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GB1526410A - 4-(e)-and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid their derivatives and preparations containing same - Google Patents

4-(e)-and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid their derivatives and preparations containing same

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Publication number
GB1526410A
GB1526410AGB49370/75AGB4937075AGB1526410AGB 1526410 AGB1526410 AGB 1526410AGB 49370/75 AGB49370/75 AGB 49370/75AGB 4937075 AGB4937075 AGB 4937075AGB 1526410 AGB1526410 AGB 1526410A
Authority
GB
United Kingdom
Prior art keywords
acid
tetraenecarboxylic
nona
cyclohexen
trimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49370/75A
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BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SEfiledCriticalBASF SE
Publication of GB1526410ApublicationCriticalpatent/GB1526410A/en
Expiredlegal-statusCriticalCurrent

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Abstract

11-cis-13-Desmethyl vitamin A acid and all-trans-13-desmethyl vitamin A acid are prepared by reacting a compound of the accompanying formula III, in which X<(-)> denotes an organic or inorganic acid radical, with a compound of the accompanying formula IV, in which R<3> denotes hydrogen, alkyl having 1 to 4 carbon atoms, ammonium or an alkali metal ion, in an inert solvent at temperatures from -20 to +30 DEG C in the presence of a base, separating the isomer mixture obtained and hydrolysing the esters obtained before or after separation. The acids thus obtained can be converted on the way into the corresponding esters, amides, azides, hydrazides or anhydrides by means of the acid chlorides. The compounds obtainable according to the invention are distinguished by a cell regeneration-promoting action and are particularly suitable for the treatment of skin diseases and skin injuries.
GB49370/75A1974-12-031975-12-024-(e)-and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid their derivatives and preparations containing sameExpiredGB1526410A (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
DE19742456959DE2456959A1 (en)1974-12-031974-12-03 4- (E) - AND 4- (Z) -7-METHYL-9- (2,6,6TRIMETHYL-1-CYCLOHEXEN-1-YL) -NONA-2,4,6,8TETRAEN CARBONIC ACID, ITS DERIVATIVES AND CONTAINING THEM PREPARATIONS

Publications (1)

Publication NumberPublication Date
GB1526410Atrue GB1526410A (en)1978-09-27

Family

ID=5932289

Family Applications (1)

Application NumberTitlePriority DateFiling Date
GB49370/75AExpiredGB1526410A (en)1974-12-031975-12-024-(e)-and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid their derivatives and preparations containing same

Country Status (7)

CountryLink
BE (1)BE835902A (en)
CH (1)CH619211A5 (en)
DE (1)DE2456959A1 (en)
FR (1)FR2293193A1 (en)
GB (1)GB1526410A (en)
SE (1)SE413139B (en)
ZA (1)ZA757545B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5780676A (en)*1992-04-221998-07-14Ligand Pharmaceuticals IncorporatedCompounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5962731A (en)*1992-04-221999-10-05Ligand Pharmaceuticals IncorporatedCompounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US7655699B1 (en)1992-04-222010-02-02Eisai Inc.Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
CN102976937A (en)*2004-06-182013-03-20华盛顿大学Retinal derivatives and methods for the use thereof for the treatment of visual disorders
US8962691B2 (en)2003-03-142015-02-24University Of WashingtonRetinoid replacements and opsin agonists and methods for the use thereof
US9173856B2 (en)2010-04-192015-11-03Qlt Inc.Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
US9233091B2 (en)2008-02-112016-01-12University Of WashingtonMethods for the treatment and prevention of age-related retinal dysfunction
US10130606B2 (en)2009-09-152018-11-20Novelion Therapeutics Inc.Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle
US10828267B2 (en)2012-03-012020-11-10Retinagenix Therapeutics, Inc.Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
DE2843811A1 (en)*1978-10-071980-04-24Basf Ag RETINIC ACID AND 7,8-DEHYDRO RETINIC ACID-N- (CARBOXY) -PHENYLAMIDE
WO1982002833A1 (en)*1981-02-171982-09-02Gail Sansone BazzanoThe use of retinoids and their derivatives to increase the rate of growth of human scalp hair and to increase the rate of growth of fur in certain fur-bearing animals
EP0093770B1 (en)*1981-11-091991-06-19BAZZANO, Gail SThe use of retinoids and minoxidil (2,4-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias
CH651007A5 (en)*1982-06-241985-08-30Hoffmann La Roche POLYEN CONNECTIONS.
US4539154A (en)*1983-06-151985-09-03Hoffmann-La Roche Inc.Polyene compounds
US4743400A (en)*1986-09-221988-05-10Mcneilab, Inc.Process for preparing retinoyl chlorides
AU5664294A (en)*1993-01-111995-02-28Ligand Pharmaceuticals, Inc.Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors
JPH09509403A (en)*1993-12-151997-09-22エイボン プロダクツ インコーポレイテッド Novel retinoid conjugate compounds and methods for treating skin aging
US7566808B2 (en)2004-02-172009-07-28President And Fellows Of Harvard CollegeManagement of ophthalmologic disorders, including macular degeneration

Cited By (24)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5780676A (en)*1992-04-221998-07-14Ligand Pharmaceuticals IncorporatedCompounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5962731A (en)*1992-04-221999-10-05Ligand Pharmaceuticals IncorporatedCompounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US6043279A (en)*1992-04-222000-03-28Ligand Pharmaceuticals, IncorporatedCompounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US7655699B1 (en)1992-04-222010-02-02Eisai Inc.Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US10238610B2 (en)2003-03-142019-03-26University Of WashingtonRetinoid replacements and opsin agonists and methods for the use thereof
US8962691B2 (en)2003-03-142015-02-24University Of WashingtonRetinoid replacements and opsin agonists and methods for the use thereof
US9149446B2 (en)2003-03-142015-10-06University Of WashingtonStabilized mutant opsin proteins
US9907762B2 (en)2003-03-142018-03-06University Of WashingtonStabilized mutant opsin proteins
US9388130B2 (en)2004-06-182016-07-12University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
CN102976937B (en)*2004-06-182016-12-21华盛顿大学For treating retinoid and the using method thereof of visual disorder
CN102976937A (en)*2004-06-182013-03-20华盛顿大学Retinal derivatives and methods for the use thereof for the treatment of visual disorders
US10117845B2 (en)2004-06-182018-11-06University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
US9169204B2 (en)2004-06-182015-10-27University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
US9403765B2 (en)2004-06-182016-08-02University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
US9162978B2 (en)2004-06-182015-10-20University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
US9174936B2 (en)2004-06-182015-11-03University Of WashingtonRetinal derivatives and methods for the use thereof for the treatment of visual disorders
US9855239B2 (en)2008-02-112018-01-02University Of WashingtonMethods for the treatment and prevention of age-related retinal dysfunction
US9408821B2 (en)2008-02-112016-08-09University Of WashingtonMethods for the treatment and prevention of age-related retinal dysfunction
US9233091B2 (en)2008-02-112016-01-12University Of WashingtonMethods for the treatment and prevention of age-related retinal dysfunction
US10130606B2 (en)2009-09-152018-11-20Novelion Therapeutics Inc.Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle
US10736865B2 (en)2009-09-152020-08-11Retinagenix Therapeutics, Inc.Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle
US9987245B2 (en)2010-04-192018-06-05Novelion Therapeutics Inc.Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
US9173856B2 (en)2010-04-192015-11-03Qlt Inc.Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
US10828267B2 (en)2012-03-012020-11-10Retinagenix Therapeutics, Inc.Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency

Also Published As

Publication numberPublication date
SE413139B (en)1980-04-21
ZA757545B (en)1976-12-29
FR2293193B1 (en)1979-09-21
DE2456959A1 (en)1976-06-16
FR2293193A1 (en)1976-07-02
CH619211A5 (en)1980-09-15
BE835902A (en)1976-05-25
SE7513080L (en)1976-06-04

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Legal Events

DateCodeTitleDescription
PSPatent sealed [section 19, patents act 1949]
PCNPPatent ceased through non-payment of renewal fee
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