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FR2761687B1 - QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS - Google Patents

QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS

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Publication number
FR2761687B1
FR2761687B1FR9704289AFR9704289AFR2761687B1FR 2761687 B1FR2761687 B1FR 2761687B1FR 9704289 AFR9704289 AFR 9704289AFR 9704289 AFR9704289 AFR 9704289AFR 2761687 B1FR2761687 B1FR 2761687B1
Authority
FR
France
Prior art keywords
aryl
group
different
alkyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9704289A
Other languages
French (fr)
Other versions
FR2761687A1 (en
Inventor
Khalid Mekouar
Angelo Jean D
Didier Desmaele
Jean Francois Mouscadet
Frederic Subra
Christian Auclair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9704289ApriorityCriticalpatent/FR2761687B1/en
Application filed by Centre National de la Recherche Scientifique CNRSfiledCriticalCentre National de la Recherche Scientifique CNRS
Priority to ES98920581Tprioritypatent/ES2332434T3/en
Priority to JP54245998Aprioritypatent/JP4697679B2/en
Priority to EP98920581Aprioritypatent/EP0975597B1/en
Priority to PCT/FR1998/000701prioritypatent/WO1998045269A1/en
Priority to US09/402,858prioritypatent/US6670377B1/en
Priority to DK98920581Tprioritypatent/DK0975597T3/en
Priority to AT98920581Tprioritypatent/ATE441634T1/en
Priority to CA2286385Aprioritypatent/CA2286385C/en
Priority to PT98920581Tprioritypatent/PT975597E/en
Priority to DE69841119Tprioritypatent/DE69841119D1/en
Publication of FR2761687A1publicationCriticalpatent/FR2761687A1/en
Application grantedgrantedCritical
Publication of FR2761687B1publicationCriticalpatent/FR2761687B1/en
Priority to CY20091101257Tprioritypatent/CY1109553T1/en
Anticipated expirationlegal-statusCritical
Expired - Fee Relatedlegal-statusCriticalCurrent

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Abstract

The invention concerns quinoline derivatives of formula (I) in which: Ra, Rb and Rc, identical or different represent one or several substituents, themselves identical or different, in any position on the cycles, this or these substituents being selected among a -(CH2)n-Y or -CH=CH-Y group, in which Y is halogen, -OH, -OR, -COH, -COR, -COOH, COOR, -COH, -COR, -CONH2, -CON(Rx, Ry)-CH=NOH, -CO- -CH=NOH, -NH2, -N(Rx, Ry), -NO2, -PO(OR)2-SH2, -SR, -SO2R, -SO2NHR, CN, or Z(Rc) in which R is a C1-C8 alkyl, or aryl or a heterocyclic compound, Rx and Ry, identical or different are C1-C5 alkyl, an aryl or heterocyclic compound and n is nil or a whole number between 1 and 5 Rb can further represent a hydrogen, and when Y is -COOH or -COOR in Rc, Z, if it represents an aryl, comprises at least 3 substituents or the quinoline ring is trisubstituted; X is an ethylene double bond; a -(CH2)n- group in which n is a whole number between 1 and 5: or a -CH(Rd-CH(Re) group, Rd and Re, identical or different, representing a hydrogen, a halogen, hydroxy or epoxy; or a -(CH2)n, -O-C-(CH2)m-, -(CH2)n, -C(O)-O-(CH2)m, -(CH2)n, -O-(CH2)m-, (CH2)n, -N(Q)-(CH2)m-, or (CH2)n, -S(O)-(CH2)m-, group, in which n=1 to 8, m=0 to 8, t=0, 1 or 2, and Q=h, aryl or alkyl. The invention also concerns the pharmaceutically acceptable salts of these derivatives, the diastereoisomeric and the enantiomeric forms thereof. The invention is useful as medicines with HIV anti-integrase inhibiting effect.
FR9704289A1997-04-081997-04-08 QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONSExpired - Fee RelatedFR2761687B1 (en)

Priority Applications (12)

Application NumberPriority DateFiling DateTitle
FR9704289AFR2761687B1 (en)1997-04-081997-04-08 QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS
CA2286385ACA2286385C (en)1997-04-081998-04-07Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
EP98920581AEP0975597B1 (en)1997-04-081998-04-07Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
PCT/FR1998/000701WO1998045269A1 (en)1997-04-081998-04-07Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
US09/402,858US6670377B1 (en)1997-04-081998-04-07Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
DK98920581TDK0975597T3 (en)1997-04-081998-04-07 Quinoline derivatives as inhibitors of HIV integrase
ES98920581TES2332434T3 (en)1997-04-081998-04-07 CHIROLINE DERIVATIVES AS INHIBITORS OF HIV INTEGRAS.
JP54245998AJP4697679B2 (en)1997-04-081998-04-07 Quinoline derivatives as inhibitors of HIV integrase
PT98920581TPT975597E (en)1997-04-081998-04-07Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof
DE69841119TDE69841119D1 (en)1997-04-081998-04-07 CHINOLINE DERIVATIVES, WITH ESPECIALLY ANTIVIRAL PROPERTIES, MANUFACTURE AND BIOLOGICAL APPLICATIONS THEREOF
AT98920581TATE441634T1 (en)1997-04-081998-04-07 QUINOLINE DERIVATIVES WITH IN PARTICULAR ANTIVIRAL PROPERTIES, PRODUCTION AND BIOLOGICAL APPLICATIONS THEREOF
CY20091101257TCY1109553T1 (en)1997-04-082009-12-01 KINOLINE PRODUCERS AS INHIBITORS OF HIV INTEGRATION

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
FR9704289AFR2761687B1 (en)1997-04-081997-04-08 QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS

Publications (2)

Publication NumberPublication Date
FR2761687A1 FR2761687A1 (en)1998-10-09
FR2761687B1true FR2761687B1 (en)2000-09-15

Family

ID=9505648

Family Applications (1)

Application NumberTitlePriority DateFiling Date
FR9704289AExpired - Fee RelatedFR2761687B1 (en)1997-04-081997-04-08 QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS

Country Status (12)

CountryLink
US (1)US6670377B1 (en)
EP (1)EP0975597B1 (en)
JP (1)JP4697679B2 (en)
AT (1)ATE441634T1 (en)
CA (1)CA2286385C (en)
CY (1)CY1109553T1 (en)
DE (1)DE69841119D1 (en)
DK (1)DK0975597T3 (en)
ES (1)ES2332434T3 (en)
FR (1)FR2761687B1 (en)
PT (1)PT975597E (en)
WO (1)WO1998045269A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CA2321348A1 (en)2000-09-272002-03-27Blaise Magloire N'zembaAromatic derivatives with hiv integrase inhibitory properties
FR2819507B1 (en)2001-01-172007-09-28Inst Rech Developpement Ird SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS
MXPA03007765A (en)2001-03-012003-12-08Shionogi & CoNitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity.
FR2830863B1 (en)*2001-10-122004-01-30Bioalliance Pharma QUINOLEIN DERIVATIVES, METHOD OF SYNTHESIS, AND MEDICAMENTS CONTAINING SUCH DERIVATIVES
FR2839646B1 (en)*2002-05-172008-04-11Bioalliance Pharma USE OF QUINOLINE DERIVATIVES WITH ANTI-INTEGRASE EFFECT AND APPLICATIONS THEREOF
AU2003257822A1 (en)2002-08-132004-04-30Shionogi And Co., Ltd.Heterocyclic compound having hiv integrase inhibitory activity
TWI248928B (en)2002-11-202006-02-11Japan Tobacco Inc4-oxoquinoline compound and use thereof as HIV integrase inhibitor
RU2275361C3 (en)*2002-11-202021-10-01Джапан Тобакко Инк. COMPOUND OF 4-OXOQUINOLINE AND ITS APPLICATION AS A HIV INTEGRASE INHIBITOR
US7531554B2 (en)2004-05-202009-05-12Japan Tobacco Inc.4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en)*2004-05-202007-12-31Japan Tobacco IncStable crystal of 4-oxoquinoline compound
KR100866296B1 (en)*2004-05-202008-11-11니뽄 다바코 산교 가부시키가이샤 Stable Crystals of 4-Oxoquinoline Compounds
US20080280849A1 (en)*2005-06-012008-11-13Herve LehSynergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents
KR101023635B1 (en)2006-03-062011-03-22니뽄 다바코 산교 가부시키가이샤 Method for preparing 4-oxoquinoline compound
ES2569660T3 (en)*2007-06-082016-05-12Mannkind Corporation IRE-1alpha inhibitors
CA2705318C (en)*2007-11-152013-12-31Boehringer Ingelheim International GmbhInhibitors of human immunodeficiency virus replication
EP2574610A1 (en)*2007-11-152013-04-03Gilead Sciences, Inc.Inhibitors of human immonodeficiency virus replication
ES2463720T3 (en)*2007-11-162014-05-29Gilead Sciences, Inc. Human immunodeficiency virus replication inhibitors
SG185995A1 (en)*2007-11-162012-12-28Gilead Sciences IncInhibitors of human immunodeficiency virus replication
EP2149557A1 (en)*2008-07-232010-02-03BioAlliance PharmaStyrylquinolines, their process of preparation and their therapeutic uses
EP2147913A1 (en)*2008-07-232010-01-27BioAlliance PharmaStyrylquinolines, their process of preparation and their therapeutic uses
EP2147912A1 (en)2008-07-232010-01-27BioAlliance PharmaStyrylquinolines, their process of preparation and their therapeutic uses
PH12013500015A1 (en)*2010-07-022013-02-18Gilead Sciences Inc2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
EP2793898A1 (en)*2011-12-222014-10-29Université LavalThree-dimensional cavities of dendritic cell immunoreceptor (dcir), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (hiv-1)
AU2014237340C1 (en)2013-03-152018-11-08Global Blood Therapeutics, Inc.Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (en)2013-11-182020-06-30Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
TWI663160B (en)2016-05-122019-06-21全球血液治療公司Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
CA3113234A1 (en)2018-09-182020-03-26Nikang Therapeutics, Inc.Tri-substituted heteroaryl derivatives as src homology-2 phosphatase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS59152891A (en)*1983-02-181984-08-31Yamada Kagaku Kogyo KkColor forming recording material
IE861607L (en)*1985-06-181986-12-18Bunce Roger A2-substituted quinolines
EP0219307A3 (en)*1985-10-161987-10-14Merck Frosst Canada Inc.2-substituted quinolines
JPS61189988A (en)*1986-08-111986-08-23Yamada Kagaku Kogyo KkColor developable recording material
JPH01199979A (en)*1987-04-071989-08-11Kanebo LtdNovel quinolinecarboxylic acid derivative and antibacterial agent comprising said compound as active ingredient
IL88433A0 (en)*1987-11-251989-06-30Merck Frosst Canada IncDiarylstyrylquinoline diacids and pharmaceutical compositions containing them
US5438141A (en)*1993-05-211995-08-01Merck Frosst Canada, Inc.Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
EP0643045B1 (en)*1993-09-102000-03-08Novartis AGQuinoline derivatives as leukotriene antagonists
GB9414590D0 (en)*1994-07-201994-09-07Leo Pharm Prod LtdChemical compounds
ES2103180B1 (en)*1994-08-011998-04-01Menarini Lab PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.
EP0725063A1 (en)*1995-02-011996-08-07Ciba-Geigy AgQuinoline derivatives
AU4172197A (en)*1996-09-101998-04-02Pharmacia & Upjohn Company8-hydroxy-7-substituted quinolines as anti-viral agents

Also Published As

Publication numberPublication date
DE69841119D1 (en)2009-10-15
EP0975597A1 (en)2000-02-02
WO1998045269A1 (en)1998-10-15
ATE441634T1 (en)2009-09-15
CA2286385C (en)2011-02-01
ES2332434T3 (en)2010-02-04
CY1109553T1 (en)2014-08-13
US6670377B1 (en)2003-12-30
JP4697679B2 (en)2011-06-08
FR2761687A1 (en)1998-10-09
PT975597E (en)2010-01-04
CA2286385A1 (en)1998-10-15
DK0975597T3 (en)2009-11-02
JP2001518890A (en)2001-10-16
EP0975597B1 (en)2009-09-02

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DateCodeTitleDescription
TQPartial transmission of property
TQPartial transmission of property
RMCorrection of a material error
STNotification of lapse

Effective date:20111230
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