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FR2885905A1 - NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT - Google Patents

NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

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Publication number
FR2885905A1
FR2885905A1FR0505144AFR0505144AFR2885905A1FR 2885905 A1FR2885905 A1FR 2885905A1FR 0505144 AFR0505144 AFR 0505144AFR 0505144 AFR0505144 AFR 0505144AFR 2885905 A1FR2885905 A1FR 2885905A1
Authority
FR
France
Prior art keywords
chemical compounds
compounds
medicinal product
family
novel chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0505144A
Other languages
French (fr)
Inventor
Rebecca Pruss
Laure Jamot
Cyrille Drouot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trophos SA
Original Assignee
Trophos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos SAfiledCriticalTrophos SA
Priority to FR0505144ApriorityCriticalpatent/FR2885905A1/en
Priority to PCT/FR2006/001107prioritypatent/WO2006125887A1/en
Publication of FR2885905A1publicationCriticalpatent/FR2885905A1/en
Withdrawnlegal-statusCriticalCurrent

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Abstract

Translated fromFrench

La présente invention se place dans le domaine de la pharmacie, particulièrement dans le domaine du traitement des maladies neurodégénératives. Très particulièrement elle concerne une famille de composés chimiques pour lesquelles une activité neuroprotectrice a pu être démontrée.Certains membres de ladite famille étant des composés nouveaux jamais décrits, l'invention concerne ces produits nouveaux, leurs procédé de synthèse ainsi que certains intermédiaires de synthèse eux-mêmes nouveaux.La présente invention concerne également des compositions comprenant les composés de la famille, l'utilisation desdits composés à titre de médicaments, particulièrement dans la préparation d'un médicament destiné au traitement des maladies neurodégénératives.The present invention is in the field of pharmacy, particularly in the field of treatment of neurodegenerative diseases. In particular, it relates to a family of chemical compounds for which neuroprotective activity has been demonstrated.Some members of said family being new compounds never described, the invention relates to these novel products, their synthesis process as well as some synthesis intermediates them. The present invention also relates to compositions comprising the compounds of the family, the use of said compounds as medicaments, particularly in the preparation of a medicament for the treatment of neurodegenerative diseases.

FR0505144A2005-05-232005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCTWithdrawnFR2885905A1 (en)

Priority Applications (2)

Application NumberPriority DateFiling DateTitle
FR0505144AFR2885905A1 (en)2005-05-232005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT
PCT/FR2006/001107WO2006125887A1 (en)2005-05-232006-05-175h-pyrido[4,3-b]indole derivative compounds and uses thereof as medicine for treating polyglutamin neurodegenerative diseases

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
FR0505144AFR2885905A1 (en)2005-05-232005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

Publications (1)

Publication NumberPublication Date
FR2885905A1true FR2885905A1 (en)2006-11-24

Family

ID=35709336

Family Applications (1)

Application NumberTitlePriority DateFiling Date
FR0505144AWithdrawnFR2885905A1 (en)2005-05-232005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

Country Status (2)

CountryLink
FR (1)FR2885905A1 (en)
WO (1)WO2006125887A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US20070117835A1 (en)*2005-10-042007-05-24David HungMethods and compositions for treating Huntington's disease
CA2700160A1 (en)2007-09-202009-03-26D2E, LlcFluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
US8932557B2 (en)2008-02-142015-01-13Eli Lilly And CompanyImaging agents for detecting neurological dysfunction
US8318132B2 (en)2008-02-142012-11-27Siemens Medical Solutions Usa, Inc.Imaging agents for detecting neurological dysfunction
CN101423517B (en)*2008-11-282011-09-14浙江大学Gamma-carbolines derivates as well as preparation method and application thereof
KR101609504B1 (en)2012-05-222016-04-05일라이 릴리 앤드 캄파니Carboline and carbazole based imaging agents for detecting neurological dysfunction

Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP0238411A1 (en)*1986-03-171987-09-23Sanofi1,2-Dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b) indoles and their preparation
EP0876818A2 (en)*1995-10-231998-11-11Nikolai Serafimovich ZefirovAgent for treating neuro-degenerative disorders
EP1015451B1 (en)*1997-09-082003-06-18Janssen Pharmaceutica N.V.Tetrahydro gamma-carbolines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP0238411A1 (en)*1986-03-171987-09-23Sanofi1,2-Dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b) indoles and their preparation
EP0876818A2 (en)*1995-10-231998-11-11Nikolai Serafimovich ZefirovAgent for treating neuro-degenerative disorders
EP1015451B1 (en)*1997-09-082003-06-18Janssen Pharmaceutica N.V.Tetrahydro gamma-carbolines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.J. COOKE, N.M. HAMILTON: "alpha-subunit selective modulators of GABAa receptor fonction as CNS therapeutics", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 12, no. 10, 2002, pages 1491 - 1501, XP002367045*
CHI HUNG NGUYEN ET AL: "Synthesis of tricyclic analogs of ellipticines: 4-methyl-5H-pyrido[4,3- b]indoles (.gamma.-carbolines) with various substituents at their apexes 1,5 and 8", TETRAHEDRON , 43(3), 527-35 CODEN: TETRAB; ISSN: 0040-4020, 1987, XP002367046*
KRICHEVSKII, E. S. ET AL: "Acetals of lactams and amides. 73. Synthesis and some properties of 6-nitro-.gamma.-carboline derivatives", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 28, no. 4, 1992, pages 420 - 423, XP009061474*

Also Published As

Publication numberPublication date
WO2006125887A1 (en)2006-11-30

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