| ZA935111B (en)* | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
| ZA935110B (en)* | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
| USRE40596E1 (en)* | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| CA2161101A1 (en) | 1993-04-23 | 1994-11-10 | Eduardo Gonzalez | Rapamycin conjugates and antibodies |
| US7279561B1 (en)* | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
| USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
| PT649651E (en)* | 1993-09-28 | 2001-03-30 | Scherer Gmbh R P | PREPARATION OF SOFT GELATINE CAPSULES |
| US5527907A (en)* | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| WO1995014023A1 (en)* | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| JP3745772B2 (en)* | 1993-12-17 | 2006-02-15 | ノバルティス アクチエンゲゼルシャフト | Rapamycin derivatives useful as immunosuppressants |
| GB9405350D0 (en)* | 1994-03-18 | 1994-05-04 | Sandoz Ltd | Organic compounds |
| CZ289773B6 (en)* | 1994-10-26 | 2002-04-17 | Novartis Ag | Pharmaceutical preparation for local application |
| US7205279B2 (en)* | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
| MY129435A (en) | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| US5561138A (en)* | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
| GB9618952D0 (en)* | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| SK284529B6 (en)* | 1995-06-09 | 2005-05-05 | Novartis Ag | Rapamycin derivatives, process of their preparation, pharmaceutical composition containing thereof and kit or package for use in immunosuppression, inflammation or infections |
| FR2736550B1 (en)* | 1995-07-14 | 1998-07-24 | Sandoz Sa | PHARMACEUTICAL COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A MACROLIDE AND A VEHICLE |
| US5780462A (en)* | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| GB9601120D0 (en)* | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| KR100616020B1 (en)* | 1996-03-27 | 2007-01-31 | 노파르티스 아게 | Use of Rapamycin Derivatives in Vasculopathies and Xenotransplantation |
| GB9606452D0 (en)* | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| PT956034E (en) | 1996-07-30 | 2002-12-31 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TRANSPLANT REJECTION OF INFLAMMATORY OR AUTO-IMMUNE STATES COMPOSING CYCOSPORINE E 40-O- (2-HYDROXYETHYL) -RAPAMICINE |
| AU4176897A (en)* | 1996-09-09 | 1998-03-26 | American Home Products Corporation | Alkylated rapamycin derivatives |
| US5922730A (en)* | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
| GB9624038D0 (en)* | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| US6220537B1 (en) | 1997-03-07 | 2001-04-24 | Daiwa Seiko, Inc. | Fishing spinning reel having smoothly shaped rail portion |
| US6306166B1 (en)* | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| RU2235554C2 (en)* | 1998-03-06 | 2004-09-10 | Новартис Аг | Preliminary prepared emulsion concentrates containing cyclosporine or macrolide |
| TW570814B (en)* | 1998-03-26 | 2004-01-11 | Fujisawa Pharmaceutical Co | Sustained-release pharmaceutical composition |
| US20050031611A1 (en)* | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
| US6015809A (en)* | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
| AU5487499A (en)* | 1998-08-17 | 2000-03-06 | American Home Products Corporation | Photocyclized rapamycins |
| GB9826882D0 (en)* | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
| US7276506B2 (en)* | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| US6946465B2 (en)* | 1999-02-02 | 2005-09-20 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| US6318654B1 (en) | 1999-03-07 | 2001-11-20 | Daiwa Seiko, Inc. | Spinning reel for fishing |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| JP2002544167A (en) | 1999-05-10 | 2002-12-24 | ノバルティス アクチエンゲゼルシャフト | Organic compounds |
| USD440626S1 (en) | 1999-06-08 | 2001-04-17 | Daiwa Seiko, Inc. | Line slider for a spinning fishing reel |
| BR0013399A (en)* | 1999-08-18 | 2002-04-30 | American Home Prod | water-soluble sdz-rad esters |
| US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| DE60010098T2 (en) | 1999-08-24 | 2005-03-31 | Ariad Gene Therapeutics, Inc., Cambridge | 28-EPIRAPALOGE |
| US20070032853A1 (en)* | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
| US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| RU2264405C2 (en)* | 1999-12-06 | 2005-11-20 | Новартис Аг | 40-o-(2-hydroxy)ethylrapamycin in crystalline nonsolvated form, pharmaceutical composition comprising such macrolide as active substance and method for its preparing |
| AU3095601A (en)* | 2000-01-14 | 2001-07-24 | Univ Pennsylvania | O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders |
| GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
| ATE278421T1 (en) | 2000-08-11 | 2004-10-15 | Wyeth Corp | METHOD FOR TREATING ESTROGEN RECEPTOR POSITIVE CARCINOMA |
| EP1319008B1 (en) | 2000-09-19 | 2008-10-15 | Wyeth | Water soluble rapamycin esters |
| US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| WO2002026139A1 (en) | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
| US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
| US6440991B1 (en)* | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| RU2264389C3 (en) | 2000-10-20 | 2018-06-01 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | NITROGEN-CONTAINING AROMATIC DERIVATIVES, THEIR APPLICATION, MEDICINE ON THEIR BASIS AND METHOD OF TREATMENT |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP3351246B8 (en) | 2001-02-19 | 2019-09-18 | Novartis Pharma AG | Rapamycin derivative for the treatment of a solid tumor associated with deregulated angiogenesis |
| AU2016206379B2 (en)* | 2001-02-19 | 2017-09-14 | Novartis Ag | Cancer Treatment |
| AU2005201004A1 (en)* | 2001-02-19 | 2005-03-24 | Novartis Ag | Cancer treatment |
| AU2011226833B9 (en)* | 2001-02-19 | 2014-07-03 | Novartis Ag | Cancer treatment |
| TWI233359B (en)* | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
| TWI296196B (en)* | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| WO2003004098A1 (en) | 2001-07-06 | 2003-01-16 | Sucampo Ag | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US7682387B2 (en)* | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US6939376B2 (en)* | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| WO2003043650A1 (en)* | 2001-11-21 | 2003-05-30 | Sucampo Ag | Use of fk506 and analogues for treating allergic diseases |
| DK1478648T3 (en) | 2002-02-01 | 2014-07-28 | Ariad Pharma Inc | PHOSPHORUS RELATIONS AND APPLICATIONS THEREOF |
| US20030176455A1 (en)* | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
| US20040024450A1 (en)* | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| JP5227492B2 (en) | 2002-05-16 | 2013-07-03 | ノバルティス アーゲー | Use of EDG receptor binding agents in cancer |
| US7300942B2 (en) | 2002-07-16 | 2007-11-27 | Biotica Technology Limited | Production of polyketides and other natural products |
| AR040693A1 (en) | 2002-07-30 | 2005-04-13 | Wyeth Corp | PARENTERAL FORMULATIONS |
| US8163726B2 (en)* | 2002-09-18 | 2012-04-24 | University Of Pennsylvania | Method of inhibiting choroidal neovascularization |
| CN1708293A (en) | 2002-09-24 | 2005-12-14 | 诺瓦提斯公司 | Sphingosine-1-phosphate receptor agonists for the treatment of demyelinating diseases |
| WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
| DE60331367D1 (en) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | ACTIVE COMPOSITION OF FAST GELING POLYMERIC COMPOSITION |
| AR042938A1 (en)* | 2003-02-06 | 2005-07-06 | Wyeth Corp | USE OF CCI-779 IN THE TREATMENT OF HEPATIC FIBROSIS |
| US20090093875A1 (en) | 2007-05-01 | 2009-04-09 | Abbott Laboratories | Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations |
| AR043504A1 (en)* | 2003-03-17 | 2005-08-03 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS THAT INCLUDE RAPAMYCIN FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| GB0307867D0 (en)* | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| US20070155771A1 (en)* | 2003-04-11 | 2007-07-05 | David Rubinsztein | Methods and means for treating protein conformational disorders |
| UA80756C2 (en)* | 2003-04-22 | 2007-10-25 | Wyeth Corp | Antineoplastic combinations of rapomicine and interferon alfa (?) in the treatment of neoplasms |
| RU2233285C1 (en)* | 2003-05-15 | 2004-07-27 | Институт молекулярной генетики РАН | Highly tritium labeled [3h]-rapamycin |
| US7160867B2 (en)* | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| ES2316995T3 (en)* | 2003-07-08 | 2009-04-16 | Novartis Ag | USE OF RAPAMYCIN AND RAPAMICIDE DERIVATIVES FOR THE TREATMENT OF OSEA LOSS. |
| PL1663244T3 (en)* | 2003-09-12 | 2008-01-31 | 4 Aza Ip Nv | Pteridine derivatives for the treatment of tnf-alpha-related diseases. |
| AU2004274026A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| US20070032477A1 (en)* | 2003-10-17 | 2007-02-08 | Waer Mark J A | Pteridine derivatives useful for making pharmaceutical compositions |
| US7220755B2 (en)* | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| US9114198B2 (en) | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
| GB0327840D0 (en)* | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| ES2315745T3 (en) | 2004-03-01 | 2009-04-01 | Terumo Kabushiki Kaisha | PROCEDURE FOR THE MANUFACTURE OF RAPAMYCIN O-RENTED DERIVATIVES. |
| ES2425167T3 (en) | 2004-03-10 | 2013-10-11 | Seradyn, Inc. | Immunoassays for everolimus |
| AR047988A1 (en)* | 2004-03-11 | 2006-03-15 | Wyeth Corp | ANTI -OPLASTIC COMBINATIONS OF CCI-779 AND RITUXIMAB |
| US8551512B2 (en)* | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
| US8778014B1 (en) | 2004-03-31 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Coatings for preventing balloon damage to polymer coated stents |
| CA2562962A1 (en)* | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| AU2005238493A1 (en)* | 2004-04-27 | 2005-11-10 | Wyeth | Labeling of rapamycin using rapamycin-specific methylases |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US8709469B2 (en) | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| JP5117190B2 (en) | 2004-08-27 | 2013-01-09 | コーディス・コーポレイション | Amorphous rapamycin without solvent |
| CN101001629B (en) | 2004-09-17 | 2010-05-05 | 卫材R&D管理有限公司 | Pharmaceutical composition |
| US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
| MX2007003789A (en)* | 2004-10-04 | 2007-07-20 | Qlt Usa Inc | Ocular delivery of polymeric delivery formulations. |
| MX2007005153A (en)* | 2004-10-28 | 2007-06-26 | Wyeth Corp | Use of an mtor inhibitor in treatment of uterine leiomyoma. |
| US8021849B2 (en)* | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
| WO2006053754A1 (en)* | 2004-11-19 | 2006-05-26 | Novartis Ag | COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE |
| US20060160837A1 (en)* | 2004-12-29 | 2006-07-20 | The Brigham And Women's Hospital, Inc. | Rapamycin compounds in the treatment of neurofibromatosis type 1 |
| US8637070B2 (en) | 2005-02-09 | 2014-01-28 | Santen Pharmaceutical Co., Ltd. | Rapamycin formulations and methods of their use |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| GB0503936D0 (en)* | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| EP1856131A1 (en) | 2005-03-07 | 2007-11-21 | Wyeth | Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin |
| WO2006095173A2 (en) | 2005-03-11 | 2006-09-14 | Biotica Technology Limited | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
| US20100061994A1 (en)* | 2005-03-11 | 2010-03-11 | Rose Mary Sheridan | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
| GB0504994D0 (en)* | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
| GT200600148A (en)* | 2005-04-14 | 2006-11-22 | | METHODS FOR THE TREATMENT AND PREVENTION OF FIBROSIS |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
| EP1890728A1 (en)* | 2005-05-31 | 2008-02-27 | Novartis AG | Combination of hmg-coa reductase inhibitors amd mtor inhibitors |
| US20070004767A1 (en)* | 2005-06-30 | 2007-01-04 | Gutmann David H | Methods for treating neurofibromatosis 1 |
| US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
| CA2615254C (en) | 2005-07-20 | 2013-09-24 | Novartis Ag | Combinations of pyrimidylaminobenzamide bcr-abl inhibitors and mtor inhibitors for the treatment of leukemia |
| EP2586798A3 (en) | 2005-07-25 | 2013-08-07 | Emergent Product Development Seattle, LLC | B-cell reduction using CD37-specific and CD20-specific binding molecules |
| JP4989476B2 (en) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Methods for assaying the effects of angiogenesis inhibitors |
| EP1919954B1 (en) | 2005-08-30 | 2016-10-19 | University of Miami | Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins |
| EP1776970A1 (en) | 2005-10-12 | 2007-04-25 | Albert Schömig | Implant with multiple coating |
| RU2451524C2 (en) | 2005-11-04 | 2012-05-27 | Вайет | Anti-tumour combinations mtor inhibitors, herceptin and/or hki-272 |
| GB0523659D0 (en)* | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| RU2008121713A (en)* | 2005-12-20 | 2010-01-27 | Вайет (Us) | CONTROL OF STABILITY OF THE MEDICINAL FORM CCI-779 BY MEANS OF CONTROL OF THE IMPURITIES OF THE MEDICINE |
| BRPI0706528A2 (en)* | 2006-01-12 | 2011-03-29 | Novartis Ag | combination of mtor inhibitor and antifolate compound |
| US20070173923A1 (en)* | 2006-01-20 | 2007-07-26 | Savage Douglas R | Drug reservoir stent |
| GB0601406D0 (en)* | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
| HUE037890T2 (en)* | 2006-02-02 | 2018-09-28 | Novartis Ag | Tuberous sclerosis treatment |
| EP2001438A2 (en) | 2006-02-09 | 2008-12-17 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| US7622477B2 (en) | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
| US7678901B2 (en)* | 2006-02-28 | 2010-03-16 | Wyeth | Rapamycin analogs containing an antioxidant moiety |
| PE20080138A1 (en)* | 2006-03-07 | 2008-03-05 | Wyeth Corp | PROCESSES FOR PREPARING WATER-SOLUBLE POLYETHYLENE GLYCOL CONJUGATES OF MACROLID IMMUNOSUPPRESSORS |
| BRPI0709016A2 (en) | 2006-03-23 | 2011-06-21 | Macusight Inc | formulations and methods for diseases or conditions related to vascular permeability |
| EP2944382A1 (en) | 2006-04-26 | 2015-11-18 | Micell Technologies, Inc. | Coatings containing multiple drugs |
| CA2652442C (en) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| GB0609962D0 (en)* | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| GB0609963D0 (en)* | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| CA2656112A1 (en)* | 2006-06-30 | 2008-05-08 | Hanje Chen | Bioresponsive polymers |
| US10144736B2 (en)* | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| EP2054061A4 (en)* | 2006-08-02 | 2009-09-02 | Ariad Pharma Inc | Combination therapy |
| US20080051691A1 (en)* | 2006-08-28 | 2008-02-28 | Wyeth | Implantable shunt or catheter enabling gradual delivery of therapeutic agents |
| EP2065372B1 (en) | 2006-08-28 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| EP2431036B1 (en) | 2006-09-13 | 2017-04-12 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US8088789B2 (en) | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US10695327B2 (en) | 2006-09-13 | 2020-06-30 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US8067055B2 (en)* | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
| US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
| CN101522691B (en) | 2006-11-27 | 2012-08-22 | 泰尔茂株式会社 | Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative |
| EP2111184B1 (en) | 2007-01-08 | 2018-07-25 | Micell Technologies, Inc. | Stents having biodegradable layers |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| KR101198980B1 (en) | 2007-01-21 | 2012-11-07 | 헤모텍 아게 | Medical product for treating stenosis of body passages and for preventing threatening restenosis |
| CN101600694A (en) | 2007-01-29 | 2009-12-09 | 卫材R&D管理有限公司 | Composition for treatment of undifferentiated gastric cancer |
| US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
| TW200845960A (en)* | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| TW200901989A (en) | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| EP2203498B1 (en) | 2007-10-05 | 2017-12-06 | Interface Biologics Inc. | Oligofluorinated cross-linked polymers and uses thereof |
| ES2623456T3 (en) | 2007-10-19 | 2017-07-11 | Interface Biologics Inc. | Self-removing coatings |
| CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| WO2009065087A1 (en) | 2007-11-14 | 2009-05-22 | Biosensors International Group, Ltd. | Automated coating apparatus and method |
| EP2245165A4 (en)* | 2008-01-11 | 2011-06-01 | Massachusetts Eye & Ear Infirm | Conditional-stop dimerizable caspase transgenic animals |
| WO2009114010A1 (en)* | 2008-03-11 | 2009-09-17 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| RU2531754C2 (en) | 2008-04-11 | 2014-10-27 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,US | Immunotherapeutic agent combined with cd37, and its combination with bifunctional chemotherapeutic agent |
| WO2009131631A1 (en)* | 2008-04-14 | 2009-10-29 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| MX350637B (en) | 2008-04-17 | 2017-09-11 | Micell Technologies Inc | Stents having bioabsorbable layers. |
| KR20110020928A (en) | 2008-06-20 | 2011-03-03 | 노파르티스 아게 | Pediatric compositions for treating multiple sclerosis |
| US8765162B2 (en) | 2008-06-30 | 2014-07-01 | Abbott Cardiovascular Systems Inc. | Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same |
| JP2011528275A (en) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ，インク． | Drug delivery medical device |
| US8092822B2 (en) | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
| EP2352459A4 (en)* | 2008-10-03 | 2013-09-25 | Elixir Medical Corp | Macrocyclic lactone compounds and methods for their use |
| BRPI0920246A2 (en) | 2008-10-17 | 2017-06-27 | Winconsin Alumni Res Foundation | Method of preparation of biologically active alpha-beta peptides. |
| CN104042612A (en) | 2008-11-11 | 2014-09-17 | 得克萨斯大学体系董事会 | Inhibition Of Mammalian Target Of Rapamycin |
| NZ617066A (en) | 2008-12-23 | 2015-02-27 | Gilead Pharmasset Llc | Nucleoside analogs |
| PA8855601A1 (en) | 2008-12-23 | 2010-07-27 | | NUCLEOSID FORFORMIDATES |
| WO2010075554A1 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthesis of purine nucleosides |
| CN102282457A (en)* | 2009-01-21 | 2011-12-14 | 拜康有限公司 | A method for determination of sirolimus stability and process for preparing its stable form |
| EP3023433A1 (en) | 2009-02-05 | 2016-05-25 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| JP5647998B2 (en) | 2009-03-13 | 2015-01-07 | カトリーケ ユニバーシテイト ルーヴェン、ケー．ユー． ルーヴェン アール アンド ディー | Thiazolopyrimidine modulators as immunosuppressants |
| US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
| CA2758297A1 (en) | 2009-04-16 | 2010-10-21 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| KR101741629B1 (en) | 2009-05-06 | 2017-05-31 | 라보라토리 스킨 케어, 인크. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
| EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | Drug delivery medical device |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| CN102770455B (en) | 2009-08-03 | 2017-02-08 | 迈阿密大学 | Method for expanding regulatory T cells in vivo |
| JP5581390B2 (en) | 2009-10-23 | 2014-08-27 | イーライ リリー アンド カンパニー | AKT inhibitor |
| WO2011053938A1 (en) | 2009-10-30 | 2011-05-05 | Ariad Pharmaceuticals, Inc. | Methods and compositions for treating cancer |
| WO2015161139A1 (en) | 2014-04-16 | 2015-10-22 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| AU2010322114B2 (en) | 2009-11-18 | 2014-07-31 | Novartis Ag | Methods and compositions for treating solid tumors and other malignancies |
| WO2011072398A1 (en) | 2009-12-18 | 2011-06-23 | Interface Biologics, Inc. | Local delivery of drugs from self assembled coatings |
| CN102127092B (en)* | 2010-01-18 | 2013-04-17 | 东南大学 | Preparation of Everolimus |
| EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| CA2792258A1 (en) | 2010-03-05 | 2011-09-09 | President And Fellows Of Harvard College | Induced dendritic cell compositions and uses thereof |
| CL2011000718A1 (en) | 2010-03-31 | 2012-04-09 | Gilead Pharmasset Llc | Process for the preparation of enantiomeric phosphorus compounds. |
| KR101830455B1 (en) | 2010-04-13 | 2018-02-20 | 노파르티스 아게 | Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase (cdk4/6) inhibitor and an mtor inhibitor for treating cancer |
| WO2011128405A1 (en) | 2010-04-16 | 2011-10-20 | Novartis Ag | Combination of organic compounds |
| WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| MX342590B (en) | 2010-04-27 | 2016-10-05 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor. |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| BR112012032462A2 (en) | 2010-06-25 | 2016-11-08 | Eisai R&D Man Co Ltd | antitumor agent employing compounds which, in combination, have kinase inhibiting effect. |
| EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN102464669B (en)* | 2010-11-17 | 2014-04-16 | 浙江海正药业股份有限公司 | Amorphous everolimus and preparation method thereof |
| ES2753529T3 (en)* | 2010-11-19 | 2020-04-13 | Biocon Ltd | Processes for the preparation of everolimus and intermediate products thereof |
| WO2012103959A1 (en) | 2011-02-04 | 2012-08-09 | Synthon Bv | Process for making everolimus |
| CA2827673C (en) | 2011-02-18 | 2020-10-27 | Novartis Pharma Ag | Mtor/jak inhibitor combination therapy |
| CN102174053B (en)* | 2011-03-09 | 2014-04-16 | 成都雅途生物技术有限公司 | Method for purifying everolimus |
| PT2683406T (en) | 2011-03-11 | 2019-07-08 | Beth Israel Deaconess Medical Ct Inc | Anti-cd40 antibodies and uses thereof |
| EP2508525A1 (en) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| US8962650B2 (en) | 2011-04-18 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2012148846A1 (en) | 2011-04-25 | 2012-11-01 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
| JP6038128B2 (en) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | A biomarker for predicting and evaluating the reactivity of thyroid and renal cancer subjects to lenvatinib compounds |
| WO2012170384A1 (en) | 2011-06-06 | 2012-12-13 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
| EP2532740A1 (en) | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
| US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2013013708A1 (en) | 2011-07-26 | 2013-01-31 | Fundació Institut D'investigació Biomèdica De Bellvitge | Treatment of acute rejection in renal transplant |
| US20130028895A1 (en) | 2011-07-27 | 2013-01-31 | Gerald Wulf | Exosome inhibiting agents and uses thereof |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| CN102268015B (en)* | 2011-08-30 | 2013-08-28 | 成都摩尔生物医药有限公司 | Synthesis method of everolimus |
| GB201115665D0 (en) | 2011-09-09 | 2011-10-26 | Univ Leuven Kath | Autoimmune and inflammatory disorder therapy |
| BR112014007902A2 (en) | 2011-10-06 | 2017-04-18 | Novartis Ag | pharmaceutical compositions comprising 40-o- (2-hydroxy) ethyl rapamycin |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| EP2589383A1 (en) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP subtype-specific rapamycin analogue for use in treatment of diseases |
| GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
| CA2868392A1 (en) | 2012-05-23 | 2013-11-28 | Estelle DOUDEMENT | Compositions and methods of obtaining and using endoderm and hepatocyte cells |
| CN102786534A (en)* | 2012-05-25 | 2012-11-21 | 上海现代制药股份有限公司 | Preparation method of everolimus |
| DK2859001T3 (en) | 2012-06-08 | 2016-05-30 | Biotronik Ag | RAPAMYCIN 40-O-CYCLIC HYDROCARBESTERS, COMPOSITIONS AND PROCEDURES |
| WO2013192367A1 (en) | 2012-06-22 | 2013-12-27 | Novartis Ag | Neuroendocrine tumor treatment |
| CN103705925B (en) | 2012-09-29 | 2018-03-30 | 段磊 | Pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway |
| US9750728B2 (en) | 2012-09-29 | 2017-09-05 | Targeted Therapeutics, Llc | Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway |
| CA2926747A1 (en) | 2012-10-12 | 2014-04-17 | Arlan RICHARDSON | Use of mtor inhibitors to treat vascular cognitive impairment |
| WO2014068070A1 (en) | 2012-10-31 | 2014-05-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
| US9757432B2 (en) | 2012-11-14 | 2017-09-12 | Ohio State Innovation Foundation | Materials and methods useful for treating glioblastorna |
| AU2012395673A1 (en)* | 2012-11-30 | 2014-08-14 | Hangzhou Zylox Pharma Co., Ltd. | Rapamycin analogs and methods for making same |
| BR112015009004A8 (en) | 2012-12-21 | 2021-07-20 | Eisai R&D Man Co Ltd | amorphous form of quinoline derivative and method of production thereof |
| CA2897826C (en) | 2013-01-09 | 2022-09-27 | Taylor H. Schreiber | Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein |
| JP6330024B2 (en) | 2013-03-12 | 2018-05-23 | マイセル・テクノロジーズ，インコーポレイテッド | Bioabsorbable biomedical implant |
| EP2968281B1 (en) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
| AU2014236135A1 (en) | 2013-03-14 | 2015-09-10 | Thomas Jefferson University | Androgen receptor down-regulating agents and uses thereof |
| US10098871B2 (en) | 2013-03-15 | 2018-10-16 | Leslie B. Gordon | Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis |
| TW201503912A (en) | 2013-03-19 | 2015-02-01 | Novartis Ag | Pharmaceutical compositions comprising everolimus |
| WO2014182635A1 (en) | 2013-05-08 | 2014-11-13 | Baldwin Megan E | Biomarkers for age-related macular degeneration (amd) |
| CA2912219C (en) | 2013-05-14 | 2021-11-16 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| KR20180059584A (en) | 2013-05-15 | 2018-06-04 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
| WO2014200659A1 (en) | 2013-06-11 | 2014-12-18 | Clontech Laboratories, Inc. | Protein enriched microvesicles and methods of making and using the same |
| CN105324386B (en)* | 2013-06-20 | 2019-02-19 | 诺华股份有限公司 | Alkylation of Alkyl Fluoroalkyl Sulfonates |
| CN103360411B (en)* | 2013-07-17 | 2015-09-30 | 成都雅途生物技术有限公司 | Everolimus crystallization and purification method |
| BR112016002970A2 (en) | 2013-08-12 | 2017-09-12 | Tokai Pharmaceuticals Inc | biomarkers for the treatment of neoplastic disorders using androgen-directed therapies |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| US20150140036A1 (en) | 2013-11-13 | 2015-05-21 | Novartis Institutes For Biomedical Research, Inc. | Low, immune enhancing, dose mtor inhibitors and uses thereof |
| CA3225453A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| KR101529963B1 (en)* | 2013-12-27 | 2015-06-19 | 주식회사 종근당바이오 | Method for preparing everolimus and its intermediates |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| EP3094314B1 (en) | 2014-01-16 | 2021-06-23 | MUSC Foundation For Research Development | Targeted nanocarriers for the administration of immunosuppressive agents |
| JP2017505345A (en) | 2014-02-11 | 2017-02-16 | ノバルティス アーゲー | Combination medicine comprising a PI3K inhibitor for the treatment of cancer |
| US20170081411A1 (en) | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
| JP2017513818A (en) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | Treatment of cancer using chimeric antigen receptors |
| CN103848849B (en)* | 2014-03-24 | 2016-02-24 | 上海医药工业研究院 | The preparation technology of everolimus |
| CA2943609A1 (en) | 2014-03-27 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Metabolically-activated drug conjugates to overcome resistance in cancer therapy |
| WO2015157252A1 (en) | 2014-04-07 | 2015-10-15 | BROGDON, Jennifer | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| WO2015171723A1 (en) | 2014-05-06 | 2015-11-12 | Research Development Foundation | Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy |
| CN105254646A (en)* | 2014-05-28 | 2016-01-20 | 上海博邦医药科技有限公司 | Everolimus preparation method |
| JP2017518307A (en) | 2014-06-02 | 2017-07-06 | チルドレンズ メディカル センター コーポレーション | Methods and compositions for immunomodulation |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| WO2016014576A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| JP2017528433A (en) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | Low immunoenhancing dose of mTOR inhibitor and CAR combination |
| EP3174546B1 (en) | 2014-07-31 | 2019-10-30 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
| EP3166950A1 (en)* | 2014-08-04 | 2017-05-17 | Cipla Limited | Process for the synthesis of everolimus and intermediates thereof |
| WO2016023082A1 (en) | 2014-08-12 | 2016-02-18 | Monash University | Lymph directing prodrugs |
| JP6919118B2 (en) | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | Treatment of cancer with GFRα-4 chimeric antigen receptor |
| RU2020117196A (en) | 2014-08-19 | 2020-10-15 | Новартис Аг | CHIMERIC ANTIGENIC RECEPTOR (CAR) AGAINST CD123 FOR USE IN THE TREATMENT OF MALIGNANT TUMORS |
| JO3783B1 (en) | 2014-08-28 | 2021-01-31 | Eisai R&D Man Co Ltd | High purity quinoline derivative and method for its production |
| EP3193902A4 (en) | 2014-09-11 | 2018-03-28 | The Regents of The University of California | mTORC1 INHIBITORS |
| ES2891332T3 (en) | 2014-09-17 | 2022-01-27 | Novartis Ag | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| CN114107424A (en) | 2014-10-08 | 2022-03-01 | 诺华股份有限公司 | Biomarkers for predicting therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| WO2016066608A1 (en) | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
| EP3977995A1 (en) | 2014-10-28 | 2022-04-06 | Koushi Yamaguchi | Tacrolimus for ameliorating pregnancy conditions |
| US10603325B2 (en) | 2014-10-29 | 2020-03-31 | University Of Maryland | Methods of treating age-related symptoms in mammals and compositions therefor |
| CN104478898A (en)* | 2014-11-18 | 2015-04-01 | 连云港恒运医药科技有限公司 | Preparation method of everolimus and intermediate of everolimus |
| WO2016135740A1 (en) | 2015-02-23 | 2016-09-01 | Natco Pharma Limited | Process for preparing stable oral compositions of everolimus |
| BR112017017428A2 (en) | 2015-02-25 | 2018-04-03 | Eisai R&D Management Co., Ltd. | A bitter taste inhibition method of a quinoline derivative |
| WO2016140717A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
| MD3097102T2 (en) | 2015-03-04 | 2018-02-28 | Gilead Sciences Inc | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-D]pyrimidine compounds |
| JP7114457B2 (en) | 2015-04-17 | 2022-08-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Methods for Improving Efficacy and Growth of Chimeric Antigen Receptor-Expressing Cells |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| CA2986359A1 (en) | 2015-05-20 | 2016-11-24 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| CN104892632B (en)* | 2015-06-03 | 2017-12-26 | 道中道（菏泽）制药有限公司 | A kind of everolimus of crystal form and preparation method thereof |
| KR102705821B1 (en) | 2015-06-16 | 2024-09-12 | 가부시키가이샤 프리즘 바이오랩 | Anticancer drug |
| EP3109250A1 (en) | 2015-06-23 | 2016-12-28 | Synbias Pharma AG | Method for the synthesis of rapamycin derivatives |
| SG11201801083UA (en) | 2015-08-20 | 2018-03-28 | Eisai R&D Man Co Ltd | Tumor therapeutic agent |
| WO2017029391A1 (en) | 2015-08-20 | 2017-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating cancer |
| PT3307322T (en) | 2015-09-04 | 2021-04-23 | Primatope Therapeutics Inc | HUMANIZED ANTI-CP40 ANTIBODIES AND THEIR USES CROSS-REFERENCE RELATED TO ASSOCIATED APPLICATIONS |
| CN118063537A (en) | 2015-09-08 | 2024-05-24 | 莫纳什大学 | Lymphatic prodrugs |
| WO2017081624A1 (en) | 2015-11-11 | 2017-05-18 | Novartis Ag | Uses of myostatin antagonists, combinations containing them and uses thereof |
| CN105566348A (en)* | 2015-12-31 | 2016-05-11 | 哈药集团技术中心 | Preparation method of everolimus |
| CN109640959B (en) | 2016-04-29 | 2023-03-17 | 西奈山伊坎医学院 | Targeting the innate immune system to induce long-term tolerance and address macrophage accumulation in atherosclerosis |
| JP6855470B2 (en) | 2016-05-27 | 2021-04-07 | 日本化薬株式会社 | Pharmaceutical composition containing rapamycin or a derivative thereof |
| US11365252B2 (en) | 2016-07-20 | 2022-06-21 | University Of Utah Research Foundation | CD229 CAR T cells and methods of use thereof |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| CA3035346A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| US10441584B2 (en) | 2016-11-23 | 2019-10-15 | Novartis Ag | Methods of enhancing immune response |
| EP3548894B1 (en) | 2016-12-02 | 2021-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for diagnosing renal cell carcinoma |
| CN116606261A (en) | 2016-12-22 | 2023-08-18 | 美国安进公司 | KRAS G12C inhibitors and methods of use thereof |
| GB201701087D0 (en) | 2017-01-23 | 2017-03-08 | Univ Leuven Kath | Novel prodrugs of mizoribine |
| BR112019014127A2 (en) | 2017-02-08 | 2020-02-11 | Eisai R&D Management Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TUMOR TREATMENT |
| CN110603038A (en)* | 2017-02-10 | 2019-12-20 | 塔姆山治疗公司 | Rapamycin analogs |
| WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3624863B1 (en) | 2017-05-15 | 2021-04-14 | C.R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
| WO2018212202A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| JOP20190272A1 (en) | 2017-05-22 | 2019-11-21 | Amgen Inc | Kras g12c inhibitors and methods of using the same |
| EP3644997A1 (en) | 2017-06-26 | 2020-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of olmsted syndrome |
| JP2020527044A (en) | 2017-07-13 | 2020-09-03 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | Methods for enhancing the growth and immunosuppressive capacity of the CD8 + CD45RCLOW / -Treg population |
| US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| WO2019046491A1 (en) | 2017-08-29 | 2019-03-07 | Ariya Therapeutics, Inc. | Lymphatic system-directing lipid prodrugs |
| CA3075046A1 (en) | 2017-09-08 | 2019-03-14 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| AR112834A1 (en) | 2017-09-26 | 2019-12-18 | Novartis Ag | RAPAMYCIN DERIVATIVES |
| CN108047265A (en)* | 2017-11-24 | 2018-05-18 | 成都海创药业有限公司 | A kind of everolimus intermediate prepares purification process |
| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| WO2019213282A1 (en) | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP4234031A3 (en) | 2018-05-01 | 2024-02-28 | Revolution Medicines, Inc. | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
| AU2019262599B2 (en) | 2018-05-04 | 2023-10-12 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| MX2020010836A (en) | 2018-05-04 | 2021-01-08 | Amgen Inc | Kras g12c inhibitors and methods of using the same. |
| MA52564A (en) | 2018-05-10 | 2021-03-17 | Amgen Inc | KRAS G12C INHIBITORS FOR CANCER TREATMENT |
| WO2019222843A1 (en) | 2018-05-22 | 2019-11-28 | Interface Biologics, Inc. | Compositions and methods for delivering drugs to a vessel wall |
| TWI869346B (en) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| MX2020012731A (en) | 2018-06-01 | 2021-02-22 | Amgen Inc | Kras g12c inhibitors and methods of using the same. |
| WO2019241157A1 (en) | 2018-06-11 | 2019-12-19 | Amgen Inc. | Kras g12c inhibitors for treating cancer |
| JP7369719B2 (en) | 2018-06-12 | 2023-10-26 | アムジエン・インコーポレーテツド | KRas G12C inhibitors and methods of using the same |
| KR20210020932A (en) | 2018-06-13 | 2021-02-24 | 노파르티스 아게 | BCMA chimeric antigen receptor and uses thereof |
| CN108676014A (en)* | 2018-06-15 | 2018-10-19 | 国药集团川抗制药有限公司 | The method for purifying the method for everolimus intermediate and preparing everolimus |
| EP3826650A4 (en) | 2018-07-23 | 2022-07-27 | Enclear Therapies, Inc. | METHODS OF TREATING NEUROLOGICAL DISORDERS |
| JP2022510573A (en) | 2018-07-23 | 2022-01-27 | エンクリアー セラピーズ， インク． | How to treat neuropathy |
| EP3849545A1 (en) | 2018-09-10 | 2021-07-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of neurofibromatosis |
| CN113167798A (en) | 2018-10-05 | 2021-07-23 | 卫材R&D管理有限公司 | Biomarkers for Combination Therapy Containing Lenvatinib and Everolimus |
| EP3880266B1 (en) | 2018-11-14 | 2025-05-07 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
| JP7516029B2 (en) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Improved synthesis of key intermediates for KRAS G12C inhibitor compounds |
| WO2020106640A1 (en) | 2018-11-19 | 2020-05-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| JP7377679B2 (en) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer |
| SI3898637T1 (en) | 2018-12-18 | 2025-04-30 | Novartis Ag | Rapamycin derivatives |
| AU2019403488B2 (en) | 2018-12-20 | 2025-07-24 | Amgen Inc. | KIF18A inhibitors |
| WO2020132653A1 (en) | 2018-12-20 | 2020-06-25 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
| MA54546A (en) | 2018-12-20 | 2022-03-30 | Amgen Inc | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS |
| CN120398830A (en) | 2018-12-20 | 2025-08-01 | 美国安进公司 | KIF18A inhibitors |
| AU2019407426A1 (en) | 2018-12-21 | 2021-07-22 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
| EA202191983A1 (en)* | 2019-01-22 | 2021-12-01 | Аеовиан Фармасьютикалз, Инк. | mTORC MODULATORS AND THEIR APPLICATIONS |
| US20230096028A1 (en) | 2019-03-01 | 2023-03-30 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| KR20210146287A (en) | 2019-03-01 | 2021-12-03 | 레볼루션 메디슨즈, 인크. | Bicyclic heteroaryl compounds and uses thereof |
| EP3952937A1 (en) | 2019-04-08 | 2022-02-16 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
| KR20220011123A (en) | 2019-04-11 | 2022-01-27 | 엔클리어 테라피스, 인크. | Cerebrospinal fluid improvement method and device and system therefor |
| TW202212339A (en) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
| TWI751516B (en) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| UA129871C2 (en) | 2019-05-21 | 2025-08-27 | Емджен Інк. | SOLID FORMS |
| TWI879779B (en) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | Processes for preparing toll-like receptor modulator compounds |
| JP2021008453A (en) | 2019-07-02 | 2021-01-28 | エフェクター・セラピューティクス，インコーポレーテッド | Translation inhibitor and use thereof |
| US20220289724A1 (en) | 2019-08-02 | 2022-09-15 | Amgen Inc. | Kif18a inhibitors |
| EP4007638A1 (en) | 2019-08-02 | 2022-06-08 | Amgen Inc. | Pyridine derivatives as kif18a inhibitors |
| CN114401953A (en) | 2019-08-02 | 2022-04-26 | 美国安进公司 | KIF18A inhibitors |
| CA3147451A1 (en) | 2019-08-02 | 2021-02-11 | Amgen Inc. | Kif18a inhibitors |
| US12208095B2 (en) | 2019-08-26 | 2025-01-28 | Arvinas Operations, Inc. | Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders |
| WO2021053559A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| EP4031542B1 (en) | 2019-09-18 | 2025-10-15 | Merck Sharp & Dohme LLC | Small molecule inhibitors of kras g12c mutant |
| CA3155857A1 (en) | 2019-10-24 | 2021-04-29 | Amgen Inc. | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS KRAS G12C AND KRAS G12D INHIBITORS IN THE TREATMENT OF CANCER |
| GEP20247710B (en) | 2019-10-28 | 2024-12-25 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras g12c mutant |
| EP4051266A1 (en) | 2019-10-31 | 2022-09-07 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| CR20220240A (en) | 2019-11-04 | 2022-08-03 | Revolution Medicines Inc | RAS INHIBITORS |
| JP2022553859A (en) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | RAS inhibitor |
| CA3159561A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| PH12022551102A1 (en) | 2019-11-08 | 2023-11-20 | Revolution Medicines Inc | Bicyclic heteroaryl compounds and uses thereof |
| AU2020383535A1 (en) | 2019-11-14 | 2022-05-05 | Amgen Inc. | Improved synthesis of KRAS G12C inhibitor compound |
| EP4058453A1 (en) | 2019-11-14 | 2022-09-21 | Amgen Inc. | Improved synthesis of kras g12c inhibitor compound |
| CN114980976A (en) | 2019-11-27 | 2022-08-30 | 锐新医药公司 | Covalent RAS inhibitors and uses thereof |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| CN118767143A (en) | 2019-12-12 | 2024-10-15 | 听治疗有限责任公司 | Compositions and methods for preventing and treating hearing loss |
| CN114929279A (en) | 2020-01-07 | 2022-08-19 | 锐新医药公司 | Methods of administering SHP2 inhibitors and treating cancer |
| EP4100017A4 (en) | 2020-02-05 | 2024-04-10 | PureTech LYT, Inc. | LIPID PRODRUGS OF NEUROSTEROIDS |
| WO2021215545A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c |
| WO2021215544A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| US20230255972A1 (en) | 2020-07-15 | 2023-08-17 | Taiho Pharmaceutical Co., Ltd. | Pyrimidine compound-containing combination to be used in tumor treatment |
| CN116209438A (en) | 2020-09-03 | 2023-06-02 | 锐新医药公司 | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors |
| CN116457358A (en) | 2020-09-15 | 2023-07-18 | 锐新医药公司 | Indole derivatives as RAS inhibitors for the treatment of cancer |
| EP4221801A4 (en) | 2020-09-29 | 2024-11-06 | Enclear Therapies, Inc. | METHOD AND SYSTEM FOR MANAGING SUBARACHNOID FLUID |
| CN117396472A (en) | 2020-12-22 | 2024-01-12 | 上海齐鲁锐格医药研发有限公司 | SOS1 inhibitors and uses thereof |
| US11859021B2 (en) | 2021-03-19 | 2024-01-02 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
| CN117500811A (en) | 2021-05-05 | 2024-02-02 | 锐新医药公司 | Covalent RAS inhibitors and uses thereof |
| WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| AR125782A1 (en) | 2021-05-05 | 2023-08-16 | Revolution Medicines Inc | RAS INHIBITORS |
| EP4347041A1 (en) | 2021-05-28 | 2024-04-10 | Taiho Pharmaceutical Co., Ltd. | Small molecule inhibitors of kras mutated proteins |
| EP4370160A1 (en) | 2021-07-15 | 2024-05-22 | President And Fellows Of Harvard College | Compositions and methods relating to cells with adhered particles |
| AR127308A1 (en) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | RAS INHIBITORS |
| JP2025500878A (en) | 2021-12-17 | 2025-01-15 | ジェンザイム・コーポレーション | PYRAZOLO-PYRAZINE COMPOUNDS AS SHP2 INHIBITORS |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| CN119136806A (en) | 2022-03-08 | 2024-12-13 | 锐新医药公司 | Methods for treating immune-refractory lung cancer |
| AU2023275778A1 (en) | 2022-05-25 | 2024-12-12 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
| KR20250022133A (en) | 2022-06-10 | 2025-02-14 | 레볼루션 메디슨즈, 인크. | macrocyclic RAS inhibitors |
| JP2025521677A (en) | 2022-07-06 | 2025-07-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Methods for Treating Proliferative Glomerulonephritis - Patent application |
| EP4565217A1 (en) | 2022-08-04 | 2025-06-11 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of lymphoproliferative disorders |
| PE20251879A1 (en) | 2022-10-14 | 2025-07-22 | Black Diamond Therapeutics Inc | Cancer treatment methods using isoquinoline or 6-azaquinoline derivatives |
| WO2024100236A1 (en) | 2022-11-11 | 2024-05-16 | Astrazeneca Ab | Combination therapies for the treatment of cancer |
| WO2024167904A1 (en) | 2023-02-07 | 2024-08-15 | Arvinas Operations, Inc. | Dosage regimens of estrogen receptor degraders in combination with an mtor inhibitor |
| TW202504611A (en) | 2023-03-30 | 2025-02-01 | 美商銳新醫藥公司 | Compositions for inducing ras gtp hydrolysis and uses thereof |
| WO2024211663A1 (en) | 2023-04-07 | 2024-10-10 | Revolution Medicines, Inc. | Condensed macrocyclic compounds as ras inhibitors |
| WO2024211712A1 (en) | 2023-04-07 | 2024-10-10 | Revolution Medicines, Inc. | Condensed macrocyclic compounds as ras inhibitors |
| WO2024216016A1 (en) | 2023-04-14 | 2024-10-17 | Revolution Medicines, Inc. | Crystalline forms of a ras inhibitor |
| WO2024216048A1 (en) | 2023-04-14 | 2024-10-17 | Revolution Medicines, Inc. | Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof |
| TW202508595A (en) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | Combination therapy for a ras related disease or disorder |
| CN116813641A (en)* | 2023-06-09 | 2023-09-29 | 杭州华东医药集团康润制药有限公司 | A kind of preparation method of everolimus |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025043187A1 (en) | 2023-08-24 | 2025-02-27 | Otsuka Pharmaceutical Co., Ltd. | Fixed dose combinations of cedazuridine and azacitidine |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250136615A1 (en) | 2023-10-20 | 2025-05-01 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2025137507A1 (en) | 2023-12-22 | 2025-06-26 | Regor Pharmaceuticals, Inc. | Sos1 inhibitors and uses thereof |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |