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FR17C1011I2 - PROTEASOME INHIBITORS - Google Patents

PROTEASOME INHIBITORS

Info

Publication number
FR17C1011I2
FR17C1011I2FR17C1011CFR17C1011CFR17C1011I2FR 17C1011 I2FR17C1011 I2FR 17C1011I2FR 17C1011 CFR17C1011 CFR 17C1011CFR 17C1011 CFR17C1011 CFR 17C1011CFR 17C1011 I2FR17C1011 I2FR 17C1011I2
Authority
FR
France
Prior art keywords
proteasome inhibitors
proteasome
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR17C1011C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR17C1011(I2)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharmaceuticals IncfiledCriticalMillennium Pharmaceuticals Inc
Publication of FR17C1011I1publicationCriticalpatent/FR17C1011I1/fr
Application grantedgrantedCritical
Publication of FR17C1011I2publicationCriticalpatent/FR17C1011I2/en
Activelegal-statusCriticalCurrent

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FR17C1011C2007-08-062017-04-14 PROTEASOME INHIBITORSActiveFR17C1011I2 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
PCT/US2007/017440WO2009020448A1 (en)2007-08-062007-08-06Proteasome inhibitors

Publications (2)

Publication NumberPublication Date
FR17C1011I1 FR17C1011I1 (en)2017-05-26
FR17C1011I2true FR17C1011I2 (en)2018-04-27

Family

ID=38691782

Family Applications (1)

Application NumberTitlePriority DateFiling Date
FR17C1011CActiveFR17C1011I2 (en)2007-08-062017-04-14 PROTEASOME INHIBITORS

Country Status (32)

CountryLink
EP (3)EP2178888B1 (en)
JP (1)JP5261488B2 (en)
KR (6)KR101474831B1 (en)
CN (1)CN101772507B (en)
AU (1)AU2007357338B2 (en)
BR (1)BRPI0721905B8 (en)
CA (1)CA2695082C (en)
CY (2)CY1113386T1 (en)
DK (1)DK2178888T3 (en)
EA (1)EA028622B1 (en)
EC (1)ECSP10010015A (en)
ES (1)ES2390606T3 (en)
FR (1)FR17C1011I2 (en)
GE (1)GEP20125599B (en)
HR (1)HRP20120745T1 (en)
HU (1)HUS1700018I1 (en)
IL (4)IL203641A (en)
LT (1)LTC2178888I2 (en)
LU (1)LUC00013I2 (en)
MY (1)MY161991A (en)
NL (1)NL300871I2 (en)
NZ (1)NZ582693A (en)
PH (1)PH12014500053B1 (en)
PL (1)PL2178888T3 (en)
PT (1)PT2178888E (en)
RS (1)RS52435B (en)
SG (1)SG10201508712QA (en)
SI (1)SI2178888T1 (en)
TN (1)TN2010000060A1 (en)
UA (1)UA97536C2 (en)
WO (1)WO2009020448A1 (en)
ZA (1)ZA201000348B (en)

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US7576206B2 (en)2003-08-142009-08-18Cephalon, Inc.Proteasome inhibitors and methods of using the same
US7468383B2 (en)2005-02-112008-12-23Cephalon, Inc.Proteasome inhibitors and methods of using the same
MY171061A (en)2005-11-092019-09-24Onyx Therapeutics IncCompounds for enzyme inhibition
AU2007261345B2 (en)2006-06-192012-02-23Onyx Therapeutics, Inc.Peptide epoxyketones for proteasome inhibition
US7442830B1 (en)2007-08-062008-10-28Millenium Pharmaceuticals, Inc.Proteasome inhibitors
KR20170040374A (en)2007-10-042017-04-12오닉스 세라퓨틱스, 인크.Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
ES2541467T5 (en)2008-06-172025-03-31Takeda Pharmaceuticals CoBoronate ester compounds and pharmaceutical compositions thereof
AR075090A1 (en)2008-09-292011-03-09Millennium Pharm Inc ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
EP3090737A1 (en)2008-10-212016-11-09Onyx Therapeutics, Inc.Combination therapy with peptide epoxyketones
AR075899A1 (en)2009-03-202011-05-04Onyx Therapeutics Inc PROTEASA INHIBITING CRYSTALLINE EPOXYCETON TRIPEPTIDES
US8853147B2 (en)2009-11-132014-10-07Onyx Therapeutics, Inc.Use of peptide epoxyketones for metastasis suppression
EP2516449A1 (en)2009-12-222012-10-31Cephalon, Inc.Proteasome inhibitors and processes for their preparation, purification and use
BR112012022060A2 (en)2010-03-012018-05-08Onyx Therapeutics Inc compound for inhibition of immunoproteasome
KR20130036228A (en)2010-03-312013-04-11밀레니엄 파머슈티컬스 인코퍼레이티드Derivatives of 1-amino-2-cyclopropylethylboronic acid
US20140121182A1 (en)*2011-06-222014-05-01Cephalon, Inc.Proteasome inhibitors and processes for their preparation, purification and use
PL2753334T3 (en)*2011-08-302022-12-12Trustees Of Tufts College FAP-ACTIVATED PROTEASOME INHIBITORS FOR THE TREATMENT OF SOLID TUMORS
EP2793900B1 (en)*2011-12-222018-08-22Ares Trading S.A.Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
JP6215234B2 (en)*2012-01-242017-10-18ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Method for treating nasopharyngeal cancer
EP2810066B1 (en)*2012-01-242019-07-31Millennium Pharmaceuticals, Inc.Methods of treatment of cancer
US9309283B2 (en)2012-07-092016-04-12Onyx Therapeutics, Inc.Prodrugs of peptide epoxy ketone protease inhibitors
CN109096370B (en)*2012-07-262022-03-18圣特莱国际公司Polypeptide epoxy ketone compound
JP2013006855A (en)*2012-09-032013-01-10Millennium Pharmaceuticals IncProteasome inhibitor
EP2925765B1 (en)*2012-12-032016-12-14F. Hoffmann-La Roche AGSubstituted triazole boronic acid compounds
CN105705149A (en)*2013-10-032016-06-22米伦纽姆医药公司Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis
MX2016015267A (en)2014-05-202017-02-22Millennium Pharm IncBoron-containing proteasome inhibitors for use after primary cancer therapy.
US10301273B2 (en)2014-08-072019-05-28Mayo Foundation For Medical Education And ResearchCompounds and methods for treating cancer
MA41555A (en)*2015-02-172017-12-26Millennium Pharm Inc POLYTHERAPY FOR CANCER TREATMENT
US10144761B2 (en)2015-06-192018-12-04Hanlin Scientific Inc.Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (en)*2015-10-212017-05-03北京大学Synthetic method of proteasome inhibitor MLN9708
CN107400142B (en)*2016-05-192019-11-19成都奥璟生物科技有限公司A kind of boric acid and boric acid ester compound and its application
CN106008572B (en)*2016-05-232018-08-17成都千禧莱医药科技有限公司A kind of dipeptide boronic acid compound and preparation method and purposes
DK3472149T3 (en)2016-06-212023-11-27Orion Ophthalmology LLC HETEROCYCLIC PROLINE MID DERIVATIVES
US10526315B2 (en)2016-06-212020-01-07Orion Ophthalmology LLCCarbocyclic prolinamide derivatives
JP6802899B2 (en)*2016-07-252020-12-23深▲セン▼市塔吉瑞生物医▲薬▼有限公司Shenzhen TargetRx,Inc. Substituted boronic acid compounds, pharmaceutical compositions containing the compounds and their use
TW201831191A (en)*2017-01-232018-09-01大陸商成都奥璟生物科技有限公司Novel boric acid derivative and pharmaceutical composition using same
ES3036483T3 (en)2017-02-282025-09-19Mayo Found Medical Education & ResCombinations for use in the treatment of cancer
CN108794516A (en)*2017-04-262018-11-13上海时莱生物技术有限公司Boric acid and boric acid ester compound and its preparation method and application
CN109305980B (en)*2017-07-282022-10-11成都奥璟生物科技有限公司Borate compound, and synthesis method and application thereof
US20200199159A1 (en)2017-08-252020-06-25Synthon B.V.Process for making ixazomib or intermediates therefor
JP2018024694A (en)*2017-10-032018-02-15ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc.Proteasome inhibitor
US11243207B2 (en)2018-03-292022-02-08Mayo Foundation For Medical Education And ResearchAssessing and treating cancer
CN110903310B (en)*2018-09-142022-11-22成都奥璟生物科技有限公司 A kind of boric acid ester drug and its application
CN110357787A (en)*2019-08-022019-10-22苏州艾和医药科技有限公司Yi Shazuo meter synthesising process research
EP4041246B1 (en)*2019-10-072024-12-04Cornell UniversityAntimicrobial and antiviral effects of c2-c7alkyl boronic acids
CN110950897B (en)*2019-12-122021-05-28山东大学 A kind of histone deacetylase, proteasome dual-target inhibitor and preparation method and application thereof

Family Cites Families (17)

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Publication numberPriority datePublication dateAssigneeTitle
US4499082A (en)1983-12-051985-02-12E. I. Du Pont De Nemours And Companyα-Aminoboronic acid peptides
US5242904A (en)1987-06-051993-09-07The Dupont Merck Pharmaceutical CompanyPeptide boronic acid inhibitors of trypsin-like proteases
US5187157A (en)1987-06-051993-02-16Du Pont Merck Pharmaceutical CompanyPeptide boronic acid inhibitors of trypsin-like proteases
US5250720A (en)1987-06-051993-10-05The Dupont Merck Pharmaceutical CompanyIntermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (en)1987-11-051990-08-22Hoechst AktiengesellschaftRenin inhibitors
US5106948A (en)1988-05-271992-04-21Mao Foundation For Medical Education And ResearchCytotoxic boronic acid peptide analogs
US6083903A (en)*1994-10-282000-07-04Leukosite, Inc.Boronic ester and acid compounds, synthesis and uses
CA2435146C (en)*2001-01-252011-03-29The United States Of America, Represented By The Secretary, Department Of Health And Human ServicesFormulation of boronic acid compounds
DE60209227T2 (en)2001-05-302006-08-17Novartis Ag 2 - ((N- (2-AMINO-3- (HETEROARYL- OR -ARYL) PROPIONYL) AMINOACYL) AMINO) -ALKYLBORONIC ACID DERIVATIVES
PE20050360A1 (en)*2003-08-142005-06-10Cephalon Inc PROTEASOME INHIBITORS
US7223745B2 (en)2003-08-142007-05-29Cephalon, Inc.Proteasome inhibitors and methods of using the same
US7576206B2 (en)*2003-08-142009-08-18Cephalon, Inc.Proteasome inhibitors and methods of using the same
KR100939598B1 (en)*2004-03-302010-02-01밀레니엄 파머슈티컬스 인코퍼레이티드Synthesis of boronic ester and acid compounds
WO2006008660A2 (en)2004-07-202006-01-26Affinium Pharmaceuticals, Inc.Streptococcus pneumoniae enoyl- (acyl-carrier-protein) reductase (fabk)
TW200618820A (en)*2004-11-052006-06-16Alza CorpLiposome formulations of boronic acid compounds
GB0513349D0 (en)2005-06-292005-08-03Torres ManelNon-woven fabric
CN101247799B (en)2005-07-052013-03-27塔夫茨大学信托人Inhibitors of fibroblast activation protein alpha

Also Published As

Publication numberPublication date
IL242290A0 (en)2015-11-30
KR101474831B1 (en)2014-12-19
HUS1700018I1 (en)2017-05-29
EP2527347A1 (en)2012-11-28
CY2017016I1 (en)2017-07-12
IL242290A (en)2017-12-31
JP5261488B2 (en)2013-08-14
AU2007357338A1 (en)2009-02-12
SI2178888T1 (en)2012-11-30
ECSP10010015A (en)2010-04-30
IL242292A (en)2017-12-31
EP2178888A1 (en)2010-04-28
ZA201000348B (en)2011-03-30
KR20100059811A (en)2010-06-04
BRPI0721905B1 (en)2020-11-17
RS52435B (en)2013-02-28
CN101772507B (en)2012-12-12
CA2695082C (en)2015-07-28
TN2010000060A1 (en)2011-09-26
UA97536C2 (en)2012-02-27
PH12014500053A1 (en)2015-03-30
EA028622B1 (en)2017-12-29
BRPI0721905B8 (en)2021-05-25
KR20170004031A (en)2017-01-10
EP3210987A1 (en)2017-08-30
KR101831674B1 (en)2018-02-23
DK2178888T3 (en)2012-10-01
LTC2178888I2 (en)2018-03-12
NL300871I2 (en)2017-12-07
KR20140042932A (en)2014-04-07
NZ582693A (en)2012-01-12
EA201070247A1 (en)2010-06-30
CY1113386T1 (en)2016-06-22
KR20150010802A (en)2015-01-28
GEP20125599B (en)2012-08-10
EP2178888B1 (en)2012-07-04
CN101772507A (en)2010-07-07
IL203641A (en)2015-11-30
FR17C1011I1 (en)2017-05-26
LUC00013I1 (en)2017-04-06
LTPA2017010I1 (en)2017-05-10
HK1143595A1 (en)2011-01-07
ES2390606T3 (en)2012-11-14
IL242291A0 (en)2015-11-30
AU2007357338B2 (en)2014-03-20
HK1182924A1 (en)2013-12-13
SG10201508712QA (en)2015-11-27
PL2178888T3 (en)2012-11-30
PH12014500053B1 (en)2015-03-30
MY161991A (en)2017-05-31
JP2010535759A (en)2010-11-25
IL242292A0 (en)2015-11-30
IL242291A (en)2017-12-31
BRPI0721905A2 (en)2014-02-25
CY2017016I2 (en)2017-07-12
LUC00013I2 (en)2017-06-19
HRP20120745T1 (en)2012-10-31
PT2178888E (en)2012-10-04
KR20160040735A (en)2016-04-14
CA2695082A1 (en)2009-02-12
WO2009020448A1 (en)2009-02-12
KR20140042933A (en)2014-04-07

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