| DE69840412D1              (en)* | 1997-10-31 | 2009-02-12 | Genentech Inc | METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS | 
| WO1999054342A1              (en)* | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity | 
| EP3031917A1              (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule | 
| US7863020B2              (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes | 
| US7449308B2              (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes | 
| US6946292B2              (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity | 
| NZ592087A              (en)* | 2001-08-03 | 2012-11-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity | 
| US7691810B2              (en) | 2003-10-09 | 2010-04-06 | Kyowa Hakko Kirin Co., Ltd | Method of producing recombinant antithrombin III composition | 
| EP1716181B1              (en) | 2004-02-19 | 2009-12-16 | Genentech, Inc. | Cdr-repaired antibodies | 
| TW201422238A              (en) | 2004-06-04 | 2014-06-16 | Genentech Inc | Use of CD20 antibody in treatment of multiple sclerosis and an article for the use | 
| KR20070100228A              (en) | 2004-10-05 | 2007-10-10 | 제넨테크, 인크. | How to treat vasculitis | 
| JO3000B1              (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. | 
| KR20150083139A              (en) | 2005-01-21 | 2015-07-16 | 제넨테크, 인크. | Fixed dosing of her antibodies | 
| DK1850874T3              (en) | 2005-02-23 | 2013-11-11 | Genentech Inc | Extension of time to disease progression or survival for ovarian cancer using pertuzumab | 
| MY149159A              (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage | 
| EP3006466B1              (en) | 2005-12-02 | 2018-08-01 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r | 
| KR101589391B1              (en) | 2006-01-05 | 2016-01-29 | 제넨테크, 인크. | Anti-ephb4 antibodies and methods using same | 
| AR059851A1              (en) | 2006-03-16 | 2008-04-30 | Genentech Inc | ANTIBODIES OF EGFL7 AND METHODS OF USE | 
| SG172656A1              (en) | 2006-05-30 | 2011-07-28 | Genentech Inc | Antibodies and immunoconjugates and uses therefor | 
| NZ572177A              (en) | 2006-06-06 | 2012-02-24 | Genentech Inc | Anti-dll4 antibodies and methods using same | 
| JP2009543579A              (en) | 2006-07-19 | 2009-12-10 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | WSX-1 / p28 as a target for anti-inflammatory response | 
| BRPI0716997B8              (en)* | 2006-09-10 | 2021-05-25 | Glycotope Gmbh | protein or composition of protein molecules, methods for producing and using it | 
| DK2502938T3              (en) | 2006-10-27 | 2015-04-20 | Genentech Inc | Antibodies and immunoconjugates and uses thereof | 
| PL1920781T3              (en) | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors | 
| KR20090114443A              (en) | 2007-02-09 | 2009-11-03 | 제넨테크, 인크. | Anti-RWF4 antibodies and uses thereof | 
| NZ578824A              (en) | 2007-03-02 | 2012-03-30 | Genentech Inc | Predicting response to a her dimerisation inhibitor based on low her3 expression | 
| SI2171090T1              (en) | 2007-06-08 | 2013-07-31 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment | 
| ES2566957T3              (en) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Constant region of modified antibody | 
| LT2514436T              (en) | 2007-11-07 | 2018-04-10 | Genentech, Inc. | Il-22 for use in treating microbial disorders | 
| TWI580694B              (en) | 2007-11-30 | 2017-05-01 | 建南德克公司 | Anti-vegf antibodies | 
| TWI472339B              (en) | 2008-01-30 | 2015-02-11 | Genentech Inc | Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof | 
| TW201438738A              (en) | 2008-09-16 | 2014-10-16 | Genentech Inc | Method for treating progressive multiple sclerosis | 
| ES2828721T3              (en) | 2008-10-14 | 2021-05-27 | Genentech Inc | Immunoglobulin variants and their uses | 
| DK2361085T4              (en) | 2008-11-22 | 2018-10-08 | Hoffmann La Roche | USE OF ANTI-VEGF ANTIBODY IN COMBINATION WITH CHEMOTHERY TO TREAT CANCER CANCER | 
| WO2010075249A2              (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists | 
| US20120009182A1              (en) | 2008-12-23 | 2012-01-12 | Genentech, Inc. | Immunoglobulin variants with altered binding to protein a | 
| KR20150036824A              (en) | 2009-03-20 | 2015-04-07 | 제넨테크, 인크. | Bispecific anti-her antibodies | 
| BRPI1006270B1              (en) | 2009-03-25 | 2022-08-16 | Genentech, Inc | ANTI-A5SS1 ANTIBODY, IMMUNOCONJUGATE, PHARMACEUTICAL COMPOSITION, IN VITRO OR EX VIVO METHOD TO DETECT A5SS1 PROTEIN, USE OF AN ANTIBODY AND KIT TO DETECT A5SS1 PROTEIN | 
| HRP20150965T1              (en) | 2009-03-25 | 2015-11-06 | Genentech, Inc. | ANTI-FGR3 ANTIBODIES AND METHODS USED | 
| PT2417156E              (en) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Trivalent, bispecific antibodies | 
| US20100316639A1              (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy | 
| US9676845B2              (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins | 
| TW201106972A              (en) | 2009-07-27 | 2011-03-01 | Genentech Inc | Combination treatments | 
| JP2013500993A              (en) | 2009-07-31 | 2013-01-10 | ジェネンテック,  インコーポレイテッド | Inhibition of tumor metastasis using BV8 antagonists or G-CSF antagonists | 
| NZ598131A              (en) | 2009-08-15 | 2014-08-29 | Genentech Inc | Anti-angiogenesis therapy for the treatment of previously treated breast cancer | 
| ES2599076T3              (en) | 2009-09-02 | 2017-01-31 | Genentech, Inc. | Smoothened mutant and methods of use thereof | 
| JP5814925B2              (en) | 2009-10-22 | 2015-11-17 | ジェネンテック, インコーポレイテッド | Anti-hepsin antibody and method of use thereof | 
| WO2011056497A1              (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use | 
| WO2011056502A1              (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use | 
| WO2011056494A1              (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations | 
| WO2011056997A1              (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization | 
| ES2636971T3              (en) | 2009-11-05 | 2017-10-10 | F. Hoffmann-La Roche Ag | Procedures and composition for secretion of heterogeneous polypeptides | 
| AR078377A1              (en) | 2009-12-11 | 2011-11-02 | Genentech Inc | ANTI-VEGF-C ANTIBODIES (ISOLATED ANTI-VASCULAR ENDOTELIAL GROWTH FACTOR C) AND ITS METHODS OF USE | 
| KR20120107503A              (en) | 2009-12-23 | 2012-10-02 | 제넨테크, 인크. | Anti-bv8 antibodies and uses thereof | 
| WO2011100403A1              (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof | 
| MY160556A              (en) | 2010-02-18 | 2017-03-15 | Genentech Inc | Neuregulin antagonists and use thereof in treating cancer | 
| UA114277C2              (en) | 2010-02-23 | 2017-05-25 | Дженентек, Інк. | Anti-angiogenesis therfpy for the treatment of ovarian cancer | 
| US8846041B2              (en) | 2010-03-24 | 2014-09-30 | Genentech, Inc. | Anti-LRP6 antibodies | 
| WO2011146568A1              (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor | 
| WO2011147834A1              (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof | 
| WO2011153243A2              (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Anti-angiogenesis therapy for treating gastric cancer | 
| RU2613886C2              (en) | 2010-06-03 | 2017-03-21 | Дженентек, Инк. | Antibodies and immunoconjugates rendered by immuno-positron emission tomography, methods of application | 
| EP3098240B1              (en) | 2010-06-18 | 2021-04-07 | F. Hoffmann-La Roche AG | Anti-axl antibodies and methods of use | 
| WO2011161119A1              (en) | 2010-06-22 | 2011-12-29 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof | 
| WO2011161189A1              (en) | 2010-06-24 | 2011-12-29 | F. Hoffmann-La Roche Ag | Anti-hepsin antibodies and methods of use | 
| CA2803792A1              (en) | 2010-07-09 | 2012-01-12 | Genentech, Inc. | Anti-neuropilin antibodies and methods of use | 
| WO2012010582A1              (en) | 2010-07-21 | 2012-01-26 | Roche Glycart Ag | Anti-cxcr5 antibodies and methods of use | 
| CN103261225A              (en) | 2010-07-23 | 2013-08-21 | 波士顿大学董事会 | Anti-desupr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery | 
| MX2013001302A              (en) | 2010-08-03 | 2013-03-08 | Hoffmann La Roche | Chronic lymphocytic leukemia (cll) biomarkers. | 
| CA2805564A1              (en) | 2010-08-05 | 2012-02-09 | Stefan Jenewein | Anti-mhc antibody anti-viral cytokine fusion protein | 
| KR101653030B1              (en) | 2010-08-13 | 2016-08-31 | 로슈 글리카트 아게 | Anti-tenascin-c a2 antibodies and methods of use | 
| PH12013500159B1              (en) | 2010-08-13 | 2018-09-26 | Roche Glycart Ag | Anti-fap antibodies and methods of use | 
| NZ604510A              (en) | 2010-08-17 | 2013-10-25 | Csl Ltd | Dilutable biocidal compositions and methods of use | 
| ES2553262T3              (en) | 2010-08-25 | 2015-12-07 | F. Hoffmann-La Roche Ag | Antibodies against IL-18R1 and their uses | 
| CA2808236A1              (en) | 2010-08-31 | 2012-03-08 | Genentech, Inc. | Biomarkers and methods of treatment | 
| AU2011312205B2              (en) | 2010-10-05 | 2015-08-13 | Curis, Inc. | Mutant smoothened and methods of using the same | 
| KR20220070586A              (en) | 2010-11-08 | 2022-05-31 | 제넨테크, 인크. | Subcutaneously administered anti-il-6 receptor antibody | 
| MX346500B              (en) | 2010-11-10 | 2017-03-22 | Genentech Inc * | Methods and compositions for neural disease immunotherapy. | 
| ES2631356T3              (en) | 2010-11-30 | 2017-08-30 | F. Hoffmann-La Roche Ag | Low affinity transferrin receptor anti-antibodies and their use to transfer therapeutic scFv through the blood brain barrier | 
| BR122020012255B1              (en) | 2010-12-16 | 2022-08-09 | Genentech, Inc | USE OF AN ANTI-IL-13 ANTIBODY, USES OF A TH2 PATHWAY INHIBITOR AND ANTI-PERIOSTIN ANTIBODIES | 
| BR112013014527A2              (en) | 2010-12-20 | 2017-03-07 | Genentech Inc | isolated antibody, isolated nucleic acid, host cell, method for producing an antibody, immunoconjugate, pharmaceutical formulation, use of immunoconjugate, method for treating an individual who has mesothelin positive cancer, for inhibiting proliferation of a mesothelin positive cell, for detecting human mesothelin in a biological sample and for detecting mesothelin positive cancer | 
| AR084456A1              (en) | 2010-12-22 | 2013-05-15 | Genentech Inc | ANTI-PCSK9 ANTIBODY AND METHODS OF USE | 
| WO2012092539A2              (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof | 
| CA2825081A1              (en) | 2011-02-28 | 2012-09-07 | Birgit Bossenmaier | Antigen binding proteins | 
| MX342034B              (en) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Monovalent antigen binding proteins. | 
| SG193554A1              (en) | 2011-03-29 | 2013-11-29 | Roche Glycart Ag | Antibody fc variants | 
| BR112013024717A2              (en) | 2011-04-07 | 2017-08-08 | Genentech Inc | isolated antibody, isolated nucleic acid, host cell, immunoconjugate, pharmaceutical formulation, method of treating an individual who has cancer and method of inhibiting cell proliferation in an individual | 
| WO2012146630A1              (en) | 2011-04-29 | 2012-11-01 | F. Hoffmann-La Roche Ag | N-terminal acylated polypeptides, methods for their production and uses thereof | 
| CN103608684B              (en) | 2011-05-12 | 2016-05-04 | 基因泰克公司 | A Multiple Reaction Monitoring LC-MS/MS Method for the Detection of Therapeutic Antibodies in Animal Samples Using Framework Signature Peptides | 
| MX370233B              (en) | 2011-05-16 | 2019-12-06 | Genentech Inc | Fgfr1 agonists and methods of use. | 
| US8623666B2              (en) | 2011-06-15 | 2014-01-07 | Hoffmann-La Roche Inc. | Method for detecting erythropoietin (EPO) receptor using anti-human EPO receptor antibodies | 
| MX354663B              (en) | 2011-06-22 | 2018-03-14 | Hoffmann La Roche | Removal of target cells by circulating virus-specific cytotoxic t-cells using mhc class i comprising complexes. | 
| CN103781493A              (en) | 2011-06-30 | 2014-05-07 | 霍夫曼-拉罗奇有限公司 | Anti-c-met antibody formulations | 
| US20130022551A1              (en) | 2011-07-22 | 2013-01-24 | Trustees Of Boston University | DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS | 
| CN103890007A              (en) | 2011-08-17 | 2014-06-25 | 霍夫曼-拉罗奇有限公司 | Neuregulin antibodies and uses thereof | 
| RU2014109985A              (en) | 2011-08-17 | 2015-09-27 | Дженентек, Инк. | INHIBITION OF ANGIOGENESIS IN REFRACTOR TUMORS | 
| CN103814123A              (en) | 2011-08-22 | 2014-05-21 | 葛莱高托普有限公司 | Microorganisms carrying a tumor antigen | 
| MX2014002053A              (en) | 2011-08-23 | 2014-04-25 | Roche Glycart Ag | Anti-mcsp antibodies. | 
| CA2846083A1              (en) | 2011-09-15 | 2013-03-21 | Genentech, Inc. | Methods of promoting differentiation | 
| WO2013043715A1              (en) | 2011-09-19 | 2013-03-28 | Genentech, Inc. | Combination treatments comprising c-met antagonists and b-raf antagonists | 
| EA035018B1              (en) | 2011-09-30 | 2020-04-17 | Тева Фармасьютикал Австралия Пти Лтд. | ANTIBODIES AGAINST TL1a AND USES THEREOF | 
| JP5854535B2              (en)* | 2011-10-05 | 2016-02-09 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Methods for the production of antibody G1 glycoforms | 
| US9663573B2              (en) | 2011-10-05 | 2017-05-30 | Genentech, Inc. | Methods of treating liver conditions using Notch2 antagonists | 
| HRP20181457T1              (en) | 2011-10-14 | 2018-11-16 | F. Hoffmann - La Roche Ag | ANTI-HTRA1 ANTIBODIES AND USE PROCEDURES | 
| MX2014004426A              (en) | 2011-10-15 | 2014-07-09 | Genentech Inc | Scd1 antagonists for treating cancer. | 
| WO2013059531A1              (en) | 2011-10-20 | 2013-04-25 | Genentech, Inc. | Anti-gcgr antibodies and uses thereof | 
| EP2771351B1              (en) | 2011-10-28 | 2017-06-14 | Patrys Limited | Pat-lm1 epitopes and methods for using same | 
| IN2014CN03062A              (en) | 2011-10-28 | 2015-07-31 | Hoffmann La Roche |  | 
| CA2854477A1              (en) | 2011-11-21 | 2013-05-30 | Genentech, Inc. | Purification of anti-c-met antibodies | 
| WO2013083497A1              (en) | 2011-12-06 | 2013-06-13 | F. Hoffmann-La Roche Ag | Antibody formulation | 
| SG10201700169PA              (en) | 2011-12-22 | 2017-02-27 | Hoffmann La Roche | Expression vector element combinations, novel production cell generation methods and their use for the recombinant production of polypeptides | 
| HK1200849A1              (en) | 2011-12-22 | 2015-08-14 | F. Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use | 
| SG10201601882PA              (en) | 2011-12-22 | 2016-04-28 | Hoffmann La Roche | Expression Vector Organization, Novel Production Cell Generation Methods And Their Use For The Recombinant Production Of Polypeptides | 
| WO2013096791A1              (en) | 2011-12-23 | 2013-06-27 | Genentech, Inc. | Process for making high concentration protein formulations | 
| WO2013101771A2              (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases | 
| JP6684490B2              (en) | 2012-01-09 | 2020-04-22 | ザ・スクリップス・リサーチ・インスティテュート | Ultralong complementarity determining regions and uses thereof | 
| CN104411717A              (en) | 2012-01-09 | 2015-03-11 | 斯克利普斯研究所 | Humanized antibodies with ultralong CDR3S | 
| CN104168920A              (en) | 2012-01-18 | 2014-11-26 | 霍夫曼-拉罗奇有限公司 | Methods of using FGF19 modulators | 
| KR20140116490A              (en) | 2012-01-18 | 2014-10-02 | 제넨테크, 인크. | Anti-lrp5 antibodies and methods of use | 
| KR102148303B1              (en) | 2012-02-11 | 2020-08-26 | 제넨테크, 인크. | R-spondin translocations and methods using the same | 
| WO2013120929A1              (en) | 2012-02-15 | 2013-08-22 | F. Hoffmann-La Roche Ag | Fc-receptor based affinity chromatography | 
| CN104220457A              (en) | 2012-03-27 | 2014-12-17 | 霍夫曼-拉罗奇有限公司 | Diagnosis and treatments relating to her3 inhibitors | 
| AR090549A1              (en) | 2012-03-30 | 2014-11-19 | Genentech Inc | ANTI-LGR5 AND IMMUNOCATE PLAYERS | 
| WO2013165940A1              (en) | 2012-05-01 | 2013-11-07 | Genentech, Inc. | Anti-pmel17 antibodies and immunoconjugates | 
| WO2013170191A1              (en) | 2012-05-11 | 2013-11-14 | Genentech, Inc. | Methods of using antagonists of nad biosynthesis from nicotinamide | 
| HUE071647T2              (en) | 2012-05-18 | 2025-09-28 | Genentech Inc | High-concentration monoclonal antibody formulations | 
| JP6419068B2              (en) | 2012-05-21 | 2018-11-07 | ジェネンテック, インコーポレイテッド | Methods for improving the safety of blood-brain barrier transport | 
| EP3605090A1              (en) | 2012-05-23 | 2020-02-05 | F. Hoffmann-La Roche AG | Selection method for therapeutic agents | 
| US9695244B2              (en) | 2012-06-01 | 2017-07-04 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab | 
| US20150125848A1              (en)* | 2012-06-01 | 2015-05-07 | Momenta Pharmaceuticals, Inc. | Methods related to alemtuzumab | 
| BR112014031310A2              (en) | 2012-06-15 | 2017-07-25 | Genentech Inc | anti-pcsk9 antibodies, formulations, dosage and methods of use | 
| KR20150030755A              (en) | 2012-07-04 | 2015-03-20 | 에프. 호프만-라 로슈 아게 | Anti-biotin antibodies and methods of use | 
| EP2869837B1              (en) | 2012-07-04 | 2016-09-14 | F. Hoffmann-La Roche AG | Anti-theophylline antibodies and methods of use | 
| KR102090849B1              (en) | 2012-07-04 | 2020-03-19 | 에프. 호프만-라 로슈 아게 | Covalently linked antigen-antibody conjugates | 
| WO2014008391A1              (en) | 2012-07-05 | 2014-01-09 | Genentech, Inc. | Expression and secretion system | 
| MX2015000357A              (en) | 2012-07-09 | 2015-05-12 | Genentech Inc | Immunoconjugates comprising anti-cd22 antibodies. | 
| EA201590172A1              (en) | 2012-07-09 | 2015-09-30 | Дженентек, Инк. | IMMUNOCONGATES CONTAINING ANTIBODIES TO CD79b | 
| MX2015000359A              (en) | 2012-07-09 | 2015-04-14 | Genentech Inc | Immunoconjugates comprising anti-cd79b antibodies. | 
| BR112015000439A2              (en) | 2012-07-09 | 2017-12-19 | Genentech Inc | immunoconjugate, pharmaceutical formulation and methods of treating an individual and inhibiting proliferation | 
| AU2013288641B2              (en) | 2012-07-13 | 2017-07-06 | Roche Glycart Ag | Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases | 
| KR20190121874A              (en) | 2012-08-29 | 2019-10-28 | 에프. 호프만-라 로슈 아게 | Blood brain barrier shuttle | 
| EP2914622B1              (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel fusion molecules and uses thereof | 
| EP2914621B1              (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof | 
| KR20150064205A              (en) | 2012-11-08 | 2015-06-10 | 에프. 호프만-라 로슈 아게 | Her3 antigen binding proteins binding to the beta-hairpin of her3 | 
| PH12019501031A1              (en) | 2012-11-13 | 2022-11-14 | Genentech Inc | Anti-hemagglutinin antibodies and methods of use | 
| ES2700984T3              (en) | 2012-12-21 | 2019-02-20 | Hoffmann La Roche | Multifunctional proteins comprising MHC class I multivalent disulfide-linked | 
| AU2014207342C1              (en) | 2013-01-18 | 2019-04-04 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma | 
| WO2014116749A1              (en) | 2013-01-23 | 2014-07-31 | Genentech, Inc. | Anti-hcv antibodies and methods of using thereof | 
| KR102204127B1              (en) | 2013-02-01 | 2021-01-20 | 키라 바이오테크 피티와이 리미티드 | Anti-cd83 antibodies and use thereof | 
| CN117843785A              (en) | 2013-02-07 | 2024-04-09 | Csl有限公司 | IL-11R binding protein and its application | 
| WO2014128235A1              (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance | 
| CA2896259A1              (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Anti-mcsp antibodies | 
| JP2016510751A              (en) | 2013-03-06 | 2016-04-11 | ジェネンテック, インコーポレイテッド | Methods of treating and preventing anticancer drug resistance | 
| KR20150127216A              (en) | 2013-03-14 | 2015-11-16 | 제넨테크, 인크. | Methods of treating cancer and preventing cancer drug resistance | 
| BR112015022576A2              (en) | 2013-03-14 | 2017-10-24 | Genentech Inc | pharmaceutical product and its use, kit and method for treating hyperproliferative dysfunction | 
| BR112015022019A2              (en) | 2013-03-14 | 2017-08-29 | Genentech Inc | ISOLATED ANTIBODIES, NUCLEIC ACID, HOST CELL, METHOD OF PRODUCING ANTIBODIES, IMMUNOCONJUGATE, PHARMACEUTICAL FORMULATION, METHODS FOR TREATMENT OF INDIVIDUALS, INHIBITION OF CELL PROLIFERATION, DETECTION OF HUMAN B7-H4 AND CANCER DETECTION | 
| US9562099B2              (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates | 
| CN105339001A              (en) | 2013-03-15 | 2016-02-17 | 基因泰克公司 | Methods of treating cancer and preventing cancer drug resistance | 
| SG11201507429TA              (en) | 2013-03-15 | 2015-10-29 | Genentech Inc | Il-22 polypeptides and il-22 fc fusion proteins and methods of use | 
| US9598485B2              (en) | 2013-03-15 | 2017-03-21 | Ac Immune S.A. | Anti-tau antibodies and methods of use | 
| KR20230070054A              (en) | 2013-03-15 | 2023-05-19 | 제넨테크, 인크. | Biomarkers and methods of treating pd-1 and pd-l1 related conditions | 
| CN105143265A              (en) | 2013-03-15 | 2015-12-09 | 豪夫迈·罗氏有限公司 | Anti-crth2 antibodies and their use | 
| CA2902765A1              (en) | 2013-03-15 | 2014-09-25 | Genentech, Inc. | Compositions and methods for diagnosis and treatment of hepatic cancers | 
| UA118028C2              (en) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Bispecific antibodies specific for fap and dr5, antibodies specific for dr5 and methods of use | 
| WO2014177460A1              (en) | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Human fcrn-binding modified antibodies and methods of use | 
| SG11201508910WA              (en) | 2013-04-29 | 2015-11-27 | Hoffmann La Roche | Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases | 
| PL2992010T3              (en) | 2013-04-29 | 2021-08-23 | F.Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use | 
| PE20151926A1              (en) | 2013-05-20 | 2016-01-07 | Genentech Inc | ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE | 
| WO2015017146A2              (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions | 
| CN105814074B              (en) | 2013-07-18 | 2020-04-21 | 图鲁斯生物科学有限责任公司 | Humanized antibodies with ultralong complementarity determining regions | 
| LT3027651T              (en) | 2013-08-01 | 2019-04-10 | Five Prime Therapeutics, Inc. | Afucosylated anti-fgfr2iiib antibodies | 
| KR20160042438A              (en) | 2013-08-12 | 2016-04-19 | 제넨테크, 인크. | Compositions and method for treating complement-associated conditions | 
| HK1218124A1              (en) | 2013-09-17 | 2017-02-03 | 豪夫迈.罗氏有限公司 | Methods of using anti-lgr5 antibodies | 
| CN105814078A              (en) | 2013-10-11 | 2016-07-27 | 豪夫迈·罗氏有限公司 | Nsp4 inhibitors and methods of use | 
| WO2015054691A2              (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Pepresented By The Secretary, Department Of Health And Human Services | Tem8 antibodies and their use | 
| EP3055329B1              (en) | 2013-10-11 | 2018-06-13 | F. Hoffmann-La Roche AG | Multispecific domain exchanged common variable light chain antibodies | 
| CN105744954B              (en) | 2013-10-18 | 2021-03-05 | 豪夫迈·罗氏有限公司 | anti-RSPO 2 and/or anti-RSPO 3 antibodies and uses thereof | 
| JP6715767B2              (en) | 2013-10-23 | 2020-07-01 | ジェネンテック, インコーポレイテッド | Method for diagnosing and treating eosinophilic disease | 
| LT3071597T              (en) | 2013-11-21 | 2020-10-12 | F. Hoffmann-La Roche Ag | ANTIBODIES TO ALPHA-SUNUCLEIN AND THEIR USES | 
| WO2015089117A1              (en) | 2013-12-09 | 2015-06-18 | Allakos Inc. | Anti-siglec-8 antibodies and methods of use thereof | 
| CN106030310B              (en) | 2013-12-13 | 2019-01-04 | 通用医疗公司 | Soluble high-molecular amount (HMW) TAU type and its application | 
| JP6502942B2              (en) | 2013-12-13 | 2019-04-17 | ジェネンテック, インコーポレイテッド | Anti-CD33 antibody and immunoconjugate | 
| AU2014364601A1              (en) | 2013-12-17 | 2016-07-07 | Genentech, Inc. | Methods of treating HER2-positive cancers using PD-1 axis binding antagonists and anti-HER2 antibodies | 
| RU2016128726A              (en) | 2013-12-17 | 2018-01-23 | Дженентек, Инк. | METHODS FOR TREATING MALIGNANT TUMORS USING PD-1 BINDING ANTAGONISTS AND ANTIBODIES AGAINST CD20 | 
| RS60443B1              (en) | 2013-12-17 | 2020-07-31 | Genentech Inc | Anti-cd3 antibodies and methods of use | 
| KR20160099092A              (en) | 2013-12-17 | 2016-08-19 | 제넨테크, 인크. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists | 
| TWI670283B              (en) | 2013-12-23 | 2019-09-01 | 美商建南德克公司 | Antibodies and methods of use | 
| JP6476194B2              (en) | 2014-01-03 | 2019-02-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Bispecific anti-hapten / anti-blood brain barrier receptor antibodies, complexes thereof, and their use as blood brain barrier shuttles | 
| WO2015103549A1              (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use | 
| MX373017B              (en) | 2014-01-03 | 2020-04-28 | Hoffmann La Roche | COVALENTLY LINKED POLYPEPTIDE TOXIN-ANTIBODY CONJUGATES. | 
| WO2015101587A1              (en) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof | 
| ES2864160T3              (en) | 2014-01-06 | 2021-10-13 | Hoffmann La Roche | Monovalent Blood Brain Barrier Shuttle Modules | 
| CA2931986A1              (en) | 2014-01-15 | 2015-07-23 | F. Hoffmann-La Roche Ag | Fc-region variants with modified fcrn- and maintained protein a-binding properties | 
| BR112016015693A2              (en) | 2014-01-24 | 2017-10-24 | Genentech Inc | Method To Treat Prostate Cancer And Antibody | 
| US20170044232A1              (en) | 2014-02-04 | 2017-02-16 | Genentech, Inc. | Mutant smoothened and methods of using the same | 
| US20150246963A1              (en) | 2014-02-08 | 2015-09-03 | Genentech, Inc. | Methods of treating alzheimer's disease | 
| CA2938731A1              (en) | 2014-02-08 | 2015-08-13 | Genentech, Inc. | Methods of treating alzheimer's disease | 
| ES2685424T3              (en) | 2014-02-12 | 2018-10-09 | F. Hoffmann-La Roche Ag | Anti-Jagged1 antibodies and procedures for use | 
| CR20160379A              (en) | 2014-02-21 | 2016-10-07 | Genentech Inc | BISPECIFIC ANTIBODIES ANTI-IL 13 / IL-17 AND ITS USES | 
| JP6825909B2              (en) | 2014-02-28 | 2021-02-03 | アラコス インコーポレイテッド | Methods and Compositions for Treating SIGLEC-8 Related Diseases | 
| CA2941687A1              (en) | 2014-03-14 | 2015-09-17 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides | 
| US20170107294A1              (en) | 2014-03-21 | 2017-04-20 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof | 
| CA2943329A1              (en) | 2014-03-24 | 2015-10-01 | Genentech, Inc. | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression | 
| CA2943834A1              (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists | 
| LT3126394T              (en) | 2014-03-31 | 2020-01-27 | F. Hoffmann-La Roche Ag | Anti-ox40 antibodies and methods of use | 
| WO2015164615A1              (en) | 2014-04-24 | 2015-10-29 | University Of Oslo | Anti-gluten antibodies and uses thereof | 
| CA2946662A1              (en) | 2014-05-22 | 2015-11-26 | Genentech, Inc. | Anti-gpc3 antibodies and immunoconjugates | 
| CA2944717A1              (en) | 2014-05-23 | 2015-11-26 | Genentech, Inc. | Mit biomarkers and methods using the same | 
| WO2015191715A1              (en) | 2014-06-11 | 2015-12-17 | Genentech, Inc. | Anti-lgr5 antibodies and uses thereof | 
| US20230190750A1              (en) | 2014-06-13 | 2023-06-22 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance | 
| WO2015197736A1              (en) | 2014-06-26 | 2015-12-30 | F. Hoffmann-La Roche Ag | Anti-brdu antibodies and methods of use | 
| CN106488775A              (en) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | NOTCH approach suppresses | 
| KR102360693B1              (en) | 2014-07-11 | 2022-02-08 | 벤타나 메디컬 시스템즈, 인코포레이티드 | Anti-pd-l1 antibodies and diagnostic uses thereof | 
| TWI805109B              (en) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | Antibodies and chimeric antigen receptors specific for cd19 | 
| MX2017002605A              (en) | 2014-08-28 | 2017-05-19 | Bioatla Llc | Conditionally active chimeric antigen receptors for modified t-cells. | 
| EP3191527B1              (en)* | 2014-09-10 | 2020-01-15 | F.Hoffmann-La Roche Ag | Galactoengineered immunoglobulin 1 antibodies | 
| CR20170095A              (en) | 2014-09-12 | 2017-07-19 | Genentech Inc | ANTI-CLL-1 ANTIBODIES AND IMMUNOCATE PLAYERS RECIPROCAL REFERENCES WITH RELATED APPLICATIONS | 
| AU2015314954B2              (en) | 2014-09-12 | 2021-05-13 | Genentech, Inc. | Anti-HER2 antibodies and immunoconjugates | 
| CN106804108B              (en) | 2014-09-12 | 2021-08-10 | 基因泰克公司 | anti-B7-H4 antibodies and immunoconjugates | 
| EP3197500A1              (en) | 2014-09-17 | 2017-08-02 | Genentech, Inc. | Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines | 
| RS60349B8              (en) | 2014-09-23 | 2022-10-31 | Hoffmann La Roche | Method of using anti-cd79b immunoconjugates | 
| WO2016061389A2              (en) | 2014-10-16 | 2016-04-21 | Genentech, Inc. | Anti-alpha-synuclein antibodies and methods of use | 
| US10870704B2              (en) | 2014-10-23 | 2020-12-22 | Kira Biotech Pty Limited | CD83 binding proteins and uses thereof | 
| US10626176B2              (en) | 2014-10-31 | 2020-04-21 | Jounce Therapeutics, Inc. | Methods of treating conditions with antibodies that bind B7-H4 | 
| KR20170074246A              (en) | 2014-11-03 | 2017-06-29 | 제넨테크, 인크. | Methods and biomarkers for predicting efficacy and evaluation of an 0x40 agonist treatment | 
| EP3215850B1              (en) | 2014-11-03 | 2019-07-03 | F. Hoffmann-La Roche AG | Assays for detecting t cell immune subsets and methods of use thereof | 
| RU2017119185A              (en) | 2014-11-05 | 2018-12-05 | Дженентек, Инк. | ANTIBODIES AGAINST FGFR2 / 3 AND WAYS OF THEIR APPLICATION | 
| AR102522A1              (en) | 2014-11-06 | 2017-03-08 | Hoffmann La Roche | FC REGION VARIATIONS WITH MODIFIED PROPERTIES OF UNION TO FCRN AND PROTEIN A | 
| CN107108720A              (en) | 2014-11-06 | 2017-08-29 | 豪夫迈·罗氏有限公司 | Fc region variants and its application method that FCRN with change is combined | 
| KR20170072343A              (en) | 2014-11-06 | 2017-06-26 | 제넨테크, 인크. | Combination therapy comprising ox40 binding agonists and tigit inhibitors | 
| KR20170080604A              (en) | 2014-11-10 | 2017-07-10 | 제넨테크, 인크. | Anti-interleukin-33 antibodies and uses thereof | 
| JP2018500882A              (en) | 2014-11-10 | 2018-01-18 | ジェネンテック, インコーポレイテッド | Animal model of nephropathy and drug for treating it | 
| WO2016077789A1              (en) | 2014-11-14 | 2016-05-19 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use | 
| CR20170194A              (en) | 2014-11-14 | 2017-07-10 | Hoffmann La Roche | ANTIGEN UNION MOLECULES UNDERSTANDING A TNF FAMILY BINDING TRIMMER | 
| CA2967368A1              (en) | 2014-11-17 | 2016-05-26 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists | 
| WO2016081639A1              (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy | 
| CN107250158B              (en) | 2014-11-19 | 2022-03-25 | 基因泰克公司 | Anti-transferrin receptor/anti-BACE 1 multispecific antibodies and methods of use | 
| WO2016079597A1              (en) | 2014-11-19 | 2016-05-26 | Axon Neuroscience Se | Humanized tau antibodies in alzheimer's disease | 
| CN107001473B              (en) | 2014-11-19 | 2021-07-09 | 豪夫迈·罗氏有限公司 | Anti-transferrin receptor antibodies and methods of use | 
| MY192999A              (en) | 2014-11-20 | 2022-09-20 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists | 
| JP6721590B2              (en) | 2014-12-03 | 2020-07-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Multispecific antibody | 
| HRP20191584T1              (en) | 2014-12-05 | 2019-11-29 | Hoffmann La Roche | ANTI-CD79B ANTIBODIES AND METHODS OF ADMINISTRATION | 
| KR20170085595A              (en) | 2014-12-10 | 2017-07-24 | 제넨테크, 인크. | Blood brain barrier receptor antibodies and methods of use | 
| PE20221834A1              (en) | 2014-12-19 | 2022-11-29 | Chugai Pharmaceutical Co Ltd | ANTIMYOSTATIN ANTIBODIES | 
| EP3981794A1              (en) | 2014-12-19 | 2022-04-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use | 
| WO2016111947A2              (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof | 
| TW202126682A              (en) | 2015-01-16 | 2021-07-16 | 美商奇諾治療有限公司 | Antibodies and chimeric antigen receptors specific for ror1 | 
| CN113956354A              (en) | 2015-01-22 | 2022-01-21 | 中外制药株式会社 | Combinations and methods of use of two or more anti-C5 antibodies | 
| EP3250927B1              (en) | 2015-01-28 | 2020-02-19 | H. Hoffnabb-La Roche Ag | Gene expression markers and treatment of multiple sclerosis | 
| HK1244512A1              (en) | 2015-02-04 | 2018-08-10 | 健泰科生物技术公司 | Mutant smoothened and methods of using the same | 
| TWI844507B              (en) | 2015-02-05 | 2024-06-11 | 日商中外製藥股份有限公司 | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, and uses therof | 
| US10301377B2              (en) | 2015-02-24 | 2019-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use | 
| HK1247287A1              (en) | 2015-03-16 | 2018-09-21 | F. Hoffmann-La Roche Ag | Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases | 
| WO2016146833A1              (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance | 
| EP4620530A2              (en) | 2015-03-20 | 2025-09-24 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to gp120 and their use | 
| PT3273992T              (en) | 2015-03-23 | 2020-08-21 | Jounce Therapeutics Inc | Antibodies to icos | 
| EP3274370B1              (en) | 2015-03-23 | 2019-11-20 | Bayer Pharma Aktiengesellschaft | Anti-ceacam6 antibodies and uses thereof | 
| KR102721595B1              (en) | 2015-04-03 | 2024-10-23 | 유레카 쎄라퓨틱스, 인코포레이티드 | Constructs targeting AFP peptide/MHC complexes and uses thereof | 
| HRP20211159T1              (en) | 2015-04-24 | 2021-10-29 | F. Hoffmann - La Roche Ag | Methods of identifying bacteria comprising binding polypeptides | 
| HK1252158A1              (en) | 2015-05-01 | 2019-05-17 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use | 
| WO2016179194A1              (en) | 2015-05-04 | 2016-11-10 | Jounce Therapeutics, Inc. | Lilra3 and method of using the same | 
| JP6963508B2              (en) | 2015-05-11 | 2021-11-10 | ジェネンテック, インコーポレイテッド | Compositions and Methods for Treating Lupus Nephritis | 
| CA2983282A1              (en) | 2015-05-12 | 2016-11-17 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer | 
| EP4335931A3              (en) | 2015-05-29 | 2024-06-19 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer | 
| WO2016196381A1              (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Pd-l1 promoter methylation in cancer | 
| JP2018520658A              (en) | 2015-05-29 | 2018-08-02 | ジェネンテック, インコーポレイテッド | Humanized anti-Ebola virus glycoprotein antibodies and uses thereof | 
| CN107810012A              (en) | 2015-06-02 | 2018-03-16 | 豪夫迈·罗氏有限公司 | Use the composition and method of the anti-Antybody therapy sacred diseases of IL 34 | 
| WO2016196975A1              (en) | 2015-06-03 | 2016-12-08 | The United States Of America, As Represented By The Secretary Department Of Health & Human Services | Neutralizing antibodies to hiv-1 env and their use | 
| KR101978765B1              (en) | 2015-06-04 | 2019-05-15 | 오스페달레 산 라파엘 에스.알.엘. | Inhibitors of IGFBP3 / TMEM219 axis and diabetes | 
| WO2016193496A1              (en) | 2015-06-04 | 2016-12-08 | Ospedale San Raffaele Srl | Igfbp3 and uses thereof | 
| EP3303386B1              (en) | 2015-06-05 | 2024-08-28 | Genentech, Inc. | Anti-tau antibodies and methods of use | 
| AU2016274584A1              (en) | 2015-06-08 | 2018-01-04 | Genentech, Inc. | Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists | 
| AU2016274585A1              (en) | 2015-06-08 | 2017-12-14 | Genentech, Inc. | Methods of treating cancer using anti-OX40 antibodies | 
| CN108064246A              (en) | 2015-06-15 | 2018-05-22 | 基因泰克公司 | Antibody and immune conjugate | 
| EP3310378B1              (en) | 2015-06-16 | 2024-01-24 | F. Hoffmann-La Roche AG | Anti-cll-1 antibodies and methods of use | 
| JP2018526972A              (en) | 2015-06-16 | 2018-09-20 | ジェネンテック, インコーポレイテッド | Anti-CD3 antibody and method of use | 
| EP3310814B1              (en) | 2015-06-16 | 2023-08-02 | F. Hoffmann-La Roche AG | Humanized and affinity matured antibodies to fcrh5 and methods of use | 
| DK3310812T3              (en) | 2015-06-17 | 2025-09-29 | Hoffmann La Roche | Anti-HER2 antibodies and methods of use | 
| CN116327953A              (en) | 2015-06-17 | 2023-06-27 | 豪夫迈·罗氏有限公司 | Methods of treating locally advanced or metastatic breast cancer using PD-1 axis binding antagonists and taxanes | 
| HK1254432A1              (en) | 2015-06-17 | 2019-07-19 | Allakos Inc. | Methods and compositions for treating fibrotic diseases | 
| CN107810199B              (en) | 2015-06-24 | 2021-11-09 | 豪夫迈·罗氏有限公司 | Anti-transferrin receptor antibodies with tailored affinity | 
| EP3313890A1              (en) | 2015-06-24 | 2018-05-02 | H. Hoffnabb-La Roche Ag | Trispecific antibodies specific for her2 and a blood brain barrier receptor and methods of use | 
| BR112017027736A2              (en) | 2015-06-29 | 2018-10-09 | Genentech Inc | anti-cd20 type ii antibody for use in organ transplantation | 
| CA3162816A1              (en) | 2015-06-29 | 2017-01-05 | Ventana Medical Systems, Inc. | Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin | 
| CN105384825B              (en) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | A kind of bispecific chimeric antigen receptor and its application based on single domain antibody | 
| WO2017040342A1              (en) | 2015-08-28 | 2017-03-09 | Genentech, Inc. | Anti-hypusine antibodies and uses thereof | 
| CA2999369C              (en) | 2015-09-22 | 2023-11-07 | Spring Bioscience Corporation | Anti-ox40 antibodies and diagnostic uses thereof | 
| CN108137681B              (en) | 2015-09-23 | 2024-06-18 | 豪夫迈·罗氏有限公司 | Optimized variants of anti-VEGF antibodies | 
| KR20180083313A              (en) | 2015-09-24 | 2018-07-20 | 에이비비트로, 엘엘씨 | HIV antibody compositions and methods of use | 
| TWI811892B              (en) | 2015-09-25 | 2023-08-11 | 美商建南德克公司 | Anti-tigit antibodies and methods of use | 
| AR106188A1              (en) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE | 
| AR106189A1              (en) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE | 
| CR20180161A              (en) | 2015-10-02 | 2018-05-25 | Hoffmann La Roche | Bispecific Antibodies for PD1 and TIM3 | 
| CN108602887B              (en) | 2015-10-02 | 2022-06-21 | 豪夫迈·罗氏有限公司 | Bispecific antibodies specific for costimulatory TNF receptors | 
| MA43345A              (en) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | 
| EP3150636A1              (en) | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies | 
| CN114057884A              (en) | 2015-10-02 | 2022-02-18 | 豪夫迈·罗氏有限公司 | Bispecific anti-human CD20/human transferrin receptor antibody and methods of use | 
| WO2017062682A2              (en) | 2015-10-06 | 2017-04-13 | Genentech, Inc. | Method for treating multiple sclerosis | 
| US10392441B2              (en) | 2015-10-07 | 2019-08-27 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services | IL-7R-alpha specific antibodies for treating acute lymphoblastic leukemia | 
| US20170247467A1              (en) | 2015-10-07 | 2017-08-31 | Hoffmann-La Roche Inc. | Bispecific antibodies with tetravalency for a costimulatory tnf receptor | 
| CN108350505A              (en) | 2015-10-22 | 2018-07-31 | 震动疗法股份有限公司 | Gene markers for determining ICOS expression | 
| US10604577B2              (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis | 
| WO2017072210A1              (en) | 2015-10-29 | 2017-05-04 | F. Hoffmann-La Roche Ag | Anti-variant fc-region antibodies and methods of use | 
| EP3184547A1              (en) | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use | 
| TW201730211A              (en) | 2015-10-30 | 2017-09-01 | 建南德克公司 | Anti-Factor D antibodies and conjugates | 
| DK3368578T3              (en) | 2015-10-30 | 2021-05-25 | Hoffmann La Roche | Anti-HtrA1 Antibodies and Methods of Using Them | 
| CA3003878A1              (en) | 2015-11-03 | 2017-05-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 gp41 and their use | 
| CN108602884B              (en) | 2015-11-08 | 2024-06-25 | 豪夫迈·罗氏有限公司 | Method for screening multispecific antibodies | 
| BR112018010410A8              (en) | 2015-11-23 | 2019-02-26 | Five Prime Therapeutics Inc | method for treating cancer in a subject, composition and methods of increasing the number of nk cells and increasing the number of one or more pd-11 positive cells | 
| EA201891420A1              (en) | 2015-12-18 | 2019-02-28 | Чугаи Сейяку Кабусики Кайся | ANTIBODIES TO MYOSTATIN, POLYPEPTIDES, CONTAINING OPTIONS OF FC-REGIONS, AND METHODS OF THEIR APPLICATION | 
| PT3390442T              (en) | 2015-12-18 | 2024-01-08 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use | 
| BR112018011029A2              (en) | 2016-01-08 | 2018-11-21 | Hoffmann La Roche | methods for treating or delaying cancer progression and improving immune function in a cancer individual, uses of a binding antagonist and a bispecific antibody, compositions and kits | 
| CN108602883A              (en) | 2016-01-20 | 2018-09-28 | 基因泰克公司 | High-dose treatment for Alzheimer's disease | 
| CA3019952A1              (en) | 2016-02-04 | 2017-08-10 | Curis, Inc. | Mutant smoothened and methods of using the same | 
| AU2017225854B2              (en) | 2016-02-29 | 2020-11-19 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer | 
| US11767362B1              (en) | 2016-03-15 | 2023-09-26 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using PD-1 axis binding antagonists and anti-GPC3 antibodies | 
| US20170315132A1              (en) | 2016-03-25 | 2017-11-02 | Genentech, Inc. | Multiplexed total antibody and antibody-conjugated drug quantification assay | 
| US20170319688A1              (en) | 2016-04-14 | 2017-11-09 | Genentech, Inc. | Anti-rspo3 antibodies and methods of use | 
| SG11201808994YA              (en) | 2016-04-15 | 2018-11-29 | Bioatla Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof | 
| ES2850428T3              (en) | 2016-04-15 | 2021-08-30 | Hoffmann La Roche | Cancer monitoring and treatment procedures | 
| MX2018012493A              (en) | 2016-04-15 | 2019-06-06 | Genentech Inc | Methods for monitoring and treating cancer. | 
| JP6675017B2              (en) | 2016-05-02 | 2020-04-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Contrast body-single chain target binding substance | 
| WO2017192589A1              (en) | 2016-05-02 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to influenza ha and their use and identification | 
| EP3243836A1              (en) | 2016-05-11 | 2017-11-15 | F. Hoffmann-La Roche AG | C-terminally fused tnf family ligand trimer-containing antigen binding molecules | 
| EP3455252B1              (en) | 2016-05-11 | 2022-02-23 | F. Hoffmann-La Roche AG | Modified anti-tenascin antibodies and methods of use | 
| JP7285076B2              (en) | 2016-05-11 | 2023-06-01 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Antigen-binding molecule comprising a TNF family ligand trimer and a tenascin-binding portion | 
| HUE060072T2              (en) | 2016-05-13 | 2023-01-28 | Bioatla Inc | Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof | 
| EP3243832A1              (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety | 
| WO2017201449A1              (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use | 
| JP7022080B2              (en) | 2016-05-27 | 2022-02-17 | ジェネンテック, インコーポレイテッド | Biochemical analytical methods for the characterization of site-specific antibody-drug conjugates | 
| KR102306744B1              (en) | 2016-06-17 | 2021-09-28 | 추가이 세이야쿠 가부시키가이샤 | Anti-myostatin antibodies and methods of use | 
| JP7133477B2              (en) | 2016-06-24 | 2022-09-08 | ジェネンテック, インコーポレイテッド | Anti-polyubiquitin multispecific antibody | 
| JP6983824B2              (en) | 2016-07-04 | 2021-12-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | New antibody format | 
| WO2018014260A1              (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof | 
| MX2019001184A              (en) | 2016-07-29 | 2019-09-26 | Juno Therapeutics Inc | Anti-idiotypic antibodies against anti-cd19 antibodies. | 
| US20190185578A1              (en) | 2016-07-29 | 2019-06-20 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity | 
| US11053308B2              (en) | 2016-08-05 | 2021-07-06 | Chugai Seiyaku Kabushiki Kaisha | Method for treating IL-8-related diseases | 
| CN109476748B              (en) | 2016-08-08 | 2023-05-23 | 豪夫迈·罗氏有限公司 | Methods for the treatment and diagnosis of cancer | 
| WO2018045379A1              (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders | 
| US11168148B2              (en) | 2016-09-07 | 2021-11-09 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes | 
| SG10201607778XA              (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use | 
| EP3515932B1              (en) | 2016-09-19 | 2023-11-22 | F. Hoffmann-La Roche AG | Complement factor based affinity chromatography | 
| IL265473B2              (en) | 2016-09-23 | 2024-01-01 | Genentech Inc | Uses of il-13 antagonists for treating atopic dermatitis | 
| JP2019536437A              (en) | 2016-10-03 | 2019-12-19 | ジュノー セラピューティクス インコーポレイテッド | HPV-specific binding molecules | 
| JP7050770B2              (en) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Method for preparing antibody drug conjugate | 
| AU2017339517B2              (en) | 2016-10-06 | 2024-03-14 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer | 
| WO2018068201A1              (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 | 
| CN110267678A              (en) | 2016-10-29 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | Anti-MIC antibodies and methods of use | 
| WO2018085358A1              (en) | 2016-11-02 | 2018-05-11 | Jounce Therapeutics, Inc. | Antibodies to pd-1 and uses thereof | 
| TWI791471B              (en) | 2016-11-15 | 2023-02-11 | 美商建南德克公司 | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies | 
| JOP20190100A1              (en) | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | Anti-gitr antigen-binding proteins and methods of use thereof | 
| CN110023334B              (en) | 2016-11-21 | 2023-11-14 | 科雅博有限责任公司 | anti-GP 73 antibodies and immunoconjugates | 
| EP3551655A2              (en) | 2016-12-07 | 2019-10-16 | Genentech, Inc. | Anti-tau antibodies and methods of their use | 
| TW202328181A              (en) | 2016-12-07 | 2023-07-16 | 美商建南德克公司 | Anti-tau antibodies and methods of use | 
| MX2019006331A              (en) | 2016-12-12 | 2019-07-12 | Genentech Inc | Methods of treating cancer using anti-pd-l1 antibodies and antiandrogens. | 
| CA3039430A1              (en) | 2016-12-19 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with targeted 4-1bb (cd137) agonists | 
| EP3559034B1              (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists | 
| JOP20190134A1              (en) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | Anti-neuropilin antigen-binding proteins and methods of use thereof | 
| CR20190309A              (en) | 2017-01-03 | 2019-08-21 | Hoffmann La Roche | BI-SPECIFIC ANTIGEN BINDING MOLECULES INCLUDING CLONE 20H4.9 ANTI-4-1BB | 
| WO2018129029A1              (en) | 2017-01-04 | 2018-07-12 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof | 
| EP3568468A4              (en) | 2017-01-12 | 2020-12-30 | Eureka Therapeutics, Inc. | AGAINST HISTONE H3 PEPTIDE / MHC COMPLEX CONSTRUCTS AND USES THEREOF | 
| CR20190387A              (en) | 2017-02-10 | 2019-09-25 | Genentech Inc | ANTIBODIES AGAINST TRYPTASE, COMPOSITIONS OF THESE AND USES OF THEM | 
| EP3580235B1              (en) | 2017-02-10 | 2024-05-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use | 
| WO2018160841A1              (en) | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer | 
| KR20190138636A              (en) | 2017-03-22 | 2019-12-13 | 제넨테크, 인크. | Optimized Antibody Compositions for the Treatment of Eye Disorders | 
| CN110494446A              (en) | 2017-03-28 | 2019-11-22 | 基因泰克公司 | The method for treating neurodegenerative disease | 
| EP3601345A1              (en) | 2017-03-29 | 2020-02-05 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor | 
| EP3601346A1              (en) | 2017-03-29 | 2020-02-05 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor | 
| JOP20190203A1              (en) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | Anti-tigit antigen-binding proteins and methods of use thereof | 
| MA49289A              (en) | 2017-04-03 | 2020-02-12 | Hoffmann La Roche | ANTIBODIES BINDING TO STEAP-1 | 
| WO2018185045A1              (en) | 2017-04-04 | 2018-10-11 | F. Hoffmann-La Roche Ag | Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap | 
| AU2018247797B2              (en) | 2017-04-05 | 2024-10-10 | F. Hoffmann-La Roche Ag | Anti-LAG3 antibodies | 
| SG11201909154SA              (en) | 2017-04-05 | 2019-10-30 | Hoffmann La Roche | Bispecific antibodies specifically binding to pd1 and lag3 | 
| MX2019012192A              (en) | 2017-04-14 | 2020-01-21 | Genentech Inc | Diagnostic and therapeutic methods for cancer. | 
| PE20200150A1              (en) | 2017-04-21 | 2020-01-17 | Genentech Inc | USE OF KLK5 ANTAGONISTS FOR THE TREATMENT OF A DISEASE | 
| JP7295030B2              (en) | 2017-04-26 | 2023-06-20 | ユーリカ セラピューティックス, インコーポレイテッド | Construct that specifically recognizes glypican 3 and use thereof | 
| SG10201913677SA              (en) | 2017-04-27 | 2020-03-30 | Tesaro Inc | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof | 
| BR112019022912A2              (en) | 2017-05-05 | 2020-05-26 | Allakos Inc. | METHODS AND COMPOSITIONS TO TREAT ALLERGIC EYE DISEASES | 
| KR20250010107A              (en) | 2017-05-16 | 2025-01-20 | 파이브 프라임 테라퓨틱스, 인크. | Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment | 
| MX2020000604A              (en) | 2017-07-21 | 2020-09-10 | Genentech Inc | Therapeutic and diagnostic methods for cancer. | 
| US10961318B2              (en) | 2017-07-26 | 2021-03-30 | Forty Seven, Inc. | Anti-SIRP-α antibodies and related methods | 
| WO2019059411A1              (en) | 2017-09-20 | 2019-03-28 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent | 
| AU2018345539A1              (en) | 2017-10-03 | 2020-04-16 | Editas Medicine, Inc. | HPV-specific binding molecules | 
| EP3694890A4              (en) | 2017-10-12 | 2021-11-03 | Immunowake Inc. | LIGHT CHAIN ANTIBODY FUSION PROTEIN WITH VEGFR | 
| TWI829658B              (en) | 2017-11-01 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | Bispecific 2+1 contorsbodies | 
| WO2019086499A1              (en) | 2017-11-01 | 2019-05-09 | F. Hoffmann-La Roche Ag | Novel tnf family ligand trimer-containing antigen binding molecules | 
| AU2018359506A1              (en) | 2017-11-01 | 2020-04-23 | F. Hoffmann-La Roche Ag | Combination therapy with targeted OX40 agonists | 
| MA49911A              (en) | 2017-11-01 | 2020-06-24 | Juno Therapeutics Inc | ANTIBODIES AND CHEMERICAL ANTIGENIC RECEPTORS SPECIFIC TO THE B-LYMPHOCYTE MATURATION ANTIGEN | 
| ES2984919T3              (en) | 2017-11-06 | 2024-10-31 | Hoffmann La Roche | Diagnostic and therapeutic procedures for cancer | 
| CN111615520A              (en) | 2017-12-01 | 2020-09-01 | 辉瑞大药厂 | Anti-CXCR5 antibodies and compositions and uses thereof | 
| CN112204048A              (en) | 2017-12-15 | 2021-01-08 | 朱诺治疗学股份有限公司 | Anti-CCT5 binding molecules and methods of use | 
| AU2018390881A1              (en) | 2017-12-21 | 2020-07-02 | F. Hoffmann-La Roche Ag | Antibodies binding to HLA-A2/WT1 | 
| EP3502140A1              (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules | 
| US20190211098A1              (en) | 2017-12-22 | 2019-07-11 | Genentech, Inc. | Use of pilra binding agents for treatment of a disease | 
| AU2018389111A1              (en) | 2017-12-22 | 2020-06-18 | Jounce Therapeutics, Inc. | Antibodies to LILRB2 | 
| TW201930350A              (en) | 2017-12-28 | 2019-08-01 | 大陸商南京傳奇生物科技有限公司 | Antibodies and variants thereof against PD-L1 | 
| JP7369127B2              (en) | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー,リミテッド | Single domain antibodies against TIGIT and variants thereof | 
| EP3731864A1              (en) | 2017-12-29 | 2020-11-04 | F. Hoffmann-La Roche SA | Anti-vegf antibodies and methods of use | 
| US11976109B2              (en) | 2018-01-02 | 2024-05-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use | 
| IL315325B1              (en) | 2018-01-04 | 2025-07-01 | Iconic Therapeutics Inc | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods | 
| US11466077B2              (en) | 2018-01-05 | 2022-10-11 | Ac Immune Sa | Misfolded TDP-43 binding molecules | 
| WO2019139987A1              (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases | 
| EP3740507A4              (en) | 2018-01-15 | 2022-08-24 | Nanjing Legend Biotech Co., Ltd. | SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST PD-1 | 
| EP3740505A1              (en) | 2018-01-16 | 2020-11-25 | Lakepharma Inc. | Bispecific antibody that binds cd3 and another target | 
| SG11202006259SA              (en) | 2018-01-26 | 2020-08-28 | Genentech Inc | Il-22 fc fusion proteins and methods of use | 
| JP7345479B2              (en) | 2018-01-26 | 2023-09-15 | ジェネンテック, インコーポレイテッド | Composition and method of use | 
| AU2019214183B2              (en) | 2018-02-01 | 2022-04-07 | Innovent Biologics (Suzhou) Co., Ltd. | Fully human anti-B cell maturation antigen (BCMA) single chain variable fragment, and application thereof | 
| CA3089287A1              (en) | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use | 
| AU2019218128A1              (en) | 2018-02-09 | 2020-09-17 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases | 
| TWI829667B              (en) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | Antibodies binding to gprc5d | 
| JP7350756B2              (en) | 2018-02-14 | 2023-09-26 | アバ セラピューティクス アーゲー | Anti-human PD-L2 antibody | 
| EP3755364A1              (en) | 2018-02-21 | 2020-12-30 | F. Hoffmann-La Roche AG | Dosing for treatment with il-22 fc fusion proteins | 
| CA3091437A1              (en) | 2018-02-21 | 2019-08-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use | 
| US20200399376A1              (en) | 2018-02-26 | 2020-12-24 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies | 
| CN119074915A              (en) | 2018-03-13 | 2024-12-06 | 豪夫迈·罗氏有限公司 | Therapeutic combinations of 4-1BB agonists and anti-CD20 antibodies | 
| TWI841551B              (en) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | Combination therapy with targeted 4-1bb (cd137) agonists | 
| CA3087423A1              (en) | 2018-03-14 | 2019-09-19 | Beijing Xuanyi Pharmasciences Co., Ltd. | Anti-claudin 18.2 antibodies | 
| US20200040103A1              (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use | 
| EP3765517A1              (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof | 
| CN116327926A              (en) | 2018-03-15 | 2023-06-27 | 中外制药株式会社 | Anti-dengue virus antibodies with cross-reactivity to Zika virus and methods of use | 
| EP3768716A1              (en) | 2018-03-21 | 2021-01-27 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph | 
| KR20200135510A              (en) | 2018-03-29 | 2020-12-02 | 제넨테크, 인크. | Regulation of lactation stimulating activity in mammalian cells | 
| JP7346790B2              (en) | 2018-03-30 | 2023-09-20 | ナンジン レジェンド バイオテック カンパニー,リミテッド | Single domain antibodies against LAG-3 and their uses | 
| TW202011029A              (en) | 2018-04-04 | 2020-03-16 | 美商建南德克公司 | Methods for detecting and quantifying FGF21 | 
| EP3773908A1              (en) | 2018-04-05 | 2021-02-17 | Juno Therapeutics, Inc. | T cell receptors and engineered cells expressing same | 
| SG11202007961QA              (en) | 2018-04-13 | 2020-09-29 | Hoffmann La Roche | Her2-targeting antigen binding molecules comprising 4-1bbl | 
| CA3100007A1              (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof | 
| WO2019222294A1              (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof | 
| TWI839357B              (en) | 2018-05-18 | 2024-04-21 | 日商第一三共股份有限公司 | Anti-muc1 antibody-drug conjugate | 
| US11987629B2              (en) | 2018-06-01 | 2024-05-21 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition | 
| WO2019227490A1              (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging | 
| US20210238308A1              (en) | 2018-06-04 | 2021-08-05 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule showing changed half-life in cytoplasm | 
| TWI851577B              (en) | 2018-06-07 | 2024-08-11 | 美商思進公司 | Camptothecin conjugates | 
| SG11202012342WA              (en) | 2018-06-18 | 2021-01-28 | Eureka Therapeutics Inc | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof | 
| SG11202012446UA              (en) | 2018-06-23 | 2021-01-28 | Genentech Inc | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor | 
| WO2020010250A2              (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof | 
| EP3818082A1              (en) | 2018-07-04 | 2021-05-12 | F. Hoffmann-La Roche AG | Novel bispecific agonistic 4-1bb antigen binding molecules | 
| JP7411627B2              (en) | 2018-07-09 | 2024-01-11 | ファイヴ プライム セラピューティクス インク | Antibody that binds to ILT4 | 
| WO2020014306A1              (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof | 
| US12091462B2              (en) | 2018-07-11 | 2024-09-17 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic pH | 
| AU2019305637A1              (en) | 2018-07-18 | 2021-03-11 | Genentech, Inc. | Methods of treating lung cancer with a PD-1 axis binding antagonist, an antimetabolite, and a platinum agent | 
| SG11202100373VA              (en) | 2018-07-20 | 2021-02-25 | Surface Oncology Inc | Anti-cd112r compositions and methods | 
| WO2020027330A1              (en) | 2018-08-03 | 2020-02-06 | 中外製薬株式会社 | Antigen-binding molecule containing two antigen-binding domains that are linked to each other | 
| US12172106B2              (en) | 2018-08-09 | 2024-12-24 | Regeneron Pharmaceuticals, Inc. | Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor | 
| UA128584C2              (en) | 2018-08-10 | 2024-08-21 | Чугаі Сейяку Кабусікі Кайся | Anti-cd137 antigen-binding molecule and utilization thereof | 
| WO2020037258A1              (en) | 2018-08-17 | 2020-02-20 | Ab Studio Inc. | Catabodies and methods of use thereof | 
| GB201814281D0              (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents | 
| CN112673022B              (en) | 2018-09-10 | 2024-07-09 | 南京传奇生物科技有限公司 | Single domain antibodies to CD33 and constructs thereof | 
| EP3853611A1              (en) | 2018-09-19 | 2021-07-28 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for bladder cancer | 
| CA3111809A1              (en) | 2018-09-21 | 2020-03-26 | Genentech, Inc. | Diagnostic methods for triple-negative breast cancer | 
| KR20210087027A              (en) | 2018-09-27 | 2021-07-09 | 실리오 디벨럽먼트, 인크. | Masked cytokine polypeptide | 
| AU2019355252A1              (en) | 2018-10-01 | 2021-04-01 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules comprising anti-FAP clone 212 | 
| CN112654641A              (en) | 2018-10-01 | 2021-04-13 | 豪夫迈·罗氏有限公司 | Bispecific antigen binding molecules with trivalent binding to CD40 | 
| EP3632929A1              (en) | 2018-10-02 | 2020-04-08 | Ospedale San Raffaele S.r.l. | Antibodies and uses thereof | 
| CN112804989A              (en) | 2018-10-05 | 2021-05-14 | 戊瑞治疗有限公司 | anti-FGFR 2 antibody formulations | 
| WO2020081493A1              (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins | 
| MX2021004348A              (en) | 2018-10-18 | 2021-05-28 | Genentech Inc | DIAGNOSTIC AND THERAPEUTIC PROCEDURES FOR SARCOMATOID KIDNEY CANCER. | 
| US20210395390A1              (en) | 2018-10-31 | 2021-12-23 | Bayer Aktiengesellschaft | Reversal agents for neutralizing the therapeutic activity of anti-fxia antibodies | 
| MX2021005751A              (en) | 2018-11-16 | 2021-10-01 | Memorial Sloan Kettering Cancer Center | ANTIBODIES AGAINST MUCIN 16 AND METHODS OF USE THEREOF. | 
| KR20210100656A              (en) | 2018-12-05 | 2021-08-17 | 제넨테크, 인크. | Diagnostic methods and compositions for cancer immunotherapy | 
| MX2021006573A              (en) | 2018-12-06 | 2021-07-15 | Genentech Inc | Combination therapy of diffuse large b-cell lymphoma comprising an anti-cd79b immunoconjugates, an alkylating agent and an anti-cd20 antibody. | 
| CN113227119A              (en) | 2018-12-10 | 2021-08-06 | 基因泰克公司 | Photocrosslinked peptides for site-specific conjugation to Fc-containing proteins | 
| EP3883609A2              (en) | 2018-12-20 | 2021-09-29 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof | 
| EP3898667A2              (en) | 2018-12-20 | 2021-10-27 | F. Hoffmann-La Roche AG | Modified antibody fcs and methods of use | 
| WO2020127628A1              (en) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted superagonistic cd28 antigen binding molecules | 
| CR20210332A              (en) | 2018-12-21 | 2021-09-09 | Hoffmann La Roche | Antibody that binds to vegf and il-1beta and methods of use | 
| MA54513A              (en) | 2018-12-21 | 2022-03-30 | Hoffmann La Roche | CD28 ANTIGEN BINDING MOLECULES TUMOR TARGETING AGONISTS | 
| KR20240155361A              (en) | 2018-12-21 | 2024-10-28 | 에프. 호프만-라 로슈 아게 | Antibodies binding to cd3 | 
| CN113490688B              (en) | 2018-12-26 | 2025-07-29 | 希望之城公司 | Activatable masked anti-CTLA 4 binding proteins | 
| WO2020141145A1              (en) | 2018-12-30 | 2020-07-09 | F. Hoffmann-La Roche Ag | Anti-rabbit cd19 antibodies and methods of use | 
| CA3124837A1              (en) | 2019-01-14 | 2020-07-23 | Genentech, Inc. | Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine | 
| EP3911675A1              (en) | 2019-01-17 | 2021-11-24 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc) | 
| JP7538130B2              (en) | 2019-01-23 | 2024-08-21 | タユー ファシャ バイオテック メディカル グループ カンパニー, リミテッド | Anti-PD-L1 diabodies and uses thereof | 
| US20220089770A1              (en) | 2019-01-24 | 2022-03-24 | Chugai Seiyaku Kabushiki Kaisha | Novel cancer antigens and antibodies of said antigens | 
| JP7678753B2              (en) | 2019-01-29 | 2025-05-16 | ジュノー セラピューティクス インコーポレイテッド | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase-like orphan receptor 1 (ROR1) | 
| GB201901197D0              (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents | 
| SG11202109061YA              (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to t cell related cancer cells and uses thereof | 
| SG11202108955QA              (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Antibody molecules that bind to nkp30 and uses thereof | 
| BR112021016923A2              (en) | 2019-02-27 | 2021-11-03 | Genentech Inc | Methods for treating a patient with hematologic cancer, methods for treating a patient with relapsed or refractory mm, methods for treating a patient having a relapsed or refractory lnh, and kits | 
| BR112021017144A2              (en) | 2019-03-08 | 2021-11-09 | Genentech Inc | Assay to detect a membrane-associated protein, methods to quantify the concentration of circulating protein, to determine whether a patient with b-cell lymphoma is likely to exhibit a response to an anti-cd20 therapy, to determine the affinity of an anti-cd20 antibody cd20, to determine the activation of t cells and method of treating a tumor | 
| MX2021010996A              (en) | 2019-03-14 | 2021-11-04 | Genentech Inc | Treatment of cancer with her2xcd3 bispecific antibodies in combination with anti-her2 mab. | 
| JP7301155B2              (en) | 2019-04-12 | 2023-06-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Bispecific antigen-binding molecules containing lipocalin muteins | 
| JP7593939B2              (en) | 2019-04-19 | 2024-12-03 | ジェネンテック, インコーポレイテッド | Anti-MERTK antibodies and methods of use thereof | 
| AU2020257748A1              (en) | 2019-04-19 | 2021-11-18 | Chugai Seiyaku Kabushiki Kaisha | Chimeric receptor recognizing modification site of antibody | 
| CN114269376A              (en) | 2019-05-03 | 2022-04-01 | 豪夫迈·罗氏有限公司 | Methods of treating cancer with anti-PD-L1 antibodies | 
| US12269872B2              (en) | 2019-05-03 | 2025-04-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to Plasmodium falciparum circumsporozoite protein and their use | 
| BR112021022815A2              (en) | 2019-05-14 | 2021-12-28 | Genentech Inc | Methods to treat follicular lymphoma, kits, immunoconjugates and polatuzumab vedotin | 
| EP3969035A4              (en) | 2019-05-14 | 2023-06-21 | Werewolf Therapeutics, Inc. | SEPARATION UNITS AND METHODS AND THEIR USE | 
| US20230085439A1              (en) | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use | 
| TW202110879A              (en) | 2019-05-23 | 2021-03-16 | 瑞士商Ac 免疫有限公司 | Anti-tdp-43 binding molecules and uses thereof | 
| CN114127123A              (en) | 2019-06-26 | 2022-03-01 | 豪夫迈·罗氏有限公司 | Fusion of CEA-binding antibodies to 4-1BBL | 
| CN114531878A              (en) | 2019-06-27 | 2022-05-24 | 豪夫迈·罗氏有限公司 | Novel ICOS antibodies and tumor-targeted antigen-binding molecules comprising same | 
| CA3142833A1              (en) | 2019-07-02 | 2021-01-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind egfrviii and their use | 
| CN114341187A              (en) | 2019-07-12 | 2022-04-12 | 中外制药株式会社 | Anti-mutant FGFR3 antibodies and uses thereof | 
| AR119382A1              (en) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | PRE-TARGETING ANTIBODIES AND METHODS OF USE | 
| AR119393A1              (en) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | ANTIBODIES THAT BIND NKG2D | 
| JP2022543551A              (en) | 2019-07-31 | 2022-10-13 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Antibody that binds to GPRC5D | 
| BR112022001460A2              (en) | 2019-07-31 | 2022-03-22 | Hoffmann La Roche | Bispecific antigen-binding molecules, one or more isolated polynucleotides, host cell, method for producing a bispecific antigen-binding molecule and for treating a disease in an individual, pharmaceutical composition, use of the bispecific antigen-binding molecule and invention | 
| TWI832183B              (en) | 2019-08-06 | 2024-02-11 | 香港商新旭生技股份有限公司 | Antibodies that bind to pathological tau species and uses thereof | 
| EP4438057A3              (en) | 2019-09-12 | 2025-01-01 | F. Hoffmann-La Roche AG | Compositions and methods of treating lupus nephritis | 
| US12312414B2              (en) | 2019-09-18 | 2025-05-27 | Genentech, Inc. | Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use | 
| BR112022004831A2              (en) | 2019-09-19 | 2022-06-07 | Bristol Myers Squibb Co | Antibodies that bind to seen at acidic pH | 
| TW202126699A              (en) | 2019-09-20 | 2021-07-16 | 美商建南德克公司 | Dosing for anti-tryptase antibodies | 
| JP2022548978A              (en) | 2019-09-27 | 2022-11-22 | ジェネンテック, インコーポレイテッド | Dosing for Treatment with Drugs Anti-TIGIT and Anti-PD-L1 Antagonist Antibodies | 
| KR20220086618A              (en) | 2019-10-18 | 2022-06-23 | 제넨테크, 인크. | Methods of Use of Anti-CD79b Immunoconjugates to Treat Diffuse Large B-Cell Lymphoma | 
| US20220389103A1              (en) | 2019-11-06 | 2022-12-08 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers | 
| WO2021096888A1              (en) | 2019-11-12 | 2021-05-20 | Foundation Medicine, Inc. | Methods of detecting a fusion gene encoding a neoantigen | 
| MX2022005666A              (en) | 2019-11-14 | 2022-10-07 | Werewolf Therapeutics Inc | ACTIVABLE CYTOKINE POLYPEPTIDES AND METHODS OF USE THEREOF. | 
| MX2022005718A              (en) | 2019-11-15 | 2022-07-12 | Enthera S R L | Tmem219 antibodies and therapeutic uses thereof. | 
| US20230039165A1              (en) | 2019-11-21 | 2023-02-09 | Enthera S.R.L. | Igfbp3 antibodies and therapeutic uses thereof | 
| CA3163897A1              (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods | 
| JP7751577B2              (en) | 2019-12-06 | 2025-10-08 | ジュノー セラピューティクス インコーポレイテッド | Anti-idiotypic antibodies to the GPRC5D target binding domain and related compositions and methods | 
| WO2021119505A1              (en) | 2019-12-13 | 2021-06-17 | Genentech, Inc. | Anti-ly6g6d antibodies and methods of use | 
| WO2021122875A1              (en) | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a2/mage-a4 | 
| CN113045655A              (en) | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | anti-OX 40 antibodies and uses thereof | 
| CA3162444C              (en) | 2019-12-27 | 2024-04-30 | Hitoshi KATADA | Anti-ctla-4 antibody and use thereof | 
| CA3162009A1              (en) | 2020-01-09 | 2021-07-15 | F. Hoffmann-La Roche Ag | New 4-1bbl trimer-containing antigen binding molecules | 
| CN110818795B              (en) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | anti-TIGIT antibodies and methods of use | 
| WO2021194481A1              (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies | 
| WO2022050954A1              (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies | 
| JP2023513059A              (en) | 2020-01-31 | 2023-03-30 | ザ クリーブランド クリニック ファウンデーション | Anti-Mullerian hormone receptor 2 antibody and method of use | 
| MX2022009391A              (en) | 2020-01-31 | 2022-09-26 | Genentech Inc | Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine. | 
| IL295382A              (en) | 2020-02-12 | 2022-10-01 | Chugai Pharmaceutical Co Ltd | An anti-cd137 antigen-binding molecule for use in cancer therapy | 
| CA3169451A1              (en) | 2020-02-14 | 2021-08-19 | Jounce Therapeutics, Inc. | Antibodies and fusion proteins that bind to ccr8 and uses thereof | 
| EP3868396A1              (en) | 2020-02-20 | 2021-08-25 | Enthera S.R.L. | Inhibitors and uses thereof | 
| US20230348568A1              (en) | 2020-02-20 | 2023-11-02 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus monoclonal antibodies and uses thereof | 
| EP4110826A4              (en) | 2020-02-28 | 2024-08-14 | Shanghai Henlius Biotech, Inc. | Anti-cd137 constructs, multispecific antibody and uses thereof | 
| CN115066440A              (en) | 2020-02-28 | 2022-09-16 | 上海复宏汉霖生物技术股份有限公司 | anti-CD 137 constructs and uses thereof | 
| EP4118114A1              (en) | 2020-03-13 | 2023-01-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof | 
| EP4121163A1              (en) | 2020-03-19 | 2023-01-25 | Genentech, Inc. | Isoform-selective anti-tgf-beta antibodies and methods of use | 
| US20240025991A1              (en) | 2020-03-23 | 2024-01-25 | Genentech, Inc. | Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist | 
| JP2023518812A              (en) | 2020-03-23 | 2023-05-08 | ジェネンテック, インコーポレイテッド | Combination of tocilizumab and remdesivir to treat COVID19 pneumonia | 
| EP4107185A1              (en) | 2020-03-23 | 2022-12-28 | Genentech, Inc. | Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia | 
| EP4126949A1              (en) | 2020-03-24 | 2023-02-08 | Genentech, Inc. | Tie2-binding agents and methods of use | 
| EP4127153A2              (en) | 2020-03-26 | 2023-02-08 | Genentech, Inc. | Modified mammalian cells having reduced host cell proteins | 
| AR121706A1              (en) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES | 
| WO2021202959A1              (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer | 
| WO2021207662A1              (en) | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome | 
| AU2021259861A1              (en) | 2020-04-24 | 2022-11-17 | Genentech, Inc. | Methods of using anti-CD79b immunoconjugates | 
| AU2021262744A1              (en) | 2020-04-27 | 2022-10-06 | The Regents Of The University Of California | Isoform-independent antibodies to lipoprotein(a) | 
| EP4143345A1              (en) | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy | 
| KR20230087414A              (en) | 2020-05-03 | 2023-06-16 | 레베나 (쑤저우) 바이오파마 컴퍼니 리미티드 | Antibody-drug conjugates (ADCS) comprising an anti-Trop-2 antibody, compositions comprising the ADCS, and methods of making and using the same | 
| CN113993900B              (en) | 2020-05-27 | 2023-08-04 | 舒泰神(北京)生物制药股份有限公司 | Antibody specifically recognizing nerve growth factor and use thereof | 
| EP4157462A1              (en) | 2020-06-02 | 2023-04-05 | Dynamicure Biotechnology LLC | Anti-cd93 constructs and uses thereof | 
| CN116529260A              (en) | 2020-06-02 | 2023-08-01 | 当康生物技术有限责任公司 | anti-CD 93 constructs and uses thereof | 
| JP2023527918A              (en) | 2020-06-08 | 2023-06-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Anti-HBV antibody and method of use | 
| WO2021252977A1              (en) | 2020-06-12 | 2021-12-16 | Genentech, Inc. | Methods and compositions for cancer immunotherapy | 
| MX2022015877A              (en) | 2020-06-16 | 2023-01-24 | Genentech Inc | Methods and compositions for treating triple-negative breast cancer. | 
| KR20230024368A              (en) | 2020-06-18 | 2023-02-20 | 제넨테크, 인크. | Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists | 
| TWI811703B              (en) | 2020-06-19 | 2023-08-11 | 瑞士商赫孚孟拉羅股份公司 | Antibodies binding to cd3 and cd19 | 
| WO2021255146A1              (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea | 
| BR112022025809A2              (en) | 2020-06-19 | 2023-01-10 | Hoffmann La Roche | ANTIBODIES, ISOLATED POLYNUCLEOTIDE, HOST CELL, METHOD FOR PRODUCING AN ANTIBODY, USE OF THE ANTIBODY, METHOD FOR TREATING A DISEASE AND INVENTION | 
| PH12022500027A1              (en) | 2020-06-19 | 2024-03-25 | Hoffmann La Roche | Antibodies binding to cd3 | 
| PH12022553167A1              (en) | 2020-06-23 | 2024-03-04 | Hoffmann La Roche | Agonistic cd28 antigen binding molecules targeting her2 | 
| EP4172192A1              (en) | 2020-06-24 | 2023-05-03 | Genentech, Inc. | Apoptosis resistant cell lines | 
| EP4172203A1              (en) | 2020-06-25 | 2023-05-03 | F. Hoffmann-La Roche AG | Anti-cd3/anti-cd28 bispecific antigen binding molecules | 
| MX2023000339A              (en) | 2020-07-10 | 2023-02-09 | Hoffmann La Roche | Antibodies which bind to cancer cells and target radionuclides to said cells. | 
| TW202216780A              (en) | 2020-07-17 | 2022-05-01 | 美商建南德克公司 | Anti-notch2 antibodies and methods of use | 
| GB2597532A              (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds | 
| US20230322935A1              (en) | 2020-07-29 | 2023-10-12 | Dynamicure Biotechnology Llc | Anti-cd93 constructs and uses thereof | 
| WO2022031749A1              (en) | 2020-08-03 | 2022-02-10 | Genentech, Inc. | Diagnostic and therapeutic methods for lymphoma | 
| WO2022029660A1              (en) | 2020-08-05 | 2022-02-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods | 
| CN116234830A              (en) | 2020-08-07 | 2023-06-06 | 基因泰克公司 | FLT3 ligand fusion proteins and methods of use | 
| JP2023537761A              (en) | 2020-08-14 | 2023-09-05 | エイシー イミューン ソシエテ アノニム | Humanized anti-TDP-43 binding molecules and uses thereof | 
| WO2022043517A2              (en) | 2020-08-27 | 2022-03-03 | Cureab Gmbh | Anti-golph2 antibodies for macrophage and dendritic cell differentiation | 
| KR20230056766A              (en) | 2020-08-28 | 2023-04-27 | 제넨테크, 인크. | CRISPR/Cas9 multiple knockout of host cell proteins | 
| JP7158626B1              (en) | 2020-09-04 | 2022-10-21 | エフ.ホフマン-ラ ロシュ アーゲー | Antibodies that bind to VEGF-A and ANG2 and methods of use | 
| CA3194792A1              (en) | 2020-09-15 | 2022-03-24 | Bayer Aktiengesellschaft | Novel anti-a2ap antibodies and uses thereof | 
| CN116685351A              (en) | 2020-09-17 | 2023-09-01 | 基因泰克公司 | Results of EMPACTA: random, double-blind, placebo-controlled, multicenter study for assessing the efficacy and safety of tobrazumab in hospitalized patients with covd-19 pneumonia | 
| IL301763A              (en) | 2020-09-28 | 2023-05-01 | Angitia Biomedicines Ltd | Antisclerostin structures and their uses | 
| TW202446417A              (en) | 2020-10-05 | 2024-12-01 | 美商建南德克公司 | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| AR123855A1              (en) | 2020-10-20 | 2023-01-18 | Genentech Inc | PEG-CONJUGATED ANTI-MERTK ANTIBODIES AND METHODS OF USE | 
| WO2022084210A1              (en) | 2020-10-20 | 2022-04-28 | F. Hoffmann-La Roche Ag | Combination therapy of pd-1 axis binding antagonists and lrrk2 inhitibors | 
| WO2022084400A1              (en) | 2020-10-20 | 2022-04-28 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof | 
| WO2022093981A1              (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists | 
| US12351643B2              (en) | 2020-11-04 | 2025-07-08 | Genentech, Inc. | Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies | 
| IL302217A              (en) | 2020-11-04 | 2023-06-01 | Genentech Inc | Dosage for treatment with bispecific anti-CD20/anti-CD3 antibodies and anti-CD79B drug antibody conjugates | 
| WO2022098628A2              (en) | 2020-11-04 | 2022-05-12 | Genentech, Inc. | Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies | 
| WO2022101458A1              (en) | 2020-11-16 | 2022-05-19 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted cd40 agonists | 
| WO2022115865A2              (en) | 2020-11-25 | 2022-06-02 | Xilio Development, Inc. | Tumor-specific cleavable linkers | 
| TW202237638A              (en) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof | 
| TW202237639A              (en) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof | 
| WO2022132904A1              (en) | 2020-12-17 | 2022-06-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies targeting sars-cov-2 | 
| EP4274658A1              (en) | 2021-01-06 | 2023-11-15 | F. Hoffmann-La Roche AG | Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody | 
| JP2024504931A              (en) | 2021-01-12 | 2024-02-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Split antibodies that bind to cancer cells and target radionuclides to said cells | 
| EP4277668A1              (en) | 2021-01-13 | 2023-11-22 | F. Hoffmann-La Roche AG | Combination therapy | 
| WO2022162587A1              (en) | 2021-01-27 | 2022-08-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection | 
| WO2022162203A1              (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses | 
| CN117120084A              (en) | 2021-01-28 | 2023-11-24 | 维肯芬特有限责任公司 | Methods and means for modulating B cell mediated immune responses | 
| AU2022212599A1              (en) | 2021-01-28 | 2023-08-17 | Universität Ulm | Method and means for modulating b-cell mediated immune responses | 
| WO2022169872A1              (en) | 2021-02-03 | 2022-08-11 | Genentech, Inc. | Multispecific binding protein degrader platform and methods of use | 
| CN117642178A              (en) | 2021-02-09 | 2024-03-01 | 美国政府(由卫生和人类服务部的部长所代表) | Antibodies targeting coronavirus spike protein | 
| CN117396502A              (en) | 2021-02-09 | 2024-01-12 | 佐治亚大学研究基金会有限公司 | Human monoclonal antibodies to pneumococcal antigens | 
| US20240226295A9              (en) | 2021-02-15 | 2024-07-11 | Takeda Pharmaceutical Company Limited | Cell therapy compositions and methods for modulating tgf-b signaling | 
| PE20231503A1              (en) | 2021-02-26 | 2023-09-26 | Bayer Ag | IL-11 OR IL-11Ra INHIBITORS FOR USE IN THE TREATMENT OF ABNORMAL UTERINE BLEEDING | 
| WO2022187270A1              (en) | 2021-03-01 | 2022-09-09 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer | 
| JP2024508488A              (en) | 2021-03-01 | 2024-02-27 | エクシリオ デベロップメント, インコーポレイテッド | Combination of masked CTLA4 and PD1/PD-L1 antibodies to treat cancer | 
| EP4301418A1              (en) | 2021-03-03 | 2024-01-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates comprising an anti-bcma antibody | 
| EP4301472A1              (en) | 2021-03-05 | 2024-01-10 | Dynamicure Biotechnology LLC | Anti-vista constructs and uses thereof | 
| JP2024512377A              (en) | 2021-03-12 | 2024-03-19 | ジェネンテック, インコーポレイテッド | Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use | 
| JP2024511970A              (en) | 2021-03-15 | 2024-03-18 | ジェネンテック, インコーポレイテッド | Compositions and methods for the treatment of lupus nephritis | 
| WO2022197877A1              (en) | 2021-03-19 | 2022-09-22 | Genentech, Inc. | Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents | 
| TW202300648A              (en) | 2021-03-25 | 2023-01-01 | 美商當康生物科技有限公司 | Anti-igfbp7 constructs and uses thereof | 
| PE20240357A1              (en) | 2021-03-30 | 2024-02-27 | Bayer Ag | ANTI-SEMA3A ANTIBODIES AND USES THEREOF | 
| AR125344A1              (en) | 2021-04-15 | 2023-07-05 | Chugai Pharmaceutical Co Ltd | ANTI-C1S ANTIBODY | 
| KR20230173164A              (en) | 2021-04-19 | 2023-12-26 | 제넨테크, 인크. | modified mammalian cells | 
| CN117321078A              (en) | 2021-04-30 | 2023-12-29 | 豪夫迈·罗氏有限公司 | Administration for combination therapy with anti-CD 20/anti-CD 3 bispecific antibody and anti-CD 79B antibody drug conjugates | 
| WO2022241446A1              (en) | 2021-05-12 | 2022-11-17 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma | 
| WO2022241235A1              (en) | 2021-05-14 | 2022-11-17 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin | 
| BR112023023777A2              (en) | 2021-05-14 | 2024-01-30 | Genentech Inc | ISOLATED ANTIBODIES, PHARMACEUTICAL COMPOSITION, ISOLATED NUCLEIC ACID, ISOLATED VECTOR, ISOLATED HOST CELL, METHOD FOR PRODUCING AN ANTIBODY, METHOD FOR TREATING A CONDITION ASSOCIATED WITH LOSS OF TREM2 FUNCTION, METHOD FOR REDUCING STREM2 LEVELS AND USE OF AN ANTIBODY | 
| WO2022243261A1              (en) | 2021-05-19 | 2022-11-24 | F. Hoffmann-La Roche Ag | Agonistic cd40 antigen binding molecules targeting cea | 
| EP4341385A1              (en) | 2021-05-21 | 2024-03-27 | Genentech, Inc. | Modified cells for the production of a recombinant product of interest | 
| AR126009A1              (en) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | CD28 ANTIGEN-BINDING AGONIST MOLECULES THAT TARGET EPCAM | 
| TW202306994A              (en) | 2021-06-04 | 2023-02-16 | 日商中外製藥股份有限公司 | Anti-ddr2 antibodies and uses thereof | 
| IL308015A              (en) | 2021-06-09 | 2023-12-01 | Hoffmann La Roche | A combination of a specific BRAF inhibitor (paradox breaker) and a PD-1 spindle-binding antagonist for use in cancer treatment | 
| KR20240019831A              (en) | 2021-06-11 | 2024-02-14 | 제넨테크, 인크. | How to treat chronic obstructive pulmonary disease using ST2 antagonists | 
| WO2022266660A1              (en) | 2021-06-17 | 2022-12-22 | Amberstone Biosciences, Inc. | Anti-cd3 constructs and uses thereof | 
| WO2022263638A1              (en) | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection | 
| JP2024525188A              (en) | 2021-06-18 | 2024-07-10 | セリーニ バイオ インコーポレイテッド | Antibodies that bind to human fibrin or fibrinogen gamma C domain and methods of use - Patents.com | 
| PE20242297A1              (en) | 2021-06-25 | 2024-12-11 | Chugai Pharmaceutical Co Ltd | ANTI-CTLA-4 ANTIBODY | 
| CA3220353A1              (en) | 2021-06-25 | 2022-12-29 | Chugai Seiyaku Kabushiki Kaisha | Use of anti-ctla-4 antibody | 
| WO2023283611A1              (en) | 2021-07-08 | 2023-01-12 | Staidson Biopharma Inc. | Antibodies specifically recognizing tnfr2 and uses thereof | 
| EP4370545A1              (en) | 2021-07-12 | 2024-05-22 | Genentech, Inc. | Structures for reducing antibody-lipase binding | 
| WO2023288241A1              (en) | 2021-07-14 | 2023-01-19 | Genentech, Inc. | Anti-c-c motif chemokine receptor 8 (ccr8) antibodies and methods of use | 
| EP4371572A4              (en) | 2021-07-14 | 2025-08-06 | Staidson Beijing Biopharmaceuticals Co Ltd | ANTIBODIES WITH SPECIFIC RECOGNITION OF CD40 AND APPLICATION THEREOF | 
| WO2023004386A1              (en) | 2021-07-22 | 2023-01-26 | Genentech, Inc. | Brain targeting compositions and methods of use thereof | 
| KR20240036570A              (en) | 2021-07-22 | 2024-03-20 | 에프. 호프만-라 로슈 아게 | Heterodimeric Fc domain antibodies | 
| EP4380980A1              (en) | 2021-08-03 | 2024-06-12 | F. Hoffmann-La Roche AG | Bispecific antibodies and methods of use | 
| US20240336697A1              (en) | 2021-08-07 | 2024-10-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma | 
| WO2023019239A1              (en) | 2021-08-13 | 2023-02-16 | Genentech, Inc. | Dosing for anti-tryptase antibodies | 
| JP2024534067A              (en) | 2021-08-19 | 2024-09-18 | エフ. ホフマン-ラ ロシュ アーゲー | Multivalent anti-variant fc region antibodies and methods of use | 
| WO2023028501A1              (en) | 2021-08-23 | 2023-03-02 | Immunitas Therapeutics, Inc. | Anti-cd161 antibodies and uses thereof | 
| KR20240049296A              (en) | 2021-08-27 | 2024-04-16 | 제넨테크, 인크. | How to Treat Tauopathy | 
| WO2023034750A1              (en) | 2021-08-30 | 2023-03-09 | Genentech, Inc. | Anti-polyubiquitin multispecific antibodies | 
| US20240401239A1              (en) | 2021-09-17 | 2024-12-05 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies | 
| WO2023056403A1              (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists | 
| AU2022361184A1              (en) | 2021-10-08 | 2024-05-09 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing prefilled syringe formulation | 
| AU2022379952A1              (en) | 2021-11-05 | 2024-05-16 | Mab Biotec, Inc. | Monoclonal antibodies against carcinoembryonic antigens, and their uses | 
| EP4430072A1              (en) | 2021-11-10 | 2024-09-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof | 
| KR20240102971A              (en) | 2021-11-16 | 2024-07-03 | 제넨테크, 인크. | Method and composition for treating systemic lupus erythematosus (SLE) using mosunetuzumab | 
| EP4433167A1              (en) | 2021-11-16 | 2024-09-25 | AC Immune SA | Novel molecules for therapy and diagnosis | 
| CN118284625A              (en) | 2021-11-26 | 2024-07-02 | 豪夫迈·罗氏有限公司 | Combination therapy of anti-TYRP 1/anti-CD 3 bispecific antibodies and TYRP 1-specific antibodies | 
| EP4445911A1              (en) | 2021-12-06 | 2024-10-16 | Beijing SoloBio Genetechnology Co., Ltd. | Bispecific antibody that specifically binds to klebsiella pneumoniae o2 and o1 antigens, and composition | 
| AR127887A1              (en) | 2021-12-10 | 2024-03-06 | Hoffmann La Roche | ANTIBODIES THAT BIND CD3 AND PLAP | 
| CA3240585A1              (en) | 2021-12-17 | 2023-06-22 | Wenfeng Xu | Anti-ox40 antibodies, multispecific antibodies and methods of use | 
| EP4448579A1              (en) | 2021-12-17 | 2024-10-23 | Shanghai Henlius Biotech, Inc. | Anti-ox40 antibodies and methods of use | 
| CR20240246A              (en) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | AGONIST ANTI-LTBR ANTIBODIES AND BISPECIFIC ANTIBODIES THAT INCLUDE THEM | 
| CN118974083A              (en) | 2022-01-07 | 2024-11-15 | 强生企业创新公司 | Materials and Methods for IL-1β Binding Protein | 
| US20230322958A1              (en) | 2022-01-19 | 2023-10-12 | Genentech, Inc. | Anti-Notch2 Antibodies and Conjugates and Methods of Use | 
| WO2023154824A1              (en) | 2022-02-10 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that broadly target coronaviruses | 
| IL315043A              (en) | 2022-02-16 | 2024-10-01 | Ac Immune Sa | Humanized molecules that bind TDP-43 and uses thereof | 
| US20250145716A1              (en) | 2022-02-18 | 2025-05-08 | Rakuten Medical, Inc. | Anti- programmed death-ligand 1 (pd-l1) antibody molecules, encoding polynucleotides, and methods of use | 
| WO2023173026A1              (en) | 2022-03-10 | 2023-09-14 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof | 
| IL314211A              (en) | 2022-03-23 | 2024-09-01 | Genentech Inc | Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy | 
| WO2023179740A1              (en) | 2022-03-25 | 2023-09-28 | Shanghai Henlius Biotech , Inc. | Anti-msln antibodies and methods of use | 
| WO2023192827A1              (en) | 2022-03-26 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bispecific antibodies to hiv-1 env and their use | 
| WO2023186756A1              (en) | 2022-03-28 | 2023-10-05 | F. Hoffmann-La Roche Ag | Interferon gamma variants and antigen binding molecules comprising these | 
| US20250197483A1              (en) | 2022-03-28 | 2025-06-19 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 env and their use | 
| WO2023191816A1              (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| AU2023250038A1              (en) | 2022-04-08 | 2024-11-14 | Ac Immune Sa | Anti-tdp-43 binding molecules | 
| US20230406930A1              (en) | 2022-04-13 | 2023-12-21 | Genentech, Inc. | Pharmaceutical compositions of therapeutic proteins and methods of use | 
| EP4508081A1              (en) | 2022-04-13 | 2025-02-19 | F. Hoffmann-La Roche AG | Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use | 
| WO2023203177A1              (en) | 2022-04-20 | 2023-10-26 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof | 
| TW202406934A              (en) | 2022-05-03 | 2024-02-16 | 美商建南德克公司 | Anti-ly6e antibodies, immunoconjugates, and uses thereof | 
| EP4524158A1              (en) | 2022-05-09 | 2025-03-19 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibody that specifically recognizes gdf15 and use thereof | 
| AR129268A1              (en) | 2022-05-11 | 2024-08-07 | Hoffmann La Roche | ANTIBODY THAT BINDS TO VEGF-A AND IL6 AND METHODS OF USE | 
| IL316738A              (en) | 2022-05-11 | 2024-12-01 | Genentech Inc | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| WO2023235699A1              (en) | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof | 
| KR20250022049A              (en) | 2022-06-07 | 2025-02-14 | 제넨테크, 인크. | Method for determining the efficacy of a treatment for lung cancer comprising an anti-PD-L1 antagonist and an anti-TIGIT antagonist antibody | 
| WO2023237706A2              (en) | 2022-06-08 | 2023-12-14 | Institute For Research In Biomedicine (Irb) | Cross-specific antibodies, uses and methods for discovery thereof | 
| AU2023305619A1              (en) | 2022-07-13 | 2025-01-23 | F. Hoffmann-La Roche Ag | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| CN120322455A              (en) | 2022-07-19 | 2025-07-15 | 舒泰神(加州)生物科技有限公司 | Antibodies specifically recognizing B and T lymphocyte attenuator (BTLA) and their applications | 
| EP4558524A1              (en) | 2022-07-19 | 2025-05-28 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| TW202417504A              (en) | 2022-07-22 | 2024-05-01 | 美商建南德克公司 | Anti-steap1 antigen-binding molecules and uses thereof | 
| CN119604537A              (en) | 2022-07-22 | 2025-03-11 | 百时美施贵宝公司 | Antibodies that bind to human PAD4 and their uses | 
| EP4565329A1              (en) | 2022-08-01 | 2025-06-11 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Monoclonal antibodies that bind to the underside of influenza viral neuraminidase | 
| MA71684A              (en) | 2022-08-05 | 2025-05-30 | Janssen Biotech, Inc. | TRANSFERRIN RECEPTOR-BINDING PROTEINS FOR THE TREATMENT OF BRAIN TUMORS | 
| JP2025525969A              (en) | 2022-08-05 | 2025-08-07 | ヤンセン バイオテツク,インコーポレーテツド | CD98-binding constructs for treating brain tumors | 
| KR20250071294A              (en) | 2022-08-22 | 2025-05-21 | 압데라 테라퓨틱스 인크. | DLL3 binding molecules and uses thereof | 
| KR20250084921A              (en) | 2022-08-26 | 2025-06-11 | 주노 쎄러퓨티크스 인코퍼레이티드 | Antibodies and chimeric antigen receptors specific for Delta-like ligand 3 (DLL3) | 
| WO2024049949A1              (en) | 2022-09-01 | 2024-03-07 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer | 
| WO2024054822A1              (en) | 2022-09-07 | 2024-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Engineered sars-cov-2 antibodies with increased neutralization breadth | 
| CN120077071A              (en) | 2022-09-07 | 2025-05-30 | 当康生物技术有限责任公司 | Anti-VISTA constructs and uses thereof | 
| WO2024064826A1              (en) | 2022-09-22 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use | 
| EP4596580A1              (en) | 2022-09-27 | 2025-08-06 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibody for specifically recognizing light and use thereof | 
| WO2024068996A1              (en) | 2022-09-30 | 2024-04-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection | 
| TW202421664A              (en) | 2022-10-07 | 2024-06-01 | 美商建南德克公司 | Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies | 
| AU2023365967A1              (en) | 2022-10-20 | 2025-06-05 | Beijing Solobio Genetechnology Co., Ltd. | Antibody combination specifically binding to trail or fasl, and bispecific antibody | 
| WO2024091991A1              (en) | 2022-10-25 | 2024-05-02 | Genentech, Inc. | Therapeutic and diagnostic methods for multiple myeloma | 
| EP4611805A1              (en) | 2022-11-04 | 2025-09-10 | Gilead Sciences, Inc. | Anticancer therapies using anti-ccr8 antibody, chemo and immunotherapy combinations | 
| AU2023375342A1              (en) | 2022-11-08 | 2025-04-24 | F. Hoffmann-La Roche Ag | Compositions and methods of treating childhood onset idiopathic nephrotic syndrome | 
| EP4615580A1              (en) | 2022-11-09 | 2025-09-17 | CIS Biopharma AG | Anti-l1-cam antibodies and their uses for diagnostic and therapeutic applications | 
| WO2024100170A1              (en) | 2022-11-11 | 2024-05-16 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a*02/foxp3 | 
| WO2024108053A1              (en) | 2022-11-17 | 2024-05-23 | Sanofi | Ceacam5 antibody-drug conjugates and methods of use thereof | 
| AR131163A1              (en) | 2022-11-25 | 2025-02-19 | Chugai Pharmaceutical Co Ltd | METHODS FOR PRODUCING PROTEINS | 
| EP4631974A1              (en) | 2022-12-08 | 2025-10-15 | Nanjing Vazyme Biotech Co., Ltd. | Antibody specifically binding to rsv | 
| WO2024137381A1              (en) | 2022-12-19 | 2024-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies for treating sars-cov-2 infection | 
| TW202432607A              (en) | 2023-01-18 | 2024-08-16 | 美商建南德克公司 | Multispecific antibodies and uses thereof | 
| CN120569410A              (en) | 2023-01-25 | 2025-08-29 | 豪夫迈·罗氏有限公司 | Antibodies that bind to CSF1R and CD3 | 
| WO2024184494A1              (en) | 2023-03-08 | 2024-09-12 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof | 
| WO2024191785A1              (en) | 2023-03-10 | 2024-09-19 | Genentech, Inc. | Fusions with proteases and uses thereof | 
| EP4428158A1              (en) | 2023-03-10 | 2024-09-11 | Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. | Lung cancer targeting human antibodies and therapeutic uses thereof | 
| EP4428159A1              (en) | 2023-03-10 | 2024-09-11 | Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. | Melanoma targeting human antibodies and therapeutic uses thereof | 
| WO2024188965A1              (en) | 2023-03-13 | 2024-09-19 | F. Hoffmann-La Roche Ag | Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody | 
| US20240327522A1              (en) | 2023-03-31 | 2024-10-03 | Genentech, Inc. | Anti-alpha v beta 8 integrin antibodies and methods of use | 
| WO2024211235A1              (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof | 
| WO2024211234A1              (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof | 
| WO2024211236A2              (en) | 2023-04-05 | 2024-10-10 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof | 
| WO2024212827A1              (en) | 2023-04-12 | 2024-10-17 | Shanghai Kangabio Co., Limited | Multifunctional molecules comprising masked interleukin 12 and methods of use | 
| WO2024220546A2              (en) | 2023-04-17 | 2024-10-24 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates | 
| WO2024233341A1              (en) | 2023-05-05 | 2024-11-14 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies | 
| WO2024231320A1              (en) | 2023-05-08 | 2024-11-14 | F. Hoffmann-La Roche Ag | Targeted interferon alpha fusion proteins and methods of use | 
| WO2024233646A1              (en) | 2023-05-10 | 2024-11-14 | Genentech, Inc. | Methods and compositions for treating cancer | 
| TW202509065A              (en) | 2023-05-16 | 2025-03-01 | 瑞士商赫孚孟拉羅股份公司 | Pd-1-regulated il-2 immunoconjugates and uses thereof | 
| WO2024243355A1              (en) | 2023-05-24 | 2024-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that target the rh5 complex of blood-stage plasmodium falciparum | 
| WO2024246086A1              (en) | 2023-06-01 | 2024-12-05 | F. Hoffmann-La Roche Ag | Immunostimulatory antigen binding molecules that specifically bind to bcma | 
| TW202504918A              (en) | 2023-06-01 | 2025-02-01 | 瑞士商赫孚孟拉羅股份公司 | Bispecific antibodies targeting bcma and cd28 | 
| WO2024254455A1              (en) | 2023-06-08 | 2024-12-12 | Genentech, Inc. | Macrophage signatures for diagnostic and therapeutic methods for lymphoma | 
| WO2024261013A1              (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists | 
| WO2024263761A1              (en) | 2023-06-22 | 2024-12-26 | Genentech, Inc. | Antibodies and uses thereof | 
| TW202504929A              (en) | 2023-06-22 | 2025-02-01 | 美商建南德克公司 | Methods and compositions for cancer treatment | 
| WO2025014896A1              (en) | 2023-07-07 | 2025-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Humanized 40h3 antibody | 
| WO2025024233A1              (en) | 2023-07-21 | 2025-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bispecific antibodies that broadly target coronaviruses | 
| WO2025024265A1              (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators | 
| WO2025021790A2              (en) | 2023-07-24 | 2025-01-30 | F. Hoffmann-La Roche Ag | Multispecific antibodies | 
| WO2025021838A1              (en) | 2023-07-26 | 2025-01-30 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 | 
| WO2025034806A1              (en) | 2023-08-08 | 2025-02-13 | Wisconsin Alumni Research Foundation | Single-domain antibodies and variants thereof against fibroblast activation protein | 
| WO2025032070A1              (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Anti-a-beta protein antibodies, methods and uses thereof | 
| WO2025032071A1              (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof | 
| WO2025032069A1              (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof | 
| WO2025038492A1              (en) | 2023-08-11 | 2025-02-20 | Abalytics Oncology, Inc. | Anti-ctla-4 antibodies and related binding molecules and methods and uses thereof | 
| WO2025045251A2              (en) | 2023-09-03 | 2025-03-06 | Kira Pharmaceuticals (Us) Llc | Multispecific constructs comprising anti-factor d moiety | 
| WO2025064539A1              (en) | 2023-09-19 | 2025-03-27 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Herv-e antibodies and methods of their use | 
| TW202517673A              (en) | 2023-09-25 | 2025-05-01 | 瑞士商赫孚孟拉羅股份公司 | Antibody that binds to c3bbb | 
| EP4537907A1              (en) | 2023-10-10 | 2025-04-16 | Enthera S.r.l. | Cd248 inhibitors and uses thereof | 
| WO2025085489A1              (en) | 2023-10-17 | 2025-04-24 | Bristol-Myers Squibb Company | Gspt1-degrading compounds, anti-cd33 antibodies and antibody-drug conjugates and uses thereof | 
| TW202517674A              (en) | 2023-10-19 | 2025-05-01 | 德商拜耳廠股份有限公司 | Anti-gpc3 antibodies and radioconjugates thereof | 
| WO2025099120A1              (en) | 2023-11-09 | 2025-05-15 | F. Hoffmann-La Roche Ag | Multispecific antibodies with conditional activity | 
| WO2025106427A1              (en) | 2023-11-14 | 2025-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing and protective monoclonal antibodies against respiratory syncytial virus (rsv) | 
| WO2025106474A1              (en) | 2023-11-14 | 2025-05-22 | Genentech, Inc. | Therapeutic and diagnostic methods for treating cancer with anti-fcrh5/anti-cd3 bispecific antibodies | 
| WO2025111402A1              (en) | 2023-11-21 | 2025-05-30 | Board Of Regents Of The University Of Nebraska | Anti-amyloid beta antibodies and related compositions and methods thereof | 
| WO2025117384A1              (en) | 2023-12-01 | 2025-06-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing influenza hemagglutinin stem-directed antibodies | 
| WO2025125118A1              (en) | 2023-12-11 | 2025-06-19 | F. Hoffmann-La Roche Ag | Protease activatable fc domain binding molecules | 
| WO2025125386A1              (en) | 2023-12-14 | 2025-06-19 | F. Hoffmann-La Roche Ag | Antibodies that bind to folr1 and methods of use | 
| US20250230251A1              (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods | 
| WO2025137523A2              (en) | 2023-12-20 | 2025-06-26 | Apogee Therapeutics, Inc. | Pharmaceutical formulations of antibodies that bind interleukin 13 | 
| WO2025137410A1              (en) | 2023-12-20 | 2025-06-26 | Apogee Therapeutics, Inc. | Pharmaceutical compositions of anti-il-13 antibodies with and without c-terminal lysine | 
| WO2025132503A1              (en) | 2023-12-20 | 2025-06-26 | F. Hoffmann-La Roche Ag | Antibodies binding to ceacam5 | 
| WO2025133290A1              (en) | 2023-12-21 | 2025-06-26 | Temper Bio | Protein for immune regulation | 
| WO2025137284A2              (en) | 2023-12-21 | 2025-06-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing antibodies against sars-cov-2 and sars-cov variants | 
| WO2025133042A2              (en) | 2023-12-22 | 2025-06-26 | F. Hoffmann-La Roche Ag | Activatable fusion proteins and methods of use | 
| WO2025149633A1              (en) | 2024-01-12 | 2025-07-17 | Laigo Bio B.V. | Bispecific antigen binding proteins | 
| WO2025174974A1              (en) | 2024-02-14 | 2025-08-21 | Bristol-Myers Squibb Company | Anti-cd33 antibodies and uses thereof | 
| WO2025179281A1              (en) | 2024-02-23 | 2025-08-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of cardiovascular disease with antxr1 antibodies | 
| WO2025184416A1              (en) | 2024-02-27 | 2025-09-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single-domain antibodies and bispecific antibodies against hiv-1 and their use | 
| WO2025184421A1              (en) | 2024-02-28 | 2025-09-04 | Juno Therapeutics, Inc. | Chimeric antigen receptors and antibodies specific for delta-like ligand 3 (dll3) and related methods | 
| WO2025181189A1              (en) | 2024-03-01 | 2025-09-04 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 | 
| WO2025199352A2              (en) | 2024-03-20 | 2025-09-25 | Juno Therapeutics, Inc. | Antibodies specific for solute carrier family 34 member 2 (slc34a2) | 
| WO2025196639A1              (en) | 2024-03-21 | 2025-09-25 | Seagen Inc. | Cd25 antibodies, antibody-drug conjugates, and uses thereof |