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GB643853A - Medicinal capsules and process of manufacture - Google Patents

Medicinal capsules and process of manufacture

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Publication number
GB643853A
GB643853AGB308/47AGB30847AGB643853AGB 643853 AGB643853 AGB 643853AGB 308/47 AGB308/47 AGB 308/47AGB 30847 AGB30847 AGB 30847AGB 643853 AGB643853 AGB 643853A
Authority
GB
United Kingdom
Prior art keywords
cellulose
capsules
per cent
glycerol
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB308/47A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and CofiledCriticalEli Lilly and Co
Publication of GB643853ApublicationCriticalpatent/GB643853A/en
Expiredlegal-statusCriticalCurrent

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Abstract

A thermo-gelled film of a water-soluble methyl cellulose having a methoxyl content of 25 to 35 per cent and an intrinsic viscosity (based on a 2 per cent solution in distilled water at 20 DEG C.) of 7 to 15 centipoises, is used in the formation of a telescoping medicinal capsule. A methoxy content of 30 per cent and a viscosity of 9 centipoises is preferred. Flexibility is improved and capsules suitable for enclosing hygroscopic medicaments are made by incorporating plasticizers such as invert sugar, sorbitol, mannitol, sucrose, dextrose, monacetin, lactose, triethyl phosphate, glycerol; monoethers of glycerol such as glycerol a -methyl ethers, a - and b -glucoheptonic acid and/or their lactones and lower alkyl and glycol esters, glucono g -lactone, g -valerolactone; a -amino acids, e.g. glycine, ethyl glycinate; amines such as monoethanolamine and triethanolamine; glycols such as propylene glycol, triethylene glycol, 2-ethyl-1,3-hexanediol, 1,3-butylene glycol; glucosides such as a -methyl glucoside; acetopropanol, amides such as acetamide and propionamide. Further there may be present: (a) electrolytes, e.g. benzene sulphonic acid, toluene sulphonic acid and citric acid; (b) colouring materials such as edible dyes of animal or vegetable origin, e.g. carmine, cudbear and caramel, or synthetic dyes, e.g. amaranth, brilliant blue F.C.F., eosin, erythrosine, guinea green certified, orange I, ponceau 3R, sunset yellow F.C.F., and tartrazine; (c) substances rendering the capsules opaque, e.g. charcoal and titanium dioxide; (d) gums, e.g. acacia; (e) wetting agents, e.g. sodium dioctyl sulphosuccinate; (f) non-thermogelling cellulose derivatives, e.g. water-soluble hydroxy ethyl cellulose; (g) Carbowax-a polyethylene glycol. The capsules are formed by dipping highly-polished, stainless steel pins, maintained at, say, 65 DEG C., into a bubble-free aqueous solution of methyl cellulose of suitable viscosity, preferably maintained at 18 DEG C., and gelling should occur within 35 seconds of such contact. The temperature of the pins may be varied over, say, 40 DEG to 80 DEG C., depending upon the size of the capsules and the viscosity of the methyl cellulose employed. Before dipping, the pins are lubricated with, e.g. a mixture of equal parts of anhydrous lanolin and soft soap containing 0.1 per cent by weight of chromium trioxide. After dipping, the coated pins are rotated to facilitate even coating and dried in a kiln through which a current of air is passed, the temperature being maintained at 40 DEG C. for 30 minutes and then slowly raised to 60 DEG C. over a further 15 minutes, such drying preventing brittleness. Infra-red radiation may be used in the drying operation. The Specification as open to inspection under Sect. 91 disclosed that any water-soluble thermogelling etherified cellulose derivative may be used, e.g. ethyl substituted ethers and p methylated cellulose ethers of glycollic acid. This subject-matter does not appear in the Specification as accepted.ALSO:A telescoping medicinal capsule is formed of a thermo-gelled film of a water-soluble methyl cellulose having a methoxy content of 25 to 35 per cent and an intrinsic viscosity (2 per cent solution in distilled water at 20 DEG C) of 7 to 15 centipoises. A methoxy content of 30 per cent and viscosity of 9 centipoises is preferred. Flexibility is improved and capsules suitable for enclosing hydroscopic medicaments are made by incorporating plasticizers such as invert sugar, sorbitol, mannitol, sucrose, dextrose, lactose, monacitin, triethyl phosphate, glycerol; monoethers of glycerol such as glycerol a - methyl ether; a - and b - gluco heptonic acid and/or their lactones and lower alkyl and glycol esters, glucono d -lactone, n -valerolactone; a -amino acids, e.g. glycine, ethyl glycinate; amines such as mono- and tri-ethanolamines; glycols such as propylene glycol, triethylene glycol, 2-ethyl-1,3 hexane diol, 1,3-butylene glycol; glycosides such as a -methyl glucoside, aceto-propanol; amides such as acetamide and propionamide. The capsule wall material may also contain (a) electrolytes, e.g. benzene sulphonic acid, toluene sulphonic acid and citric acid; (b) colouring materials such as edible of animal or vegetable origin, e.g. carmine, cudbear and caramel or synthetic dyes, e.g. amaranth, brilliant blue F.C.F., losin, erythrosine, guinea green certified, orange I, porceau 3R, sunset yellow F.C.F. and tartrazine; (c) substances rendering the capsule opaque, e.g. charcoal and titanium dioxide; (d) gums, e.g. acacia; (e) wetting agents, e.g. sodium dioctyl sulphosuccinate; (f) non-thermo-gelling cellulose derivatives, e.g. water soluble hydroxyethyl cellulose; (g) carbowax-a polyethylene glycol. The capsules are formed by dipping highly polished, stainless steel pins, maintained at say 65 DEG C, into a bubble-free aqueous solution of methyl cellulose of suitable viscosity preferably maintained at 18 DEG C (see Group IVa). The Specification as open to inspection under Sect. 91 comprises capsules having as an essential ingredient any water-soluble thermo-gelling etherified cellulose derivative, e.g. ethyl substituted ethers and methylated cellulose ethers of glycollic acid. This subject-matter does not appear in the Specification as accepted.
GB308/47A1946-04-131947-01-03Medicinal capsules and process of manufactureExpiredGB643853A (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
US643853XA1946-04-131946-04-13

Publications (1)

Publication NumberPublication Date
GB643853Atrue GB643853A (en)1950-09-27

Family

ID=22055582

Family Applications (1)

Application NumberTitlePriority DateFiling Date
GB308/47AExpiredGB643853A (en)1946-04-131947-01-03Medicinal capsules and process of manufacture

Country Status (1)

CountryLink
GB (1)GB643853A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
DE1617432B1 (en)*1965-09-071972-05-31Dow Chemical Co Process for the production of medical capsules from a solution of a cellulose ether with low viscosity
EP0180287A3 (en)*1984-10-231987-04-29Shin-Etsu Chemical Co., Ltd.A cellulose ether composition and a hard medicinal capsule prepared therefrom
FR2757173A1 (en)*1996-12-171998-06-19Warner Lambert Co POLYMERIC COMPOSITIONS OF NON-ANIMAL ORIGIN FOR FILM FORMATION
EP1093845A3 (en)*1999-10-202001-05-30Henkel Kommanditgesellschaft auf AktienMicrocapsules
WO2002016020A1 (en)*2000-08-222002-02-28Henkel Kommanditgesellschaft Auf AktienMicrocapsules
EP1547583A3 (en)*2003-12-252005-11-16Shin-Etsu Chemical Co., Ltd.Capsule comprising low-substituted cellulose ether
CN100420487C (en)*2007-04-242008-09-24辽宁大生药业有限公司 A kind of soft capsule skin composition
WO2009006378A1 (en)*2007-07-052009-01-08Dow Global Technologies Inc.Dissolvable film with detection functionality
RU2349311C1 (en)*2007-08-022009-03-20Михаил Владимирович КутушовApplication of naphthalene derivative as oncological disease treatment medicine
US8547524B2 (en)2006-03-212013-10-01Lau Consulting, Inc.Active mask variable data integral imaging system and method
WO2013164122A1 (en)*2012-05-022013-11-07Capsugel France SASAqueous dispersions of controlled release polymers and shells and capsules thereof
US10813886B2 (en)2013-11-042020-10-27Capsugel Belgium NvMethods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole

Cited By (20)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
DE1617432B1 (en)*1965-09-071972-05-31Dow Chemical Co Process for the production of medical capsules from a solution of a cellulose ether with low viscosity
EP0180287A3 (en)*1984-10-231987-04-29Shin-Etsu Chemical Co., Ltd.A cellulose ether composition and a hard medicinal capsule prepared therefrom
CN1088075C (en)*1996-12-172002-07-24沃尼尔·朗伯公司Polymer film composition for capsules
FR2757173A1 (en)*1996-12-171998-06-19Warner Lambert Co POLYMERIC COMPOSITIONS OF NON-ANIMAL ORIGIN FOR FILM FORMATION
WO1998027151A1 (en)*1996-12-171998-06-25Warner-Lambert CompanyPolymer film compositions for capsules
EP1057862A3 (en)*1996-12-172001-02-07Warner-Lambert CompanyPolymer film compositions for capsules
EP1093845A3 (en)*1999-10-202001-05-30Henkel Kommanditgesellschaft auf AktienMicrocapsules
WO2002016020A1 (en)*2000-08-222002-02-28Henkel Kommanditgesellschaft Auf AktienMicrocapsules
EP1547583A3 (en)*2003-12-252005-11-16Shin-Etsu Chemical Co., Ltd.Capsule comprising low-substituted cellulose ether
US8029821B2 (en)2003-12-252011-10-04Shin-Etsu Chemical Co. Ltd.Capsule comprising low-substituted cellulose ether and method for preparing the same
US8784883B2 (en)2003-12-252014-07-22Shin-Etsu Chemical Co., Ltd.Capsule comprising low-substituted cellulose ether and method for preparing the same
US8547524B2 (en)2006-03-212013-10-01Lau Consulting, Inc.Active mask variable data integral imaging system and method
CN100420487C (en)*2007-04-242008-09-24辽宁大生药业有限公司 A kind of soft capsule skin composition
WO2009006378A1 (en)*2007-07-052009-01-08Dow Global Technologies Inc.Dissolvable film with detection functionality
JP2010532421A (en)*2007-07-052010-10-07ダウ グローバル テクノロジーズ インコーポレイティド Soluble film with detection function
RU2349311C1 (en)*2007-08-022009-03-20Михаил Владимирович КутушовApplication of naphthalene derivative as oncological disease treatment medicine
WO2013164122A1 (en)*2012-05-022013-11-07Capsugel France SASAqueous dispersions of controlled release polymers and shells and capsules thereof
EP3446713A3 (en)*2012-05-022019-05-15Capsugel Belgium NVAqueous dispersions of controlled release polymers and shells and capsules thereof
US10525010B2 (en)2012-05-022020-01-07Capsugel Belgium NvAqueous dispersions of controlled release polymers and shells and capsules thereof
US10813886B2 (en)2013-11-042020-10-27Capsugel Belgium NvMethods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole

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