ES554449A0 - Un metodo de purificar activador de plasminogeno de tejido uterino - Google Patents

Un metodo de purificar activador de plasminogeno de tejido uterino

Info

Publication number: ES554449A0
Authority: ES; Spain
Prior art keywords: purifying; plasminogen activator; tissue plasminogen; uterine tissue; uterine
Prior art date: 1984-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Other versions

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Integrated Genetics Inc

Original Assignee

Integrated Genetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-01

Filing date

1986-04-28

Publication date

1987-07-01

1986-04-28Application filed by Integrated Genetics IncfiledCriticalIntegrated Genetics Inc

1987-07-01Publication of ES8706726A1publicationCriticalpatent/ES8706726A1/es

1987-07-01Publication of ES554449A0publicationCriticalpatent/ES554449A0/es

StatusExpiredlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/70—Vector systems having a special element relevant for transcription from fungi
- C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Control Of Ac Motors In General (AREA)
Saccharide Compounds (AREA)

ES554449A1984-10-011986-04-28Un metodo de purificar activador de plasminogeno de tejido uterinoExpiredES8706726A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US65677084A	1984-10-01	1984-10-01

Publications (2)

Publication Number	Publication Date
ES8706726A1 ES8706726A1 (es)	1987-07-01
ES554449A0true ES554449A0 (es)	1987-07-01

Family

ID=24634490

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES547416AExpiredES8702945A1 (es)	1984-10-01	1985-09-30	Un metodo de producir activador de plasminogeno de tejido uterino humano
ES554450AExpiredES8801306A1 (es)	1984-10-01	1986-04-28	Un metodo de purificar activador de plasminogeno de tejido humano
ES554449AExpiredES8706726A1 (es)	1984-10-01	1986-04-28	Un metodo de purificar activador de plasminogeno de tejido uterino

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES547416AExpiredES8702945A1 (es)	1984-10-01	1985-09-30	Un metodo de producir activador de plasminogeno de tejido uterino humano
ES554450AExpiredES8801306A1 (es)	1984-10-01	1986-04-28	Un metodo de purificar activador de plasminogeno de tejido humano

Country Status (14)

Country	Link
US (1)	US5344773A (es)
EP (1)	EP0178105B1 (es)
JP (1)	JPS61149094A (es)
AT (1)	ATE151111T1 (es)
AU (1)	AU599576B2 (es)
DE (1)	DE3588149T2 (es)
DK (1)	DK175327B1 (es)
ES (3)	ES8702945A1 (es)
FI (1)	FI89723C (es)
IE (1)	IE81135B1 (es)
NO (1)	NO175158C (es)
NZ (1)	NZ213647A (es)
PT (1)	PT81231B (es)
ZA (1)	ZA857574B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR80966B (en)*	1983-11-21	1985-03-15	Ciba Geigy Ag	Synthesis of fibrinolytic agents by yeast
US5073494A (en)*	1985-04-22	1991-12-17	Genentech, Inc.	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
GB8528321D0 (en)*	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
JP2581668B2 (ja)*	1985-11-27	1997-02-12	三井東圧化学株式会社	ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
DE3684680D1 (de)*	1985-12-23	1992-05-07	Chiron Corp	Peptidplasminogenaktivatoren.
US5837518A (en)*	1986-01-31	1998-11-17	Genetics Institute, Inc.	Thrombolytic proteins
WO1987004722A1 (en)*	1986-01-31	1987-08-13	Genetics Institute, Inc.	Novel thrombolytic proteins
US5258298A (en)*	1986-01-31	1993-11-02	Genetics Institute, Inc.	Deletion and glycosylation mutant of human tissue plasminogen activator
IE81073B1 (en)*	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation
US5589361A (en)*	1986-03-18	1996-12-31	Genentech, Inc.	Human tissue-type plasminogen activator variant
DE3751873T2 (de)	1986-04-09	1997-02-13	Genzyme Corp	Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US5047241A (en)*	1986-07-11	1991-09-10	American Home Products Corporation	Tris-Kringle plasminogen activator with novel K2 insert
AU7709287A (en)*	1986-07-16	1988-02-10	Celltech Limited	Process for purifying a plasminogen activator
US5242819A (en)*	1986-12-05	1993-09-07	Ciba-Geigy Corporation	DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en)*	1986-12-05	1996-12-03	Ciba-Geigy Corporation	Hybrid plasminogen activator
EP0276846A3 (en)*	1987-01-29	1989-07-26	Zymogenetics, Inc.	Colony-stimulating factor derivatives
GB2200640B (en)*	1987-01-30	1991-07-10	American Home Prod	Des-epidermal growth factor plasminogen activators
JPH084501B2 (ja)*	1987-03-20	1996-01-24	エーザイ株式会社	糖鎖に関する変異ｔＰＡ
FI882407L (fi)*	1987-05-22	1988-11-23	Zymogenetics Inc	Fibrinolytiska proteiner.
AU1668988A (en)*	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
US6682733B1 (en)*	1987-06-18	2004-01-27	Roche Diagnostics, Gmbh	Fibrinolytic enzymes
DE3726019A1 (de)*	1987-08-05	1989-02-16	Boehringer Mannheim Gmbh	Verfahren zur abtrennung und reinigung von t-pa
US5100666A (en)*	1987-10-09	1992-03-31	Monsanto Company	Modified tissue plasminogen activator K2K2SP
US4963357A (en)*	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en)*	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5244676A (en)*	1987-10-09	1993-09-14	Monsanto Company	Modified tissue plasminogen activator with modified glycosylation site
US5270198A (en)*	1988-05-20	1993-12-14	Genentech, Inc.	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5665583A (en)	1988-08-12	1997-09-09	Arch Dev Corp	Methods and materials relating to IMPDH and GMP production
US5714145A (en)*	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en)*	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5070021A (en)*	1989-01-10	1991-12-03	Monsanto Company	Method of modifying oligosaccharide structure of tissue plasminogen activator
US5268273A (en)*	1990-12-14	1993-12-07	Phillips Petroleum Company	Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
ATE246000T1 (de)*	1992-06-03	2003-08-15	Genentech Inc	Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US7299805B2 (en)	2002-06-07	2007-11-27	Marctec, Llc	Scaffold and method for implanting cells
WO2014116706A1 (en)*	2013-01-22	2014-07-31	University Of Tennessee Research Foundation	Tissue plasminogen activator antibodies and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370417A (en)*	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4419446A (en)*	1980-12-31	1983-12-06	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant DNA process utilizing a papilloma virus DNA as a vector
GR79202B (es)*	1982-05-05	1984-10-22	Genentech Inc
HU200615B (en)*	1982-05-05	1990-07-28	Genentech Inc	Methods of preparing tissue plasiminogen activator derivative composition
EP0125254A1 (en)*	1982-10-28	1984-11-21	Beecham Group Plc	Enzyme derivatives and their use in the treatment of thrombosis
AU554862B2 (en)*	1982-12-14	1986-09-04	Implico B.V.	Plasminogen activator isolated by affinity chromatography
AU572108B2 (en)*	1983-01-19	1988-05-05	Genentech Inc.	Human tpa production using vectors coding for dhfr protein
GR80966B (en)*	1983-11-21	1985-03-15	Ciba Geigy Ag	Synthesis of fibrinolytic agents by yeast
US4753879A (en)*	1984-08-27	1988-06-28	Biogen N.V.	Modified tissue plasminogen activators
GB8528321D0 (en)*	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
DE3684680D1 (de)*	1985-12-23	1992-05-07	Chiron Corp	Peptidplasminogenaktivatoren.
IE81073B1 (en)*	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation

1985
- 1985-09-30FIFI853761Apatent/FI89723C/finot_activeIP Right Cessation
- 1985-09-30EPEP85306957Apatent/EP0178105B1/ennot_activeExpired - Lifetime
- 1985-09-30DKDK198504415Apatent/DK175327B1/danot_activeIP Right Cessation
- 1985-09-30ATAT85306957Tpatent/ATE151111T1/denot_activeIP Right Cessation
- 1985-09-30IEIE239485Apatent/IE81135B1/ennot_activeIP Right Cessation
- 1985-09-30NZNZ213647Apatent/NZ213647A/xxunknown
- 1985-09-30ESES547416Apatent/ES8702945A1/esnot_activeExpired
- 1985-09-30NONO853851Apatent/NO175158C/nonot_activeIP Right Cessation
- 1985-09-30DEDE3588149Tpatent/DE3588149T2/denot_activeExpired - Lifetime
- 1985-10-01USUS06/782,686patent/US5344773A/ennot_activeExpired - Lifetime
- 1985-10-01AUAU48148/85Apatent/AU599576B2/ennot_activeExpired
- 1985-10-01JPJP60216313Apatent/JPS61149094A/jaactivePending
- 1985-10-01PTPT81231Apatent/PT81231B/ptunknown
- 1985-10-01ZAZA857574Apatent/ZA857574B/xxunknown
1986
- 1986-04-28ESES554450Apatent/ES8801306A1/esnot_activeExpired
- 1986-04-28ESES554449Apatent/ES8706726A1/esnot_activeExpired

Also Published As

Publication number	Publication date
ES8801306A1 (es)	1988-01-01
PT81231A (en)	1985-11-01
EP0178105B1 (en)	1997-04-02
FI853761L (fi)	1986-04-02
DK175327B1 (da)	2004-08-23
EP0178105A3 (en)	1988-11-17
ZA857574B (en)	1986-06-25
EP0178105A2 (en)	1986-04-16
AU599576B2 (en)	1990-07-26
DK441585D0 (da)	1985-09-30
ES8706726A1 (es)	1987-07-01
DE3588149D1 (de)	1997-05-07
DE3588149T2 (de)	1997-10-09
IE852394L (en)	1986-04-01
FI853761A0 (fi)	1985-09-30
ES554450A0 (es)	1988-01-01
PT81231B (pt)	1987-10-20
NZ213647A (en)	1989-05-29
AU4814885A (en)	1986-04-10
NO175158C (no)	1994-09-07
JPS61149094A (ja)	1986-07-07
DK441585A (da)	1986-04-02
IE81135B1 (en)	2000-03-22
US5344773A (en)	1994-09-06
FI89723C (fi)	1993-11-10
FI89723B (fi)	1993-07-30
NO175158B (no)	1994-05-30
ES547416A0 (es)	1987-01-16
ES8702945A1 (es)	1987-01-16
ATE151111T1 (de)	1997-04-15
NO853851L (no)	1986-04-02

Publication	Publication Date	Title
ES554449A0 (es)	1987-07-01	Un metodo de purificar activador de plasminogeno de tejido uterino
NO831575L (no)	1983-11-07	Menneskevev-plasminogenaktivator
MX197183A (es)	1994-02-28	Activador de plasminogeno de tejido humano
DK618387D0 (da)	1987-11-25	Fremgangsmaade til sterilisering
ES557374A0 (es)	1988-06-01	Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa).
ES531754A0 (es)	1985-07-01	Un metodo para estabilizar un activador de plasminogeno de tejido.
FI872526L (fi)	1987-12-07	Menetelmä biologisesti aktiivisen plasminogeeniaktivaattorin tuottamiseksi
DK96787A (da)	1987-10-23	Human vaevs-plasminogenaktivator
NO873332D0 (no)	1987-08-10	Fremgangsmaate for rensing av vevplasminogenaktivator (tpa)
GB2147206B (en)	1988-01-27	Proteolytic enzyme treatment of wounds
FI881713L (fi)	1988-10-16	Menetelmä urokinaasityyppisen plasminogeenin aktivaattorin tuottamiseksi
EP0210870A3 (en)	1988-01-07	Method of purifying crude tissue plasminogen activator
NZ219920A (en)	1989-08-29	Purification of t.p.a. (tissue plasminogen activator)
DE3674321D1 (de)	1990-10-25	Behandlung geschmeidiger gewebe.
ES539925A0 (es)	1986-03-16	Un procedimiento de producir un activador de plasminogeno monocatenario
EP0225177A3 (en)	1987-11-25	Dna sequence coding for human tissue plasminogen activator
IL78450A0 (en)	1986-08-31	Agent containing tissue plasminogen activator(t-pa)
NO880831D0 (no)	1988-02-25	Rekombinant human vevsplasminogen-aktivatorblanding.
LV5289A3 (lv)	1993-10-10	Plazminogena audu aktivatora aktivacijas panemiens (varianti)
IE861388L (en)	1986-11-28	Tissue plasminogen activator
CU20929A (es)	1979-06-01	Metodo de purificacion de un activador plasmatico humanodel plasminogeno
GB8726683D0 (en)	1987-12-16	Tissue plasminogen activator
GB8718298D0 (en)	1987-09-09	Tissue plasminogen activator
GB8725052D0 (en)	1987-12-02	Tissue plasminogen activator
IE870208L (en)	1987-07-29	Modified tissue plasminogen activator

Legal Events

Date	Code	Title	Description
2008-06-16	FD1A	Patent lapsed	Effective date:20070423

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