FI935485L - PEG-hydrazone and PEG-oxime bond-forming reagents and their protein derivatives - Google Patents

PEG-hydrazone and PEG-oxime bond-forming reagents and their protein derivatives Download PDF

Info

Publication number: FI935485L
Authority: FI; Finland
Prior art keywords: peg; hydrazone; protein derivatives; oxime bond; forming reagents
Prior art date: 1992-12-09

Application number

FI935485A

Other languages

Other versions

Inventor

David E Wright

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-09

Filing date

1993-12-08

Publication date

1994-06-10

1993-12-08Application filed by Ortho Pharma CorpfiledCriticalOrtho Pharma Corp

1993-12-08Publication of FI935485A0publicationCriticalpatent/FI935485A0/en

1994-06-10Publication of FI935485A7publicationCriticalpatent/FI935485A7/en

1994-06-10Publication of FI935485LpublicationCriticalpatent/FI935485L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/16—Cyclic ethers having four or more ring atoms
- C08G65/20—Tetrahydrofuran

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

FI935485A1992-12-091993-12-08 PEG-hydrazone and PEG-oxime bond-forming reagents and their protein derivativesFI935485L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98773992A	1992-12-09	1992-12-09
US4505293A	1993-04-07	1993-04-07

Publications (3)

Publication Number	Publication Date
FI935485A0 FI935485A0 (en)	1993-12-08
FI935485A7 FI935485A7 (en)	1994-06-10
FI935485Ltrue FI935485L (en)	1994-06-10

Family

ID=26722325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI935485AFI935485L (en)	1992-12-09	1993-12-08	PEG-hydrazone and PEG-oxime bond-forming reagents and their protein derivatives

Country Status (5)

Country	Link
JP (1)	JPH07196925A (en)
KR (1)	KR100254650B1 (en)
AU (1)	AU5238393A (en)
FI (1)	FI935485L (en)
NO (1)	NO934477L (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586398B1 (en)*	2000-04-07	2003-07-01	Amgen, Inc.	Chemically modified novel erythropoietin stimulating protein compositions and methods
US20040082765A1 (en)*	2000-10-16	2004-04-29	Teruo Nakamura	Peg-modified erythropoietin
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7247609B2 (en)	2001-12-18	2007-07-24	Universitat Zurich	Growth factor modified protein matrices for tissue engineering
US20050148763A1 (en)*	2002-02-01	2005-07-07	Chugai Seiyaku Kabushiki Kaisha	Peg-binding pth or peg-binding pth derivative
DE10209822A1 (en)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Coupling of low molecular weight substances to a modified polysaccharide
DE10209821A1 (en)	2002-03-06	2003-09-25	Biotechnologie Ges Mittelhesse	Coupling of proteins to a modified polysaccharide
WO2004024761A1 (en)*	2002-09-11	2004-03-25	Fresenius Kabi Deutschland Gmbh	Hasylated polypeptides, especially hasylated erythropoietin
ES2214166T1 (en)*	2002-09-11	2004-09-16	Fresenius Kabi Deutschland Gmbh	HAS-ILLATED POLYPEPTIDES, ESPECIALLY, HAS-ILADA ERIPTROPOYETINA.
EP2338333B1 (en)	2003-04-09	2017-09-06	ratiopharm GmbH	Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en)	2003-07-25	2015-04-14	Novo Nordisk A/S	Antibody toxin conjugates
WO2005014655A2 (en)	2003-08-08	2005-02-17	Fresenius Kabi Deutschland Gmbh	Conjugates of hydroxyalkyl starch and a protein
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
AR048035A1 (en)	2004-03-11	2006-03-22	Fresenius Kabi De Gmbh	CONJUGADOS DE ALMIDON DE HIDROXIALQUILO AND A PROTEIN, PREPARED BY REDUCING AMINATION
WO2006010143A2 (en)	2004-07-13	2006-01-26	Neose Technologies, Inc.	Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP3061461A1 (en)	2004-10-29	2016-08-31	ratiopharm GmbH	Remodeling and glycopegylation of fibroblast growth factor (fgf)
KR20070090023A (en)*	2004-12-22	2007-09-04	암브룩스, 인코포레이티드	Modified human growth hormone
MX2007008229A (en)	2005-01-10	2007-09-11	Neose Technologies Inc	Glycopegylated granulocyte colony stimulating factor.
US9187546B2 (en)	2005-04-08	2015-11-17	Novo Nordisk A/S	Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en)	2005-11-03	2009-02-19	Neose Technologies, Inc.	Nucleotide Sugar Purification Using Membranes
WO2008011633A2 (en)	2006-07-21	2008-01-24	Neose Technologies, Inc.	Glycosylation of peptides via o-linked glycosylation sequences
ES2531934T3 (en)*	2006-09-01	2015-03-20	Novo Nordisk Health Care Ag	Modified glycoproteins
EP2054521A4 (en)	2006-10-03	2012-12-19	Novo Nordisk As	METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
PL2144923T3 (en)	2007-04-03	2013-12-31	Biogenerix Ag	Methods of treatment using glycopegylated g-csf
CN101778859B (en)	2007-06-12	2014-03-26	诺和诺德公司	Improved process for the production of nucleotide sugars
EP2227263A2 (en)	2007-12-28	2010-09-15	Kuros Biosurgery AG	Pdgf fusion proteins incorporated into fibrin foams
CA2715465C (en)	2008-02-27	2017-03-21	Novo Nordisk A/S	Conjugated factor viii molecules
EP2275202A1 (en)	2008-03-13	2011-01-19	Ajinomoto Co., Inc.	Carbonyl compound remover
US8067526B2 (en)	2009-03-27	2011-11-29	Nof Corporation	Method for producing polyoxalkylene derivative
MX2012001207A (en)*	2009-07-27	2012-05-08	Baxter Int	Blood coagulation protein conjugates.
CN106110311A (en)*	2009-07-27	2016-11-16	百深公司	Blood coagulation protein conjugates
EP3081233B1 (en)*	2009-07-27	2020-12-23	Baxalta GmbH	Glycopolysialylation of proteins other than blood coagulation proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1676992A (en)*	1991-03-18	1992-10-21	Enzon, Inc.	Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers

1993
- 1993-12-08FIFI935485Apatent/FI935485L/ennot_activeApplication Discontinuation
- 1993-12-08NONO934477Apatent/NO934477L/enunknown
- 1993-12-09KRKR1019930027329Apatent/KR100254650B1/ennot_activeExpired - Fee Related
- 1993-12-09JPJP5340709Apatent/JPH07196925A/enactivePending
- 1993-12-09AUAU52383/93Apatent/AU5238393A/ennot_activeAbandoned

Also Published As

Publication number	Publication date
FI935485A7 (en)	1994-06-10
JPH07196925A (en)	1995-08-01
FI935485A0 (en)	1993-12-08
KR940014430A (en)	1994-07-18
NO934477D0 (en)	1993-12-08
KR100254650B1 (en)	2000-05-01
NO934477L (en)	1994-06-10
AU5238393A (en)	1994-06-23

Publication	Publication Date	Title
FI935485A7 (en)	1994-06-10	PEG-hydrazone and PEG-oxime bond-forming reagents and their protein derivatives
FI924747A7 (en)	1993-04-22	PEG-imidates and their protein derivatives
FI961599A7 (en)	1996-06-07	1N-Alkyl-N-arylpyrimidineamines and their derivatives
FI20000516A7 (en)	2000-03-07	Bis-indolylmaleimide derivatives and their preparation
FI922609A7 (en)	1992-06-05	Proteins and nucleic acids
FI963185L (en)	1996-08-14	Hematopoietic protein and materials and methods for its preparation
FI941137L (en)	1994-09-12	2-Debenzoyl-2-acyltaxol derivatives and methods for their preparation
FI960888L (en)	1996-02-26	Protocadherin proteins and their use
FI943345L (en)	1995-01-15	Organo-aluminoxy products and their uses
FI932282L (en)	1993-11-22	PROTEIN C DERIVATIVES
FI945625A7 (en)	1994-11-29	Indolocarbazoleimides and their use
DK91192D0 (en)	1992-07-10	PROTEIN
FI20105336L (en)	2010-03-31	Zinc finger protein derivatives and methods thereof
FI953479A7 (en)	1996-01-20	1-Arylpyrimidine derivatives and their pharmaceutical use
FI932425A7 (en)	1993-11-29	Protease and related DNA compounds
FI940640L (en)	1994-08-13	Organoaluminoxy products and uses
DK299087D0 (en)	1987-06-12	PROTEINS AND DERIVATIVES THEREOF
FI953919A7 (en)	1995-08-21	Pyrrolydenemethyl derivatives and process for their preparation
FI935728L (en)	1994-06-22	Substituted 4-phenylpyridones and 4-phenyl-2-alkoxypyridines
FI952574L (en)	1995-05-26	Glycosyltransferase-active proteins
DK132892D0 (en)	1992-10-30	PROTEINS
FI944713L (en)	1994-12-02	4-Diphenylmethylpiperidine derivatives and process for their preparation
FI944906L (en)	1994-10-19	New cyclic amino acids and their derivatives
FI981359L (en)	1998-06-12	New thiomarinol derivatives and methods for their preparation
FI971085L (en)	1997-03-17	New PKA-binding proteins and their uses

Legal Events

Date	Code	Title	Description
1997-07-14	FD	Application lapsed

Movatterモバイル変換