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GB1074235A - Antibiotics r-451b(x)and r-451d(x)and processes for their manufacture - Google Patents

Antibiotics r-451b(x)and r-451d(x)and processes for their manufacture

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Publication number
GB1074235A
GB1074235AGB28829/64AGB2882964AGB1074235AGB 1074235 AGB1074235 AGB 1074235AGB 28829/64 AGB28829/64 AGB 28829/64AGB 2882964 AGB2882964 AGB 2882964AGB 1074235 AGB1074235 AGB 1074235A
Authority
GB
United Kingdom
Prior art keywords
antibiotics
methanol
spectrum
pict
infra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28829/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US211153Aexternal-prioritypatent/US3091572A/en
Application filed by Scherico LtdfiledCriticalScherico Ltd
Publication of GB1074235ApublicationCriticalpatent/GB1074235A/en
Expiredlegal-statusCriticalCurrent

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Abstract

The invention relates to the broad spectrum antibiotics R-451 B(X) and R-451 D(X) which are obtained by recrystallizing from an organic solvent the antibiotics R-451 B and R-451 D produced by cultivating micromonospora carbonacea according to Specification 1,021,402. Antibiotic R-451 B(X) has a m.pt. 154-157 DEG C., an elementary analysis C=51.02%, H=6.68%, N=1.23%, O=34.72%, Cl=3.97%, optical rotation [a ]25D= -25.5 (1% pyridine), U.V. max. absorption at 288 mm with E1% in <PICT:1074235/C2/1> <PICT:1074235/C2/2> methanol = 12 and an infra-red absorption spectrum as in Fig. 1. Antibiotic R-451 D(X) has a m.pt. 160-161 DEG C., an elementary analysis C=51.79%, H=6.35%, N=1.40%, O=36.35%, Cl=3.98%; an optical rotation [a ]25D= -25.3 DEG (1% in methanol); ultra-violet absorption maximum at 289 mm with E1% in methanol=22, and infra-red spectrum as shown in Fig. 2. R-451 D(X) methyl ether is prepared by treating R-451 D(X) with diazomethane in a solvent. R-451 D(X) acetate is prepared by treating R-451 D(X) with acetic anhydride in pyridine. The antibiotics form salts with bases, ethers (as above) and O-acyl dervatives (as above). Pharmaceutical compositions comprise one or more antibiotics identified as R-451 B(X), R-451 D(X) and R-451 D(X) acetate and a carrier. They are active against gram-positive pathogenic microorganisms in man and animals, e.g. mastitis in cattle and pleuropneumonia diseases in poultry.
GB28829/64A1961-11-141964-07-13Antibiotics r-451b(x)and r-451d(x)and processes for their manufactureExpiredGB1074235A (en)

Applications Claiming Priority (10)

Application NumberPriority DateFiling DateTitle
US15226261A1961-11-141961-11-14
US18448462A1962-04-021962-04-02
US19841462A1962-05-231962-05-23
US21115462A1962-07-161962-07-16
US211153AUS3091572A (en)1962-07-161962-07-16Gentamycin and method of production
US21180662A1962-07-231962-07-23
US29799963A1963-07-241963-07-24
US35416864A1964-03-231964-03-23
US76250468A1968-09-251968-09-25
US76912268A1968-10-211968-10-21

Publications (1)

Publication NumberPublication Date
GB1074235Atrue GB1074235A (en)1967-07-05

Family

ID=27581070

Family Applications (1)

Application NumberTitlePriority DateFiling Date
GB28829/64AExpiredGB1074235A (en)1961-11-141964-07-13Antibiotics r-451b(x)and r-451d(x)and processes for their manufacture

Country Status (6)

CountryLink
BE (1)BE650943A (en)
FR (1)FR117F (en)
GB (1)GB1074235A (en)
LU (1)LU42688A1 (en)
NL (3)NL6408506A (en)
OA (1)OA00868A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP1178311A4 (en)*1999-05-102003-04-09Tomoya SatoMethod and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug

Cited By (2)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP1178311A4 (en)*1999-05-102003-04-09Tomoya SatoMethod and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug
US6743637B2 (en)1999-05-102004-06-01Tomoya SatoDisease type and/or condition determination method and apparatus and drug screening method and apparatus

Also Published As

Publication numberPublication date
NL285188A (en)
FR117F (en)
LU42688A1 (en)1963-01-13
NL7201760A (en)1972-05-25
BE650943A (en)1964-11-16
NL6408506A (en)1965-01-25
OA00868A (en)1968-03-22

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