ES519030A0 - A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCICLOBUTANE. (AS DIVISIONAL OF PATENT NUMBER 511.152) - Google Patents

A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCICLOBUTANE. (AS DIVISIONAL OF PATENT NUMBER 511.152)

Info

Publication number: ES519030A0
Authority: ES; Spain
Prior art keywords: phenylciclobutane; divisional; procedure; patent number; preparing derivatives
Prior art date: 1981-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Other versions

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boots Co PLC

Original Assignee

Boots Co PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-06

Filing date

1983-01-17

Publication date

1984-08-01

Family has litigation

First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES519030(A0)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-01-17Application filed by Boots Co PLCfiledCriticalBoots Co PLC

1984-08-01Publication of ES519030A0publicationCriticalpatent/ES519030A0/en

1984-08-01Publication of ES8406414A1publicationCriticalpatent/ES8406414A1/en

StatusExpiredlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
- C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
- C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

ES519030A1981-04-061983-01-17Therapeutic agentsExpiredES8406414A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8110709		1981-04-06
GB8110710		1981-04-06

Publications (2)

Publication Number	Publication Date
ES519030A0true ES519030A0 (en)	1984-08-01
ES8406414A1 ES8406414A1 (en)	1984-08-01

Family

ID=26279045

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
ES511152AExpiredES8305678A1 (en)	1981-04-06	1982-04-05	Therapeutic agents
ES519029AGrantedES519029A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE (AS A DIVISIONAL OF PATENT NUMBER 511.152)
ES519032AGrantedES519032A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE.
ES519030AExpiredES8406414A1 (en)	1981-04-06	1983-01-17	Therapeutic agents
ES519031AGrantedES519031A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE.

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
ES511152AExpiredES8305678A1 (en)	1981-04-06	1982-04-05	Therapeutic agents
ES519029AGrantedES519029A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE (AS A DIVISIONAL OF PATENT NUMBER 511.152)
ES519032AGrantedES519032A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES519031AGrantedES519031A0 (en)	1981-04-06	1983-01-17	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE.

Country Status (40)

Country	Link
KR (1)	KR900000274B1 (en)
AT (1)	AT382612B (en)
AU (1)	AU545595B2 (en)
BG (2)	BG40651A3 (en)
CA (1)	CA1248955A (en)
CH (1)	CH652117A5 (en)
CS (1)	CS244672B2 (en)
CY (1)	CY1408A (en)
DD (1)	DD208348A5 (en)
DE (1)	DE3212682A1 (en)
DK (1)	DK161770C (en)
ES (5)	ES8305678A1 (en)
FI (1)	FI77223C (en)
FR (1)	FR2504920B1 (en)
GB (1)	GB2098602B (en)
GE (1)	GEP19970661B (en)
GR (1)	GR76697B (en)
HK (1)	HK13888A (en)
HU (1)	HU186582B (en)
IE (1)	IE52768B1 (en)
IL (1)	IL65257A0 (en)
IN (1)	IN155773B (en)
IT (1)	IT1235758B (en)
JO (1)	JO1184B1 (en)
KE (1)	KE3753A (en)
LU (1)	LU84070A1 (en)
MY (1)	MY8800048A (en)
NL (1)	NL192201C (en)
NO (1)	NO156785C (en)
NZ (1)	NZ200178A (en)
PH (1)	PH22762A (en)
PL (2)	PL139120B1 (en)
PT (1)	PT74580B (en)
RO (2)	RO84802B (en)
SE (1)	SE452611B (en)
SG (1)	SG67287G (en)
SU (2)	SU1482522A3 (en)
UA (2)	UA7589A1 (en)
YU (2)	YU44336B (en)
ZW (1)	ZW4982A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE56001B1 (en)*	1982-09-30	1991-03-13	Boots Co Plc	1-arylcyclobutylmethylamine compounds
IE56000B1 (en)*	1982-09-30	1991-03-13	Boots Co Plc	1-arylcyclobutylalkylamine compounds
GB8412480D0 (en)*	1984-05-16	1984-06-20	Elliott M	Pesticides
DK58285D0 (en)*	1984-05-30	1985-02-08	Novo Industri As	PEPTIDES AND MANUFACTURING AND USING THEREOF
GB8501192D0 (en)*	1985-01-17	1985-02-20	Boots Co Plc	Therapeutic agents
DK119785D0 (en)*	1985-03-15	1985-03-15	Nordisk Gentofte	INSULIN PREPARATION
US5157021A (en)*	1985-03-15	1992-10-20	Novo Nordisk A/S	Insulin derivatives and pharmaceutical preparations containing these derivatives
GB2184122B (en)*	1985-12-17	1989-10-18	Boots Co Plc	N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8531071D0 (en)*	1985-12-17	1986-01-29	Boots Co Plc	Therapeutic compound
GB8704777D0 (en)*	1987-02-28	1987-04-01	Boots Co Plc	Medical treatment
JP2675573B2 (en)*	1988-03-31	1997-11-12	科研製薬株式会社	Brain function improver
EP0647134A4 (en)*	1992-06-23	1997-07-30	Sepracor Inc	Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine.
GB9309749D0 (en)*	1993-05-12	1993-06-23	Boots Co Plc	Therapeutic agents
US5459164A (en)*	1994-02-03	1995-10-17	Boots Pharmaceuticals, Inc.	Medical treatment
DE19518988A1 (en)*	1995-05-29	1996-12-05	Basf Ag	Use of aryl substituted cyclobutylalkylamines to treat obesity
GB9524681D0 (en)*	1995-12-02	1996-01-31	Knoll Ag	Chemical process
GB9619757D0 (en)*	1996-09-21	1996-11-06	Knoll Ag	Chemical process
GB9619962D0 (en)*	1996-09-25	1996-11-13	Knoll Ag	Medical treatment
GB9619961D0 (en)*	1996-09-25	1996-11-13	Knoll Ag	Medical treatment
GB9727131D0 (en)	1997-12-24	1998-02-25	Knoll Ag	Therapeutic agents
US6339106B1 (en)	1999-08-11	2002-01-15	Sepracor, Inc.	Methods and compositions for the treatment and prevention of sexual dysfunction
US6974838B2 (en)	1998-08-24	2005-12-13	Sepracor Inc.	Methods of treating or preventing pain using sibutramine metabolites
US6476078B2 (en)	1999-08-11	2002-11-05	Sepracor, Inc.	Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6331571B1 (en)*	1998-08-24	2001-12-18	Sepracor, Inc.	Methods of treating and preventing attention deficit disorders
AU2007200334B8 (en)*	1998-08-24	2010-10-21	Sepracor, Inc.	Methods of using and compositions comprising dopamine reuptake inhibitors
BG65170B1 (en)*	1999-03-17	2007-05-31	Knoll Gmbh	Use of n-substituted derivatives of 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine for the production of a medicine for treating eating disorders
US6552087B1 (en)	1999-03-19	2003-04-22	Abbott Gmbh & Co. Kg	Therapeutic agent comprising (+)-sibutramine
GB9915617D0 (en)	1999-07-05	1999-09-01	Knoll Ag	Therapeutic agents
RU2238084C2 (en)*	1999-08-11	2004-10-20	Сепракор Инк.	Compositions comprising inhibitors of dopamine re-uptake and methods for their using
US6399826B1 (en)	1999-08-11	2002-06-04	Sepracor Inc.	Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
AU2002210816A1 (en)*	2000-11-02	2002-05-15	Torrent Pharmaceuticals Ltd	Process for preparation of beta-phenethylamine derivative
WO2002083631A1 (en)	2001-04-13	2002-10-24	Sepracor Inc.	Methods of preparing didesmethylsibutramine and other sibutramine derivatives
KR100536750B1 (en)*	2002-10-05	2005-12-16	한미약품 주식회사	Pharmaceutical composition comprising crystalline hemihydrate of sibutramine methanesulfonate
FR2870537A1 (en)*	2004-05-19	2005-11-25	Servier Lab	NOVEL PROCESS FOR SYNTHESIZING (1S) -4,5-DIMETHOXY-1- (METHYL AMINOMETHYL) BENZOCYCLOBUTANE AND ITS ADDITION SALTS AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALTS PHARMACEUTICALLY ACCEPTABLE ACID
KR100606533B1 (en)	2004-08-27	2006-08-01	한올제약주식회사	Improved Synthesis of Sibutramine
KR100606534B1 (en)	2004-11-01	2006-08-01	한올제약주식회사	Improved Synthesis of Sibutramine with Improved Productivity
KR100618176B1 (en)*	2004-12-02	2006-09-01	휴먼팜 주식회사	Sibutramine stannate, preparation method thereof and pharmaceutical composition comprising the same
WO2006073292A1 (en)	2005-01-06	2006-07-13	Cj Corporation	Inorganic acid salts of sibutramine
BRPI0716952A2 (en)	2006-09-15	2013-10-29	Reviva Pharmaceuticals Inc	COMPOUND, METHODS FOR TREATING AND / OR PREVENTING OBESITY OR CO-MORBID INDICATION RELATED TO OBESITY, AND FOR SYNTHESIZING CYCLOalkylmethylamine Derivatives
US8604244B2 (en)	2010-07-02	2013-12-10	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
CN101555214B (en)*	2008-04-08	2012-07-11	北京嘉事联博医药科技有限公司	Phenylcyclobutylamide derivatives and optical isomers, preparation methods and uses thereof
FR2935381B1 (en)*	2008-08-29	2010-12-17	Servier Lab	NOVEL METHOD FOR THE RESOLUTION OF ENANTIOMERES OF (3,4-DIMETHOXY-BICYCLOO-4.2.0-OCTA-1,3,5-TRIEN-7-YL) NITRILE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE
WO2010082216A2 (en)*	2008-12-08	2010-07-22	Matrix Laboratories Ltd	Novel salts of sibutramine and their crystal forms
KR101426180B1 (en)	2009-11-02	2014-07-31	화이자 인코포레이티드	Dioxa-bicyclo［3.2.1］octane-2,3,4-triol derivatives
CA2858837C (en)*	2011-12-30	2022-08-30	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
FR2993561B1 (en)*	2012-07-17	2014-10-31	Servier Lab	PROCESS FOR ENZYMATIC SYNTHESIS OF (7S) -1- (3,4-DIMETHOXY BICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-YL) N-METHYL METHANAMINE, AND APPLICATION TO THE SYNTHESIS OF THE IVABRADINE AND ITS SALTS

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Publication number	Priority date	Publication date	Assignee	Title
DE1124485B (en)*	1960-02-12	1962-03-01	Hoechst Ag	Process for the preparation of analeptically active phenylcycloalkylmethylamines
US3526656A (en)*	1967-05-25	1970-09-01	Parke Davis & Co	(1-arylcyclobutyl)carbonyl carbamic acid derivatives

1982
- 1982-03-03IEIE481/82Apatent/IE52768B1/enactiveProtection Beyond IP Right Term
- 1982-03-15ILIL65257Apatent/IL65257A0/enunknown
- 1982-03-15PTPT74580Apatent/PT74580B/enunknown
- 1982-03-16PHPH27003Apatent/PH22762A/enunknown
- 1982-03-16ZWZW49/82Apatent/ZW4982A1/enunknown
- 1982-03-30NZNZ200178Apatent/NZ200178A/enunknown
- 1982-03-31CACA000400146Apatent/CA1248955A/ennot_activeExpired
- 1982-03-31AUAU82213/82Apatent/AU545595B2/ennot_activeExpired
- 1982-03-31NONO821087Apatent/NO156785C/ennot_activeIP Right Cessation
- 1982-03-31DKDK146482Apatent/DK161770C/ennot_activeIP Right Cessation
- 1982-03-31NLNL8201347Apatent/NL192201C/ennot_activeIP Right Cessation
- 1982-04-01RORO107119Apatent/RO84802B/enunknown
- 1982-04-01CHCH2020/82Apatent/CH652117A5/ennot_activeIP Right Cessation
- 1982-04-01FRFR8205634Apatent/FR2504920B1/ennot_activeExpired
- 1982-04-01CYCY140882Apatent/CY1408A/enunknown
- 1982-04-01RORO82114421Apatent/RO89436A2/enunknown
- 1982-04-01GBGB8209591Apatent/GB2098602B/ennot_activeExpired
- 1982-04-02ITIT8248157Apatent/IT1235758B/enactive
- 1982-04-02YUYU750/82Apatent/YU44336B/enunknown
- 1982-04-02ATAT0132582Apatent/AT382612B/ennot_activeIP Right Cessation
- 1982-04-05ININ383/CAL/82Apatent/IN155773B/enunknown
- 1982-04-05SESE8202166Apatent/SE452611B/ennot_activeIP Right Cessation
- 1982-04-05GRGR67812Apatent/GR76697B/elunknown
- 1982-04-05HUHU821040Apatent/HU186582B/enunknown
- 1982-04-05UAUA3834158Apatent/UA7589A1/enunknown
- 1982-04-05LULU84070Apatent/LU84070A1/enunknown
- 1982-04-05SUSU823426748Apatent/SU1482522A3/enactive
- 1982-04-05DEDE19823212682patent/DE3212682A1/enactiveGranted
- 1982-04-05ESES511152Apatent/ES8305678A1/ennot_activeExpired
- 1982-04-05JOJO19821184Apatent/JO1184B1/enactive
- 1982-04-05UAUA3426748Apatent/UA7838A1/enunknown
- 1982-04-05FIFI821197Apatent/FI77223C/ennot_activeIP Right Cessation
- 1982-04-06PLPL1982235832Apatent/PL139120B1/enunknown
- 1982-04-06BGBG056100Apatent/BG40651A3/enunknown
- 1982-04-06CSCS822457Apatent/CS244672B2/enunknown
- 1982-04-06PLPL1982240079Apatent/PL136242B1/enunknown
- 1982-04-06DDDD82238787Apatent/DD208348A5/ennot_activeIP Right Cessation
- 1982-04-06KRKR828201506Apatent/KR900000274B1/ennot_activeExpired
- 1982-04-06BGBG060417Apatent/BG40652A3/enunknown
1983
- 1983-01-17ESES519029Apatent/ES519029A0/enactiveGranted
- 1983-01-17ESES519032Apatent/ES519032A0/enactiveGranted
- 1983-01-17ESES519030Apatent/ES8406414A1/ennot_activeExpired
- 1983-01-17ESES519031Apatent/ES519031A0/enactiveGranted
1985
- 1985-01-09SUSU853834158Apatent/SU1461372A3/enactive
- 1985-01-17YUYU63/85Apatent/YU44253B/enunknown
1987
- 1987-08-19SGSG67287Apatent/SG67287G/enunknown
- 1987-08-20KEKE3753Apatent/KE3753A/enunknown
1988
- 1988-02-15HKHK138/88Apatent/HK13888A/ennot_activeIP Right Cessation
- 1988-12-30MYMY48/88Apatent/MY8800048A/enunknown
1994
- 1994-09-07GEGEAP19942156Apatent/GEP19970661B/enunknown

Also Published As

Publication number	Publication date
JO1184B1 (en)	1983-11-30
CH652117A5 (en)	1985-10-31
PL136242B1 (en)	1986-02-28
MY8800048A (en)	1988-12-31
NL8201347A (en)	1982-11-01
CS244672B2 (en)	1986-08-14
FI821197A0 (en)	1982-04-05
IE820481L (en)	1982-10-06
ES8406413A1 (en)	1984-08-01
NO156785B (en)	1987-08-17
UA7838A1 (en)	1995-12-26
YU44253B (en)	1990-04-30
YU75082A (en)	1985-08-31
PL139120B1 (en)	1986-12-31
SU1482522A3 (en)	1989-05-23
NZ200178A (en)	1985-07-31
PT74580A (en)	1982-04-01
DK161770B (en)	1991-08-12
UA7589A1 (en)	1995-09-29
ES8407002A1 (en)	1984-08-16
AT382612B (en)	1987-03-25
FI77223C (en)	1989-02-10
GEP19970661B (en)	1997-01-04
NO821087L (en)	1982-10-07
CA1248955A (en)	1989-01-17
ES8403097A1 (en)	1984-03-01
GR76697B (en)	1984-08-28
PL235832A1 (en)	1983-09-12
IN155773B (en)	1985-03-09
FR2504920A1 (en)	1982-11-05
BG40651A3 (en)	1986-01-15
PL240079A1 (en)	1983-09-12
ES511152A0 (en)	1983-04-16
KE3753A (en)	1987-10-02
LU84070A1 (en)	1983-06-07
NO156785C (en)	1987-11-25
GB2098602B (en)	1984-08-22
FR2504920B1 (en)	1985-06-28
ATA132582A (en)	1986-08-15
GB2098602A (en)	1982-11-24
DK146482A (en)	1982-10-07
DE3212682A1 (en)	1982-10-21
ZW4982A1 (en)	1982-11-03
AU8221382A (en)	1982-10-14
ES519031A0 (en)	1984-08-16
DE3212682C2 (en)	1992-03-26
RO89436A2 (en)	1986-06-30
IE52768B1 (en)	1988-02-17
HU186582B (en)	1985-08-28
ES8305678A1 (en)	1983-04-16
BG40652A3 (en)	1986-01-15
PH22762A (en)	1988-12-12
SG67287G (en)	1988-02-19
SE452611B (en)	1987-12-07
IT8248157A0 (en)	1982-04-02
RO84802A (en)	1984-09-29
SU1461372A3 (en)	1989-02-23
HK13888A (en)	1988-02-26
CY1408A (en)	1988-04-22
PT74580B (en)	1983-12-23
ES8406414A1 (en)	1984-08-01
IL65257A0 (en)	1983-12-30
SE8202166L (en)	1982-11-25
DK161770C (en)	1992-02-10
IT1235758B (en)	1992-09-28
DD208348A5 (en)	1984-05-02
CS245782A2 (en)	1985-08-15
NL192201B (en)	1996-11-01
RO84802B (en)	1984-10-30
ES519032A0 (en)	1984-03-01
AU545595B2 (en)	1985-07-18
YU44336B (en)	1990-06-30
FI821197L (en)	1982-10-07
KR900000274B1 (en)	1990-01-24
YU6385A (en)	1985-08-31
FI77223B (en)	1988-10-31
KR830010065A (en)	1983-12-26
ES519029A0 (en)	1984-08-01
NL192201C (en)	1997-03-04

Publication	Publication Date	Title
ES519029A0 (en)	1984-08-01	A PROCEDURE FOR PREPARING DERIVATIVES OF PHENYLCYCLOBUTANE (AS A DIVISIONAL OF PATENT NUMBER 511.152)
ES521527A0 (en)	1984-08-01	PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF ARILFENILICO ETHER. (AS DIVISIONAL OF THE PATENT NUMBER 512.067)
ES522450A0 (en)	1984-08-01	A PROCEDURE FOR THE PRODUCTION OF A CONDENSED FENILURAZOLE (AS A DIVISIONAL OF PATENT NUMBER 515,806)
ES548073A0 (en)	1986-04-01	A PROCEDURE FOR THE PREPARATION OF 2,4-DISSTITUTED TIAZOL DERIVATIVES
ES480149A0 (en)	1980-11-01	A PROCEDURE FOR THE PREPARATION OF NEW OXYGENATED CYCLE DERIVATIVES. (AS DIVISIONAL OF PATENT NUMBER 480.149)
ES512852A0 (en)	1983-03-01	"A PROCEDURE FOR PREPARING NEW DERIVATIVES OF N-DIHYDROTIAZOLYL-3-QUINOLEIN-CARBOXAMIDE".
ES543517A0 (en)	1987-11-01	PROCEDURE FOR PREPARING A DERIVATIVE OF 1,3-OXAZOLIDINE-2-ONA.
NO162718C (en)	1990-02-07	PROCEDURE FOR PREPARING BIS- (BETA (3,5-DIBUTYL-4-HYDROXYBENZYL) -METHYL-CARBOXYTHYL) SULPHIDE.
ES540748A0 (en)	1986-05-16	A PROCEDURE FOR THE PREPARATION OF NEW 2,5-DIARIL-TETRAHIDROTIOFENOS AND ANALOGS THEREOF.
ES525668A0 (en)	1985-02-01	A PROCEDURE FOR PRODUCING DERIVATIVES OF DIHYDROPIRAZOLE (3,4-B) PIRIDINE
ES500032A0 (en)	1982-06-01	A PROCEDURE FOR THE PREPARATION OF ACID DERIVATIVES 7-OXO-1-AZABICICLO (3,2,0) HEPT-2-EN-2-CARBOXILICO.
ES543997A0 (en)	1987-04-01	A PROCEDURE FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES.
ES539592A0 (en)	1986-02-16	A PROCEDURE FOR THE PREPARATION OF NEW 1,4-DIHYDROPYRIDINE DERIVATIVES.
ES527906A0 (en)	1984-08-01	PROCEDURE FOR THE PREPARATION OF PYRIMIDINONES (AS A DIVISIONAL OF PATENT NUMBER 522.898)
ES487565A0 (en)	1980-11-01	A PROCEDURE FOR THE PREPARATION OF NEW TRICYCLIC DERIVATIVES CAGE. (AS DIVISIONAL OF PATENT NUMBER 479.572)
ES508152A0 (en)	1983-02-16	"A PROCEDURE FOR THE PREPARATION OF NEW OXODIAZOLOPIRIMIDINE DERIVATIVES".
ES527155A0 (en)	1984-08-01	PROCEDURE FOR THE PREPARATION OF N-PTERIDINYL-UREAS (AS DIVISIONAL OF PATENT NUMBER 521.331)
ES508346A0 (en)	1982-11-16	A PROCEDURE FOR THE PREPARATION OF ACID DERIVATIVES 2 BETA-CHLOROMETIL-2 ALFA-METILPENAM-3 ALFA-CARBOXILICO.
ES520624A0 (en)	1984-04-01	A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 3-CXA-1-AZABICICLO (4,2,0) OCTANO.
ES513398A0 (en)	1983-03-01	"A PROCEDURE FOR PREPARING DERIVATIVES OF DIALCOHILPIRAZOL".
ES504525A0 (en)	1982-11-16	A PROCEDURE FOR THE PREPARATION OF PYROLE (3,4-D) (2) BENZACEPINES
ES522063A0 (en)	1984-09-01	A PROCEDURE FOR THE PREPARATION OF DEXTROGIROS ISOMERS OF DERIVATIVES OF 1-AZABICICLO (2,2,2) OCTANO.
ES487588A0 (en)	1980-11-01	PROCEDURE FOR THE PREPARATION OF DITIOCARBAMATES. (AS DIVISIONAL OF PATENT NUMBER 486050)
ES483052A0 (en)	1980-11-01	A PROCEDURE FOR PREPARING OCTAHIDRO AND HEXAHIDRO (B) CICLOHEPTA (D) PIRANOS. (AS DIVISIONAL OF PATENT NUMBER 478.415)
ES487564A0 (en)	1980-11-01	A PROCEDURE FOR THE PREPARATION OF NEW TRICYCLIC DERIVATIVES CAGE. (AS DIVISIONAL OF PATENT NUMBER 479.572)

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