Movatterモバイル変換

[0]ホーム
URL:

GB856409A - Improvements in and relating to a new pyridazine derivative and its process of preparation - Google Patents

Improvements in and relating to a new pyridazine derivative and its process of preparation

Info

Publication number
GB856409A
GB856409AGB25444/59AGB2544459AGB856409AGB 856409 AGB856409 AGB 856409AGB 25444/59 AGB25444/59 AGB 25444/59AGB 2544459 AGB2544459 AGB 2544459AGB 856409 AGB856409 AGB 856409A
Authority
GB
United Kingdom
Prior art keywords
acid
preparation
pyridazone
halogeno
pyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25444/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHIME ET ATOMISTIQUE
Original Assignee
CHIME ET ATOMISTIQUE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHIME ET ATOMISTIQUEfiledCriticalCHIME ET ATOMISTIQUE
Publication of GB856409ApublicationCriticalpatent/GB856409A/en
Expiredlegal-statusCriticalCurrent

Links

Classifications

Landscapes

Abstract

The invention comprises 3-hydrazino-pyridazine-6-carboxamide, and acid addition salts thereof ; and the preparation thereof by reacting a 3-halogeno-pyridazine-6-carboxamide with hydrazine. The process is advantageouly conducted by refluxing the halogen compound with hydrazine hydrate in an anhydrous organic solvent such as ethanol. This process may be combined with the preparation of the 3-halogenopyridazine-6-carboxamide by the following sequence of reactions : levulinic acid is condensed with hydrazine to form 6-methyl-3-pyridazinone, this is halogenated, e.g. with bromine in acetic acid, to a 6-methyl-4-halogeno-3-pyridazinone, this is dehydrohalogenated with alkali, e.g. KOH, to 6-methyl-3-pyridazone, this is oxidized, e.g. with bichromate and sulphuric acid, to 3-pyridazone-6-carboxylic acid, this is esterified, e.g. to an alkyl 3-pyridazone-6-carboxylate with an alkanol, this is treating with a halogenating agent, e.g. phosphorus oxychloride, to give, for example, an alkyl 3-halogeno-pyridazine-6-carboxylate, and this is treated with ammonia to give the required starting material. Acid-addition salts referred to are the tartrate, maleate, citrate and sulphate.
GB25444/59A1958-07-261959-07-24Improvements in and relating to a new pyridazine derivative and its process of preparationExpiredGB856409A (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
FR856409X1958-07-26

Publications (1)

Publication NumberPublication Date
GB856409Atrue GB856409A (en)1960-12-14

Family

ID=9328853

Family Applications (1)

Application NumberTitlePriority DateFiling Date
GB25444/59AExpiredGB856409A (en)1958-07-261959-07-24Improvements in and relating to a new pyridazine derivative and its process of preparation

Country Status (1)

CountryLink
GB (1)GB856409A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2001007416A1 (en)*1999-07-282001-02-01Lonza AgMethod of producing pyridazine carboxylic acid derivatives
WO2004017964A1 (en)2002-08-192004-03-04Pfizer Products Inc.Combination therapy for hyperproliferative diseases
WO2007062314A2 (en)2005-11-232007-05-31Bristol-Myers Squibb CompanyHeterocyclic cetp inhibitors
WO2008070496A2 (en)2006-12-012008-06-12Bristol-Myers Squibb CompanyN- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2392567A1 (en)2005-10-212011-12-07Bristol-Myers Squibb CompanyBenzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en)2013-04-172014-10-23Pfizer Inc.N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)2014-10-082016-04-14Pfizer Inc.Substituted amide compounds
WO2020150473A2 (en)2019-01-182020-07-23Dogma Therapeutics, Inc.Pcsk9 inhibitors and methods of use thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2001007416A1 (en)*1999-07-282001-02-01Lonza AgMethod of producing pyridazine carboxylic acid derivatives
WO2004017964A1 (en)2002-08-192004-03-04Pfizer Products Inc.Combination therapy for hyperproliferative diseases
EP2392567A1 (en)2005-10-212011-12-07Bristol-Myers Squibb CompanyBenzothiazine derivatives and their use as lxr modulators
WO2007062314A2 (en)2005-11-232007-05-31Bristol-Myers Squibb CompanyHeterocyclic cetp inhibitors
WO2008070496A2 (en)2006-12-012008-06-12Bristol-Myers Squibb CompanyN- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2014170786A1 (en)2013-04-172014-10-23Pfizer Inc.N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)2014-10-082016-04-14Pfizer Inc.Substituted amide compounds
WO2020150473A2 (en)2019-01-182020-07-23Dogma Therapeutics, Inc.Pcsk9 inhibitors and methods of use thereof
EP4470609A2 (en)2019-01-182024-12-04Astrazeneca ABPcsk9 inhibitors and methods of use thereof

Similar Documents

PublicationPublication DateTitle
GB856409A (en)Improvements in and relating to a new pyridazine derivative and its process of preparation
GB951107A (en)Improvements relating to a-nor-steroid compounds
GB939287A (en)New morphinone and codeinone derivatives and process for preparing the same
GB1100714A (en)3-deoxy-ribofuranosyl derivatives
GB971608A (en)17ª‡-methyl steroids and their production and use
GB785047A (en)Anhydrotetracycline compounds
GB970481A (en)Improvements in or relating to the bromination of steroid compounds
MX3409E (en) PROCEDURE FOR OBTAINING PIRIDINSULFONAMIDE DERIVATIVES
GB911804A (en)6ª--fluoro-21-methyl-í~-pregnadien-17ª--ol-3,20-dione intermediate therefor and preparation thereof
GB939510A (en)Process for the manufacture of pregnadienes
ES298219A1 (en)A procedure for preparing new steroid compounds (Machine-translation by Google Translate, not legally binding)
GB890472A (en)New steroid compounds, and processes for their preparation
GB798846A (en)N-picolinoyl-phthalic acid hydrazide
GB1011116A (en)Process of producing a 1-halo-1-nitroalkane, and 1-halo-1-nitroalkanes produced by the process
GB672164A (en)A process for the manufacture of pentaenes
GB937879A (en)New pyrazole-carboxylic acid hydrazides
GB1491649A (en)Process for the preparation of bromoacetic acid and esters thereof
GB430282A (en)The manufacture of new alkylated 5:5-phenylethyl-hydantoins
GB983606A (en)Improvements in or relating to processes for the production of steroid compounds
GB952922A (en)Preparation of substituted 3h-1,4-benzodiazepine 4-oxides
GB922315A (en)New compounds useful in steroid synthesis and processes for the preparation thereof
GB805497A (en)Steroid intermediates for the preparation of adreno-cortical hormones
GB669220A (en)Manufacture of 4-nitro-1-aminonaphthalene-5-sulphonic acid
GB969513A (en)Improvements in or relating to processes for the fluorination of steroid compounds
GB899996A (en)New steroid compound and processes
[8]ページ先頭
©2009-2025 Movatter.jp