GB1174411A - Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture - Google Patents

Abstract

1,174,411. Medicines comprising benzothiophenes. ASPRO-NICHOLAS Ltd. 3 March, 1967 [3 March, 1966 (5); 30 Jan., 1967 (2)], Nos. 9295/66; 9296/66; 9297/66; 9298/66; 9299/ 66; 4548/67 and 4549/67. Heading A5B. [Also in Divisions C2 and C4] Pharmaceutical preparations which are antagonists of serotonin contain as active ingredient compounds I (including salts thereof) wherein B is an unsubstituted or substituted benzo ring (substituents include, e.g. CN, NO 2 , CF 3 , halogen, amino, alkoxy, alkenyloxy, alkynyloxy, acyl and alkyl, alkenyl and alkynyl optionally substituted by OH, alkoxy, aryl or halogen), Y is H, alkyl, acyl or the group Z and Z signifies A.CH 2 NR<SP>1</SP>R<SP>2</SP> wherein A is keto or methylene which may be substituted by OH or halogen and R<SP>1</SP> and R<SP>2</SP> signify H or alkyl (may be unsaturated by one or more double or triple bonds and may be substituted by OH, halogen, mercapto or aryl) but R<SP>2</SP> is not a 3- or 4- carbon unsubstituted alkyl when R<SP>1</SP> is hydrogen A is hydroxymethylene, Y is hydrogen and B is an unsubstituted or monochlorosubstituted benzene ring, or R<SP>1</SP> and R<SP>2</SP> together with the adjacent nitrogen form a heterocycle optionally containing one or more other hetero atoms. Administration is orally, rectally, topically, parenterally or by continuous or discontinuous intra-arterial infusion.