FR2676230B1 - NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM. - Google Patents

NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.

Info

Publication number: FR2676230B1
Authority: FR; France
Prior art keywords: preparation; medicaments containing; novel pyrrolo; benzodiazepines derivatives; benzodiazepines
Prior art date: 1991-05-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Other versions

Inventor

Langlois Nicole

Favre Florence

Tempete-Gaillourdet Christiane

Werner Georges Hubert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Centre National de la Recherche Scientifique CNRS

Original Assignee

Centre National de la Recherche Scientifique CNRS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-07

Filing date

1991-05-07

Publication date

1993-08-27

1991-05-07Application filed by Centre National de la Recherche Scientifique CNRSfiledCriticalCentre National de la Recherche Scientifique CNRS

1991-05-07Priority to FR9105636ApriorityCriticalpatent/FR2676230B1/en

1992-05-06Priority to PCT/FR1992/000410prioritypatent/WO1992019620A1/en

1992-11-13Publication of FR2676230A1publicationCriticalpatent/FR2676230A1/en

1993-08-27Application grantedgrantedCritical

1993-08-27Publication of FR2676230B1publicationCriticalpatent/FR2676230B1/en

2011-05-07Anticipated expirationlegal-statusCritical

StatusExpired - Fee Relatedlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FR9105636A1991-05-071991-05-07 NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.Expired - Fee RelatedFR2676230B1 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
FR9105636AFR2676230B1 (en)	1991-05-07	1991-05-07	NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.
PCT/FR1992/000410WO1992019620A1 (en)	1991-05-07	1992-05-06	Novel derivatives of pyrrolo [1, 4]-benzodiazepines, method of preparation and medicaments containing them

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9105636AFR2676230B1 (en)	1991-05-07	1991-05-07	NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.

Publications (2)

Publication Number	Publication Date
FR2676230A1 FR2676230A1 (en)	1992-11-13
FR2676230B1true FR2676230B1 (en)	1993-08-27

Family

ID=9412628

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR9105636AExpired - Fee RelatedFR2676230B1 (en)	1991-05-07	1991-05-07	NOVEL PYRROLO [1,4] -BENZODIAZEPINES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.

Country Status (2)

Country	Link
FR (1)	FR2676230B1 (en)
WO (1)	WO1992019620A1 (en)

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AU757510C (en)	1998-08-27	2003-09-11	Medimmune Limited	Pyrrolobenzodiazepines
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
GB9818732D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collection of compounds
GB9818731D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Compounds
US6909006B1 (en)	1999-08-27	2005-06-21	Spirogen Limited	Cyclopropylindole derivatives
FR2835186B1 (en)	2002-01-28	2006-10-20	Aventis Pharma Sa	NOVEL HETEROCYCLIC COMPOUNDS ACTIVE AS BETA-LACTAMASES INHIBITORS
FR2844273B1 (en)	2002-09-05	2008-04-04	Aventis Pharma Sa	NOVEL HETEROCYCLIC COMPOUNDS, METHOD AND INTERMEDIARY PREPARATION AND USE AS MEDICAMENT, IN PARTICULAR AS INHIBITORS OF BETA-LACTAMASES AND ANTI-BACTERIALS.
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
US7439253B2 (en)	2002-12-06	2008-10-21	Novexel	Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (en)*	2002-12-06	2007-10-19	Aventis Pharma Sa	NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-BACTERIALS AND INHIBITORS OF BETA-LACTAMASES
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en)	2004-03-01	2004-04-07	Spirogen Ltd	Pyrrolobenzodiazepines
ES2398975T3 (en)	2004-03-01	2013-03-25	Spirogen Sàrl	11-Hydroxy-5H-pyrrolo [2,1-c] [1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines
EP1723152B1 (en)	2004-03-09	2015-02-11	Spirogen Sàrl	Pyrrolobenzodiazepines
GB0819095D0 (en)	2008-10-17	2008-11-26	Spirogen Ltd	Pyrrolobenzodiazepines
AU2011239522B2 (en)	2010-04-15	2014-10-23	Medimmune Limited	Targeted pyrrolobenzodiazapine conjugates
NZ602933A (en)	2010-04-15	2014-09-26	Seattle Genetics Inc	Pyrrolobenzodiazepines used to treat proliferative diseases
GB201006340D0 (en)	2010-04-15	2010-06-02	Spirogen Ltd	Synthesis method and intermediates
CN103987718A (en)	2011-09-20	2014-08-13	斯皮罗根有限公司	Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
ES2945932T3 (en)	2011-10-14	2023-07-10	Seagen Inc	Pyrrolobenzodiazepines and targeted conjugates
JP6166728B2 (en)	2011-10-14	2017-07-19	メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅＬｉｍｉｔｅｄ	Synthetic methods and intermediates useful for the preparation of pyrrolobenzodiazepines
AU2012322613B2 (en)	2011-10-14	2016-04-21	Medimmune Limited	Pyrrolobenzodiazepines and targeted conjugates
EA028457B1 (en)	2011-10-14	2017-11-30	Медимьюн Лимитед	Pyrrolobenzodiazepines
BR112014008981A2 (en)	2011-10-14	2017-05-02	Spirogen Sàrl	pyrrolobenzodiazepines
WO2014057114A1 (en)	2012-10-12	2014-04-17	Adc Therapeutics Sàrl	Pyrrolobenzodiazepine-anti-psma antibody conjugates
KR20150083994A (en)	2012-10-12	2015-07-21	스피로즌 살	Pyrrolobenzodiazepines and conjugates thereof
PT2766048E (en)	2012-10-12	2015-02-25	Spirogen Sarl	PYRROLOBENZODIAZEPINES AND CONJUGATES OF THE SAME
TR201808051T4 (en)	2012-10-12	2018-06-21	Adc Therapeutics Sa	Pyrrolobenzodiazepine antibody conjugates.
ES2660029T3 (en)	2012-10-12	2018-03-20	Medimmune Limited	Antibody-pyrrolobenzodiazepine conjugates
DK2906251T3 (en)	2012-10-12	2017-11-20	Adc Therapeutics Sa	Pyrrolobenzodiazepine-anti-CD22-antibody conjugates
AU2013328673B2 (en)	2012-10-12	2017-07-13	Medimmune Limited	Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
DK2906253T3 (en)	2012-10-12	2018-10-22	Adc Therapeutics Sa	Pyrrolobenzodiazepine anti-PSMA antibody conjugates
SMT201900017T1 (en)	2012-10-12	2019-02-28	Medimmune Ltd	Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en)	2013-10-11	2013-11-27	Spirogen Sarl	Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en)	2013-10-11	2013-11-27	Spirogen Sarl	Pyrrolobenzodiazepines and conjugates thereof
WO2015052534A1 (en)	2013-10-11	2015-04-16	Spirogen Sàrl	Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en)	2013-10-11	2015-04-16	Spirogen Sàrl	Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en)	2013-10-11	2018-07-03	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en)	2014-09-12	2014-10-29	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
BR112017011111A2 (en)	2014-11-25	2017-12-26	Adc Therapeutics Sa	pyrrolobenzodiazepine-antibody conjugates
GB201506402D0 (en)	2015-04-15	2015-05-27	Berkel Patricius H C Van And Howard Philip W	Site-specific antibody-drug conjugates
GB201506411D0 (en)	2015-04-15	2015-05-27	Bergenbio As	Humanized anti-axl antibodies
GB201601431D0 (en)	2016-01-26	2016-03-09	Medimmune Ltd	Pyrrolobenzodiazepines
GB201602359D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en)	2016-04-29	2016-06-15	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en)	2016-10-14	2016-11-30	Medimmune Ltd	Pyrrolobenzodiazepine conjugates
DK3544636T3 (en)	2017-02-08	2021-05-10	Adc Therapeutics Sa	Pyrrolobenzodiazepine antibody conjugates
GB201702031D0 (en)	2017-02-08	2017-03-22	Medlmmune Ltd	Pyrrolobenzodiazepine-antibody conjugates
SI3612537T1 (en)	2017-04-18	2022-10-28	Medimmune Limited	Pyrrolobenzodiazepine conjugates
US20200129637A1 (en)	2017-04-20	2020-04-30	Adc Therapeutics Sa	Combination therapy with an anti-axl antibody-drug conjugate
WO2018229222A1 (en)	2017-06-14	2018-12-20	Adc Therapeutics Sa	Dosage regimes for the administration of an anti-cd19 adc
KR102270107B1 (en)	2017-08-18	2021-06-30	메디뮨 리미티드	pyrrolobenzodiazepine conjugate
GB201803342D0 (en)	2018-03-01	2018-04-18	Medimmune Ltd	Methods
GB201806022D0 (en)	2018-04-12	2018-05-30	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
ES2967878T3 (en)	2019-03-15	2024-05-06	Medimmune Ltd	Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3524849A (en)*	1967-10-27	1970-08-18	Hoffmann La Roche	Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

1991
- 1991-05-07FRFR9105636Apatent/FR2676230B1/ennot_activeExpired - Fee Related
1992
- 1992-05-06WOPCT/FR1992/000410patent/WO1992019620A1/enunknown

Also Published As

Publication number	Publication date
WO1992019620A1 (en)	1992-11-12
FR2676230A1 (en)	1992-11-13

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Legal Events

Date	Code	Title	Description
1998-03-27	ST	Notification of lapse

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