FI932695A7 - Angiotensin I chymase(s) inhibitors, including human cardiac chymase - Google Patents

Angiotensin I chymase(s) inhibitors, including human cardiac chymase Download PDF

Info

Publication number: FI932695A7
Authority: FI; Finland
Prior art keywords: chymase; angiotensin; inhibitors; including human; human cardiac
Prior art date: 1992-06-12

Application number

FI932695A

Other languages

Other versions

Inventor

Dennis J Hoover

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-12

Filing date

1993-06-11

Publication date

1993-12-13

1993-06-11Application filed by PfizerfiledCriticalPfizer

1993-06-11Publication of FI932695A0publicationCriticalpatent/FI932695A0/en

1993-12-13Publication of FI932695LpublicationCriticalpatent/FI932695L/en

1993-12-13Publication of FI932695A7publicationCriticalpatent/FI932695A7/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Urology & Nephrology (AREA)
Crystallography & Structural Chemistry (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)

FI932695A1992-06-121993-06-11 Angiotensin I chymase(s) inhibitors, including human cardiac chymaseFI932695A7 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US89772392A	1992-06-12	1992-06-12

Publications (3)

Publication Number	Publication Date
FI932695A0 FI932695A0 (en)	1993-06-11
FI932695L FI932695L (en)	1993-12-13
FI932695A7true FI932695A7 (en)	1993-12-13

Family

ID=25408314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI932695AFI932695A7 (en)	1992-06-12	1993-06-11	Angiotensin I chymase(s) inhibitors, including human cardiac chymase

Country Status (5)

Country	Link
EP (1)	EP0644892A1 (en)
JP (1)	JP2668003B2 (en)
CA (1)	CA2137832C (en)
FI (1)	FI932695A7 (en)
WO (1)	WO1993025574A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9524267D0 (en)*	1995-11-28	1996-01-31	Isis Innovation	Enzyme inhibitor and method
ES2314305T3 (en)*	1996-09-10	2009-03-16	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	MODIFIED AMINO ACIDS, MEDICINES CONTAINING THESE COMPOUNDS AND PROCEDURE FOR OBTAINING THEM.
DE69709671T2 (en)	1996-10-18	2002-08-22	Vertex Pharmaceuticals Inc., Cambridge	INHIBITORS OF SERINE PROTEASES, ESPECIALLY NS3 PROTEASE OF THE HEPATITIS C VIRUS
SI0932617T1 (en)*	1996-10-18	2002-06-30	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
WO1998018794A1 (en)*	1996-10-25	1998-05-07	Yoshitomi Pharmaceutical Industries, Ltd.	Novel heterocyclic amide compounds and medicinal uses thereof
US20030069231A1 (en)*	1999-10-12	2003-04-10	Klaus Rudolf	Modified aminoacids, pharmaceuticals containing these compounds and method for their production
US6300337B1 (en)	1998-02-17	2001-10-09	Nippon Kayaku Kabushiki Kaisha	Acetamide derivative and use thereof
CA2341195A1 (en)*	1998-08-20	2000-03-02	Mitsunori Waki	Prophylactic or therapeutic composition for ocular circulation disorders
EP1136488A4 (en)*	1998-12-01	2002-06-12	Meiji Seika Kaisha	Sf2809-i, ii, iii, iv, v and vi substances exhibiting chymase-inhibiting activities
DE60034545T2 (en)	1999-11-01	2007-10-25	Asubio Pharma Co., Ltd.	USE OF CHYMASE INHIBITORS AGAINST VASCULAR LIPID DEPOSITION
US7618977B2 (en)	2000-02-22	2009-11-17	Asubio Pharma Co., Ltd.	Method of treating dermatitis comprising administering a chymase inhibitor
WO2001062292A1 (en)	2000-02-22	2001-08-30	Suntory Limited	Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient
ES2275652T3 (en)	2000-02-22	2007-06-16	Daiichi Asubio Pharma Co., Ltd.	THERAPEUTIC TREATMENT OF EOSINOPHILY USING CHEMASA INHIDERS AS ACTIVE INGREDIENT.
EP1284266A4 (en)*	2000-05-02	2005-11-16	Meiji Seika Kaisha	Novel indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof
AU2002222933A1 (en)*	2000-07-13	2002-01-30	Millennium Pharamaceuticals, Inc.	Inhibitors of factor xa
GB0021315D0 (en)	2000-08-30	2000-10-18	Dainippon Pharmaceutical Co	Heterocyclic compounds and intermediates thereof
EP1362846A4 (en)	2001-01-26	2006-10-04	Takeda Pharmaceutical	AMINOETHANOLDERIVATE
GB0205175D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205162D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205165D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205170D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205166D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205176D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
US7595312B2 (en)	2002-10-25	2009-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
ES2636943T3 (en)	2003-05-09	2017-10-10	Toray Industries, Inc.	Beraprost and a renin-angiotensin system inhibitor for use in the treatment of kidney diseases
TWI359147B (en)	2003-09-05	2012-03-01	Vertex Pharma	Inhibitors of serine proteases, particularly hcv n
DE102004015723A1 (en)	2004-03-29	2005-10-20	Boehringer Ingelheim Pharma	Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
CA2657618C (en)	2006-07-13	2016-10-11	Achillion Pharmaceuticals, Inc.	4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
BRPI0922912A8 (en)	2008-12-10	2018-01-02	Achillion Pharmaceuticals Inc	4-amino-4-oxobutanoyl peptides as viral replication inhibitors
WO2014145600A1 (en)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof
WO2014144087A1 (en)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	Sovaprevir polymorphs and methods of manufacture thereof
US10526315B2 (en)	2016-06-21	2020-01-07	Orion Ophthalmology LLC	Carbocyclic prolinamide derivatives
DK3472149T3 (en)	2016-06-21	2023-11-27	Orion Ophthalmology LLC	HETEROCYCLIC PROLINE MID DERIVATIVES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4499082A (en)*	1983-12-05	1985-02-12	E. I. Du Pont De Nemours And Company	α-Aminoboronic acid peptides
CA2021660A1 (en)*	1989-07-26	1991-01-27	Philippe Bey	Peptidase inhibitors
DK0587799T3 (en)*	1991-05-23	1999-11-22	Merrell Pharma Inc	Inhibitors of cathepsin G and elastase to prevent connective tissue degradation

1993
- 1993-04-23WOPCT/US1993/003625patent/WO1993025574A1/ennot_activeApplication Discontinuation
- 1993-04-23CACA002137832Apatent/CA2137832C/ennot_activeExpired - Fee Related
- 1993-04-23JPJP6501449Apatent/JP2668003B2/ennot_activeExpired - Fee Related
- 1993-04-23EPEP93909587Apatent/EP0644892A1/ennot_activeWithdrawn
- 1993-06-11FIFI932695Apatent/FI932695A7/enunknown

Also Published As

Publication number	Publication date
EP0644892A1 (en)	1995-03-29
JPH07507069A (en)	1995-08-03
FI932695L (en)	1993-12-13
WO1993025574A1 (en)	1993-12-23
CA2137832A1 (en)	1993-12-23
FI932695A0 (en)	1993-06-11
CA2137832C (en)	2000-09-26
JP2668003B2 (en)	1997-10-27

Publication	Publication Date	Title
FI932695A7 (en)	1993-12-13	Angiotensin I chymase(s) inhibitors, including human cardiac chymase
DE69614680D1 (en)	2001-09-27	IMPLANTABLE OSTEOSYNTHESIS DEVICE
DE69429905D1 (en)	2002-03-28	Heart rate monitor
DK0660689T3 (en)	1997-04-14	Osteosynthesis aid
NO953838D0 (en)	1995-09-28	Removable medical electrode system
DE69836589D1 (en)	2007-01-18	IMPLANTABLE TWO-CHANNEL NEUROSTIMULATOR
NL1003300A1 (en)	1996-12-10	Implantable therapeutic device.
DE69430186D1 (en)	2002-04-25	Active implantable device
DE69723899D1 (en)	2003-09-11	Heart rate sensitive pacemaker
DK0747069T3 (en)	2002-12-09	Implantable medical device
DE69627026D1 (en)	2003-04-30	osteosynthesis
EP0635222A3 (en)	1995-03-29	Comb.
FI932518A7 (en)	1993-12-04	Angiotensin II antagonists
DE69322899D1 (en)	1999-02-18	Biomedical amplifier circuit
DE69627539D1 (en)	2003-05-22	PACKAGING-FREE BIOELECTRODE
DE69624739D1 (en)	2002-12-19	Active pulse magnetometer
DE69829554D1 (en)	2005-05-04	OVALGEFORTME HEART CANNULA
NO932005D0 (en)	1993-06-02	Angiotensin II antagonists
DE69629255D1 (en)	2003-09-04	Heart assist device
DE69630054D1 (en)	2003-10-23	ATRIAL DEFIBRILLATOR
DE69631568D1 (en)	2004-03-25	Dual-chamber pacemakers
DE69306719D1 (en)	1997-01-30	Heart rate sensitive pacemaker
DE59307865D1 (en)	1998-01-29	HEART PACEMAKER SYSTEM
ITTO930196V0 (en)	1993-08-09	PERFECTED PARTITION FOR FOOTWEAR.
FI950089A7 (en)	1995-03-07	Dioxocyclobutene derivatives as angiotensin II antagonists

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