GB1147210A - Improvements in or relating to vitamins - Google Patents

Abstract

1,147,210. Vitamin beadlets. EASTMAN KODAK CO. 24 June, 1966 [30 June, 1965], No. 28352/66. Heading A5B. A process for making a dry, free flowing, finely divided, fat-soluble vitamin-active product, comprises (1) preparing a colloidal solution of cold water dispersible, non-gelling colloid material and water; (2) dispersing in said colloidal solution a water insoluble, fat soluble vitamin active composition to form a first dispersion; (3) dispersing the latter in a water immiscible liquid dispersing medium to form a second dispersion; (4) extracting water at - 10 to 0‹C from the latter with a water extraction agent until droplets of the first dispersion solidify to form particles; (5) separating the latter from the dispersing medium and water extraction agent at -10 to 0‹C; and (6) removing residual moisture from the solid particles. Lecithin may be added as a stabilising agent to the second dispersion. The colloid material may be gum acacia, gum ghatti, amylopectin, pre-gelatinised and thin boiling starches, substituted starches, e.g. corn starch which has 'been partially reacted with octenyl succinic anhydride, or mixtures thereof. Water soluble, edible, plasticizers e.g. glucose, sucrose, dextrose, lactose, and corn syrup may 'be used with the colloid material. The vitamin-active composition consists of at least one water insoluble, fat soluble, vitamin active compound e.g. vitamin A, D, E, and K compounds. The compounds may be in solution or suspended in oil. The vitamin active composition may 'be liquid, solid, or a mixture of solids and liquid. An antioxidant may be incorporated in the vitamin active composition. The water immiscible dispersing medium may be mineral oil. Specified water extracting agents are methanol, ethanol, isopropanol, acetone, methyl ethyl ketone, 1,4-dioxan, pyridine, and mixtures thereof. The particles may be separated from the dispersing medium by filtration and washed with additional water extraction agent and then with a solvent for the dispersing medium e.g. hexane when the medium is mineral oil. Residual moisture may be removed by air drying, for instance, using a fluidised bed.