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GB1492997A - Insulin derivatives - Google Patents

Insulin derivatives

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Publication number
GB1492997A
GB1492997AGB3147575AGB3147575AGB1492997AGB 1492997 AGB1492997 AGB 1492997AGB 3147575 AGB3147575 AGB 3147575AGB 3147575 AGB3147575 AGB 3147575AGB 1492997 AGB1492997 AGB 1492997A
Authority
GB
United Kingdom
Prior art keywords
group
lysine
july
amino acid
insulin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3147575A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAT RES DEV
National Research Development Corp UK
Original Assignee
NAT RES DEV
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAT RES DEV, National Research Development Corp UKfiledCriticalNAT RES DEV
Priority to GB3147575ApriorityCriticalpatent/GB1492997A/en
Publication of GB1492997ApublicationCriticalpatent/GB1492997A/en
Expiredlegal-statusCriticalCurrent

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Abstract

1492997 Insulin derivatives NATIONAL RESEARCH DEVELOPMENT CORP 21 July 1976 [28 July 1975] 31475/75 Addition to 1408757 Heading A5B [Also in Division C3] A pharmaceutical composition comprises an N - substituted insulin wherein the primary amino group of the B 29 (lysine) amino acid unit carries a carbamoyl group, N - substitution being absent from the primary group of the A 1 (glycine) and B 1 (phenylalanine) amino acid units, together with a physiologically - acceptable diluent or carrier. The composition is preferably in a form for parenteral administration and the preferred compound is B 29 (lysine) - N - carbamylinsulin.
GB3147575A1976-07-211976-07-21Insulin derivativesExpiredGB1492997A (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
GB3147575AGB1492997A (en)1976-07-211976-07-21Insulin derivatives

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
GB3147575AGB1492997A (en)1976-07-211976-07-21Insulin derivatives

Publications (1)

Publication NumberPublication Date
GB1492997Atrue GB1492997A (en)1977-11-23

Family

ID=10323647

Family Applications (1)

Application NumberTitlePriority DateFiling Date
GB3147575AExpiredGB1492997A (en)1976-07-211976-07-21Insulin derivatives

Country Status (1)

CountryLink
GB (1)GB1492997A (en)

Cited By (42)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5631347A (en)*1995-06-071997-05-20Eli Lilly And CompanyReducing gelation of a fatty acid-acylated protein
US5646242A (en)*1994-11-171997-07-08Eli Lilly And CompanySelective acylation of epsilon-amino groups
US5693609A (en)*1994-11-171997-12-02Eli Lilly And CompanyAcylated insulin analogs
US5700904A (en)*1995-06-071997-12-23Eli Lilly And CompanyPreparation of an acylated protein powder
US6011007A (en)*1993-09-172000-01-04Novo Nordisk A/SAcylated insulin
US6251856B1 (en)1995-03-172001-06-26Novo Nordisk A/SInsulin derivatives
US6713452B2 (en)2001-06-042004-03-30Nobex CorporationMixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en)2001-06-042004-12-07Nobex CorporationMixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en)2001-06-042004-12-07Nobex CorporationMixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en)2001-06-042004-12-28Nobex CorporationMethods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en)2001-06-042005-02-22Nobex CorporationMixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6867183B2 (en)2001-02-152005-03-15Nobex CorporationPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6869930B1 (en)1993-09-172005-03-22Novo Nordisk A/SAcylated insulin
US6913903B2 (en)2001-09-072005-07-05Nobex CorporationMethods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030084B2 (en)1999-06-192006-04-18Nobex CorporationDrug-oligomer conjugates with polyethylene glycol components
WO2006082204A1 (en)2005-02-022006-08-10Novo Nordisk A/SInsulin derivatives
US7166571B2 (en)2001-09-072007-01-23Biocon LimitedInsulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en)2001-09-072007-03-27Biocon LimitedPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en)2001-09-072007-12-25Biocon LimitedInsulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7381702B2 (en)2001-02-152008-06-03Biocon LimitedMethods of treating diabetes mellitus
EP2033662A1 (en)2004-01-212009-03-11Novo Nordisk Health Care AGTransglutaminase mediated conjugation of peptides
EP2107069A2 (en)2003-08-052009-10-07Novo Nordisk A/SNovel insulin derivatives
US7601688B2 (en)2002-06-132009-10-13Biocon LimitedMethods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7713932B2 (en)2001-06-042010-05-11Biocon LimitedCalcitonin drug-oligomer conjugates, and uses thereof
EP2264066A2 (en)2003-08-052010-12-22Novo Nordisk A/SNovel insulin derivatives
EP2292653A1 (en)2005-02-022011-03-09Novo Nordisk A/SNovel insulin derivatives
US8710001B2 (en)2006-07-312014-04-29Novo Nordisk A/SPEGylated, extended insulins
US8710000B2 (en)2007-11-082014-04-29Novo Nordisk A/SInsulin derivative
US9018161B2 (en)2006-09-222015-04-28Novo Nordisk A/SProtease resistant insulin analogues
US9034818B2 (en)2007-06-132015-05-19Novo Nordisk A/SPharmaceutical formulations comprising an insulin derivative
US9260502B2 (en)2008-03-142016-02-16Novo Nordisk A/SProtease-stabilized insulin analogues
US9387176B2 (en)2007-04-302016-07-12Novo Nordisk A/SMethod for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9481721B2 (en)2012-04-112016-11-01Novo Nordisk A/SInsulin formulations
US9603904B2 (en)2008-10-302017-03-28Novo Nordisk A/STreating diabetes melitus using insulin injections with less than daily injection frequency
US9688737B2 (en)2008-03-182017-06-27Novo Nordisk A/SProtease stabilized acylated insulin analogues
US9896496B2 (en)2013-10-072018-02-20Novo Nordisk A/SDerivative of an insulin analogue
US10137172B2 (en)2013-04-302018-11-27Novo Nordisk A/SAdministration regime
US10265385B2 (en)2016-12-162019-04-23Novo Nordisk A/SInsulin containing pharmaceutical compositions
US10335464B1 (en)2018-06-262019-07-02Novo Nordisk A/SDevice for titrating basal insulin
US10596229B2 (en)2010-10-272020-03-24Novo Nordisk A/SMethod of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action
US11167035B2 (en)2005-12-282021-11-09Novo Nordisk A/SInsulin compositions and method of making a composition
US12343383B2 (en)2019-07-122025-07-01Novo Nordisk A/SHigh concentration insulin formulation

Cited By (66)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6869930B1 (en)1993-09-172005-03-22Novo Nordisk A/SAcylated insulin
US6011007A (en)*1993-09-172000-01-04Novo Nordisk A/SAcylated insulin
USRE37971E1 (en)1994-11-172003-01-28Eli Lilly And CompanySelective acylation of epsilon-amino groups
US5646242A (en)*1994-11-171997-07-08Eli Lilly And CompanySelective acylation of epsilon-amino groups
US5693609A (en)*1994-11-171997-12-02Eli Lilly And CompanyAcylated insulin analogs
US5922675A (en)*1994-11-171999-07-13Eli Lilly And CompanyAcylated Insulin Analogs
US7229964B2 (en)1995-03-172007-06-12Novo Nordisk A/SInsulin derivatives
US6251856B1 (en)1995-03-172001-06-26Novo Nordisk A/SInsulin derivatives
US6620780B2 (en)1995-03-172003-09-16Novo Nordisk A/SInsulin derivatives
US5700904A (en)*1995-06-071997-12-23Eli Lilly And CompanyPreparation of an acylated protein powder
US5631347A (en)*1995-06-071997-05-20Eli Lilly And CompanyReducing gelation of a fatty acid-acylated protein
US7169889B1 (en)1999-06-192007-01-30Biocon LimitedInsulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7030084B2 (en)1999-06-192006-04-18Nobex CorporationDrug-oligomer conjugates with polyethylene glycol components
US7381702B2 (en)2001-02-152008-06-03Biocon LimitedMethods of treating diabetes mellitus
US6867183B2 (en)2001-02-152005-03-15Nobex CorporationPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6835802B2 (en)2001-06-042004-12-28Nobex CorporationMethods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US8030269B2 (en)2001-06-042011-10-04Biocon LimitedCalcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en)2001-06-042005-02-22Nobex CorporationMixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7084114B2 (en)2001-06-042006-08-01Nobex CorporationMixtures of insulin drug-oligomer comprising polyalkylene glycol
US7084121B2 (en)2001-06-042006-08-01Nobex CorporationMixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en)2001-06-042010-05-11Biocon LimitedCalcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en)2001-06-042004-12-07Nobex CorporationMixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en)2001-06-042004-12-07Nobex CorporationMixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7470663B2 (en)2001-06-042008-12-30Biocon LimitedMixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en)2001-06-042004-03-30Nobex CorporationMixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7611864B2 (en)2001-09-072009-11-03Biocon LimitedProinsulin polypeptide-oligomer conjugates
US7166571B2 (en)2001-09-072007-01-23Biocon LimitedInsulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en)2001-09-072007-03-27Biocon LimitedPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en)2001-09-072007-12-25Biocon LimitedInsulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en)2001-09-072005-07-05Nobex CorporationMethods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7601688B2 (en)2002-06-132009-10-13Biocon LimitedMethods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US8828923B2 (en)2003-08-052014-09-09Novo Nordisk A/SInsulin derivatives
EP2287184A2 (en)2003-08-052011-02-23Novo Nordisk A/SNovel insulin derivatives
US7615532B2 (en)2003-08-052009-11-10Novo Nordisk A/SInsulin derivatives
EP2107069A2 (en)2003-08-052009-10-07Novo Nordisk A/SNovel insulin derivatives
EP2264065A2 (en)2003-08-052010-12-22Novo Nordisk A/SNovel Insulin Derivatives
EP2264066A2 (en)2003-08-052010-12-22Novo Nordisk A/SNovel insulin derivatives
EP2275439A2 (en)2003-08-052011-01-19Novo Nordisk A/SNovel insulin derivatives
EP2368579A1 (en)2004-01-212011-09-28Novo Nordisk Health Care AGTransglutaminase mediated conjugation of peptides
EP2033662A1 (en)2004-01-212009-03-11Novo Nordisk Health Care AGTransglutaminase mediated conjugation of peptides
EP2292653A1 (en)2005-02-022011-03-09Novo Nordisk A/SNovel insulin derivatives
USRE46170E1 (en)2005-02-022016-10-04Novo Nordisk A/SInsulin derivatives
EP2256130A1 (en)2005-02-022010-12-01Novo Nordisk A/SNovel insulin derivatives
US8067362B2 (en)2005-02-022011-11-29Novo Nordisk AsInsulin derivatives
US8476228B2 (en)2005-02-022013-07-02Novo Nordisk A/SInsulin derivatives
US8859493B2 (en)2005-02-022014-10-14Novo Nordisk A/SInsulin derivatives
WO2006082204A1 (en)2005-02-022006-08-10Novo Nordisk A/SInsulin derivatives
US11167035B2 (en)2005-12-282021-11-09Novo Nordisk A/SInsulin compositions and method of making a composition
US8710001B2 (en)2006-07-312014-04-29Novo Nordisk A/SPEGylated, extended insulins
US9018161B2 (en)2006-09-222015-04-28Novo Nordisk A/SProtease resistant insulin analogues
US9387176B2 (en)2007-04-302016-07-12Novo Nordisk A/SMethod for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en)2007-06-132015-05-19Novo Nordisk A/SPharmaceutical formulations comprising an insulin derivative
US8710000B2 (en)2007-11-082014-04-29Novo Nordisk A/SInsulin derivative
US9260502B2 (en)2008-03-142016-02-16Novo Nordisk A/SProtease-stabilized insulin analogues
US10259856B2 (en)2008-03-182019-04-16Novo Nordisk A/SProtease stabilized acylated insulin analogues
US9688737B2 (en)2008-03-182017-06-27Novo Nordisk A/SProtease stabilized acylated insulin analogues
US9603904B2 (en)2008-10-302017-03-28Novo Nordisk A/STreating diabetes melitus using insulin injections with less than daily injection frequency
US10596229B2 (en)2010-10-272020-03-24Novo Nordisk A/SMethod of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action
US9481721B2 (en)2012-04-112016-11-01Novo Nordisk A/SInsulin formulations
US10137172B2 (en)2013-04-302018-11-27Novo Nordisk A/SAdministration regime
US9896496B2 (en)2013-10-072018-02-20Novo Nordisk A/SDerivative of an insulin analogue
US10265385B2 (en)2016-12-162019-04-23Novo Nordisk A/SInsulin containing pharmaceutical compositions
US10596231B2 (en)2016-12-162020-03-24Novo Nordisk A/SInsulin containing pharmaceutical compositions
US10335464B1 (en)2018-06-262019-07-02Novo Nordisk A/SDevice for titrating basal insulin
US12226458B2 (en)2018-06-262025-02-18Novo Nordisk A/SSystem for providing an up-to-date and long-acting or ultra-long-acting insulin dose guidance recommendation to treat diabetes mellitus
US12343383B2 (en)2019-07-122025-07-01Novo Nordisk A/SHigh concentration insulin formulation

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