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GB2539857A - Devices and methods for purification, detection and use of biological cells - Google Patents

Devices and methods for purification, detection and use of biological cellsDownload PDF

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Publication number
GB2539857A
GB2539857AGB1618356.8AGB201618356AGB2539857AGB 2539857 AGB2539857 AGB 2539857AGB 201618356 AGB201618356 AGB 201618356AGB 2539857 AGB2539857 AGB 2539857A
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United Kingdom
Prior art keywords
column
cells
methods
devices
purification
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GB1618356.8A
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GB201618356D0 (en
GB2539857B (en
Inventor
T Gjerde Douglas
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Priority to GB2102155.5ApriorityCriticalpatent/GB2587768B/en
Publication of GB201618356D0publicationCriticalpatent/GB201618356D0/en
Publication of GB2539857ApublicationCriticalpatent/GB2539857A/en
Application grantedgrantedCritical
Publication of GB2539857BpublicationCriticalpatent/GB2539857B/en
Activelegal-statusCriticalCurrent
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Abstract

This invention relates to devices and methods for purifying, detecting and using biological cells. A variety of cell types including viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a column, including a pipette tip column. Methods of the invention can aid research, diagnosis and treatment of cancer. Purified viable cells can be detected on the column or eluted from the column and detected. Cells on a column can be used as a stationary phase for liquid chromatography. Cells may be removed, recovered and analyzed.
GB1618356.8A2014-04-032015-04-03Devices and methods for purification, detection and use of biological cellsActiveGB2539857B (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
GB2102155.5AGB2587768B (en)2014-04-032015-04-03Devices and methods for purification, detection and use of biological cells

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
US201461974950P2014-04-032014-04-03
US201462061636P2014-10-082014-10-08
PCT/US2015/024374WO2015154048A1 (en)2014-04-032015-04-03Devices and methods for purification, detection and use of biological cells

Publications (3)

Publication NumberPublication Date
GB201618356D0 GB201618356D0 (en)2016-12-14
GB2539857Atrue GB2539857A (en)2016-12-28
GB2539857B GB2539857B (en)2021-03-31

Family

ID=54241352

Family Applications (2)

Application NumberTitlePriority DateFiling Date
GB1618356.8AActiveGB2539857B (en)2014-04-032015-04-03Devices and methods for purification, detection and use of biological cells
GB2102155.5AActiveGB2587768B (en)2014-04-032015-04-03Devices and methods for purification, detection and use of biological cells

Family Applications After (1)

Application NumberTitlePriority DateFiling Date
GB2102155.5AActiveGB2587768B (en)2014-04-032015-04-03Devices and methods for purification, detection and use of biological cells

Country Status (3)

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EP (1)EP3126027A4 (en)
GB (2)GB2539857B (en)
WO (1)WO2015154048A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
GB201521784D0 (en)2015-12-102016-01-27Univ BirminghamCell purification
SG11202103572VA (en)*2018-10-092021-05-28C Technologies IncMass control system for chromatography
GB2616583B (en)*2020-12-212025-08-13T Gjerde DouglasPiston Pump Syringe Column Method and Device

Citations (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5215927A (en)*1986-01-301993-06-01Fred Hutchinson Cancer Research CenterMethod for immunoselection of cells using avidin and biotin
US6362008B1 (en)*1997-12-232002-03-26Barbara A. KohnGeneric signalling mechanism for detection of analytes
US20040121382A1 (en)*2002-12-182004-06-24Linda LiuMultiplexed immunohistochemical assays using molecular tags
WO2013124474A2 (en)*2012-02-232013-08-29Stage Cell Therapeutics GmbhChromatographic isolation of cells and other complex biological materials
WO2014001326A1 (en)*2012-06-272014-01-03F. Hoffmann-La Roche AgMethod for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof
US20140234890A1 (en)*2013-02-152014-08-21Douglas T. GjerdeMethods for Purifying Biological Cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5773224A (en)*1996-02-121998-06-30Grandics; PeterImmunoselection system for cell elution
US20090081084A1 (en)*2003-07-142009-03-26Gjerde Douglas TLow Dead Volume Extraction Column Device
US8377715B2 (en)*2003-07-142013-02-19Phynexus, Inc.Method and device for sample preparation
US20100140173A1 (en)*2004-12-032010-06-10Chris SuhMethod and Device for Gravity Flow Chromatography
EP2956541B1 (en)*2013-02-152018-12-26Douglas T. GjerdeDevices and methods for purification of biological cells

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5215927A (en)*1986-01-301993-06-01Fred Hutchinson Cancer Research CenterMethod for immunoselection of cells using avidin and biotin
US6362008B1 (en)*1997-12-232002-03-26Barbara A. KohnGeneric signalling mechanism for detection of analytes
US20040121382A1 (en)*2002-12-182004-06-24Linda LiuMultiplexed immunohistochemical assays using molecular tags
WO2013124474A2 (en)*2012-02-232013-08-29Stage Cell Therapeutics GmbhChromatographic isolation of cells and other complex biological materials
WO2014001326A1 (en)*2012-06-272014-01-03F. Hoffmann-La Roche AgMethod for the selection and production of tailor-made, selective and multi-specific therapeutic molecules comprising at least two different targeting entities and uses thereof
US20140234890A1 (en)*2013-02-152014-08-21Douglas T. GjerdeMethods for Purifying Biological Cells

Also Published As

Publication numberPublication date
GB2587768B (en)2021-08-18
WO2015154048A1 (en)2015-10-08
GB2587768A (en)2021-04-07
GB202102155D0 (en)2021-03-31
EP3126027A1 (en)2017-02-08
EP3126027A4 (en)2017-11-01
GB201618356D0 (en)2016-12-14
GB2539857B (en)2021-03-31

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