D2 (en) |
| HU (1) | HUP0103660A2 (en) |
| IL (1) | IL138051A0 (en) |
| PL (1) | PL344745A1 (en) |
| WO (1) | WO2000039290A2 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19963538A1 (en)* | 1999-12-22 | 2001-07-05 | Univ Schiller Jena | Use of an enzyme to improve tissue absorption of drugs |
| DE10103271A1 (en)* | 2001-01-23 | 2002-07-25 | Knoell Hans Forschung Ev | Pharmaceutical formulation containing hyaluronatlyase, useful for softening of connective tissue in medical and cosmetic treatment, especially in shape correction |
| CN1942588B (en) | 2003-03-05 | 2013-06-12 | 海洋酶公司 | Soluble hyaluronidase glycoproteins (sHASEGP), methods for their preparation, their use and pharmaceutical compositions comprising them |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en)* | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| AU2003239763A1 (en)* | 2003-05-27 | 2005-01-04 | Friedrich-Schiller- Universität Jena | Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia |
| DE102007031417A1 (en) | 2007-07-04 | 2009-01-08 | Friedrich-Schiller-Universität Jena | Hyaluronate lyase with a histidine tag e.g. useful in pharmaceutical formulations and medical products |
| KR20100094982A (en) | 2007-11-13 | 2010-08-27 | 바이오-테크널러지 제너럴 (이스라엘) 리미티드 | Dilute filtration sterilization process for viscoelastic biopolymers |
| ES2724588T3 (en) | 2008-12-09 | 2019-09-12 | Halozyme Inc | Extended soluble PH20 polypeptides and uses thereof |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1120298A (en)* | 1966-07-11 | 1968-07-17 | Biorex Laboratories Ltd | Stabilised enzymes |
| US3708575A (en)* | 1970-05-13 | 1973-01-02 | Biorex Laboratories Ltd | Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase |
| US3728223A (en)* | 1971-10-08 | 1973-04-17 | Amano Pharma Co Ltd | Production of hyaluronidase from a strain of streptomyces |
| JP2002533417A (en)* | 1998-12-23 | 2002-10-08 | エスパルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hyaluronate lyase used to enhance penetration of topically applied drugs |
| Publication number | Publication date |
|---|---|
| CA2318356A1 (en) | 2000-07-06 |
| AU3032400A (en) | 2000-07-31 |
| DE19982882D2 (en) | 2001-10-04 |
| HUP0103660A2 (en) | 2002-01-28 |
| PL344745A1 (en) | 2001-11-19 |
| WO2000039290A2 (en) | 2000-07-06 |
| WO2000039290A3 (en) | 2001-03-08 |
| EP1056839A1 (en) | 2000-12-06 |
| WO2000039290A8 (en) | 2000-10-19 |
| KR20010041235A (en) | 2001-05-15 |
| JP2002533473A (en) | 2002-10-08 |
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